An amino acid chain that is canonically produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof.
Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Note also that the definition excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to PR:000064867 ("protein-containing molecular entity"). Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB).
A protein that has a core domain composition consisting of a signal peptide, a variable propeptide region and a Transforming growth factor beta like domain (Pfam:PF00019), which is a cystine-knot domain containing four conserved beta strands, S1-S4, which form two antiparallel beta sheets (SI-S2 and S3-S4) interconnected by three disulfide bridges in a knot-like topology. Cystines [II-V] and [III-VI] form a ring through which the remaining disulfide bond (Cys[I-IV]) penetrates. Insertion of different variable regions into this common motif has given rise to various subclasses of the growth factor cystine-knot domain.
A type II interferon that is a translation product of the human IFNG gene or a 1:1 ortholog thereof. The core domain structure consists of an Interferon gamma domain (Pfam:PF00714) that is four-helical cytokine domain with an additional helix in one of the crossover connections. It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions.
A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (mitogens) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY.
A protein that has a core domain composition consisting of a Ras family domain (Pfam:PF00071). The small GTPases are monomeric G-proteins which function as GDP/GTP-regulated molecular switches.
A protein that has a core domain composition consisting of an N-terminal cytosolic domain, a type II transmembrane domain and a C-terminal TNF domain (Pfam:PF00229).
A TGF-beta-like cystine-knot cytokine that is related to the transforming growth factor-beta, anti-Muellerian hormone, and activin/inhibin protein families, which are all involved in the regulation of cell growth and differentiation. These are produced as dimeric precursors and undergo post-translational processing for activation, requiring cleavage to release bioactive the C-terminal peptide. BMP is involved in body patterning and morphogenesis. BMP signals are transmitted through specific type 2 and type 1 receptors.
A TGF-beta-like cystine-knot cytokine whose propeptide region is a latent associated peptide (LAP) that remains associated to the mature TGF-beta after cleavage and secretion, keeping TGF-beta inactive. TGF-beta is the founding member of the cystine-knot cytokine family, and is related to the activin/inhibin, anti-Muellerian hormone, and bone morphogenic protein families, which are all involved in the regulation of cell growth and differentiation.
A TGF-beta-like cystine-knot cytokine that is a translation product of the human NODAL gene or a 1:1 ortholog thereof. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation.
A protein that has a core domain composition consisting of a propeptide region and an Interleukin-1 / 18 domain.
A protein that is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Except for IL-17B, all other IL-17 family members are homodimers containing five highly conserved cysteine residues forming characteristic cystein-knot structure, similar to that found in the TGF-beta-like cystine-knot (PR:000000008). This class consists of six cytokines. Among them, interleukin 17A (IL-17) and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play a critical role in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses.
A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions.
Category=family. Classification based on GRAFS system. [PMID:12761335]
rhodopsin-like G-protein coupled receptor
A G-protein coupled receptor that contains the 7 transmembrane receptor (secretin family) domain (Pfam:PF00002) and has an amino-terminal segment of about 50-80 residues that contains conserved disulfide bonds and participates in ligand binding.
secretin-like G-protein coupled receptor
A protein that has a core domain composition consisting of a signal peptide, an extracellular domain with multiple Leucine rich repeat (Pfam:PF13855) domain (LRR), a cysteine-rich region, a single-pass transmembrane domain and a C-terminal cytoplasmic tail containing a TIR domain (Pfam:PF01582).
A complement peptide receptor whose active form binds C5a anaphylatoxin.
An interleukin-17 that is a translation product of the human IL25 gene or a 1:1 ortholog thereof.
An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that activate a phosphatidylinositol-calcium second messenger system.
An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that cause inhibition of adenylate cyclase.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human OPN1LW, OPN1MW, OPN1SW, RHO, OPN3, OPN4, or OPN5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof in Metazoa. The active form binds a vitamin A-based retinaldehyde chromophore through a Schiff base linkage to a Lys residue in the seventh transmembrane alpha helix.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human APLNR gene or a 1:1 ortholog thereof. The preferred ligand is apelin.
An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that cause activation of adenylate cyclase.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human NMBR, GRPR, or BRS3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds bombesin (a 14 amino acid peptide originally isolated from the skin of a frog) or its homologs. Mammalian homologs of bombesin include gastrin-releasing peptide and neuromedin-B.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human BDKRB1 or BDKRB2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds bradykinin.
A rhodopsin-like G-protein coupled receptor that in active form binds to one or more chemokines.
Category=family. Note: Only those that have been unequivocally shown to activate a G-protein coupled signaling pathway appear on the official IUPHAR list.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human CCKAR or CCKBR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds cholecystokinin (CCK).
A leukotriene receptor that in active form binds cysteinyl leukotriene.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human EDNRA or EDNRB genes, 1:1 orthologs thereof, or pro-orthologs thereof. The active form binds endothelins.
Category=family. Pro-orthology refers to, in this case, after-speciation gene duplication in the non-human species (aka 1:many orthology).
A rhodopsin-like G-protein coupled receptor whose active form binds either growth hormone secretagogues (principally ghrelin) or motilin. The motilin and ghrelin receptors are about 45% identical in amino acid sequence.
growth hormone secretagogue/motilin receptor
An interleukin-17 that is a translation product of the human IL17D gene or a 1:1 ortholog thereof.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human MC1R to MC5R genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds one or more melanocortins, the pituitary peptides ACTH and alpha-, beta-, and gamma-melanocyte-stimulating hormone.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human TACR1 to TACR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. These receptors bind tachykinin peptides--neuropeptides of 10-12 amino acids derived from the translation products of the TAC1 and TAC3 genes. Tachykinin receptors are not specific but have different affinities for the various peptides.
A Toll-like receptor that is a translation product of the human TLR2 gene or a 1:1 ortholog thereof.
Toll/interleukin-1 receptor-like protein 4
A Toll-like receptor that is a translation product of the human TLR4 gene or a 1:1 ortholog thereof.
A bradykinin receptor that is a translation product of the human BDKRB1 gene or a 1:1 ortholog thereof. The preferred ligand is bradykinin.
A bradykinin receptor that is a translation product of the human BDKRB2 gene or a 1:1 ortholog thereof. The preferred ligand is bradykinin.
A melanocortin receptor that is a translation product of the human MC2R gene or a 1:1 ortholog thereof. The preferred ligand is ACTH.
An alpha-1 adrenergic receptor that is a translation product of the human ADRA1A gene or a 1:1 ortholog thereof.
An alpha-1 adrenergic receptor that is a translation product of the human ADRA1B gene or a 1:1 ortholog thereof.
An alpha-1 adrenergic receptor that is a translation product of the human ADRA1D gene or a 1:1 ortholog thereof.
An alpha-2 adrenergic receptor that is a translation product of the human ADRA2A gene or a 1:1 ortholog thereof.
An alpha-2 adrenergic receptor that is a translation product of the human ADRA2B gene or a 1:1 ortholog thereof.
An alpha-2 adrenergic receptor that is a translation product of the human ADRA2C gene or a 1:1 ortholog thereof.
A beta adrenergic receptor that is a translation product of the human ADRB1 gene or a 1:1 ortholog thereof.
A beta adrenergic receptor that is a translation product of the human ADRB2 gene or a 1:1 ortholog thereof.
A beta adrenergic receptor that is a translation product of the human ADRB3 gene or a 1:1 ortholog thereof.
A chemokine receptor that is a translation product of the human CCR1 or CCR3 genes, the mouse CCR1L1 gene, 1:1 orthologs thereof, or a semi-ortholog thereof.
A chemokine receptor that is a translation product of the human CCR2 gene or a 1:1 ortholog thereof. The preferred ligands include CCL2, CCL7, CCL8, CCL13.
monocyte chemoattractant protein 1 receptor
A chemokine receptor that is a translation product of the human CCR6 gene or a 1:1 ortholog thereof. The preferred ligand is CCL20.
A chemokine receptor that is a translation product of the human CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21.
EBV-induced G-protein coupled receptor 1
epstein-Barr virus-induced G-protein coupled receptor 1
A chemokine receptor that is a translation product of the human CX3CR1 gene or a 1:1 ortholog thereof. The preferred ligand is CX3CL1.
A chemokine receptor that is a translation product of the human CXCR4 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL12.
leukocyte-derived seven transmembrane domain receptor
A chemokine receptor that is a translation product of the human XCR1 gene or a 1:1 ortholog thereof. The preferred ligands are XCL1 and XCL2.
An endothelin receptor that is a translation product of the human EDNRA gene or a 1:1 ortholog thereof. The active form binds endothelin 1 (ET-1) and ET-2 with much higher affinity than ET-3.
A bombesin receptor that is a translation product of the human GRPR gene or a 1:1 ortholog thereof. The preferred ligand is gastrin releasing peptide.
A growth hormone secretagogue/motilin receptor that is a translation product of the human GHSR gene or a 1:1 ortholog thereof. Although its preferred ligand is ghrelin, it also binds other growth hormone releasing peptides and some nonpeptide ligands.
A growth hormone secretagogue/motilin receptor that is a translation product of the human MLNR gene or a 1:1 ortholog thereof. The preferred ligand is motilin, an intestinal peptide that stimulates contraction of gut smooth muscle.
An animal opsin that is a translation product of the human RHO gene or a 1:1 ortholog thereof.
A chemokine receptor CCR1/3/1L that is a translation product of the human CCR3 gene or a 1:1 ortholog thereof.
macrophage inflammatory protein 1-alpha receptor-like 2
A G-protein coupled receptor with core architecture consisting of an Fz domain (Pfam:PF01392), also known as Frizzled CRD (cysteine rich domain), followed by a Frizzled/Smoothened family membrane region (Pfam:PF01534), which includes 7 transmembrane helices, and a cytoplasmic domain containing the motif Lys-Thr-x-x-x-Trp. They generally function as cell-surface receptors for Wnts.
frizzled-like G-protein coupled receptor
A protein that is a translation product of the human IL7 gene or a 1:1 ortholog thereof.
A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues.
A protein with a core domain architecture consisting of an N-terminal Interleukin 10 (Pfam:PF00726) domain.
A protein that is a stand alone version of the Ammonium Transporter Family domain in vertebrates. This protein is related to the ammonium transporters in fungi and bacteria. In mammals, this protein defines the Rh blood group antigens.
A protein with an extracellular region containing three copies of the Immunoglobulin domain (Pfam:PF00047), a single transmembrane region, and an intracellular region containing a Protein tyrosine kinase domain (Pfam:PF07714). Its active form binds fibroblast growth factor (FGF). FGFs and its receptor comprise a signaling system that is conserved throughout metazoan evolution.
A protein that is a translation product of the human CSF3R gene or a 1:1 ortholog thereof. The active receptor is a homodimer which can bind G-CSF and transduce G-CSF-triggered growth signals into cells. Its extracellular domain contains a sequence of about 200 amino acids which can be found in various cytokine receptors. In addition, it contains an immunoglobulin-like domain and three fibronectin type III domains.
granulocyte colony-stimulating factor receptor
A protein with a core domain architecture consisting of an Intercellular adhesion molecule (ICAM), N-terminal domain (Pfam:PF03921), a type of Ig-like domain, and four copies of the Immunoglobulin domain (Pfam:PF00047), most of which are not detected by Pfam.
A protein that is a translation product of the human IL11 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human IL12A gene or a 1:1 ortholog thereof. It associates with interleukin-12 subunit beta to form the interleukin-23. Interleukin-12 subunit alpha associates with interleukin-27 subunit beta to form the interleukin-35.
cytotoxic lymphocyte maturation factor 35 kDa subunit
A protein that is a translation product of the human IL12B gene or a 1:1 ortholog thereof. Interleukin-12 subunit beta associates with interleukin-12 subunit alpha or interleukin-23 subunit alpha to form the interleukin-23.
cytotoxic lymphocyte maturation factor 40 kDa subunit
A protein that is a translation product of the human IL13 gene or a 1:1 ortholog thereof. Interleukin-13 is a pleiotropic cytokine which may be important in the regulation of the inflammatory and immune responses. It inhibits inflammatory cytokine production and synergises with IL-2 in regulating interferon-gamma synthesis. The sequences of IL-4 and IL-13 are distantly related.
A protein that is a translation product of the human IL15 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human IL16 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human IL18 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human IL2 gene or a 1:1 ortholog thereof. Interleukin-2 has a dual role in maintaining tolerance and contributing to immunity.
A protein that is a translation product of the human IL21 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human IL22 gene or a 1:1 ortholog thereof.
IL-10-related T-cell-derived-inducible factor
A protein that is a translation product of the human IL3 gene or a 1:1 ortholog thereof.
multipotential colony-stimulating factor
A protein that is a translation product of the human IL33 gene or a 1:1 ortholog thereof.
nuclear factor from high endothelial venules
A protein that is a translation product of the human IL4 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human IL5 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human IL6 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human CXCL8 gene or a 1:1 ortholog thereof.
monocyte-derived neutrophil chemotactic factor
monocyte-derived neutrophil-activating peptide
A protein that is a translation product of the human IL9 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human IL9R gene or a 1:1 ortholog thereof.
A histamine receptor that is a translation product of the human HRH1 gene or a 1:1 ortholog thereof.
Category=gene. Note: The preferred ligand is histamine. This receptor mediates smooth muscle contraction, NO formation, increased vascular permeability, and other diverse effects. [PMID:9311023]
A histamine receptor that is a translation product of the human HRH2 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor mediates smooth muscle relaxation, gastric acid secretion, and other diverse effects.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human KISS1R gene or a 1:1 ortholog thereof. The preferred ligands are peptides of 10-54 residues derived from the metastasis-suppressor KiSS-1 protein.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human FPR1, FPR2, or FPR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds N-formyl methionyl peptides.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human ADORA1, ADORA2A, ADORA2B, or ADORA3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds adenosine.
An erythrocyte membrane protein Rh that is a translation product of the human RHD gene or a 1:1 ortholog thereof.
A fibroblast growth factor receptor that is a translation product of the human FGFR2 gene or a 1:1 ortholog thereof.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human GALR1 to GALR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds the neuropeptide galanin.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human FSHR, LHCGR, or TSHR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds glycoprotein hormones (thyrotropin, follitropin, lutropin, choriogonadotropin).
A rhodopsin-like G-protein coupled receptor that is a translation product of the human GNRHR or GNRHR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds gonadotropin-releasing hormone I or II.
An intercellular adhesion molecule 1/3 that is a translation product of the human ICAM3 gene or a 1:1 ortholog thereof.
Category=gene. This gene has been found in primates and Bos taurus, but not in mouse and rat.
A class 2 cytokine, IL-10 type that is a translation product of the human IL10 gene or a 1:1 ortholog thereof.
Category=gene. Note: Active interleukin-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells. Structurally, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulfide bonds.
A class 2 cytokine, IL-10 type that is a translation product of the human IL19 gene or a 1:1 ortholog thereof.
melanoma differentiation-associated protein-like protein
A class 2 cytokine, IL-10 type that is a translation product of the human IL20 gene or a 1:1 ortholog thereof.
A class 2 cytokine, IL-10 type that is a translation product of the human IL24 gene or a 1:1 ortholog thereof.
melanoma differentiation-associated gene 7 protein
suppression of tumorigenicity 16 protein
A class 2 cytokine, IL-10 type that is a translation product of the human IL26 gene or a 1:1 ortholog thereof.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human CHRM1 to CHRM5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
Category=family. Note: The active form binds the neurotransmitter acetylcholine. They are more sensitive to muscarine than to nicotine.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human NMUR1 or NMUR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
Category=family. Note: The active form binds the neuropeptide neuromedin-U.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human OPRD1, OPRK1, OPRM1, or OPRL1 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
Category=family. Note: The active form binds opioids.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human QRFPR gene or a 1:1 ortholog thereof.
Category=gene. Note: This receptor is expressed at high levels in brain and retina and at moderate levels in the heart, kidney, testis and thyroid.
pyroglutamylated RF-amide peptide receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human HCRTR1 or HCRTR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
Category=family. Note: The active form binds the neuropeptide hormone orexin (hypocretin).
A rhodopsin-like G-protein coupled receptor that is a translation product of the human PRLHR gene or a 1:1 ortholog thereof.
A prostanoid receptor that is a translation product of the human PTGER4 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2. This receptor is not closely related to other prostaglandin E2 receptors.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human PTGDR, PTGDR2, PTGER1 to PTGER4, PTGFR, PTGIR, or TBXA2R genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds prostanoids (prostaglandins and thromboxanes).
A rhodopsin-like G-protein coupled receptor that is a translation product of the human F2R, or F2RL1 to F2RL3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds trypsin-related proteinases. The proteinase cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human SSTR1 to SSTR5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds somatostatin.
A thyrotropin-releasing hormone receptor that is a translation product of the human TRHR gene or a 1:1 ortholog thereof. The preferred ligand is thyrotropin-releasing hormone.
thyrotropin-releasing hormone receptor type 1
A rhodopsin-like G-protein coupled receptor that is a translation product of the human AVPR1A, AVPR1B, AVPR2, or OXTR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. These receptors bind vasopressin or oxytocin or related nonapeptides.
A histamine receptor that is a translation product of the human HRH3 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor mediates inhibition of gastric acid release, inhibition of neurotransmitter release, and other diverse effects.
A histamine receptor that is a translation product of the human HRH4 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor is expressed primarily in the bone marrow and eosinophils but also in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node.
An opioid receptor protein that is a translation product of the human OPRD1 gene or a 1:1 ortholog thereof. The preferred ligands are enkephalins.
An opioid receptor protein that is a translation product of the human OPRK1 gene or a 1:1 ortholog thereof. The preferred ligand is dynorphin.
A glycoprotein hormone receptor that is a translation product of the human LHCGR gene or a 1:1 ortholog thereof. The preferred ligands are lutropin (luteinizing hormone) and choriogonadotropin (choriogonadotropic hormone).
lutropin-choriogonadotropic hormone receptor
An opioid receptor protein that is a translation product of the human OPRM1 gene or a 1:1 ortholog thereof. The preferred ligands are beta-endorphin and enkephalins.
An opioid receptor protein that is a translation product of the human OPRL1 gene or a 1:1 ortholog thereof. The preferred ligand is nociceptin.
A vasopressin/oxytocin receptor that is a translation product of the human OXTR gene or a 1:1 ortholog thereof. The preferred ligand is oxytocin.
A prostanoid receptor that is a translation product of the human PTGIR gene or a 1:1 ortholog thereof. The preferred ligand is prostacyclin (prostaglandin I2, PGI2). This receptor is widely distributed in blood platelets, vascular smooth muscle and nerve cells.
A prostanoid receptor that is a translation product of the human PTGDR gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin D2 (PGD2). This receptor is found mainly in blood platelets, vascular smooth muscle, and nervous tissue. It is the least upiquitous of the prostanoid receptors, almost always occurring in association with other prostanoid receptor types.
A prostanoid receptor that is a translation product of the human PTGER1 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor has limited expression, although it is more evident in rodents than in other mammals.
A prostanoid receptor that is a translation product of the human PTGER2 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor is expressed mediates various effects, including relaxation of vascular smooth muscles, nonacid secretion from epithelial cells, inhibition of mediator release from mast cells and basophils, and activation of sensory afferent nerves.
A prostanoid receptor that is a translation product of the human PTGER3 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor is the most ubiquitous of the prostaglandin E2 receptors, mediating contraction of gastrointestinal, uterine, and vascular smooth muscle, inhibition of neurotransmitter release from autonomic nerves, inhibition of lipolysis in adipocytes, inhibition of acid secretion from gastric mucosa, and inhibition of water reabsorption in kidney.
A prostanoid receptor that is a translation product of the human PTGFR gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin F2a. This receptor is particularly prevalent in the corpus luteum, but is expressed in other tissues also.
A proteinase-activated receptor that is a translation product of the human F2R gene or a 1:1 ortholog thereof. It is activated by thrombin, which cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity.
A prostanoid receptor that is a translation product of the human TBXA2R gene or a 1:1 ortholog thereof. The preferred ligand is thromboxane A2. This receptor is found mainly in vascular smooth muscle, where it mediates vasoconstriction, in platelets, where it mediates aggregation, and in airway smooth muscle.
A protein that has a core domain composition consisting of a Rel homology domain (RHD) (Pfam:PF00554), an IPT/TIG domain (Pfam:PF01833), six copies of the Ankyrin repeat (Pfam:PF00023), a Death domain (Pfam:PF00531) and a C-terminal PEST region.
A protein with core architecture consisting of a Small cytokines (intecrine/chemokine), interleukin-8 like (Pfam:PF00048) domain.
A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (Pfam:PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. Pfam:PF00047 is most common, but other members of the Ig domain clan, Pfam:PF07679 and Pfam:PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines.
CSF-1/PDGF receptor-type tyrosine-protein kinase
A protein with core architecture consisting of a signal sequence, a Receptor L domain (Pfam:PF01030), a Furin-like cysteine rich region (Pfam:PF00757), another Receptor L domain, a transmembrane domain, and a Protein tyrosine kinase domain (Pfam:PF07714), that may be followed by up to two YLP motifs (Pfam:PF02757).
EGF receptor type tyrosine-protein kinase
A protein with core architecture consisting of a signal sequence, followed by a Sema domain (Pfam:PF01403), three IPT/TIG domains (Pfam:PF01833), a transmembrane region, and a Protein tyrosine kinase domain (Pfam:PF07714).
HGF/MSP receptor type tyrosine-protein kinase
A protein that is a translation product of the human LIFR gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human MELTF gene or a 1:1 ortholog thereof.
membrane-bound transferrin-like protein p97
A protein that is a translation product of the human RORC gene or a 1:1 ortholog thereof.
nuclear receptor subfamily 1 group F member 3
A protein with core architecture consisting of a signal sequence,a Sema domain (Pfam:PF01403), a Plexin repeat (Pfam:PF01437), and an Ig-like domain (Pfam:PF00047, Pfam:PF07686, or Pfam:PF07679).
A protein with core architecture consisting of a fairly small cytoplasmic region, a transmembrane domain, and an extracellular domain containing a TNF(Tumour Necrosis Factor) family domain (Pfam:PF00229).
tumor necrosis factor ligand superfamily member 10/11
A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain.
vascular endothelial growth factor receptor
A C/C-C motif small inducible chemokine that is a translation product of the human CCL19 gene or a 1:1 ortholog thereof.
epstein-Barr virus-induced molecule 1 ligand chemokine
A C/C-C motif small inducible chemokine that is a translation product of the human CCL21 gene or a 1:1 ortholog thereof.
Category=gene. Three genes code for CCL21 in mouse. Ccl21b and Ccl21c genes encode identical proteins while the protein encoded by Ccl21a differs at only one position.
A C/C-C motif small inducible chemokine that is a member of a subfamily that includes eotaxin.
A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof.
A C/C-C motif small inducible chemokine that is a translation product of the human CCL5 gene or a 1:1 ortholog thereof.
A tumor necrosis factor ligand superfamily member 10/11 that is a translation product of the human TNFSF10 gene or a 1:1 ortholog thereof.
tumor necrosis factor ligand superfamily member 10
A tumor necrosis factor ligand superfamily member 10/11 that is a translation product of the human TNFSF11 gene or a 1:1 ortholog thereof.
receptor activator of nuclear factor kappa-B ligand
tumor necrosis factor ligand superfamily member 11
A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof.
vascular endothelial growth factor receptor 2
An eotaxin-like cytokine that is a translation product of the human CCL2 gene or a 1:1 ortholog thereof.
monocyte chemotactic and activating factor
platelet-derived growth factor-inducible protein JE
An eotaxin-like cytokine that is a translation product of the human CCL7 gene or a 1:1 ortholog thereof.
An AKT kinase that is a translation product of the human AKT1 gene or a 1:1 ortholog thereof.
RAC-alpha serine/threonine-protein kinase
A protein that is a translation product of the human CTNNB1 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human DYNLL1 or DYNLL2 genes, or 1:1 orthologs thereof. The protein is small (89 residues in human and mouse) with core architecture consisting of a Dynein light chain type 1 domain (Pfam:PF01221).
A lymphotoxin that is a translation product of the human LTA gene or a 1:1 ortholog thereof.
tumor necrosis factor ligand superfamily member 1
A protein that is a translation product of the human TP53 gene or a 1:1 ortholog thereof.
A protein that contains a Rel homology domain (RHD) (Pfam:PF00554) followed by an IPT/TIG domain (Pfam:PF01833).
An NFAT protein that is a translation product of the human NFATC1 gene or a 1:1 ortholog thereof.
NFAT transcription complex cytosolic component
nuclear factor of activated T-cells, cytoplasmic 1
A protein that is a stand alone version of the 14-3-3 protein (Pfam:PF00244) domain.
A protein that is a stand alone version of the Hsp70 protein (Pfam:PF00012) domain, which comprises two major regions: an N-terminal ATP-binding domain and a C-terminal substrate-binding domain.
A protein that is a translation product of the human ACR gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human ADCYAP1 gene or a 1:1 ortholog thereof.
pituitary adenylate cyclase-activating polypeptide
A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof.
30 kDa adipocyte complement-related protein
adipocyte complement-related 30 kDa protein
adipocyte, C1q and collagen domain-containing protein
adipose most abundant gene transcript 1 protein
A protein that is a translation product of the human AHR gene or a 1:1 ortholog thereof.
class E basic helix-loop-helix protein 76
A protein that is a translation product of the human APLN gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human APOA1 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human APP gene or a 1:1 ortholog thereof.
alzheimer disease amyloid A4 protein homolog
A protein that is a translation product of the human AR gene or a 1:1 ortholog thereof.
nuclear receptor subfamily 3 group C member 4
A protein that is a translation product of the human B2M gene or a 1:1 ortholog thereof.
A neurotrophin that is a translation product of the human BDNF gene or a 1:1 ortholog thereof.
A calcitonin receptor protein that is a translation product of the human CALCR gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human CALM1, CALM2, or CALM3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
Category=gene. Note: The human CALM1, CALM2, and CALM3 genes encode identical proteins.
A protein that is a translation product of the human CCK gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human CGA gene or a 1:1 ortholog thereof.
anterior pituitary glycoprotein hormones common subunit alpha
follicle-stimulating hormone alpha chain
A protein that is a translation product of the human CNTF gene or a 1:1 ortholog thereof.
A corticotropin-releasing factor receptor that is a translation product of the human CRHR1 gene or a 1:1 ortholog thereof.
corticotropin-releasing hormone receptor 1
corticotropin-releasing factor receptor 1
A corticotropin-releasing factor receptor that is a translation product of the human CRHR2 gene or a 1:1 ortholog thereof.
corticotropin-releasing hormone receptor 2
corticotropin-releasing factor receptor 2
A protein that is a translation product of the human CSF2 gene or a 1:1 ortholog thereof.
granulocyte-macrophage colony-stimulating factor
A protein that is a translation product of the human CSF3 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human CTNND2 gene or a 1:1 ortholog thereof.
neural plakophilin-related ARM-repeat protein
An eotaxin-like cytokine that is a translation product of the mouse Ccl12 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human DAG1 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human EEF2 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human EGF gene or a 1:1 ortholog thereof.
An EGF receptor type tyrosine-protein kinase that is a translation product of the human EGFR gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human EIF4E gene or a 1:1 ortholog thereof.
eukaryotic translation initiation factor 4E
A protein that is a translation product of the human EPO gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human EPOR gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human ESR1 gene or a 1:1 ortholog thereof.
nuclear receptor subfamily 3 group A member 1
A protein that is a translation product of the human FGF3 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human FGF4 gene or a 1:1 ortholog thereof.
heparin secretory-transforming protein 1
A protein that is a translation product of the human FGF5 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human FGF6 gene or a 1:1 ortholog thereof.
heparin secretory-transforming protein 2
A protein that is a translation product of the human FLNA gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human FLNB gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human FLNC gene or a 1:1 ortholog thereof.
A vascular endothelial growth factor receptor that is a translation product of the human FLT1 gene or a 1:1 ortholog thereof.
vascular endothelial growth factor receptor 1
A vascular endothelial growth factor receptor that is a translation product of the human FLT4 gene or a 1:1 ortholog thereof.
vascular endothelial growth factor receptor 3
A protein that is a translation product of the human FN1 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human GAL gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human GAST gene or a 1:1 ortholog thereof.
A glucagon-like receptor that is a translation product of the human GCGR gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human GCH1 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human GDNF gene or a 1:1 ortholog thereof.
glial cell line-derived neurotrophic factor
A protein that is a translation product of the human GHR gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human GHRH gene or a 1:1 ortholog thereof.
A glucagon-like receptor that is a translation product of the human GHRHR gene or a 1:1 ortholog thereof.
growth hormone-releasing factor receptor
growth hormone-releasing hormone receptor
A protein that is a translation product of the human GHRL gene or a 1:1 ortholog thereof.
A glucagon-like receptor that is a translation product of the human GIPR gene or a 1:1 ortholog thereof.
glucose-dependent insulinotropic polypeptide receptor
A protein that is a translation product of the human HCRT gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human HGF gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human HMGB1 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human HMGCR gene or a 1:1 ortholog thereof.
3-hydroxy-3-methylglutaryl-coenzyme A reductase
A protein that is a translation product of the human HP gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human IAPP gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human IBSP gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human IDH2 gene or a 1:1 ortholog thereof.
isocitrate dehydrogenase [NADP], mitochondrial
A protein that is a translation product of the human IFIH1 gene or a 1:1 ortholog thereof.
interferon induced with helicase C domain protein 1
interferon-induced with helicase C domain protein 1
melanoma differentiation-associated protein 5
interferon-induced helicase C domain-containing protein 1
A protein that is a translation product of the human IGF2 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human IL21R gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human IL23R gene or a 1:1 ortholog thereof.
An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human INSR gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human IGF1 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human KITLG gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human LIF gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof.
An HGF/MSP receptor type tyrosine-protein kinase that is a translation product of the human MET gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human MIF gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human MAP3K21 gene or a 1:1 ortholog thereof.
mitogen-activated protein kinase kinase kinase MLK4
mitogen-activated protein kinase kinase kinase 21
A protein that is a translation product of the human MYF5 gene or a 1:1 ortholog thereof.
class C basic helix-loop-helix protein 2
A protein that is a translation product of the human MYO1A gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human MYOG gene or a 1:1 ortholog thereof.
class C basic helix-loop-helix protein 3
A protein that is a translation product of the human MYOZ1 gene or a 1:1 ortholog thereof.
filamin-, actinin- and telethonin-binding protein
A protein that is a translation product of the human NEDD8 gene or a 1:1 ortholog thereof.
neural precursor cell expressed developmentally down-regulated protein 8
A protein that is a translation product of the human NFATC2 gene or a 1:1 ortholog thereof.
nuclear factor of activated T-cells, cytoplasmic 2
A protein that is a translation product of the human NFATC3 gene or a 1:1 ortholog thereof.
nuclear factor of activated T-cells, cytoplasmic 3
A protein that is a translation product of the human NFATC4 gene or a 1:1 ortholog thereof.
nuclear factor of activated T-cells, cytoplasmic 4
A neurotrophin that is a translation product of the human NGF gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human NPPA gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human NPY gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human NR3C1 gene or a 1:1 ortholog thereof.
nuclear receptor subfamily 3 group C member 1
A protein that is a translation product of the human NR3C2 gene or a 1:1 ortholog thereof.
nuclear receptor subfamily 3 group C member 2
A neurotrophin that is a translation product of the human NTF3 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human OSM gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human PCNA gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human PGR gene or a 1:1 ortholog thereof.
nuclear receptor subfamily 3 group C member 3
A protein that is a translation product of the human PIGR gene or a 1:1 ortholog thereof.
hepatocellular carcinoma-associated protein TB6
A protein that is a translation product of the human PLAU gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human PPY gene or a 1:1 ortholog thereof.
A somatotropin hormone family member that is a translation product of the human PRL gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human PRLR gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human PTH gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human PYY gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human RASA1 gene or a 1:1 ortholog thereof.
An angiotensinogenase that is a translation product of the human REN gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human RPS27A gene or a 1:1 ortholog thereof.
ubiquitin-ribosomal protein eS31 fusion protein
A protein that is a translation product of the human SCT gene or a 1:1 ortholog thereof.
A glucagon-like receptor that is a translation product of the human SCTR gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human SET gene or a 1:1 ortholog thereof.
A frizzled-like G-protein coupled receptor that is a translation product of the human SMO gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human STX2 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human STX3 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human STX5 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human STX6 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human TAP1 gene or a 1:1 ortholog thereof.
ATP-binding cassette sub-family B member 2
peptide transporter involved in antigen processing 1
A protein that is a translation product of the human TAP2 gene or a 1:1 ortholog thereof.
ATP-binding cassette sub-family B member 3
peptide transporter involved in antigen processing 2
A protein that is a translation product of the human TAPBP gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human TCAP gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human TF gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human TH gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human TOP1 gene or a 1:1 ortholog thereof.
A glycoprotein hormone beta chain that is a translation product of the human TSHB gene or a 1:1 ortholog thereof.
thyroid-stimulating hormone subunit beta
A protein that is a translation product of the human TTN gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human UBA52 gene or a 1:1 ortholog thereof.
ubiquitin A-52 residue ribosomal protein fusion product 1
ubiquitin-ribosomal protein eL40 fusion protein
A tandem-copy polyubiquitin that is a translation product of the human UBC gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human UBD gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human VCL gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human VDR gene or a 1:1 ortholog thereof.
nuclear receptor subfamily 1 group I member 1
A molecule that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds.
A protein that is produced as the result of proteolytic processing of a longer protein.
An interferon gamma that has been processed by proteolytic cleavage.
interferon gamma proteolytic cleavage product
A pro-interleukin-16 that has been processed by proteolytic cleavage.
pro-interleukin-16 proteolytic cleavage product
An interleukin-18 that has been processed by proteolytic cleavage.
interleukin-18 proteolytic cleavage product
An interleukin-8 that has been processed by proteolytic cleavage.
interleukin-8 proteolytic cleavage product
A proteinase-activated receptor 1 that has been processed by proteolytic cleavage.
proteinase-activated receptor 1 proteolytic cleavage product
A C-C motif chemokine 5 that has been processed by proteolytic cleavage.
C-C motif chemokine 5 proteolytic cleavage product
A tumor necrosis factor ligand superfamily member 11 that has been processed by proteolytic cleavage.
tumor necrosis factor ligand superfamily member 11 proteolytic cleavage product
An acrosin that has been processed by proteolytic cleavage.
A pituitary adenylate cyclase-activating polypeptide that has been processed by proteolytic cleavage.
pituitary adenylate cyclase-activating polypeptide proteolytic cleavage product
An aryl hydrocarbon receptor that has been processed by proteolytic cleavage.
aryl hydrocarbon receptor proteolytic cleavage product
An apolipoprotein A-I that has been processed by proteolytic cleavage.
apolipoprotein A-I proteolytic cleavage product
An amyloid-beta precursor protein that has been processed by proteolytic cleavage.
Category=modification. Requested by=Alzforum.
amyloid-beta precursor protein proteolytic cleavage product
A beta-2-microglobulin that has been processed by proteolytic cleavage.
beta-2-microglobulin proteolytic cleavage product
A neurotrophic factor BDNF precursor form that has been processed by proteolytic cleavage.
neurotrophic factor BDNF precursor form proteolytic cleavage product
A cholecystokinin that has been processed by proteolytic cleavage.
cholecystokinin proteolytic cleavage product
A dystroglycan 1 that has been processed by proteolytic cleavage.
dystroglycan 1 proteolytic cleavage product
An erythropoietin that has been processed by proteolytic cleavage.
erythropoietin proteolytic cleavage product
A fibronectin that has been processed by proteolytic cleavage.
fibronectin proteolytic cleavage product
A galanin that has been processed by proteolytic cleavage.
A gastrin that has been processed by proteolytic cleavage.
A growth hormone receptor that has been processed by proteolytic cleavage.
growth hormone receptor proteolytic cleavage product
A somatoliberin that has been processed by proteolytic cleavage.
somatoliberin proteolytic cleavage product
An appetite-regulating hormone that has been processed by proteolytic cleavage.
appetite-regulating hormone proteolytic cleavage product
A hypocretin neuropeptide precursor that has been processed by proteolytic cleavage.
hypocretin neuropeptide precursor proteolytic cleavage product
A hepatocyte growth factor that has been processed by proteolytic cleavage.
hepatocyte growth factor proteolytic cleavage product
A haptoglobin that has been processed by proteolytic cleavage.
haptoglobin proteolytic cleavage product
An islet amyloid polypeptide that has been processed by proteolytic cleavage.
islet amyloid polypeptide proteolytic cleavage product
An insulin-like growth factor 2 that has been processed by proteolytic cleavage.
insulin-like growth factor 2 proteolytic cleavage product
An insulin receptor that has been processed by proteolytic cleavage.
insulin receptor proteolytic cleavage product
An insulin-like growth factor 1 that has been processed by proteolytic cleavage.
insulin-like growth factor 1 proteolytic cleavage product
A lactotransferrin that has been processed by proteolytic cleavage.
lactotransferrin proteolytic cleavage product
A ubiquitin-like protein NEDD8 that has been processed by proteolytic cleavage.
ubiquitin-like protein NEDD8 proteolytic cleavage product
A beta-nerve growth factor that has been processed by proteolytic cleavage.
beta-nerve growth factor proteolytic cleavage product
An atrial natriuretic factor that has been processed by proteolytic cleavage.
atrial natriuretic factor proteolytic cleavage product
A neuropeptide Y that has been processed by proteolytic cleavage.
neuropeptide Y proteolytic cleavage product
A neurotrophin-3 that has been processed by proteolytic cleavage.
neurotrophin-3 proteolytic cleavage product
An oncostatin-M that has been processed by proteolytic cleavage.
oncostatin-M proteolytic cleavage product
A polymeric immunoglobulin receptor that has been processed by proteolytic cleavage.
polymeric immunoglobulin receptor proteolytic cleavage product
A urokinase-type plasminogen activator that has been processed by proteolytic cleavage.
urokinase-type plasminogen activator proteolytic cleavage product
A pancreatic polypeptide prohormone that has been processed by proteolytic cleavage.
pancreatic polypeptide prohormone proteolytic cleavage product
A parathyroid hormone that has been processed by proteolytic cleavage.
parathyroid hormone proteolytic cleavage product
A peptide YY that has been processed by proteolytic cleavage.
A secretin that has been processed by proteolytic cleavage.
A thyrotropin subunit beta that has been processed by proteolytic cleavage.
thyrotropin subunit beta proteolytic cleavage product
A protein that is a neurotrophic polypeptide factor that regulates neuronal differentiation and is essential for neuronal survival, neurite growth and plasticity. It contains a signal peptide, a propeptide, and a C-terminal Nerve growth factor family (Pfam:PF00243) domain.
A protein that contains multiple TNFR/NGFR cysteine-rich region (Pfam:PF00020) within the extracellular ligand-binding domain, a type I (single pass) transmembrane domain, and a cytoplasmic Death domain (Pfam:PF00531) required for intracellular signaling.
A protein that is a translation product of the Escherichia coli K-12 cyaA gene or a 1:1 ortholog thereof.
A protein that is a translation product of the Escherichia coli K-12 tap gene or a 1:1 ortholog thereof.
A protein that is a translation product of the Escherichia coli K-12 thrB gene or a 1:1 ortholog thereof.
A protein that binds to a specific cell surface receptor complex known as the IFN-gamma receptor (IFNGR), a complex of two IFNGR1 and two IFNGR2 chains.
Category=family. Note: Some references consider 'gamma' and 'type II' to be synonyms. This is likely because gamma is the only type II interferon identified. However, the classification criteria for each nomenclature system differ.
An Hsp70 family chaperone that contains an ATPase and HSP90 domains.
A nodal protein that has been processed by proteolytic cleavage.
nodal protein proteolytic cleavage product
A protein that consists of an Ephrin receptor ligand binding domain (Pfam:PF01404), two copies of the Fibronectin type III domain (Pfam:PF00041), and a copy of either type of SAM domain (Sterile alpha motif) (Pfam:PF00536 or Pfam:PF07647).
A protein that consists solely of an Interferon alpha/beta domain (Pfam:PF00143) and which binds to a specific cell surface receptor complex known as the IFN-alpha receptor (IFNAR), a heterodimer of IFNAR1 and IFNAR2 chains.
A class 2 cytokine, IL-10 type that binds to a specific cell surface receptor complex known as the IFN type III receptor, a heterodimer consisting of IFNLR1 and IL-10R2.
Category=family. Note: Some references consider 'lambda' and 'type III' to be synonyms. This is likely because lambda is the only type III interferon identified. However, the classification criteria for each nomenclature system differ.
A protein-containing complex that is a heterodimer of an alpha subunit (CGA) common to several glycoprotein hormones and a beta subunit (TSHB) unique to thyroid stimulating hormone.
A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites.
A protein that is a translation product of the human RIGI gene or a 1:1 ortholog thereof.
probable ATP-dependent RNA helicase DDX58
antiviral innate immune response receptor RIG-I
A protein that is a standalone version of the Hormone_1 domain (Pfam:PF00103). In the immature form, the domain is preceded by a signal peptide.
A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit.
A tandem-copy polyubiquitin that is a translation product of the human UBB gene or a 1:1 ortholog thereof.
A ubiquitin-ribosomal protein eS31 fusion protein that has been processed by proteolytic cleavage. This form is the N-terminal region consisting of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P62979, 1-76.
A polyubiquitin-C that has been processed by proteolytic cleavage to produce a protein consisting of a Ubiquitin (Pfam:PF00240) domain. There are nine copies of ubiquitin in polyubiquitin C. Example: UniProtKB:P0CG48, (1-76) or (77-152) or (153-228) or (229-304) or (305-380) or (381-456) or (457-532) or (533-608) or (609-684).
A ubiquitin-ribosomal protein eL40 fusion protein that has been processed by proteolytic cleavage. This form is the N-terminal region consisting of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P62987, 1-76.
A polyubiquitin-B that has been processed by proteolytic cleavage to produce a protein consisting of a Ubiquitin (Pfam:PF00240) domain. There are three copies of ubiquitin in polyubiquitin B. Example: UniProtKB:P0CG47, (1-76) or (77-152) or (153-228).
A proteolytic cleavage product that gives rise to a protein that corresponds to the stand-alone version of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P0CG48, 1-76.
A protein that is encoded in the genome of some Eukaryota.
A protein that contains multiple tandem copies of the Ubiquitin (Pfam:PF00240) domain within a single amino acid chain.
A protein that includes at least one phosphorylated residue.
A secretin-like G-protein coupled receptor that is a translation product of the human CRHR1 or CRHR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, or ADRB3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human CALCR or CALCRL genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human C3AR1, C5AR1, or C5AR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
A protein that has a core domain composition consisting of a signal peptide followed by a single copy of the Cys_knot (Pfam:PF00007) domain. The Cysteine knot is a protein structural motif containing three disulfide bridges.
A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide.
A secretin-like G-protein coupled receptor that is a translation product of the human GHRHR, GIPR, GLP1R, GLP2R, GCGR, or SCTR genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human HRH1 to HRH4 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
A rhodopsin-like G-protein coupled receptor that is a translation product of the human LTB4R, LTB4R2, CYSLTR1, CYSLTR2, or OXER1 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
A protein that is a translation product of the mouse Ren1 or Ren2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
A rhodopsin-like G-protein coupled receptor that has thyrotropin-releasing hormone receptor activity.
A tumor necrosis factor, TNF-like that is a translation product of the human LTA or LTB genes, or 1:1 orthologs thereof.
Category=polymer. Requested by=Reactome.