protein
type: Class
equivalent class: Class
  intersection of: amino acid chain
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0006412
  intersection of: Restriction
    on property: has gene template
    some values from: SO_0000704
subclass of: amino acid chain
subclass of: Restriction
  on property: BFO_0000051
  some values from: protein
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0006412
subclass of: Restriction
  on property: has gene template
  some values from: SO_0000704
IAO_0000115: An amino acid chain that is canonically produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof.
has exact synonym: natural protein
has narrow synonym: native protein
has OBO namespace: protein
id: PR:000000001
comment: Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Note also that the definition excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to PR:000064867 ("protein-containing molecular entity"). Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB).

Axiom
annotated source: protein
annotated property: IAO_0000115
annotated target: An amino acid chain that is canonically produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof.
has db xref: PRO:DAN
has db xref: PRO:WCB

Axiom
annotated source: protein
annotated property: hasExactSynonym
annotated target: natural protein
has db xref: PRO:DAN

Axiom
annotated source: protein
annotated property: hasNarrowSynonym
annotated target: native protein
has db xref: IEDB:BP

TGF-beta-like cystine-knot cytokine
type: Class
subclass of: protein
IAO_0000115: A protein that has a core domain composition consisting of a signal peptide, a variable propeptide region and a Transforming growth factor beta like domain (Pfam:PF00019), which is a cystine-knot domain containing four conserved beta strands, S1-S4, which form two antiparallel beta sheets (SI-S2 and S3-S4) interconnected by three disulfide bridges in a knot-like topology. Cystines [II-V] and [III-VI] form a ring through which the remaining disulfide bond (Cys[I-IV]) penetrates. Insertion of different variable regions into this common motif has given rise to various subclasses of the growth factor cystine-knot domain.
has db xref: PIRSF:PIRSF800009
has OBO namespace: protein
has related synonym: TGF-beta superfamily
id: PR:000000008
comment: Category=family.

Axiom
annotated source: TGF-beta-like cystine-knot cytokine
annotated property: IAO_0000115
annotated target: A protein that has a core domain composition consisting of a signal peptide, a variable propeptide region and a Transforming growth factor beta like domain (Pfam:PF00019), which is a cystine-knot domain containing four conserved beta strands, S1-S4, which form two antiparallel beta sheets (SI-S2 and S3-S4) interconnected by three disulfide bridges in a knot-like topology. Cystines [II-V] and [III-VI] form a ring through which the remaining disulfide bond (Cys[I-IV]) penetrates. Insertion of different variable regions into this common motif has given rise to various subclasses of the growth factor cystine-knot domain.
has db xref: PRO:CNA

interferon gamma
type: Class
subclass of: type II interferon
IAO_0000115: A type II interferon that is a translation product of the human IFNG gene or a 1:1 ortholog thereof. The core domain structure consists of an Interferon gamma domain (Pfam:PF00714) that is four-helical cytokine domain with an additional helix in one of the crossover connections. It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions.
has db xref: PIRSF:PIRSF001936
has exact synonym: IFN-gamma
has exact synonym: IFNG
has exact synonym: immune interferon
has OBO namespace: protein
id: PR:000000017
comment: Category=gene.

Axiom
annotated source: interferon gamma
annotated property: IAO_0000115
annotated target: A type II interferon that is a translation product of the human IFNG gene or a 1:1 ortholog thereof. The core domain structure consists of an Interferon gamma domain (Pfam:PF00714) that is four-helical cytokine domain with an additional helix in one of the crossover connections. It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions.
has db xref: PRO:CNA

Axiom
annotated source: interferon gamma
annotated property: hasExactSynonym
annotated target: IFNG
has db xref: PRO:DNx
has synonym type: PRO-short-label

mitogen-activated protein kinase
type: Class
subclass of: protein
IAO_0000115: A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (mitogens) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY.
has db xref: PIRSF:PIRSF501110
has exact synonym: MAPK
has OBO namespace: protein
has related synonym: kinase-related transforming protein
id: PR:000000019
comment: Category=family.

Axiom
annotated source: mitogen-activated protein kinase
annotated property: IAO_0000115
annotated target: A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (mitogens) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY.
has db xref: PRO:CNA
has db xref: Wikipedia:Mitogen-activated_protein_kinase

small GTPase
type: Class
subclass of: protein
IAO_0000115: A protein that has a core domain composition consisting of a Ras family domain (Pfam:PF00071). The small GTPases are monomeric G-proteins which function as GDP/GTP-regulated molecular switches.
has OBO namespace: protein
id: PR:000000028
comment: Category=family.

Axiom
annotated source: small GTPase
annotated property: IAO_0000115
annotated target: A protein that has a core domain composition consisting of a Ras family domain (Pfam:PF00071). The small GTPases are monomeric G-proteins which function as GDP/GTP-regulated molecular switches.
has db xref: PMID:15731001

tumor necrosis factor, TNF-like
type: Class
subclass of: protein
IAO_0000115: A protein that has a core domain composition consisting of an N-terminal cytosolic domain, a type II transmembrane domain and a C-terminal TNF domain (Pfam:PF00229).
has db xref: PIRSF:PIRSF001873
has OBO namespace: protein
id: PR:000000033
comment: Category=family.

Axiom
annotated source: tumor necrosis factor, TNF-like
annotated property: IAO_0000115
annotated target: A protein that has a core domain composition consisting of an N-terminal cytosolic domain, a type II transmembrane domain and a C-terminal TNF domain (Pfam:PF00229).
has db xref: PRO:CNA

bone morphogenetic protein
type: Class
subclass of: TGF-beta-like cystine-knot cytokine
IAO_0000115: A TGF-beta-like cystine-knot cytokine that is related to the transforming growth factor-beta, anti-Muellerian hormone, and activin/inhibin protein families, which are all involved in the regulation of cell growth and differentiation. These are produced as dimeric precursors and undergo post-translational processing for activation, requiring cleavage to release bioactive the C-terminal peptide. BMP is involved in body patterning and morphogenesis. BMP signals are transmitted through specific type 2 and type 1 receptors.
has db xref: PIRSF:PIRSF037272
has OBO namespace: protein
id: PR:000000034
comment: Category=family.

Axiom
annotated source: bone morphogenetic protein
annotated property: IAO_0000115
annotated target: A TGF-beta-like cystine-knot cytokine that is related to the transforming growth factor-beta, anti-Muellerian hormone, and activin/inhibin protein families, which are all involved in the regulation of cell growth and differentiation. These are produced as dimeric precursors and undergo post-translational processing for activation, requiring cleavage to release bioactive the C-terminal peptide. BMP is involved in body patterning and morphogenesis. BMP signals are transmitted through specific type 2 and type 1 receptors.
has db xref: PIRSF:PIRSF037272

TGF-beta
type: Class
subclass of: TGF-beta-like cystine-knot cytokine
IAO_0000115: A TGF-beta-like cystine-knot cytokine whose propeptide region is a latent associated peptide (LAP) that remains associated to the mature TGF-beta after cleavage and secretion, keeping TGF-beta inactive. TGF-beta is the founding member of the cystine-knot cytokine family, and is related to the activin/inhibin, anti-Muellerian hormone, and bone morphogenic protein families, which are all involved in the regulation of cell growth and differentiation.
has db xref: PIRSF:PIRSF001787
has exact synonym: transforming growth factor beta
has OBO namespace: protein
id: PR:000000046
comment: Category=family.

Axiom
annotated source: TGF-beta
annotated property: IAO_0000115
annotated target: A TGF-beta-like cystine-knot cytokine whose propeptide region is a latent associated peptide (LAP) that remains associated to the mature TGF-beta after cleavage and secretion, keeping TGF-beta inactive. TGF-beta is the founding member of the cystine-knot cytokine family, and is related to the activin/inhibin, anti-Muellerian hormone, and bone morphogenic protein families, which are all involved in the regulation of cell growth and differentiation.
has db xref: PIRSF:PIRSF001787

nodal protein
type: Class
subclass of: TGF-beta-like cystine-knot cytokine
IAO_0000115: A TGF-beta-like cystine-knot cytokine that is a translation product of the human NODAL gene or a 1:1 ortholog thereof. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation.
has db xref: PIRSF:PIRSF037400
has exact synonym: NODAL
has OBO namespace: protein
id: PR:000000105
comment: Category=gene.

Axiom
annotated source: nodal protein
annotated property: IAO_0000115
annotated target: A TGF-beta-like cystine-knot cytokine that is a translation product of the human NODAL gene or a 1:1 ortholog thereof. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation.
has db xref: PRO:CNA

Axiom
annotated source: nodal protein
annotated property: hasExactSynonym
annotated target: NODAL
has db xref: PRO:DNx
has synonym type: PRO-short-label

interleukin-1
type: Class
subclass of: protein
IAO_0000115: A protein that has a core domain composition consisting of a propeptide region and an Interleukin-1 / 18 domain.
has db xref: PIRSF:PIRSF001937
has OBO namespace: protein
id: PR:000001091
comment: Category=family.

Axiom
annotated source: interleukin-1
annotated property: IAO_0000115
annotated target: A protein that has a core domain composition consisting of a propeptide region and an Interleukin-1 / 18 domain.
has db xref: PMID:8001745
has db xref: PRO:CNA

interleukin-17
type: Class
subclass of: protein
IAO_0000115: A protein that is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Except for IL-17B, all other IL-17 family members are homodimers containing five highly conserved cysteine residues forming characteristic cystein-knot structure, similar to that found in the TGF-beta-like cystine-knot (PR:000000008). This class consists of six cytokines. Among them, interleukin 17A (IL-17) and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play a critical role in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses.
has db xref: PIRSF:PIRSF003430
has exact synonym: IL17
has exact synonym: fam:IL-17
has OBO namespace: protein
id: PR:000001092
comment: Category=family.

Axiom
annotated source: interleukin-17
annotated property: IAO_0000115
annotated target: A protein that is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Except for IL-17B, all other IL-17 family members are homodimers containing five highly conserved cysteine residues forming characteristic cystein-knot structure, similar to that found in the TGF-beta-like cystine-knot (PR:000000008). This class consists of six cytokines. Among them, interleukin 17A (IL-17) and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play a critical role in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses.
has db xref: PMID:17982105
has db xref: PMID:18280574

Axiom
annotated source: interleukin-17
annotated property: hasExactSynonym
annotated target: fam:IL-17
has db xref: PRO:DAN
has synonym type: PRO-short-label

rhodopsin-like G-protein coupled receptor
type: Class
subclass of: G-protein coupled receptor
IAO_0000115: A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions.
has db xref: IUPHAR:GPCRListForward?class=A
has db xref: PIRSF:PIRSF800006
has exact synonym: class 1 G-protein coupled receptor
has exact synonym: class A G-protein coupled receptor
has exact synonym: fam:rhodopsin
has OBO namespace: protein
id: PR:000001094
comment: Category=family. Classification based on GRAFS system. [PMID:12761335]

Axiom
annotated source: rhodopsin-like G-protein coupled receptor
annotated property: IAO_0000115
annotated target: A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions.
has db xref: PMID:12761335
has db xref: PRO:DAN
has db xref: PRO:WCB

Axiom
annotated source: rhodopsin-like G-protein coupled receptor
annotated property: hasExactSynonym
annotated target: class 1 G-protein coupled receptor
has db xref: PMID:15914470

Axiom
annotated source: rhodopsin-like G-protein coupled receptor
annotated property: hasExactSynonym
annotated target: class A G-protein coupled receptor
has db xref: IUPHAR:GPCRListForward?class=A

Axiom
annotated source: rhodopsin-like G-protein coupled receptor
annotated property: hasExactSynonym
annotated target: fam:rhodopsin
has db xref: PRO:DAN
has synonym type: PRO-short-label

secretin-like G-protein coupled receptor
type: Class
subclass of: G-protein coupled receptor
IAO_0000115: A G-protein coupled receptor that contains the 7 transmembrane receptor (secretin family) domain (Pfam:PF00002) and has an amino-terminal segment of about 50-80 residues that contains conserved disulfide bonds and participates in ligand binding.
has broad synonym: class 2 G-protein coupled receptor
has db xref: IUPHAR:GPCRListForward?class=B
has exact synonym: class B G-protein coupled receptor
has exact synonym: fam:secretin
has exact synonym: subfamily B1 G-protein coupled receptor
has OBO namespace: protein
id: PR:000001095
comment: Category=family. Classification based on GRAFS system. [PMID:12761335]

Axiom
annotated source: secretin-like G-protein coupled receptor
annotated property: IAO_0000115
annotated target: A G-protein coupled receptor that contains the 7 transmembrane receptor (secretin family) domain (Pfam:PF00002) and has an amino-terminal segment of about 50-80 residues that contains conserved disulfide bonds and participates in ligand binding.
has db xref: PMID:15862553
has db xref: PRO:WCB

Axiom
annotated source: secretin-like G-protein coupled receptor
annotated property: hasBroadSynonym
annotated target: class 2 G-protein coupled receptor
has db xref: PMID:15914470

Axiom
annotated source: secretin-like G-protein coupled receptor
annotated property: hasExactSynonym
annotated target: class B G-protein coupled receptor
has db xref: IUPHAR:GPCRListForward?class=B

Axiom
annotated source: secretin-like G-protein coupled receptor
annotated property: hasExactSynonym
annotated target: fam:secretin
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: secretin-like G-protein coupled receptor
annotated property: hasExactSynonym
annotated target: subfamily B1 G-protein coupled receptor
has db xref: PMID:11790261

Toll-like receptor
type: Class
subclass of: protein
IAO_0000115: A protein that has a core domain composition consisting of a signal peptide, an extracellular domain with multiple Leucine rich repeat (Pfam:PF13855) domain (LRR), a cysteine-rich region, a single-pass transmembrane domain and a C-terminal cytoplasmic tail containing a TIR domain (Pfam:PF01582).
has db xref: PIRSF:PIRSF800008
has exact synonym: fam:TLR
has OBO namespace: protein
id: PR:000001096
comment: Category=family.

Axiom
annotated source: Toll-like receptor
annotated property: IAO_0000115
annotated target: A protein that has a core domain composition consisting of a signal peptide, an extracellular domain with multiple Leucine rich repeat (Pfam:PF13855) domain (LRR), a cysteine-rich region, a single-pass transmembrane domain and a C-terminal cytoplasmic tail containing a TIR domain (Pfam:PF01582).
has db xref: PMID:11022119

Axiom
annotated source: Toll-like receptor
annotated property: hasExactSynonym
annotated target: fam:TLR
has db xref: PRO:DAN
has synonym type: PRO-short-label

C5a anaphylatoxin chemotactic receptor
type: Class
subclass of: complement peptide receptor
IAO_0000115: A complement peptide receptor whose active form binds C5a anaphylatoxin.
has db xref: PIRSF:PIRSF038566
has OBO namespace: protein
id: PR:000001105
comment: Category=family.

Axiom
annotated source: C5a anaphylatoxin chemotactic receptor
annotated property: IAO_0000115
annotated target: A complement peptide receptor whose active form binds C5a anaphylatoxin.
has db xref: PRO:WCB

interleukin-25
type: Class
subclass of: interleukin-17
IAO_0000115: An interleukin-17 that is a translation product of the human IL25 gene or a 1:1 ortholog thereof.
has exact synonym: IL-17E
has exact synonym: IL-25
has exact synonym: IL25
has exact synonym: interleukin-17E
has OBO namespace: protein
has related synonym: IL17E
has related synonym: UNQ3120/PRO10272
id: PR:000001113
comment: Category=gene.

Axiom
annotated source: interleukin-25
annotated property: IAO_0000115
annotated target: An interleukin-17 that is a translation product of the human IL25 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-25
annotated property: hasExactSynonym
annotated target: IL25
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-25
annotated property: hasRelatedSynonym
annotated target: IL17E
has synonym type: Gene-based

Axiom
annotated source: interleukin-25
annotated property: hasRelatedSynonym
annotated target: UNQ3120/PRO10272
has synonym type: Gene-based

alpha-1 adrenergic receptor
type: Class
subclass of: adrenoceptor protein
IAO_0000115: An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that activate a phosphatidylinositol-calcium second messenger system.
has db xref: PIRSF:PIRSF038550
has OBO namespace: protein
id: PR:000001115
comment: Category=family.

Axiom
annotated source: alpha-1 adrenergic receptor
annotated property: IAO_0000115
annotated target: An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that activate a phosphatidylinositol-calcium second messenger system.
has db xref: PRO:WCB
has db xref: Wikipedia:Adrenergic_receptor

alpha-2 adrenergic receptor
type: Class
subclass of: adrenoceptor protein
IAO_0000115: An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that cause inhibition of adenylate cyclase.
has db xref: PIRSF:PIRSF038554
has OBO namespace: protein
id: PR:000001116
comment: Category=family.

Axiom
annotated source: alpha-2 adrenergic receptor
annotated property: IAO_0000115
annotated target: An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that cause inhibition of adenylate cyclase.
has db xref: PRO:WCB
has db xref: Wikipedia:Adrenergic_receptor

animal opsin
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
subclass of: eukaryotic protein
subclass of: Restriction
  on property: RO_0002160
  some values from: NCBITaxon_33208
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human OPN1LW, OPN1MW, OPN1SW, RHO, OPN3, OPN4, or OPN5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof in Metazoa. The active form binds a vitamin A-based retinaldehyde chromophore through a Schiff base linkage to a Lys residue in the seventh transmembrane alpha helix.
has db xref: IUPHARfam:975
has db xref: PIRSF:PIRSF038544
has exact synonym: opsin receptor
has exact synonym: type II opsin
has OBO namespace: protein
id: PR:000001119
comment: Category=family.

Axiom
annotated source: animal opsin
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human OPN1LW, OPN1MW, OPN1SW, RHO, OPN3, OPN4, or OPN5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof in Metazoa. The active form binds a vitamin A-based retinaldehyde chromophore through a Schiff base linkage to a Lys residue in the seventh transmembrane alpha helix.
has db xref: PRO:WCB
has db xref: PRO:XQ
has db xref: Wikipedia:Opsin

Axiom
annotated source: animal opsin
annotated property: hasExactSynonym
annotated target: opsin receptor
has db xref: IUPHARfam:975

Axiom
annotated source: animal opsin
annotated property: hasExactSynonym
annotated target: type II opsin
has db xref: Wikipedia:Opsin

apelin receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human APLNR gene or a 1:1 ortholog thereof. The preferred ligand is apelin.
has db xref: IUPHARobj:36
has db xref: PIRSF:PIRSF038558
has exact synonym: APLNR
has exact synonym: G-protein coupled receptor APJ
has exact synonym: G-protein coupled receptor HG11
has exact synonym: angiotensin receptor-like 1
has OBO namespace: protein
has related synonym: AGTRL1
has related synonym: APJ
has related synonym: MSR
id: PR:000001120
comment: Category=gene.

Axiom
annotated source: apelin receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human APLNR gene or a 1:1 ortholog thereof. The preferred ligand is apelin.
has db xref: PRO:WCB

Axiom
annotated source: apelin receptor
annotated property: hasExactSynonym
annotated target: APLNR
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: apelin receptor
annotated property: hasRelatedSynonym
annotated target: AGTRL1
has synonym type: Gene-based

Axiom
annotated source: apelin receptor
annotated property: hasRelatedSynonym
annotated target: APJ
has synonym type: Gene-based

beta adrenergic receptor
type: Class
subclass of: adrenoceptor protein
IAO_0000115: An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that cause activation of adenylate cyclase.
has db xref: PIRSF:PIRSF038556
has OBO namespace: protein
id: PR:000001121
comment: Category=family.

Axiom
annotated source: beta adrenergic receptor
annotated property: IAO_0000115
annotated target: An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that cause activation of adenylate cyclase.
has db xref: PRO:WCB
has db xref: Wikipedia:Adrenergic_receptor

bombesin receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human NMBR, GRPR, or BRS3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds bombesin (a 14 amino acid peptide originally isolated from the skin of a frog) or its homologs. Mammalian homologs of bombesin include gastrin-releasing peptide and neuromedin-B.
has db xref: IUPHARfam:9
has db xref: PIRSF:PIRSF038623
has OBO namespace: protein
id: PR:000001122
comment: Category=family.

Axiom
annotated source: bombesin receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human NMBR, GRPR, or BRS3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds bombesin (a 14 amino acid peptide originally isolated from the skin of a frog) or its homologs. Mammalian homologs of bombesin include gastrin-releasing peptide and neuromedin-B.
has db xref: PRO:WCB
has db xref: PRO:XQ

bradykinin receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human BDKRB1 or BDKRB2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds bradykinin.
has db xref: IUPHARfam:10
has db xref: PIRSF:PIRSF038572
has OBO namespace: protein
id: PR:000001123
comment: Category=family.

Axiom
annotated source: bradykinin receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human BDKRB1 or BDKRB2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds bradykinin.
has db xref: PRO:WCB
has db xref: PRO:XQ

chemokine receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that in active form binds to one or more chemokines.
has db xref: IUPHARfam:14
has db xref: PIRSF:PIRSF038545
has OBO namespace: protein
id: PR:000001128
comment: Category=family. Note: Only those that have been unequivocally shown to activate a G-protein coupled signaling pathway appear on the official IUPHAR list.

Axiom
annotated source: chemokine receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that in active form binds to one or more chemokines.
has db xref: PMID:12037138
has db xref: PRO:WCB
has db xref: PRO:XQ

cholecystokinin receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human CCKAR or CCKBR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds cholecystokinin (CCK).
has db xref: IUPHARfam:15
has db xref: PIRSF:PIRSF038581
has exact synonym: fam:CCK_R
has OBO namespace: protein
id: PR:000001130
comment: Category=family.

Axiom
annotated source: cholecystokinin receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human CCKAR or CCKBR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds cholecystokinin (CCK).
has db xref: PRO:WCB
has db xref: PRO:XQ

Axiom
annotated source: cholecystokinin receptor
annotated property: hasExactSynonym
annotated target: fam:CCK_R
has db xref: PRO:DAN
has synonym type: PRO-short-label

cysteinyl leukotriene receptor
type: Class
subclass of: leukotriene receptor
IAO_0000115: A leukotriene receptor that in active form binds cysteinyl leukotriene.
has db xref: PIRSF:PIRSF038618
has OBO namespace: protein
id: PR:000001131
comment: Category=family.

Axiom
annotated source: cysteinyl leukotriene receptor
annotated property: IAO_0000115
annotated target: A leukotriene receptor that in active form binds cysteinyl leukotriene.
has db xref: PRO:WCB

endothelin receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human EDNRA or EDNRB genes, 1:1 orthologs thereof, or pro-orthologs thereof. The active form binds endothelins.
has db xref: IUPHARfam:21
has db xref: PIRSF:PIRSF001842
has OBO namespace: protein
id: PR:000001133
comment: Category=family. Pro-orthology refers to, in this case, after-speciation gene duplication in the non-human species (aka 1:many orthology).

Axiom
annotated source: endothelin receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human EDNRA or EDNRB genes, 1:1 orthologs thereof, or pro-orthologs thereof. The active form binds endothelins.
has db xref: PRO:WCB
has db xref: PRO:XQ

growth hormone secretagogue/motilin receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor whose active form binds either growth hormone secretagogues (principally ghrelin) or motilin. The motilin and ghrelin receptors are about 45% identical in amino acid sequence.
has db xref: PIRSF:PIRSF038641
has OBO namespace: protein
id: PR:000001134
comment: Category=family.

Axiom
annotated source: growth hormone secretagogue/motilin receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor whose active form binds either growth hormone secretagogues (principally ghrelin) or motilin. The motilin and ghrelin receptors are about 45% identical in amino acid sequence.
has db xref: PRO:WCB

interleukin-17D
type: Class
subclass of: interleukin-17
IAO_0000115: An interleukin-17 that is a translation product of the human IL17D gene or a 1:1 ortholog thereof.
has exact synonym: IL-17D
has exact synonym: IL-27
has exact synonym: IL17D
has exact synonym: interleukin-27
has OBO namespace: protein
has related synonym: IL27
has related synonym: UNQ3096/PRO21175
id: PR:000001141
comment: Category=gene.

Axiom
annotated source: interleukin-17D
annotated property: IAO_0000115
annotated target: An interleukin-17 that is a translation product of the human IL17D gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-17D
annotated property: hasExactSynonym
annotated target: IL17D
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-17D
annotated property: hasRelatedSynonym
annotated target: UNQ3096/PRO21175
has synonym type: Gene-based

melanocortin receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human MC1R to MC5R genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds one or more melanocortins, the pituitary peptides ACTH and alpha-, beta-, and gamma-melanocyte-stimulating hormone.
has db xref: IUPHARfam:38
has db xref: PIRSF:PIRSF005524
has OBO namespace: protein
id: PR:000001146
comment: Category=family.

Axiom
annotated source: melanocortin receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human MC1R to MC5R genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds one or more melanocortins, the pituitary peptides ACTH and alpha-, beta-, and gamma-melanocyte-stimulating hormone.
has db xref: PRO:WCB
has db xref: PRO:XQ
has db xref: Wikipedia:Melanocortin

tachykinin receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human TACR1 to TACR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. These receptors bind tachykinin peptides--neuropeptides of 10-12 amino acids derived from the translation products of the TAC1 and TAC3 genes. Tachykinin receptors are not specific but have different affinities for the various peptides.
has db xref: IUPHARfam:62
has db xref: PIRSF:PIRSF001840
has OBO namespace: protein
id: PR:000001150
comment: Category=family.

Axiom
annotated source: tachykinin receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human TACR1 to TACR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. These receptors bind tachykinin peptides--neuropeptides of 10-12 amino acids derived from the translation products of the TAC1 and TAC3 genes. Tachykinin receptors are not specific but have different affinities for the various peptides.
has db xref: PRO:WCB
has db xref: PRO:XQ
has db xref: Wikipedia:Tachykinin_peptides

Toll-like receptor 2
type: Class
subclass of: Toll-like receptor
IAO_0000115: A Toll-like receptor that is a translation product of the human TLR2 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1752
has exact synonym: CD282
has exact synonym: TLR2
has exact synonym: Toll/interleukin-1 receptor-like protein 4
has OBO namespace: protein
has related synonym: TIL4
id: PR:000001153
comment: Category=gene.

Axiom
annotated source: Toll-like receptor 2
annotated property: IAO_0000115
annotated target: A Toll-like receptor that is a translation product of the human TLR2 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: Toll-like receptor 2
annotated property: hasExactSynonym
annotated target: TLR2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: Toll-like receptor 2
annotated property: hasRelatedSynonym
annotated target: TIL4
has synonym type: Gene-based

Toll-like receptor 4
type: Class
subclass of: Toll-like receptor
IAO_0000115: A Toll-like receptor that is a translation product of the human TLR4 gene or a 1:1 ortholog thereof.
has broad synonym: Toll
has db xref: IUPHARobj:1754
has exact synonym: CD284
has exact synonym: TLR4
has OBO namespace: protein
has related synonym: Lps
id: PR:000001155
comment: Category=gene.

Axiom
annotated source: Toll-like receptor 4
annotated property: IAO_0000115
annotated target: A Toll-like receptor that is a translation product of the human TLR4 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: Toll-like receptor 4
annotated property: hasBroadSynonym
annotated target: Toll
has db xref: PRO:DAN

Axiom
annotated source: Toll-like receptor 4
annotated property: hasExactSynonym
annotated target: TLR4
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: Toll-like receptor 4
annotated property: hasRelatedSynonym
annotated target: Lps
has synonym type: Gene-based

B1 bradykinin receptor
type: Class
subclass of: bradykinin receptor
IAO_0000115: A bradykinin receptor that is a translation product of the human BDKRB1 gene or a 1:1 ortholog thereof. The preferred ligand is bradykinin.
has db xref: IUPHARobj:41
has exact synonym: B1R
has exact synonym: BDKRB1
has exact synonym: BK-1 receptor
has OBO namespace: protein
has related synonym: BRADYB1
has related synonym: Bdkrb
id: PR:000001171
comment: Category=gene.

Axiom
annotated source: B1 bradykinin receptor
annotated property: IAO_0000115
annotated target: A bradykinin receptor that is a translation product of the human BDKRB1 gene or a 1:1 ortholog thereof. The preferred ligand is bradykinin.
has db xref: PRO:WCB

Axiom
annotated source: B1 bradykinin receptor
annotated property: hasExactSynonym
annotated target: BDKRB1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: B1 bradykinin receptor
annotated property: hasRelatedSynonym
annotated target: BRADYB1
has synonym type: Gene-based

Axiom
annotated source: B1 bradykinin receptor
annotated property: hasRelatedSynonym
annotated target: Bdkrb
has synonym type: Gene-based

B2 bradykinin receptor
type: Class
subclass of: bradykinin receptor
IAO_0000115: A bradykinin receptor that is a translation product of the human BDKRB2 gene or a 1:1 ortholog thereof. The preferred ligand is bradykinin.
has db xref: IUPHARobj:42
has exact synonym: B2R
has exact synonym: BDKRB2
has exact synonym: BK-2 receptor
has OBO namespace: protein
has related synonym: BKR2
id: PR:000001172
comment: Category=gene.

Axiom
annotated source: B2 bradykinin receptor
annotated property: IAO_0000115
annotated target: A bradykinin receptor that is a translation product of the human BDKRB2 gene or a 1:1 ortholog thereof. The preferred ligand is bradykinin.
has db xref: PRO:WCB

Axiom
annotated source: B2 bradykinin receptor
annotated property: hasExactSynonym
annotated target: BDKRB2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: B2 bradykinin receptor
annotated property: hasRelatedSynonym
annotated target: BKR2
has synonym type: Gene-based

adrenocorticotropic hormone receptor
type: Class
subclass of: melanocortin receptor
IAO_0000115: A melanocortin receptor that is a translation product of the human MC2R gene or a 1:1 ortholog thereof. The preferred ligand is ACTH.
has db xref: IUPHARobj:283
has exact synonym: ACTH receptor
has exact synonym: ACTH-R
has exact synonym: MC2-R
has exact synonym: MC2R
has exact synonym: adrenocorticotropin receptor
has exact synonym: melanocortin receptor 2
has OBO namespace: protein
has related synonym: ACTHR
id: PR:000001182
comment: Category=gene.

Axiom
annotated source: adrenocorticotropic hormone receptor
annotated property: IAO_0000115
annotated target: A melanocortin receptor that is a translation product of the human MC2R gene or a 1:1 ortholog thereof. The preferred ligand is ACTH.
has db xref: PRO:WCB

Axiom
annotated source: adrenocorticotropic hormone receptor
annotated property: hasExactSynonym
annotated target: MC2R
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: adrenocorticotropic hormone receptor
annotated property: hasRelatedSynonym
annotated target: ACTHR
has synonym type: Gene-based

alpha-1A adrenergic receptor
type: Class
subclass of: alpha-1 adrenergic receptor
IAO_0000115: An alpha-1 adrenergic receptor that is a translation product of the human ADRA1A gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:22
has exact synonym: ADRA1A
has exact synonym: alpha-1A adrenoceptor
has exact synonym: alpha-1A adrenoreceptor
has exact synonym: alpha-1C adrenergic receptor
has exact synonym: alpha-adrenergic receptor 1c
has OBO namespace: protein
has related synonym: ADRA1C
id: PR:000001183
comment: Category=gene.

Axiom
annotated source: alpha-1A adrenergic receptor
annotated property: IAO_0000115
annotated target: An alpha-1 adrenergic receptor that is a translation product of the human ADRA1A gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: alpha-1A adrenergic receptor
annotated property: hasExactSynonym
annotated target: ADRA1A
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: alpha-1A adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: ADRA1C
has synonym type: Gene-based

alpha-1B adrenergic receptor
type: Class
subclass of: alpha-1 adrenergic receptor
IAO_0000115: An alpha-1 adrenergic receptor that is a translation product of the human ADRA1B gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:23
has exact synonym: ADRA1B
has exact synonym: alpha-1B adrenoceptor
has exact synonym: alpha-1B adrenoreceptor
has OBO namespace: protein
id: PR:000001184
comment: Category=gene.

Axiom
annotated source: alpha-1B adrenergic receptor
annotated property: IAO_0000115
annotated target: An alpha-1 adrenergic receptor that is a translation product of the human ADRA1B gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: alpha-1B adrenergic receptor
annotated property: hasExactSynonym
annotated target: ADRA1B
has db xref: PRO:DNx
has synonym type: PRO-short-label

alpha-1D adrenergic receptor
type: Class
subclass of: alpha-1 adrenergic receptor
IAO_0000115: An alpha-1 adrenergic receptor that is a translation product of the human ADRA1D gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:24
has exact synonym: ADRA1D
has exact synonym: alpha-1D adrenoceptor
has exact synonym: alpha-1D adrenoreceptor
has exact synonym: alpha-adrenergic receptor 1a
has OBO namespace: protein
has related synonym: ADRA1A
has related synonym: Gpcr8
has related synonym: alpha-1A adrenergic receptor
id: PR:000001185
comment: Category=gene.

Axiom
annotated source: alpha-1D adrenergic receptor
annotated property: IAO_0000115
annotated target: An alpha-1 adrenergic receptor that is a translation product of the human ADRA1D gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: alpha-1D adrenergic receptor
annotated property: hasExactSynonym
annotated target: ADRA1D
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: alpha-1D adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: ADRA1A
has synonym type: Gene-based

Axiom
annotated source: alpha-1D adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: Gpcr8
has synonym type: Gene-based

alpha-2A adrenergic receptor
type: Class
subclass of: alpha-2 adrenergic receptor
IAO_0000115: An alpha-2 adrenergic receptor that is a translation product of the human ADRA2A gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:25
has exact synonym: ADRA2A
has exact synonym: alpha-2 adrenergic receptor subtype C10
has exact synonym: alpha-2A adrenoceptor
has exact synonym: alpha-2A adrenoreceptor
has exact synonym: alpha-2AAR
has OBO namespace: protein
has related synonym: ADRA2R
has related synonym: ADRAR
id: PR:000001186
comment: Category=gene.

Axiom
annotated source: alpha-2A adrenergic receptor
annotated property: IAO_0000115
annotated target: An alpha-2 adrenergic receptor that is a translation product of the human ADRA2A gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: alpha-2A adrenergic receptor
annotated property: hasExactSynonym
annotated target: ADRA2A
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: alpha-2A adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: ADRA2R
has synonym type: Gene-based

Axiom
annotated source: alpha-2A adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: ADRAR
has synonym type: Gene-based

alpha-2B adrenergic receptor
type: Class
subclass of: alpha-2 adrenergic receptor
IAO_0000115: An alpha-2 adrenergic receptor that is a translation product of the human ADRA2B gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:26
has exact synonym: ADRA2B
has exact synonym: alpha-2 adrenergic receptor subtype C2
has exact synonym: alpha-2B adrenoceptor
has exact synonym: alpha-2B adrenoreceptor
has exact synonym: alpha-2BAR
has OBO namespace: protein
has related synonym: ADRA2L1
has related synonym: ADRA2RL1
id: PR:000001187
comment: Category=gene.

Axiom
annotated source: alpha-2B adrenergic receptor
annotated property: IAO_0000115
annotated target: An alpha-2 adrenergic receptor that is a translation product of the human ADRA2B gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: alpha-2B adrenergic receptor
annotated property: hasExactSynonym
annotated target: ADRA2B
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: alpha-2B adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: ADRA2L1
has synonym type: Gene-based

Axiom
annotated source: alpha-2B adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: ADRA2RL1
has synonym type: Gene-based

alpha-2C adrenergic receptor
type: Class
subclass of: alpha-2 adrenergic receptor
IAO_0000115: An alpha-2 adrenergic receptor that is a translation product of the human ADRA2C gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:27
has exact synonym: ADRA2C
has exact synonym: alpha-2 adrenergic receptor subtype C4
has exact synonym: alpha-2C adrenoceptor
has exact synonym: alpha-2C adrenoreceptor
has exact synonym: alpha-2CAR
has OBO namespace: protein
has related synonym: ADRA2L2
has related synonym: ADRA2RL2
id: PR:000001188
comment: Category=gene.

Axiom
annotated source: alpha-2C adrenergic receptor
annotated property: IAO_0000115
annotated target: An alpha-2 adrenergic receptor that is a translation product of the human ADRA2C gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: alpha-2C adrenergic receptor
annotated property: hasExactSynonym
annotated target: ADRA2C
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: alpha-2C adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: ADRA2L2
has synonym type: Gene-based

Axiom
annotated source: alpha-2C adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: ADRA2RL2
has synonym type: Gene-based

beta-1 adrenergic receptor
type: Class
subclass of: beta adrenergic receptor
IAO_0000115: A beta adrenergic receptor that is a translation product of the human ADRB1 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:28
has exact synonym: ADRB1
has exact synonym: beta-1 adrenoceptor
has exact synonym: beta-1 adrenoreceptor
has OBO namespace: protein
has related synonym: ADRB1R
has related synonym: B1AR
id: PR:000001192
comment: Category=gene.

Axiom
annotated source: beta-1 adrenergic receptor
annotated property: IAO_0000115
annotated target: A beta adrenergic receptor that is a translation product of the human ADRB1 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: beta-1 adrenergic receptor
annotated property: hasExactSynonym
annotated target: ADRB1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: beta-1 adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: ADRB1R
has synonym type: Gene-based

Axiom
annotated source: beta-1 adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: B1AR
has synonym type: Gene-based

beta-2 adrenergic receptor
type: Class
subclass of: beta adrenergic receptor
IAO_0000115: A beta adrenergic receptor that is a translation product of the human ADRB2 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:29
has exact synonym: ADRB2
has exact synonym: beta(2)-adrenergic receptor
has exact synonym: beta-2 adrenoceptor
has exact synonym: beta-2 adrenoreceptor
has OBO namespace: protein
has related synonym: ADRB2R
has related synonym: B2AR
id: PR:000001193
comment: Category=gene.

Axiom
annotated source: beta-2 adrenergic receptor
annotated property: IAO_0000115
annotated target: A beta adrenergic receptor that is a translation product of the human ADRB2 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: beta-2 adrenergic receptor
annotated property: hasExactSynonym
annotated target: ADRB2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: beta-2 adrenergic receptor
annotated property: hasExactSynonym
annotated target: beta(2)-adrenergic receptor
has db xref: PMID:10567420

Axiom
annotated source: beta-2 adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: ADRB2R
has synonym type: Gene-based

Axiom
annotated source: beta-2 adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: B2AR
has synonym type: Gene-based

beta-3 adrenergic receptor
type: Class
subclass of: beta adrenergic receptor
IAO_0000115: A beta adrenergic receptor that is a translation product of the human ADRB3 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:30
has exact synonym: ADRB3
has exact synonym: beta-3 adrenoceptor
has exact synonym: beta-3 adrenoreceptor
has OBO namespace: protein
has related synonym: ADRB3R
has related synonym: B3AR
has related synonym: B3bar
id: PR:000001194
comment: Category=gene.

Axiom
annotated source: beta-3 adrenergic receptor
annotated property: IAO_0000115
annotated target: A beta adrenergic receptor that is a translation product of the human ADRB3 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: beta-3 adrenergic receptor
annotated property: hasExactSynonym
annotated target: ADRB3
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: beta-3 adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: ADRB3R
has synonym type: Gene-based

Axiom
annotated source: beta-3 adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: B3AR
has synonym type: Gene-based

Axiom
annotated source: beta-3 adrenergic receptor
annotated property: hasRelatedSynonym
annotated target: B3bar
has synonym type: Gene-based

chemokine receptor CCR1/3/1L
type: Class
subclass of: chemokine receptor
IAO_0000115: A chemokine receptor that is a translation product of the human CCR1 or CCR3 genes, the mouse CCR1L1 gene, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PIRSF:PIRSF501024
has OBO namespace: protein
id: PR:000001197
comment: Category=family.

Axiom
annotated source: chemokine receptor CCR1/3/1L
annotated property: IAO_0000115
annotated target: A chemokine receptor that is a translation product of the human CCR1 or CCR3 genes, the mouse CCR1L1 gene, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PRO:DAN
has db xref: PRO:WCB

C-C chemokine receptor type 2
type: Class
subclass of: chemokine receptor
IAO_0000115: A chemokine receptor that is a translation product of the human CCR2 gene or a 1:1 ortholog thereof. The preferred ligands include CCL2, CCL7, CCL8, CCL13.
has db xref: IUPHARobj:59
has exact synonym: C-C CKR-2
has exact synonym: CC-CKR-2
has exact synonym: CCR-2
has exact synonym: CCR2
has exact synonym: CD192
has exact synonym: JE/FIC receptor
has exact synonym: MCP-1 receptor
has exact synonym: MCP-1-R
has exact synonym: chemokine receptor CCR2
has exact synonym: monocyte chemoattractant protein 1 receptor
has OBO namespace: protein
has related synonym: CMKBR2
id: PR:000001199
comment: Category=gene. Requested by=CL.

Axiom
annotated source: C-C chemokine receptor type 2
annotated property: IAO_0000115
annotated target: A chemokine receptor that is a translation product of the human CCR2 gene or a 1:1 ortholog thereof. The preferred ligands include CCL2, CCL7, CCL8, CCL13.
has db xref: PMID:12037138
has db xref: PRO:WCB

Axiom
annotated source: C-C chemokine receptor type 2
annotated property: hasExactSynonym
annotated target: CCR2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: C-C chemokine receptor type 2
annotated property: hasRelatedSynonym
annotated target: CMKBR2
has synonym type: Gene-based

C-C chemokine receptor type 6
type: Class
subclass of: chemokine receptor
IAO_0000115: A chemokine receptor that is a translation product of the human CCR6 gene or a 1:1 ortholog thereof. The preferred ligand is CCL20.
has db xref: IUPHARobj:63
has exact synonym: C-C CKR-6
has exact synonym: CC-CKR-6
has exact synonym: CCR-6
has exact synonym: CCR6
has exact synonym: CD196
has exact synonym: CKR-L3
has exact synonym: DRY6
has exact synonym: G-protein coupled receptor 29
has exact synonym: GPR-CY4
has exact synonym: GPRCY4
has exact synonym: KY411
has exact synonym: LARC receptor
has exact synonym: chemokine receptor CCR6
has exact synonym: chemokine receptor-like 3
has OBO namespace: protein
has related synonym: CKRL3
has related synonym: CMKBR6
has related synonym: GPR29
has related synonym: STRL22
id: PR:000001202
comment: Category=gene. Requested by=CL.

Axiom
annotated source: C-C chemokine receptor type 6
annotated property: IAO_0000115
annotated target: A chemokine receptor that is a translation product of the human CCR6 gene or a 1:1 ortholog thereof. The preferred ligand is CCL20.
has db xref: PMID:12037138
has db xref: PRO:WCB

Axiom
annotated source: C-C chemokine receptor type 6
annotated property: hasExactSynonym
annotated target: CCR6
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: C-C chemokine receptor type 6
annotated property: hasRelatedSynonym
annotated target: CKRL3
has synonym type: Gene-based

Axiom
annotated source: C-C chemokine receptor type 6
annotated property: hasRelatedSynonym
annotated target: CMKBR6
has synonym type: Gene-based

Axiom
annotated source: C-C chemokine receptor type 6
annotated property: hasRelatedSynonym
annotated target: GPR29
has synonym type: Gene-based

Axiom
annotated source: C-C chemokine receptor type 6
annotated property: hasRelatedSynonym
annotated target: STRL22
has synonym type: Gene-based

C-C chemokine receptor type 7
type: Class
subclass of: chemokine receptor
IAO_0000115: A chemokine receptor that is a translation product of the human CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21.
has db xref: IUPHARobj:64
has exact synonym: BLR2
has exact synonym: C-C CKR-7
has exact synonym: CC-CKR-7
has exact synonym: CCR-7
has exact synonym: CCR7
has exact synonym: CD197
has exact synonym: CDw197
has exact synonym: EBV-induced G-protein coupled receptor 1
has exact synonym: MIP-3 beta receptor
has exact synonym: chemokine receptor CCR7
has exact synonym: epstein-Barr virus-induced G-protein coupled receptor 1
has OBO namespace: protein
has related synonym: CMKBR7
has related synonym: EBI1
has related synonym: EVI1
has related synonym: Ebi1h
id: PR:000001203
comment: Category=gene. Requested by=CL.

Axiom
annotated source: C-C chemokine receptor type 7
annotated property: IAO_0000115
annotated target: A chemokine receptor that is a translation product of the human CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21.
has db xref: PMID:12037138
has db xref: PRO:WCB

Axiom
annotated source: C-C chemokine receptor type 7
annotated property: hasExactSynonym
annotated target: CCR7
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: C-C chemokine receptor type 7
annotated property: hasRelatedSynonym
annotated target: CMKBR7
has synonym type: Gene-based

Axiom
annotated source: C-C chemokine receptor type 7
annotated property: hasRelatedSynonym
annotated target: EBI1
has synonym type: Gene-based

Axiom
annotated source: C-C chemokine receptor type 7
annotated property: hasRelatedSynonym
annotated target: EVI1
has synonym type: Gene-based

Axiom
annotated source: C-C chemokine receptor type 7
annotated property: hasRelatedSynonym
annotated target: Ebi1h
has synonym type: Gene-based

CX3C chemokine receptor 1
type: Class
subclass of: chemokine receptor
IAO_0000115: A chemokine receptor that is a translation product of the human CX3CR1 gene or a 1:1 ortholog thereof. The preferred ligand is CX3CL1.
has db xref: IUPHARobj:74
has db xref: PIRSF:PIRSF501025
has exact synonym: C-X3-C CKR-1
has exact synonym: CMK-BRL-1
has exact synonym: CMK-BRL1
has exact synonym: CX3CR1
has exact synonym: G-protein coupled receptor 13
has exact synonym: V28
has exact synonym: beta chemokine receptor-like 1
has exact synonym: chemokine receptor CX3CR1
has exact synonym: fractalkine receptor
has OBO namespace: protein
has related synonym: CMKBRL1
has related synonym: GPR13
id: PR:000001206
comment: Category=gene. Requested by=CL.

Axiom
annotated source: CX3C chemokine receptor 1
annotated property: IAO_0000115
annotated target: A chemokine receptor that is a translation product of the human CX3CR1 gene or a 1:1 ortholog thereof. The preferred ligand is CX3CL1.
has db xref: PMID:12037138
has db xref: PRO:WCB

Axiom
annotated source: CX3C chemokine receptor 1
annotated property: hasExactSynonym
annotated target: CX3CR1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: CX3C chemokine receptor 1
annotated property: hasRelatedSynonym
annotated target: CMKBRL1
has synonym type: Gene-based

Axiom
annotated source: CX3C chemokine receptor 1
annotated property: hasRelatedSynonym
annotated target: GPR13
has synonym type: Gene-based

C-X-C chemokine receptor type 4
type: Class
subclass of: chemokine receptor
IAO_0000115: A chemokine receptor that is a translation product of the human CXCR4 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL12.
has db xref: IUPHARobj:71
has db xref: PIRSF:PIRSF501021
has exact synonym: CD184
has exact synonym: CXC-R4
has exact synonym: CXCR-4
has exact synonym: CXCR4
has exact synonym: FB22
has exact synonym: HM89
has exact synonym: LCR1
has exact synonym: LESTR
has exact synonym: NPYRL
has exact synonym: PB-CKR
has exact synonym: SDF-1 receptor
has exact synonym: chemokine receptor CXCR4
has exact synonym: fusin
has exact synonym: leukocyte-derived seven transmembrane domain receptor
has exact synonym: pre-B-cell-derived chemokine receptor
has exact synonym: stromal cell-derived factor 1 receptor
has OBO namespace: protein
has related synonym: Cmkar4
has related synonym: Sdf1r
id: PR:000001208
comment: Category=gene. Requested by=CL.

Axiom
annotated source: C-X-C chemokine receptor type 4
annotated property: IAO_0000115
annotated target: A chemokine receptor that is a translation product of the human CXCR4 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL12.
has db xref: PMID:12037138
has db xref: PRO:WCB

Axiom
annotated source: C-X-C chemokine receptor type 4
annotated property: hasExactSynonym
annotated target: CXCR4
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: C-X-C chemokine receptor type 4
annotated property: hasRelatedSynonym
annotated target: Cmkar4
has synonym type: Gene-based

Axiom
annotated source: C-X-C chemokine receptor type 4
annotated property: hasRelatedSynonym
annotated target: Sdf1r
has synonym type: Gene-based

chemokine XC receptor 1
type: Class
subclass of: chemokine receptor
IAO_0000115: A chemokine receptor that is a translation product of the human XCR1 gene or a 1:1 ortholog thereof. The preferred ligands are XCL1 and XCL2.
has db xref: IUPHARobj:75
has exact synonym: G-protein coupled receptor 5
has exact synonym: SCM1 receptor
has exact synonym: XC chemokine receptor 1
has exact synonym: XCR1
has exact synonym: chemokine receptor XCR1
has exact synonym: lymphotactin receptor
has OBO namespace: protein
has related synonym: CCXCR1
has related synonym: GPR5
id: PR:000001212
comment: Category=gene.

Axiom
annotated source: chemokine XC receptor 1
annotated property: IAO_0000115
annotated target: A chemokine receptor that is a translation product of the human XCR1 gene or a 1:1 ortholog thereof. The preferred ligands are XCL1 and XCL2.
has db xref: PMID:12037138
has db xref: PRO:WCB

Axiom
annotated source: chemokine XC receptor 1
annotated property: hasExactSynonym
annotated target: XCR1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: chemokine XC receptor 1
annotated property: hasRelatedSynonym
annotated target: CCXCR1
has synonym type: Gene-based

Axiom
annotated source: chemokine XC receptor 1
annotated property: hasRelatedSynonym
annotated target: GPR5
has synonym type: Gene-based

endothelin-1 receptor
type: Class
subclass of: endothelin receptor
IAO_0000115: An endothelin receptor that is a translation product of the human EDNRA gene or a 1:1 ortholog thereof. The active form binds endothelin 1 (ET-1) and ET-2 with much higher affinity than ET-3.
has broad synonym: ET-A
has db xref: IUPHARobj:219
has exact synonym: EDNRA
has exact synonym: ET-AR
has exact synonym: ETA-R
has exact synonym: endothelin A receptor
has exact synonym: endothelin receptor A
has exact synonym: endothelin receptor type A
has OBO namespace: protein
has related synonym: ETA
has related synonym: ETRA
has related synonym: Gpcr10
id: PR:000001221
comment: Category=gene.

Axiom
annotated source: endothelin-1 receptor
annotated property: IAO_0000115
annotated target: An endothelin receptor that is a translation product of the human EDNRA gene or a 1:1 ortholog thereof. The active form binds endothelin 1 (ET-1) and ET-2 with much higher affinity than ET-3.
has db xref: PMID:12037137
has db xref: PRO:WCB

Axiom
annotated source: endothelin-1 receptor
annotated property: hasBroadSynonym
annotated target: ET-A
has db xref: PRO:DNx

Axiom
annotated source: endothelin-1 receptor
annotated property: hasExactSynonym
annotated target: EDNRA
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: endothelin-1 receptor
annotated property: hasRelatedSynonym
annotated target: ETA
has synonym type: Gene-based

Axiom
annotated source: endothelin-1 receptor
annotated property: hasRelatedSynonym
annotated target: ETRA
has synonym type: Gene-based

Axiom
annotated source: endothelin-1 receptor
annotated property: hasRelatedSynonym
annotated target: Gpcr10
has synonym type: Gene-based

gastrin-releasing peptide receptor
type: Class
subclass of: bombesin receptor
IAO_0000115: A bombesin receptor that is a translation product of the human GRPR gene or a 1:1 ortholog thereof. The preferred ligand is gastrin releasing peptide.
has db xref: IUPHARobj:39
has exact synonym: GRP-R
has exact synonym: GRP-preferring bombesin receptor
has exact synonym: GRPR
has OBO namespace: protein
id: PR:000001223
comment: Category=gene.

Axiom
annotated source: gastrin-releasing peptide receptor
annotated property: IAO_0000115
annotated target: A bombesin receptor that is a translation product of the human GRPR gene or a 1:1 ortholog thereof. The preferred ligand is gastrin releasing peptide.
has db xref: PRO:WCB

Axiom
annotated source: gastrin-releasing peptide receptor
annotated property: hasExactSynonym
annotated target: GRPR
has db xref: PRO:DNx
has synonym type: PRO-short-label

growth hormone secretagogue receptor
type: Class
subclass of: growth hormone secretagogue/motilin receptor
IAO_0000115: A growth hormone secretagogue/motilin receptor that is a translation product of the human GHSR gene or a 1:1 ortholog thereof. Although its preferred ligand is ghrelin, it also binds other growth hormone releasing peptides and some nonpeptide ligands.
has db xref: IUPHARobj:246
has exact synonym: GH-releasing peptide receptor
has exact synonym: GHRP
has exact synonym: GHS-R
has exact synonym: GHSR
has exact synonym: ghrelin receptor
has OBO namespace: protein
id: PR:000001225
comment: Category=gene.

Axiom
annotated source: growth hormone secretagogue receptor
annotated property: IAO_0000115
annotated target: A growth hormone secretagogue/motilin receptor that is a translation product of the human GHSR gene or a 1:1 ortholog thereof. Although its preferred ligand is ghrelin, it also binds other growth hormone releasing peptides and some nonpeptide ligands.
has db xref: PRO:WCB
has db xref: Wikipedia:Growth_hormone_secretagogue_receptor

Axiom
annotated source: growth hormone secretagogue receptor
annotated property: hasExactSynonym
annotated target: GHSR
has db xref: PRO:DNx
has synonym type: PRO-short-label

motilin receptor
type: Class
subclass of: growth hormone secretagogue/motilin receptor
IAO_0000115: A growth hormone secretagogue/motilin receptor that is a translation product of the human MLNR gene or a 1:1 ortholog thereof. The preferred ligand is motilin, an intestinal peptide that stimulates contraction of gut smooth muscle.
has db xref: IUPHARobj:297
has exact synonym: G-protein coupled receptor 38
has exact synonym: MLNR
has OBO namespace: protein
has related synonym: GPR38
has related synonym: MTLR
has related synonym: MTLR1
id: PR:000001240
comment: Category=gene.

Axiom
annotated source: motilin receptor
annotated property: IAO_0000115
annotated target: A growth hormone secretagogue/motilin receptor that is a translation product of the human MLNR gene or a 1:1 ortholog thereof. The preferred ligand is motilin, an intestinal peptide that stimulates contraction of gut smooth muscle.
has db xref: PRO:WCB
has db xref: Wikipedia:Motilin_receptor

Axiom
annotated source: motilin receptor
annotated property: hasExactSynonym
annotated target: MLNR
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: motilin receptor
annotated property: hasRelatedSynonym
annotated target: GPR38
has synonym type: Gene-based

Axiom
annotated source: motilin receptor
annotated property: hasRelatedSynonym
annotated target: MTLR
has synonym type: Gene-based

Axiom
annotated source: motilin receptor
annotated property: hasRelatedSynonym
annotated target: MTLR1
has synonym type: Gene-based

rhodopsin
type: Class
subclass of: animal opsin
IAO_0000115: An animal opsin that is a translation product of the human RHO gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:2963
has exact synonym: RHO
has exact synonym: opsin-2
has OBO namespace: protein
has related synonym: OPN2
id: PR:000001245
comment: Category=gene.

Axiom
annotated source: rhodopsin
annotated property: IAO_0000115
annotated target: An animal opsin that is a translation product of the human RHO gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: rhodopsin
annotated property: hasExactSynonym
annotated target: RHO
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: rhodopsin
annotated property: hasRelatedSynonym
annotated target: OPN2
has synonym type: Gene-based

C-C chemokine receptor type 3
type: Class
subclass of: chemokine receptor CCR1/3/1L
IAO_0000115: A chemokine receptor CCR1/3/1L that is a translation product of the human CCR3 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:60
has exact synonym: C-C CKR-3
has exact synonym: CC-CKR-3
has exact synonym: CCR-3
has exact synonym: CCR3
has exact synonym: CD193
has exact synonym: CKR3
has exact synonym: MIP-1 alpha RL2
has exact synonym: chemokine receptor CCR3
has exact synonym: eosinophil eotaxin receptor
has exact synonym: macrophage inflammatory protein 1-alpha receptor-like 2
has OBO namespace: protein
has related synonym: CMKBR3
has related synonym: Cmkbr1l2
id: PR:000001255
comment: Category=gene. Requested by=CL.

Axiom
annotated source: C-C chemokine receptor type 3
annotated property: IAO_0000115
annotated target: A chemokine receptor CCR1/3/1L that is a translation product of the human CCR3 gene or a 1:1 ortholog thereof.
has db xref: PMID:12037138
has db xref: PRO:WCB

Axiom
annotated source: C-C chemokine receptor type 3
annotated property: hasExactSynonym
annotated target: CCR3
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: C-C chemokine receptor type 3
annotated property: hasRelatedSynonym
annotated target: CMKBR3
has synonym type: Gene-based

Axiom
annotated source: C-C chemokine receptor type 3
annotated property: hasRelatedSynonym
annotated target: Cmkbr1l2
has synonym type: Gene-based

frizzled-like G-protein coupled receptor
type: Class
subclass of: G-protein coupled receptor
IAO_0000115: A G-protein coupled receptor with core architecture consisting of an Fz domain (Pfam:PF01392), also known as Frizzled CRD (cysteine rich domain), followed by a Frizzled/Smoothened family membrane region (Pfam:PF01534), which includes 7 transmembrane helices, and a cytoplasmic domain containing the motif Lys-Thr-x-x-x-Trp. They generally function as cell-surface receptors for Wnts.
has db xref: IUPHAR:GPCRListForward?class=frizzled
has db xref: IUPHARfam:25
has db xref: PIRSF:PIRSF006696
has exact synonym: class F G-protein coupled receptor
has exact synonym: fam:frizzled
has OBO namespace: protein
id: PR:000001315
comment: Category=family. Classification based on GRAFS system. [PMID:12761335]

Axiom
annotated source: frizzled-like G-protein coupled receptor
annotated property: IAO_0000115
annotated target: A G-protein coupled receptor with core architecture consisting of an Fz domain (Pfam:PF01392), also known as Frizzled CRD (cysteine rich domain), followed by a Frizzled/Smoothened family membrane region (Pfam:PF01534), which includes 7 transmembrane helices, and a cytoplasmic domain containing the motif Lys-Thr-x-x-x-Trp. They generally function as cell-surface receptors for Wnts.
has db xref: InterPro:IPR015526
has db xref: PRO:DAN
has db xref: PRO:WCB

Axiom
annotated source: frizzled-like G-protein coupled receptor
annotated property: hasExactSynonym
annotated target: class F G-protein coupled receptor
has db xref: IUPHARfam:25

Axiom
annotated source: frizzled-like G-protein coupled receptor
annotated property: hasExactSynonym
annotated target: fam:frizzled
has db xref: PRO:DAN
has synonym type: PRO-short-label

interleukin-7
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL7 gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF001942
has exact synonym: IL-7
has exact synonym: IL7
has OBO namespace: protein
id: PR:000001317
comment: Category=gene.

Axiom
annotated source: interleukin-7
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL7 gene or a 1:1 ortholog thereof.
has db xref: PRO:JAN

Axiom
annotated source: interleukin-7
annotated property: hasExactSynonym
annotated target: IL7
has db xref: PRO:DNx
has synonym type: PRO-short-label

cadherin
type: Class
subclass of: protein
IAO_0000115: A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues.
has db xref: PIRSF:PIRSF002504
has OBO namespace: protein
id: PR:000001327
comment: Category=family.

Axiom
annotated source: cadherin
annotated property: IAO_0000115
annotated target: A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues.
has db xref: PRO:WCB

class 2 cytokine, IL-10 type
type: Class
subclass of: protein
IAO_0000115: A protein with a core domain architecture consisting of an N-terminal Interleukin 10 (Pfam:PF00726) domain.
has db xref: PIRSF:PIRSF003542
has OBO namespace: protein
id: PR:000001335
comment: Category=family.

Axiom
annotated source: class 2 cytokine, IL-10 type
annotated property: IAO_0000115
annotated target: A protein with a core domain architecture consisting of an N-terminal Interleukin 10 (Pfam:PF00726) domain.
has db xref: PRO:CNA

erythrocyte membrane protein Rh
type: Class
subclass of: protein
IAO_0000115: A protein that is a stand alone version of the Ammonium Transporter Family domain in vertebrates. This protein is related to the ammonium transporters in fungi and bacteria. In mammals, this protein defines the Rh blood group antigens.
has db xref: PIRSF:PIRSF017968
has OBO namespace: protein
id: PR:000001348
comment: Category=family.

Axiom
annotated source: erythrocyte membrane protein Rh
annotated property: IAO_0000115
annotated target: A protein that is a stand alone version of the Ammonium Transporter Family domain in vertebrates. This protein is related to the ammonium transporters in fungi and bacteria. In mammals, this protein defines the Rh blood group antigens.
has db xref: PMID:7888828
has db xref: PMID:9433124

fibroblast growth factor receptor
type: Class
subclass of: protein
IAO_0000115: A protein with an extracellular region containing three copies of the Immunoglobulin domain (Pfam:PF00047), a single transmembrane region, and an intracellular region containing a Protein tyrosine kinase domain (Pfam:PF07714). Its active form binds fibroblast growth factor (FGF). FGFs and its receptor comprise a signaling system that is conserved throughout metazoan evolution.
has db xref: PIRSF:PIRSF000628
has OBO namespace: protein
id: PR:000001349
comment: Category=family.

Axiom
annotated source: fibroblast growth factor receptor
annotated property: IAO_0000115
annotated target: A protein with an extracellular region containing three copies of the Immunoglobulin domain (Pfam:PF00047), a single transmembrane region, and an intracellular region containing a Protein tyrosine kinase domain (Pfam:PF07714). Its active form binds fibroblast growth factor (FGF). FGFs and its receptor comprise a signaling system that is conserved throughout metazoan evolution.
has db xref: PMID:15475116

granulocyte colony-stimulating factor receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human CSF3R gene or a 1:1 ortholog thereof. The active receptor is a homodimer which can bind G-CSF and transduce G-CSF-triggered growth signals into cells. Its extracellular domain contains a sequence of about 200 amino acids which can be found in various cytokine receptors. In addition, it contains an immunoglobulin-like domain and three fibronectin type III domains.
has db xref: IUPHARobj:1719
has exact synonym: CD114
has exact synonym: CSF3R
has exact synonym: G-CSF receptor
has exact synonym: G-CSF-R
has OBO namespace: protein
has related synonym: Csfgr
has related synonym: GCSFR
id: PR:000001353
comment: Category=gene.

Axiom
annotated source: granulocyte colony-stimulating factor receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human CSF3R gene or a 1:1 ortholog thereof. The active receptor is a homodimer which can bind G-CSF and transduce G-CSF-triggered growth signals into cells. Its extracellular domain contains a sequence of about 200 amino acids which can be found in various cytokine receptors. In addition, it contains an immunoglobulin-like domain and three fibronectin type III domains.
has db xref: PMID:1723014
has db xref: PRO:CNA

Axiom
annotated source: granulocyte colony-stimulating factor receptor
annotated property: hasExactSynonym
annotated target: CSF3R
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: granulocyte colony-stimulating factor receptor
annotated property: hasRelatedSynonym
annotated target: Csfgr
has synonym type: Gene-based

Axiom
annotated source: granulocyte colony-stimulating factor receptor
annotated property: hasRelatedSynonym
annotated target: GCSFR
has synonym type: Gene-based

intercellular adhesion molecule 1/3
type: Class
subclass of: protein
IAO_0000115: A protein with a core domain architecture consisting of an Intercellular adhesion molecule (ICAM), N-terminal domain (Pfam:PF03921), a type of Ig-like domain, and four copies of the Immunoglobulin domain (Pfam:PF00047), most of which are not detected by Pfam.
has db xref: PIRSF:PIRSF002510
has OBO namespace: protein
has related synonym: ICAM
id: PR:000001357
comment: Category=family.

Axiom
annotated source: intercellular adhesion molecule 1/3
annotated property: IAO_0000115
annotated target: A protein with a core domain architecture consisting of an Intercellular adhesion molecule (ICAM), N-terminal domain (Pfam:PF03921), a type of Ig-like domain, and four copies of the Immunoglobulin domain (Pfam:PF00047), most of which are not detected by Pfam.
has db xref: PRO:WCB

interleukin-11
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL11 gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF001944
has exact synonym: AGIF
has exact synonym: IL-11
has exact synonym: IL11
has exact synonym: adipogenesis inhibitory factor
has exact synonym: oprelvekin
has OBO namespace: protein
id: PR:000001366
comment: Category=gene.

Axiom
annotated source: interleukin-11
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL11 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-11
annotated property: hasExactSynonym
annotated target: IL11
has db xref: PRO:DNx
has synonym type: PRO-short-label

interleukin-12 subunit alpha
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL12A gene or a 1:1 ortholog thereof. It associates with interleukin-12 subunit beta to form the interleukin-23. Interleukin-12 subunit alpha associates with interleukin-27 subunit beta to form the interleukin-35.
has db xref: PIRSF:PIRSF037684
has exact synonym: CLMF p35
has exact synonym: IL-12 subunit p35
has exact synonym: IL-12A
has exact synonym: IL12A
has exact synonym: NK cell stimulatory factor chain 1
has exact synonym: cytotoxic lymphocyte maturation factor 35 kDa subunit
has OBO namespace: protein
has related synonym: NKSF1
id: PR:000001368
comment: Category=gene.

Axiom
annotated source: interleukin-12 subunit alpha
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL12A gene or a 1:1 ortholog thereof. It associates with interleukin-12 subunit beta to form the interleukin-23. Interleukin-12 subunit alpha associates with interleukin-27 subunit beta to form the interleukin-35.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-12 subunit alpha
annotated property: hasExactSynonym
annotated target: IL12A
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-12 subunit alpha
annotated property: hasRelatedSynonym
annotated target: NKSF1
has synonym type: Gene-based

interleukin-12 subunit beta
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL12B gene or a 1:1 ortholog thereof. Interleukin-12 subunit beta associates with interleukin-12 subunit alpha or interleukin-23 subunit alpha to form the interleukin-23.
has db xref: PIRSF:PIRSF038007
has exact synonym: CLMF p40
has exact synonym: IL-12 subunit p40
has exact synonym: IL-12B
has exact synonym: IL12B
has exact synonym: NK cell stimulatory factor chain 2
has exact synonym: cytotoxic lymphocyte maturation factor 40 kDa subunit
has OBO namespace: protein
has related synonym: NKSF2
id: PR:000001369
comment: Category=gene.

Axiom
annotated source: interleukin-12 subunit beta
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL12B gene or a 1:1 ortholog thereof. Interleukin-12 subunit beta associates with interleukin-12 subunit alpha or interleukin-23 subunit alpha to form the interleukin-23.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-12 subunit beta
annotated property: hasExactSynonym
annotated target: IL12B
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-12 subunit beta
annotated property: hasRelatedSynonym
annotated target: NKSF2
has synonym type: Gene-based

interleukin-13
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL13 gene or a 1:1 ortholog thereof. Interleukin-13 is a pleiotropic cytokine which may be important in the regulation of the inflammatory and immune responses. It inhibits inflammatory cytokine production and synergises with IL-2 in regulating interferon-gamma synthesis. The sequences of IL-4 and IL-13 are distantly related.
has db xref: PIRSF:PIRSF001945
has exact synonym: IL-13
has exact synonym: IL13
has exact synonym: T-cell activation protein P600
has OBO namespace: protein
has related synonym: NC30
id: PR:000001370
comment: Category=gene.

Axiom
annotated source: interleukin-13
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL13 gene or a 1:1 ortholog thereof. Interleukin-13 is a pleiotropic cytokine which may be important in the regulation of the inflammatory and immune responses. It inhibits inflammatory cytokine production and synergises with IL-2 in regulating interferon-gamma synthesis. The sequences of IL-4 and IL-13 are distantly related.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-13
annotated property: hasExactSynonym
annotated target: IL13
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-13
annotated property: hasRelatedSynonym
annotated target: NC30
has synonym type: Gene-based

interleukin-15
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL15 gene or a 1:1 ortholog thereof.
has exact synonym: IL-15
has exact synonym: IL15
has OBO namespace: protein
id: PR:000001373
comment: Category=gene.

Axiom
annotated source: interleukin-15
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL15 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-15
annotated property: hasExactSynonym
annotated target: IL15
has db xref: PRO:DNx
has synonym type: PRO-short-label

pro-interleukin-16
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL16 gene or a 1:1 ortholog thereof.
has exact synonym: IL16
has OBO namespace: protein
id: PR:000001374
comment: Category=gene.

Axiom
annotated source: pro-interleukin-16
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL16 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: pro-interleukin-16
annotated property: hasExactSynonym
annotated target: IL16
has db xref: PRO:DNx
has synonym type: PRO-short-label

interleukin-18
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL18 gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF015162
has exact synonym: IFN-gamma-inducing factor
has exact synonym: IL-1 gamma
has exact synonym: IL-18
has exact synonym: IL18
has exact synonym: iboctadekin
has exact synonym: interferon gamma-inducing factor
has exact synonym: interleukin-1 gamma
has OBO namespace: protein
has related synonym: IGIF
has related synonym: IL1F4
id: PR:000001376
comment: Category=gene.

Axiom
annotated source: interleukin-18
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL18 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-18
annotated property: hasExactSynonym
annotated target: IL18
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-18
annotated property: hasRelatedSynonym
annotated target: IGIF
has synonym type: Gene-based

Axiom
annotated source: interleukin-18
annotated property: hasRelatedSynonym
annotated target: IL1F4
has synonym type: Gene-based

interleukin-2
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL2 gene or a 1:1 ortholog thereof. Interleukin-2 has a dual role in maintaining tolerance and contributing to immunity.
has db xref: PIRSF:PIRSF001938
has exact synonym: IL-2
has exact synonym: IL2
has exact synonym: T-cell growth factor
has exact synonym: TCGF
has exact synonym: aldesleukin
has OBO namespace: protein
id: PR:000001379
comment: Category=gene.

Axiom
annotated source: interleukin-2
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL2 gene or a 1:1 ortholog thereof. Interleukin-2 has a dual role in maintaining tolerance and contributing to immunity.
has db xref: PMID:18062768
has db xref: PRO:CNA

Axiom
annotated source: interleukin-2
annotated property: hasExactSynonym
annotated target: IL2
has db xref: PRO:DNx
has synonym type: PRO-short-label

interleukin-21
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL21 gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF038753
has exact synonym: IL-21
has exact synonym: IL21
has exact synonym: Za11
has OBO namespace: protein
id: PR:000001382
comment: Category=gene.

Axiom
annotated source: interleukin-21
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL21 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-21
annotated property: hasExactSynonym
annotated target: IL21
has db xref: PRO:DNx
has synonym type: PRO-short-label

interleukin-22
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL22 gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF037726
has exact synonym: IL-10-related T-cell-derived-inducible factor
has exact synonym: IL-22
has exact synonym: IL-22a
has exact synonym: IL-TIF
has exact synonym: IL-TIF alpha
has exact synonym: IL22
has exact synonym: cytokine Zcyto18
has exact synonym: interleukin-22a
has OBO namespace: protein
has related synonym: ILTIF
has related synonym: Il22a
has related synonym: Iltifa
has related synonym: UNQ3099/PRO10096
has related synonym: ZCYTO18
id: PR:000001383
comment: Category=gene.

Axiom
annotated source: interleukin-22
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL22 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-22
annotated property: hasExactSynonym
annotated target: IL22
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-22
annotated property: hasRelatedSynonym
annotated target: ILTIF
has synonym type: Gene-based

Axiom
annotated source: interleukin-22
annotated property: hasRelatedSynonym
annotated target: UNQ3099/PRO10096
has synonym type: Gene-based

Axiom
annotated source: interleukin-22
annotated property: hasRelatedSynonym
annotated target: ZCYTO18
has synonym type: Gene-based

interleukin-3
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL3 gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF001939
has exact synonym: IL-3
has exact synonym: IL3
has exact synonym: MCGF
has exact synonym: P-cell-stimulating factor
has exact synonym: hematopoietic growth factor
has exact synonym: multipotential colony-stimulating factor
has OBO namespace: protein
has related synonym: Csfmu
has related synonym: mast cell growth factor
id: PR:000001387
comment: Category=gene.

Axiom
annotated source: interleukin-3
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL3 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-3
annotated property: hasExactSynonym
annotated target: IL3
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-3
annotated property: hasRelatedSynonym
annotated target: Csfmu
has synonym type: Gene-based

interleukin-33
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL33 gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF038478
has exact synonym: IL-1F11
has exact synonym: IL-33
has exact synonym: IL33
has exact synonym: NF-HEV
has exact synonym: interleukin-1 family member 11
has exact synonym: nuclear factor from high endothelial venules
has OBO namespace: protein
has related synonym: C9orf26
has related synonym: IL1F11
has related synonym: NFHEV
id: PR:000001389
comment: Category=gene.

Axiom
annotated source: interleukin-33
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL33 gene or a 1:1 ortholog thereof.
has db xref: PRO:JAN

Axiom
annotated source: interleukin-33
annotated property: hasExactSynonym
annotated target: IL33
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-33
annotated property: hasRelatedSynonym
annotated target: C9orf26
has synonym type: Gene-based

Axiom
annotated source: interleukin-33
annotated property: hasRelatedSynonym
annotated target: IL1F11
has synonym type: Gene-based

Axiom
annotated source: interleukin-33
annotated property: hasRelatedSynonym
annotated target: NFHEV
has synonym type: Gene-based

interleukin-4
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL4 gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF001941
has exact synonym: B-cell IgG differentiation factor
has exact synonym: B-cell growth factor 1
has exact synonym: B-cell stimulatory factor 1
has exact synonym: BSF-1
has exact synonym: IGG1 induction factor
has exact synonym: IL-4
has exact synonym: IL4
has exact synonym: binetrakin
has exact synonym: lymphocyte stimulatory factor 1
has exact synonym: pitrakinra
has OBO namespace: protein
id: PR:000001391
comment: Category=gene.

Axiom
annotated source: interleukin-4
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL4 gene or a 1:1 ortholog thereof.
has db xref: PRO:JAN

Axiom
annotated source: interleukin-4
annotated property: hasExactSynonym
annotated target: IL4
has db xref: PRO:DNx
has synonym type: PRO-short-label

interleukin-5
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL5 gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF001940
has exact synonym: B-cell differentiation factor I
has exact synonym: B-cell growth factor II
has exact synonym: BCGF-II
has exact synonym: IL-5
has exact synonym: IL5
has exact synonym: T-cell replacing factor
has exact synonym: TRF
has exact synonym: cytotoxic T-lymphocyte inducer
has exact synonym: eosinophil differentiation factor
has OBO namespace: protein
id: PR:000001392
comment: Category=gene.

Axiom
annotated source: interleukin-5
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL5 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-5
annotated property: hasExactSynonym
annotated target: IL5
has db xref: PRO:DNx
has synonym type: PRO-short-label

interleukin-6
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL6 gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF001935
has exact synonym: B-cell hybridoma growth factor
has exact synonym: B-cell stimulatory factor 2
has exact synonym: BSF-2
has exact synonym: CDF
has exact synonym: CTL differentiation factor
has exact synonym: IFN-beta-2
has exact synonym: IL-6
has exact synonym: IL6
has exact synonym: hybridoma growth factor
has exact synonym: interferon beta-2
has exact synonym: interleukin HP-1
has OBO namespace: protein
has related synonym: IFNB2
id: PR:000001393
comment: Category=gene.

Axiom
annotated source: interleukin-6
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL6 gene or a 1:1 ortholog thereof.
has db xref: PRO:JAN

Axiom
annotated source: interleukin-6
annotated property: hasExactSynonym
annotated target: IL6
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-6
annotated property: hasRelatedSynonym
annotated target: IFNB2
has synonym type: Gene-based

interleukin-8
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human CXCL8 gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF500564
has exact synonym: C-X-C motif chemokine 8
has exact synonym: CXCL8
has exact synonym: IL-8
has exact synonym: MDNCF
has exact synonym: MONAP
has exact synonym: NAP-1
has exact synonym: T-cell chemotactic factor
has exact synonym: emoctakin
has exact synonym: granulocyte chemotactic protein 1
has exact synonym: monocyte-derived neutrophil chemotactic factor
has exact synonym: monocyte-derived neutrophil-activating peptide
has exact synonym: neutrophil-activating protein 1
has exact synonym: protein 3-10C
has OBO namespace: protein
has related synonym: GCP-1
has related synonym: IL8
id: PR:000001395
comment: Category=gene.

Axiom
annotated source: interleukin-8
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human CXCL8 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: interleukin-8
annotated property: hasExactSynonym
annotated target: CXCL8
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-8
annotated property: hasRelatedSynonym
annotated target: IL8
has synonym type: Gene-based

interleukin-9
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL9 gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF001943
has exact synonym: IL-9
has exact synonym: IL9
has exact synonym: T-cell growth factor P40
has exact synonym: cytokine P40
has OBO namespace: protein
id: PR:000001396
comment: Category=gene.

Axiom
annotated source: interleukin-9
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL9 gene or a 1:1 ortholog thereof.
has db xref: PRO:JAN

Axiom
annotated source: interleukin-9
annotated property: hasExactSynonym
annotated target: IL9
has db xref: PRO:DNx
has synonym type: PRO-short-label

interleukin-9 receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL9R gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1699
has db xref: PIRSF:PIRSF018548
has exact synonym: CD129
has exact synonym: IL-9 receptor
has exact synonym: IL-9R
has exact synonym: IL9R
has OBO namespace: protein
id: PR:000001397
comment: Category=gene.

Axiom
annotated source: interleukin-9 receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL9R gene or a 1:1 ortholog thereof.
has db xref: PRO:JAN

Axiom
annotated source: interleukin-9 receptor
annotated property: hasExactSynonym
annotated target: IL9R
has db xref: PRO:DNx
has synonym type: PRO-short-label

histamine H1 receptor
type: Class
subclass of: histamine receptor
IAO_0000115: A histamine receptor that is a translation product of the human HRH1 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:262
has db xref: PIRSF:PIRSF038644
has exact synonym: H1 histamine receptor
has exact synonym: H1R
has exact synonym: HH1R
has exact synonym: HRH1
has OBO namespace: protein
has related synonym: Bphs
id: PR:000001422
comment: Category=gene. Note: The preferred ligand is histamine. This receptor mediates smooth muscle contraction, NO formation, increased vascular permeability, and other diverse effects. [PMID:9311023]

Axiom
annotated source: histamine H1 receptor
annotated property: IAO_0000115
annotated target: A histamine receptor that is a translation product of the human HRH1 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: histamine H1 receptor
annotated property: hasExactSynonym
annotated target: HRH1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: histamine H1 receptor
annotated property: hasRelatedSynonym
annotated target: Bphs
has synonym type: Gene-based

histamine H2 receptor
type: Class
subclass of: histamine receptor
IAO_0000115: A histamine receptor that is a translation product of the human HRH2 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor mediates smooth muscle relaxation, gastric acid secretion, and other diverse effects.
has db xref: IUPHARobj:263
has db xref: PIRSF:PIRSF038634
has exact synonym: H2 histamine receptor
has exact synonym: H2R
has exact synonym: HH2R
has exact synonym: HRH2
has exact synonym: gastric receptor I
has OBO namespace: protein
id: PR:000001423
comment: Category=gene.

Axiom
annotated source: histamine H2 receptor
annotated property: IAO_0000115
annotated target: A histamine receptor that is a translation product of the human HRH2 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor mediates smooth muscle relaxation, gastric acid secretion, and other diverse effects.
has db xref: PMID:9311023
has db xref: PRO:WCB

Axiom
annotated source: histamine H2 receptor
annotated property: hasExactSynonym
annotated target: HRH2
has db xref: PRO:DNx
has synonym type: PRO-short-label

KiSS-1 receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human KISS1R gene or a 1:1 ortholog thereof. The preferred ligands are peptides of 10-54 residues derived from the metastasis-suppressor KiSS-1 protein.
has db xref: IUPHARobj:266
has db xref: PIRSF:PIRSF038571
has exact synonym: G-protein coupled receptor 54
has exact synonym: G-protein coupled receptor OT7T175
has exact synonym: KISS1R
has exact synonym: KiSS-1R
has exact synonym: OT7T175
has exact synonym: hypogonadotropin-1
has exact synonym: kisspeptins receptor
has exact synonym: metastin receptor
has OBO namespace: protein
has related synonym: AXOR12
has related synonym: GPR54
id: PR:000001426
comment: Category=gene.

Axiom
annotated source: KiSS-1 receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human KISS1R gene or a 1:1 ortholog thereof. The preferred ligands are peptides of 10-54 residues derived from the metastasis-suppressor KiSS-1 protein.
has db xref: PRO:WCB
has db xref: UniProtKB:Q15726

Axiom
annotated source: KiSS-1 receptor
annotated property: hasExactSynonym
annotated target: KISS1R
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: KiSS-1 receptor
annotated property: hasRelatedSynonym
annotated target: AXOR12
has synonym type: Gene-based

Axiom
annotated source: KiSS-1 receptor
annotated property: hasRelatedSynonym
annotated target: GPR54
has synonym type: Gene-based

N-formyl peptide receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human FPR1, FPR2, or FPR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds N-formyl methionyl peptides.
has db xref: IUPHARfam:23
has db xref: PIRSF:PIRSF038561
has exact synonym: formylpeptide receptor
has OBO namespace: protein
id: PR:000001431
comment: Category=family.

Axiom
annotated source: N-formyl peptide receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human FPR1, FPR2, or FPR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds N-formyl methionyl peptides.
has db xref: InterPro:IPR000826
has db xref: PRO:DAN
has db xref: PRO:WCB
has db xref: PRO:XQ

Axiom
annotated source: N-formyl peptide receptor
annotated property: hasExactSynonym
annotated target: formylpeptide receptor
has db xref: IUPHARfam:23

adenosine receptor protein
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human ADORA1, ADORA2A, ADORA2B, or ADORA3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds adenosine.
has db xref: IUPHARfam:3
has db xref: PIRSF:PIRSF005692
has OBO namespace: protein
id: PR:000001439
comment: Category=family.

Axiom
annotated source: adenosine receptor protein
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human ADORA1, ADORA2A, ADORA2B, or ADORA3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds adenosine.
has db xref: PRO:WCB
has db xref: PRO:XQ

blood group Rh(D) polypeptide
type: Class
subclass of: erythrocyte membrane protein Rh
IAO_0000115: An erythrocyte membrane protein Rh that is a translation product of the human RHD gene or a 1:1 ortholog thereof.
has exact synonym: CD240D
has exact synonym: RHD
has exact synonym: RHXIII
has exact synonym: Rh polypeptide 2
has exact synonym: RhPII
has exact synonym: blood group RhD polypeptide
has exact synonym: rhesus D antigen
has OBO namespace: protein
id: PR:000001442
comment: Category=gene.

Axiom
annotated source: blood group Rh(D) polypeptide
annotated property: IAO_0000115
annotated target: An erythrocyte membrane protein Rh that is a translation product of the human RHD gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: blood group Rh(D) polypeptide
annotated property: hasExactSynonym
annotated target: RHD
has db xref: PRO:DNx
has synonym type: PRO-short-label

fibroblast growth factor receptor 2
type: Class
subclass of: fibroblast growth factor receptor
IAO_0000115: A fibroblast growth factor receptor that is a translation product of the human FGFR2 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1809
has exact synonym: CD332
has exact synonym: FGFR-2
has exact synonym: FGFR2
has exact synonym: K-sam
has exact synonym: keratinocyte growth factor receptor
has OBO namespace: protein
has related synonym: BEK
has related synonym: Ect1
has related synonym: KGFR
has related synonym: KSAM
id: PR:000001449
comment: Category=gene.

Axiom
annotated source: fibroblast growth factor receptor 2
annotated property: IAO_0000115
annotated target: A fibroblast growth factor receptor that is a translation product of the human FGFR2 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: fibroblast growth factor receptor 2
annotated property: hasExactSynonym
annotated target: FGFR2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: fibroblast growth factor receptor 2
annotated property: hasRelatedSynonym
annotated target: BEK
has synonym type: Gene-based

Axiom
annotated source: fibroblast growth factor receptor 2
annotated property: hasRelatedSynonym
annotated target: Ect1
has synonym type: Gene-based

Axiom
annotated source: fibroblast growth factor receptor 2
annotated property: hasRelatedSynonym
annotated target: KGFR
has synonym type: Gene-based

Axiom
annotated source: fibroblast growth factor receptor 2
annotated property: hasRelatedSynonym
annotated target: KSAM
has synonym type: Gene-based

galanin receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human GALR1 to GALR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds the neuropeptide galanin.
has db xref: IUPHARfam:27
has db xref: PIRSF:PIRSF038570
has OBO namespace: protein
id: PR:000001457
comment: Category=family.

Axiom
annotated source: galanin receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human GALR1 to GALR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds the neuropeptide galanin.
has db xref: PMID:10689365
has db xref: PRO:WCB
has db xref: PRO:XQ

glycoprotein hormone receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human FSHR, LHCGR, or TSHR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds glycoprotein hormones (thyrotropin, follitropin, lutropin, choriogonadotropin).
has db xref: IUPHARfam:30
has db xref: PIRSF:PIRSF002408
has OBO namespace: protein
id: PR:000001463
comment: Category=family.

Axiom
annotated source: glycoprotein hormone receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human FSHR, LHCGR, or TSHR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds glycoprotein hormones (thyrotropin, follitropin, lutropin, choriogonadotropin).
has db xref: PRO:WCB
has db xref: PRO:XQ

gonadotropin-releasing hormone receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human GNRHR or GNRHR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds gonadotropin-releasing hormone I or II.
has db xref: IUPHARfam:31
has db xref: PIRSF:PIRSF038576
has OBO namespace: protein
id: PR:000001464
comment: Category=family.

Axiom
annotated source: gonadotropin-releasing hormone receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human GNRHR or GNRHR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds gonadotropin-releasing hormone I or II.
has db xref: PRO:WCB
has db xref: PRO:XQ

intercellular adhesion molecule 3
type: Class
subclass of: intercellular adhesion molecule 1/3
IAO_0000115: An intercellular adhesion molecule 1/3 that is a translation product of the human ICAM3 gene or a 1:1 ortholog thereof.
has exact synonym: CD50
has exact synonym: CDw50
has exact synonym: ICAM-3
has exact synonym: ICAM-R
has exact synonym: ICAM3
has OBO namespace: protein
id: PR:000001468
comment: Category=gene. This gene has been found in primates and Bos taurus, but not in mouse and rat.

Axiom
annotated source: intercellular adhesion molecule 3
annotated property: IAO_0000115
annotated target: An intercellular adhesion molecule 1/3 that is a translation product of the human ICAM3 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: intercellular adhesion molecule 3
annotated property: hasExactSynonym
annotated target: ICAM3
has db xref: PRO:DNx
has synonym type: PRO-short-label

interleukin-10
type: Class
subclass of: class 2 cytokine, IL-10 type
IAO_0000115: A class 2 cytokine, IL-10 type that is a translation product of the human IL10 gene or a 1:1 ortholog thereof.
has exact synonym: CSIF
has exact synonym: IL-10
has exact synonym: IL10
has exact synonym: cytokine synthesis inhibitory factor
has OBO namespace: protein
id: PR:000001471
comment: Category=gene. Note: Active interleukin-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells. Structurally, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulfide bonds.

Axiom
annotated source: interleukin-10
annotated property: IAO_0000115
annotated target: A class 2 cytokine, IL-10 type that is a translation product of the human IL10 gene or a 1:1 ortholog thereof.
has db xref: PRO:JAN

Axiom
annotated source: interleukin-10
annotated property: hasExactSynonym
annotated target: IL10
has db xref: PRO:DNx
has synonym type: PRO-short-label

interleukin-19
type: Class
subclass of: class 2 cytokine, IL-10 type
IAO_0000115: A class 2 cytokine, IL-10 type that is a translation product of the human IL19 gene or a 1:1 ortholog thereof.
has exact synonym: IL-19
has exact synonym: IL19
has exact synonym: NG.1
has exact synonym: melanoma differentiation-associated protein-like protein
has OBO namespace: protein
has related synonym: ZMDA1
id: PR:000001472
comment: Category=gene.

Axiom
annotated source: interleukin-19
annotated property: IAO_0000115
annotated target: A class 2 cytokine, IL-10 type that is a translation product of the human IL19 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-19
annotated property: hasExactSynonym
annotated target: IL19
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-19
annotated property: hasRelatedSynonym
annotated target: ZMDA1
has synonym type: Gene-based

interleukin-20
type: Class
subclass of: class 2 cytokine, IL-10 type
IAO_0000115: A class 2 cytokine, IL-10 type that is a translation product of the human IL20 gene or a 1:1 ortholog thereof.
has exact synonym: IL-20
has exact synonym: IL20
has exact synonym: cytokine Zcyto10
has OBO namespace: protein
has related synonym: UNQ852/PRO1801
has related synonym: ZCYTO10
id: PR:000001473
comment: Category=gene.

Axiom
annotated source: interleukin-20
annotated property: IAO_0000115
annotated target: A class 2 cytokine, IL-10 type that is a translation product of the human IL20 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-20
annotated property: hasExactSynonym
annotated target: IL20
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-20
annotated property: hasRelatedSynonym
annotated target: UNQ852/PRO1801
has synonym type: Gene-based

Axiom
annotated source: interleukin-20
annotated property: hasRelatedSynonym
annotated target: ZCYTO10
has synonym type: Gene-based

interleukin-24
type: Class
subclass of: class 2 cytokine, IL-10 type
IAO_0000115: A class 2 cytokine, IL-10 type that is a translation product of the human IL24 gene or a 1:1 ortholog thereof.
has exact synonym: IL-24
has exact synonym: IL-4-induced secreted protein
has exact synonym: IL24
has exact synonym: MDA-7
has exact synonym: Th2-specific cytokine FISP
has exact synonym: melanoma differentiation-associated gene 7 protein
has exact synonym: suppression of tumorigenicity 16 protein
has OBO namespace: protein
has related synonym: MDA7
has related synonym: ST16
id: PR:000001474
comment: Category=gene.

Axiom
annotated source: interleukin-24
annotated property: IAO_0000115
annotated target: A class 2 cytokine, IL-10 type that is a translation product of the human IL24 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-24
annotated property: hasExactSynonym
annotated target: IL24
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-24
annotated property: hasRelatedSynonym
annotated target: MDA7
has synonym type: Gene-based

Axiom
annotated source: interleukin-24
annotated property: hasRelatedSynonym
annotated target: ST16
has synonym type: Gene-based

interleukin-26
type: Class
subclass of: class 2 cytokine, IL-10 type
IAO_0000115: A class 2 cytokine, IL-10 type that is a translation product of the human IL26 gene or a 1:1 ortholog thereof.
has exact synonym: IL-26
has exact synonym: IL26
has exact synonym: protein AK155
has OBO namespace: protein
has related synonym: AK155
id: PR:000001475
comment: Category=gene.

Axiom
annotated source: interleukin-26
annotated property: IAO_0000115
annotated target: A class 2 cytokine, IL-10 type that is a translation product of the human IL26 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: interleukin-26
annotated property: hasExactSynonym
annotated target: IL26
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-26
annotated property: hasRelatedSynonym
annotated target: AK155
has synonym type: Gene-based

muscarinic acetylcholine receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human CHRM1 to CHRM5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: IUPHARfam:2
has db xref: PIRSF:PIRSF038548
has OBO namespace: protein
id: PR:000001488
comment: Category=family. Note: The active form binds the neurotransmitter acetylcholine. They are more sensitive to muscarine than to nicotine.

Axiom
annotated source: muscarinic acetylcholine receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human CHRM1 to CHRM5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PRO:WCB
has db xref: PRO:XQ
has db xref: Wikipedia:Muscarinic_acetylcholine_receptor

neuromedin-U receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human NMUR1 or NMUR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: IUPHARfam:42
has db xref: PIRSF:PIRSF038640
has exact synonym: fam:NMU_R
has exact synonym: neuromedin U receptor
has OBO namespace: protein
id: PR:000001489
comment: Category=family. Note: The active form binds the neuropeptide neuromedin-U.

Axiom
annotated source: neuromedin-U receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human NMUR1 or NMUR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: neuromedin-U receptor
annotated property: hasExactSynonym
annotated target: fam:NMU_R
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: neuromedin-U receptor
annotated property: hasExactSynonym
annotated target: neuromedin U receptor
has db xref: IUPHARfam:42

opioid receptor protein
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human OPRD1, OPRK1, OPRM1, or OPRL1 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: IUPHARfam:50
has db xref: PIRSF:PIRSF038567
has OBO namespace: protein
id: PR:000001497
comment: Category=family. Note: The active form binds opioids.

Axiom
annotated source: opioid receptor protein
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human OPRD1, OPRK1, OPRM1, or OPRL1 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PRO:WCB
has db xref: PRO:XQ

pyroglutamylated RF-amide peptide receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human QRFPR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:333
has db xref: PIRSF:PIRSF038648
has exact synonym: AQ27
has exact synonym: G-protein coupled receptor 103
has exact synonym: QRFPR
has exact synonym: SP9155
has exact synonym: orexigenic neuropeptide QRFP receptor
has OBO namespace: protein
has related synonym: GPR103
id: PR:000001498
comment: Category=gene. Note: This receptor is expressed at high levels in brain and retina and at moderate levels in the heart, kidney, testis and thyroid.

Axiom
annotated source: pyroglutamylated RF-amide peptide receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human QRFPR gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB
has db xref: UniProtKB:Q96P65

Axiom
annotated source: pyroglutamylated RF-amide peptide receptor
annotated property: hasExactSynonym
annotated target: QRFPR
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: pyroglutamylated RF-amide peptide receptor
annotated property: hasRelatedSynonym
annotated target: GPR103
has synonym type: Gene-based

orexin receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human HCRTR1 or HCRTR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: IUPHARfam:51
has db xref: PIRSF:PIRSF038624
has exact synonym: hypocretin receptor
has OBO namespace: protein
id: PR:000001499
comment: Category=family. Note: The active form binds the neuropeptide hormone orexin (hypocretin).

Axiom
annotated source: orexin receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human HCRTR1 or HCRTR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PRO:WCB
has db xref: PRO:XQ

prolactin-releasing peptide receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human PRLHR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:337
has db xref: PIRSF:PIRSF038611
has exact synonym: G-protein coupled receptor 10
has exact synonym: PRLHR
has exact synonym: PrRP receptor
has exact synonym: PrRPR
has OBO namespace: protein
has related synonym: GPR10
has related synonym: GR3
has related synonym: Gm339
id: PR:000001546
comment: Category=gene.

Axiom
annotated source: prolactin-releasing peptide receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human PRLHR gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: prolactin-releasing peptide receptor
annotated property: hasExactSynonym
annotated target: PRLHR
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: prolactin-releasing peptide receptor
annotated property: hasRelatedSynonym
annotated target: GPR10
has synonym type: Gene-based

Axiom
annotated source: prolactin-releasing peptide receptor
annotated property: hasRelatedSynonym
annotated target: GR3
has synonym type: Gene-based

Axiom
annotated source: prolactin-releasing peptide receptor
annotated property: hasRelatedSynonym
annotated target: Gm339
has synonym type: Gene-based

prostaglandin E2 receptor EP4 subtype
type: Class
subclass of: prostanoid receptor
IAO_0000115: A prostanoid receptor that is a translation product of the human PTGER4 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2. This receptor is not closely related to other prostaglandin E2 receptors.
has db xref: IUPHARobj:343
has db xref: PIRSF:PIRSF038586
has exact synonym: PGE receptor EP4 subtype
has exact synonym: PGE2 receptor EP4 subtype
has exact synonym: PTGER4
has exact synonym: prostaglandin E2 receptor EP4
has exact synonym: prostanoid EP4 receptor
has OBO namespace: protein
has related synonym: PTGER2
has related synonym: Ptgerep4
id: PR:000001548
comment: Category=gene.

Axiom
annotated source: prostaglandin E2 receptor EP4 subtype
annotated property: IAO_0000115
annotated target: A prostanoid receptor that is a translation product of the human PTGER4 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2. This receptor is not closely related to other prostaglandin E2 receptors.
has db xref: PRO:WCB

Axiom
annotated source: prostaglandin E2 receptor EP4 subtype
annotated property: hasExactSynonym
annotated target: PTGER4
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: prostaglandin E2 receptor EP4 subtype
annotated property: hasRelatedSynonym
annotated target: PTGER2
has synonym type: Gene-based

Axiom
annotated source: prostaglandin E2 receptor EP4 subtype
annotated property: hasRelatedSynonym
annotated target: Ptgerep4
has synonym type: Gene-based

prostanoid receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human PTGDR, PTGDR2, PTGER1 to PTGER4, PTGFR, PTGIR, or TBXA2R genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds prostanoids (prostaglandins and thromboxanes).
has db xref: IUPHARfam:58
has db xref: PIRSF:PIRSF001962
has OBO namespace: protein
id: PR:000001549
comment: Category=family.

Axiom
annotated source: prostanoid receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human PTGDR, PTGDR2, PTGER1 to PTGER4, PTGFR, PTGIR, or TBXA2R genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds prostanoids (prostaglandins and thromboxanes).
has db xref: PMID:7938166
has db xref: PRO:WCB
has db xref: PRO:XQ

proteinase-activated receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human F2R, or F2RL1 to F2RL3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds trypsin-related proteinases. The proteinase cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity.
has db xref: IUPHARfam:59
has db xref: PIRSF:PIRSF037996
has exact synonym: fam:PAR
has OBO namespace: protein
id: PR:000001550
comment: Category=family.

Axiom
annotated source: proteinase-activated receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human F2R, or F2RL1 to F2RL3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds trypsin-related proteinases. The proteinase cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity.
has db xref: PRO:WCB
has db xref: PRO:XQ

Axiom
annotated source: proteinase-activated receptor
annotated property: hasExactSynonym
annotated target: fam:PAR
has db xref: PRO:DAN
has synonym type: PRO-short-label

somatostatin receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human SSTR1 to SSTR5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds somatostatin.
has db xref: IUPHARfam:61
has db xref: PIRSF:PIRSF038568
has OBO namespace: protein
id: PR:000001555
comment: Category=family.

Axiom
annotated source: somatostatin receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human SSTR1 to SSTR5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds somatostatin.
has db xref: PRO:WCB
has db xref: PRO:XQ

thyrotropin-releasing hormone receptor type 1
type: Class
subclass of: thyrotropin-releasing hormone receptor
IAO_0000115: A thyrotropin-releasing hormone receptor that is a translation product of the human TRHR gene or a 1:1 ortholog thereof. The preferred ligand is thyrotropin-releasing hormone.
has broad synonym: TRH-R
has db xref: IUPHARobj:363
has db xref: PIRSF:PIRSF038645
has exact synonym: TRH-R1
has exact synonym: TRHR
has exact synonym: thyroliberin receptor
has OBO namespace: protein
id: PR:000001557
comment: Category=gene.

Axiom
annotated source: thyrotropin-releasing hormone receptor type 1
annotated property: IAO_0000115
annotated target: A thyrotropin-releasing hormone receptor that is a translation product of the human TRHR gene or a 1:1 ortholog thereof. The preferred ligand is thyrotropin-releasing hormone.
has db xref: PRO:WCB

Axiom
annotated source: thyrotropin-releasing hormone receptor type 1
annotated property: hasBroadSynonym
annotated target: TRH-R
has db xref: PRO:DNx

Axiom
annotated source: thyrotropin-releasing hormone receptor type 1
annotated property: hasExactSynonym
annotated target: TRHR
has db xref: PRO:DNx
has synonym type: PRO-short-label

vasopressin/oxytocin receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human AVPR1A, AVPR1B, AVPR2, or OXTR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. These receptors bind vasopressin or oxytocin or related nonapeptides.
has db xref: IUPHARfam:66
has db xref: PIRSF:PIRSF001841
has exact synonym: name: vasopressin and oxytocin receptor
has OBO namespace: protein
id: PR:000001562
comment: Category=family.

Axiom
annotated source: vasopressin/oxytocin receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human AVPR1A, AVPR1B, AVPR2, or OXTR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. These receptors bind vasopressin or oxytocin or related nonapeptides.
has db xref: PRO:WCB
has db xref: PRO:XQ
has db xref: Wikipedia:Vasopressin
has db xref: Wikipedia:Vasopressin_receptor

Axiom
annotated source: vasopressin/oxytocin receptor
annotated property: hasExactSynonym
annotated target: name: vasopressin and oxytocin receptor
has db xref: IUPHARfam:66

histamine H3 receptor
type: Class
subclass of: histamine receptor
IAO_0000115: A histamine receptor that is a translation product of the human HRH3 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor mediates inhibition of gastric acid release, inhibition of neurotransmitter release, and other diverse effects.
has db xref: IUPHARobj:264
has exact synonym: H3 histamine receptor
has exact synonym: H3R
has exact synonym: HH3R
has exact synonym: HRH3
has OBO namespace: protein
has related synonym: G-protein coupled receptor 97
has related synonym: GPCR97
id: PR:000001564
comment: Category=gene.

Axiom
annotated source: histamine H3 receptor
annotated property: IAO_0000115
annotated target: A histamine receptor that is a translation product of the human HRH3 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor mediates inhibition of gastric acid release, inhibition of neurotransmitter release, and other diverse effects.
has db xref: PMID:9311023
has db xref: PRO:WCB

Axiom
annotated source: histamine H3 receptor
annotated property: hasExactSynonym
annotated target: HRH3
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: histamine H3 receptor
annotated property: hasRelatedSynonym
annotated target: GPCR97
has synonym type: Gene-based

H4 histamine receptor
type: Class
subclass of: histamine receptor
IAO_0000115: A histamine receptor that is a translation product of the human HRH4 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor is expressed primarily in the bone marrow and eosinophils but also in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node.
has db xref: IUPHARobj:265
has exact synonym: AXOR35
has exact synonym: GPRv53
has exact synonym: H4R
has exact synonym: HH4R
has exact synonym: HRH4
has exact synonym: Pfi-013
has exact synonym: SP9144
has OBO namespace: protein
has related synonym: G-protein coupled receptor 105
has related synonym: GPCR105
id: PR:000001565
comment: Category=gene.

Axiom
annotated source: H4 histamine receptor
annotated property: IAO_0000115
annotated target: A histamine receptor that is a translation product of the human HRH4 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor is expressed primarily in the bone marrow and eosinophils but also in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node.
has db xref: PRO:WCB
has db xref: UniProtKB:Q9H3N8

Axiom
annotated source: H4 histamine receptor
annotated property: hasExactSynonym
annotated target: HRH4
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: H4 histamine receptor
annotated property: hasRelatedSynonym
annotated target: GPCR105
has synonym type: Gene-based

delta-type opioid receptor
type: Class
subclass of: opioid receptor protein
IAO_0000115: An opioid receptor protein that is a translation product of the human OPRD1 gene or a 1:1 ortholog thereof. The preferred ligands are enkephalins.
has db xref: IUPHARobj:317
has exact synonym: D-OR-1
has exact synonym: DOR-1
has exact synonym: K56
has exact synonym: OPRD1
has exact synonym: delta-opioid receptor
has OBO namespace: protein
has related synonym: MSL-2
has related synonym: OPRD
id: PR:000001579
comment: Category=gene.

Axiom
annotated source: delta-type opioid receptor
annotated property: IAO_0000115
annotated target: An opioid receptor protein that is a translation product of the human OPRD1 gene or a 1:1 ortholog thereof. The preferred ligands are enkephalins.
has db xref: PRO:WCB
has db xref: Wikipedia:delta_Opioid_receptor

Axiom
annotated source: delta-type opioid receptor
annotated property: hasExactSynonym
annotated target: OPRD1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: delta-type opioid receptor
annotated property: hasRelatedSynonym
annotated target: OPRD
has synonym type: Gene-based

kappa-type opioid receptor
type: Class
subclass of: opioid receptor protein
IAO_0000115: An opioid receptor protein that is a translation product of the human OPRK1 gene or a 1:1 ortholog thereof. The preferred ligand is dynorphin.
has db xref: IUPHARobj:318
has exact synonym: K-OR-1
has exact synonym: KOR-1
has exact synonym: OPRK1
has exact synonym: kappa-opioid receptor
has OBO namespace: protein
has related synonym: MSL-1
has related synonym: OPRK
id: PR:000001590
comment: Category=gene.

Axiom
annotated source: kappa-type opioid receptor
annotated property: IAO_0000115
annotated target: An opioid receptor protein that is a translation product of the human OPRK1 gene or a 1:1 ortholog thereof. The preferred ligand is dynorphin.
has db xref: PRO:WCB
has db xref: Wikipedia:kappa_Opioid_receptor

Axiom
annotated source: kappa-type opioid receptor
annotated property: hasExactSynonym
annotated target: OPRK1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: kappa-type opioid receptor
annotated property: hasRelatedSynonym
annotated target: OPRK
has synonym type: Gene-based

lutropin-choriogonadotropic hormone receptor
type: Class
subclass of: glycoprotein hormone receptor
IAO_0000115: A glycoprotein hormone receptor that is a translation product of the human LHCGR gene or a 1:1 ortholog thereof. The preferred ligands are lutropin (luteinizing hormone) and choriogonadotropin (choriogonadotropic hormone).
has db xref: IUPHARobj:254
has exact synonym: LH/CG-R
has exact synonym: LHCGR
has exact synonym: LHR
has exact synonym: LSH-R
has exact synonym: luteinizing hormone receptor
has exact synonym: lutropin/choriogonadotropin receptor
has OBO namespace: protein
has related synonym: LCGR
has related synonym: LGR2
has related synonym: LHRHR
id: PR:000001596
comment: Category=gene.

Axiom
annotated source: lutropin-choriogonadotropic hormone receptor
annotated property: IAO_0000115
annotated target: A glycoprotein hormone receptor that is a translation product of the human LHCGR gene or a 1:1 ortholog thereof. The preferred ligands are lutropin (luteinizing hormone) and choriogonadotropin (choriogonadotropic hormone).
has db xref: PRO:WCB

Axiom
annotated source: lutropin-choriogonadotropic hormone receptor
annotated property: hasExactSynonym
annotated target: LHCGR
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: lutropin-choriogonadotropic hormone receptor
annotated property: hasRelatedSynonym
annotated target: LCGR
has synonym type: Gene-based

Axiom
annotated source: lutropin-choriogonadotropic hormone receptor
annotated property: hasRelatedSynonym
annotated target: LGR2
has synonym type: Gene-based

Axiom
annotated source: lutropin-choriogonadotropic hormone receptor
annotated property: hasRelatedSynonym
annotated target: LHRHR
has synonym type: Gene-based

mu-type opioid receptor
type: Class
subclass of: opioid receptor protein
IAO_0000115: An opioid receptor protein that is a translation product of the human OPRM1 gene or a 1:1 ortholog thereof. The preferred ligands are beta-endorphin and enkephalins.
has db xref: IUPHARobj:319
has exact synonym: M-OR-1
has exact synonym: MOP
has exact synonym: MOR-1
has exact synonym: OPRM1
has exact synonym: mu opiate receptor
has exact synonym: mu opioid receptor
has exact synonym: mu-opioid receptor
has OBO namespace: protein
has related synonym: MOR1
has related synonym: Mor
has related synonym: Oprm
id: PR:000001612
comment: Category=gene.

Axiom
annotated source: mu-type opioid receptor
annotated property: IAO_0000115
annotated target: An opioid receptor protein that is a translation product of the human OPRM1 gene or a 1:1 ortholog thereof. The preferred ligands are beta-endorphin and enkephalins.
has db xref: PRO:WCB
has db xref: Wikipedia:mu_Opioid_receptor

Axiom
annotated source: mu-type opioid receptor
annotated property: hasExactSynonym
annotated target: OPRM1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: mu-type opioid receptor
annotated property: hasRelatedSynonym
annotated target: MOR1
has synonym type: Gene-based

Axiom
annotated source: mu-type opioid receptor
annotated property: hasRelatedSynonym
annotated target: Mor
has synonym type: Gene-based

Axiom
annotated source: mu-type opioid receptor
annotated property: hasRelatedSynonym
annotated target: Oprm
has synonym type: Gene-based

nociceptin receptor
type: Class
subclass of: opioid receptor protein
IAO_0000115: An opioid receptor protein that is a translation product of the human OPRL1 gene or a 1:1 ortholog thereof. The preferred ligand is nociceptin.
has db xref: IUPHARobj:320
has exact synonym: K3 opiate receptor
has exact synonym: KOR-3
has exact synonym: OPRL1
has exact synonym: ORGC
has exact synonym: kappa-type 3 opioid receptor
has exact synonym: orphanin FQ receptor
has OBO namespace: protein
has related synonym: OOR
has related synonym: ORL1
has related synonym: Oprl
id: PR:000001631
comment: Category=gene.

Axiom
annotated source: nociceptin receptor
annotated property: IAO_0000115
annotated target: An opioid receptor protein that is a translation product of the human OPRL1 gene or a 1:1 ortholog thereof. The preferred ligand is nociceptin.
has db xref: PRO:WCB

Axiom
annotated source: nociceptin receptor
annotated property: hasExactSynonym
annotated target: OPRL1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: nociceptin receptor
annotated property: hasRelatedSynonym
annotated target: OOR
has synonym type: Gene-based

Axiom
annotated source: nociceptin receptor
annotated property: hasRelatedSynonym
annotated target: ORL1
has synonym type: Gene-based

Axiom
annotated source: nociceptin receptor
annotated property: hasRelatedSynonym
annotated target: Oprl
has synonym type: Gene-based

oxytocin receptor
type: Class
subclass of: vasopressin/oxytocin receptor
IAO_0000115: A vasopressin/oxytocin receptor that is a translation product of the human OXTR gene or a 1:1 ortholog thereof. The preferred ligand is oxytocin.
has db xref: IUPHARobj:369
has exact synonym: OT-R
has exact synonym: OXTR
has OBO namespace: protein
id: PR:000001635
comment: Category=gene.

Axiom
annotated source: oxytocin receptor
annotated property: IAO_0000115
annotated target: A vasopressin/oxytocin receptor that is a translation product of the human OXTR gene or a 1:1 ortholog thereof. The preferred ligand is oxytocin.
has db xref: PRO:WCB

Axiom
annotated source: oxytocin receptor
annotated property: hasExactSynonym
annotated target: OXTR
has db xref: PRO:DNx
has synonym type: PRO-short-label

prostacyclin receptor
type: Class
subclass of: prostanoid receptor
IAO_0000115: A prostanoid receptor that is a translation product of the human PTGIR gene or a 1:1 ortholog thereof. The preferred ligand is prostacyclin (prostaglandin I2, PGI2). This receptor is widely distributed in blood platelets, vascular smooth muscle and nerve cells.
has db xref: IUPHARobj:345
has exact synonym: PGI receptor
has exact synonym: PGI2 receptor
has exact synonym: PTGIR
has exact synonym: prostaglandin I2 receptor
has exact synonym: prostanoid IP receptor
has OBO namespace: protein
has related synonym: PRIPR
id: PR:000001655
comment: Category=gene.

Axiom
annotated source: prostacyclin receptor
annotated property: IAO_0000115
annotated target: A prostanoid receptor that is a translation product of the human PTGIR gene or a 1:1 ortholog thereof. The preferred ligand is prostacyclin (prostaglandin I2, PGI2). This receptor is widely distributed in blood platelets, vascular smooth muscle and nerve cells.
has db xref: PMID:7938166
has db xref: PRO:WCB

Axiom
annotated source: prostacyclin receptor
annotated property: hasExactSynonym
annotated target: PTGIR
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: prostacyclin receptor
annotated property: hasRelatedSynonym
annotated target: PRIPR
has synonym type: Gene-based

prostaglandin D2 receptor
type: Class
subclass of: prostanoid receptor
IAO_0000115: A prostanoid receptor that is a translation product of the human PTGDR gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin D2 (PGD2). This receptor is found mainly in blood platelets, vascular smooth muscle, and nervous tissue. It is the least upiquitous of the prostanoid receptors, almost always occurring in association with other prostanoid receptor types.
has db xref: IUPHARobj:338
has exact synonym: PGD receptor
has exact synonym: PGD2 receptor
has exact synonym: PTGDR
has exact synonym: prostanoid DP receptor
has OBO namespace: protein
id: PR:000001656
comment: Category=gene.

Axiom
annotated source: prostaglandin D2 receptor
annotated property: IAO_0000115
annotated target: A prostanoid receptor that is a translation product of the human PTGDR gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin D2 (PGD2). This receptor is found mainly in blood platelets, vascular smooth muscle, and nervous tissue. It is the least upiquitous of the prostanoid receptors, almost always occurring in association with other prostanoid receptor types.
has db xref: PMID:7938166
has db xref: PRO:WCB

Axiom
annotated source: prostaglandin D2 receptor
annotated property: hasExactSynonym
annotated target: PTGDR
has db xref: PRO:DNx
has synonym type: PRO-short-label

prostaglandin E2 receptor EP1 subtype
type: Class
subclass of: prostanoid receptor
IAO_0000115: A prostanoid receptor that is a translation product of the human PTGER1 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor has limited expression, although it is more evident in rodents than in other mammals.
has db xref: IUPHARobj:340
has exact synonym: PGE receptor EP1 subtype
has exact synonym: PGE2 receptor EP1 subtype
has exact synonym: PTGER1
has exact synonym: prostaglandin E2 receptor EP1
has exact synonym: prostanoid EP1 receptor
has OBO namespace: protein
has related synonym: Ptgerep1
id: PR:000001657
comment: Category=gene.

Axiom
annotated source: prostaglandin E2 receptor EP1 subtype
annotated property: IAO_0000115
annotated target: A prostanoid receptor that is a translation product of the human PTGER1 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor has limited expression, although it is more evident in rodents than in other mammals.
has db xref: PMID:7938166
has db xref: PRO:WCB

Axiom
annotated source: prostaglandin E2 receptor EP1 subtype
annotated property: hasExactSynonym
annotated target: PTGER1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: prostaglandin E2 receptor EP1 subtype
annotated property: hasRelatedSynonym
annotated target: Ptgerep1
has synonym type: Gene-based

prostaglandin E2 receptor EP2 subtype
type: Class
subclass of: prostanoid receptor
IAO_0000115: A prostanoid receptor that is a translation product of the human PTGER2 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor is expressed mediates various effects, including relaxation of vascular smooth muscles, nonacid secretion from epithelial cells, inhibition of mediator release from mast cells and basophils, and activation of sensory afferent nerves.
has db xref: IUPHARobj:341
has exact synonym: PGE receptor EP2 subtype
has exact synonym: PGE2 receptor EP2 subtype
has exact synonym: PTGER2
has exact synonym: prostaglandin E2 receptor EP2
has exact synonym: prostanoid EP2 receptor
has OBO namespace: protein
has related synonym: Ptgerep2
id: PR:000001658
comment: Category=gene.

Axiom
annotated source: prostaglandin E2 receptor EP2 subtype
annotated property: IAO_0000115
annotated target: A prostanoid receptor that is a translation product of the human PTGER2 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor is expressed mediates various effects, including relaxation of vascular smooth muscles, nonacid secretion from epithelial cells, inhibition of mediator release from mast cells and basophils, and activation of sensory afferent nerves.
has db xref: PMID:7938166
has db xref: PRO:WCB

Axiom
annotated source: prostaglandin E2 receptor EP2 subtype
annotated property: hasExactSynonym
annotated target: PTGER2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: prostaglandin E2 receptor EP2 subtype
annotated property: hasRelatedSynonym
annotated target: Ptgerep2
has synonym type: Gene-based

prostaglandin E2 receptor EP3 subtype
type: Class
subclass of: prostanoid receptor
IAO_0000115: A prostanoid receptor that is a translation product of the human PTGER3 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor is the most ubiquitous of the prostaglandin E2 receptors, mediating contraction of gastrointestinal, uterine, and vascular smooth muscle, inhibition of neurotransmitter release from autonomic nerves, inhibition of lipolysis in adipocytes, inhibition of acid secretion from gastric mucosa, and inhibition of water reabsorption in kidney.
has db xref: IUPHARobj:342
has exact synonym: PGE receptor EP3 subtype
has exact synonym: PGE2 receptor EP3 subtype
has exact synonym: PGE2-R
has exact synonym: PTGER3
has exact synonym: prostaglandin E2 receptor EP3
has exact synonym: prostanoid EP3 receptor
has OBO namespace: protein
has related synonym: Ptgerep3
id: PR:000001659
comment: Category=gene.

Axiom
annotated source: prostaglandin E2 receptor EP3 subtype
annotated property: IAO_0000115
annotated target: A prostanoid receptor that is a translation product of the human PTGER3 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor is the most ubiquitous of the prostaglandin E2 receptors, mediating contraction of gastrointestinal, uterine, and vascular smooth muscle, inhibition of neurotransmitter release from autonomic nerves, inhibition of lipolysis in adipocytes, inhibition of acid secretion from gastric mucosa, and inhibition of water reabsorption in kidney.
has db xref: PMID:7938166
has db xref: PRO:WCB

Axiom
annotated source: prostaglandin E2 receptor EP3 subtype
annotated property: hasExactSynonym
annotated target: PTGER3
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: prostaglandin E2 receptor EP3 subtype
annotated property: hasRelatedSynonym
annotated target: Ptgerep3
has synonym type: Gene-based

prostaglandin F2-alpha receptor
type: Class
subclass of: prostanoid receptor
IAO_0000115: A prostanoid receptor that is a translation product of the human PTGFR gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin F2a. This receptor is particularly prevalent in the corpus luteum, but is expressed in other tissues also.
has db xref: IUPHARobj:344
has exact synonym: PGF receptor
has exact synonym: PGF2-alpha receptor
has exact synonym: PTGFR
has exact synonym: prostanoid FP receptor
has OBO namespace: protein
id: PR:000001660
comment: Category=gene.

Axiom
annotated source: prostaglandin F2-alpha receptor
annotated property: IAO_0000115
annotated target: A prostanoid receptor that is a translation product of the human PTGFR gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin F2a. This receptor is particularly prevalent in the corpus luteum, but is expressed in other tissues also.
has db xref: PMID:7938166
has db xref: PRO:WCB

Axiom
annotated source: prostaglandin F2-alpha receptor
annotated property: hasExactSynonym
annotated target: PTGFR
has db xref: PRO:DNx
has synonym type: PRO-short-label

proteinase-activated receptor 1
type: Class
subclass of: proteinase-activated receptor
IAO_0000115: A proteinase-activated receptor that is a translation product of the human F2R gene or a 1:1 ortholog thereof. It is activated by thrombin, which cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity.
has db xref: IUPHARobj:347
has exact synonym: F2R
has exact synonym: PAR-1
has exact synonym: coagulation factor II receptor
has exact synonym: thrombin receptor
has OBO namespace: protein
has related synonym: CF2R
has related synonym: PAR1
has related synonym: TR
id: PR:000001661
comment: Category=gene.

Axiom
annotated source: proteinase-activated receptor 1
annotated property: IAO_0000115
annotated target: A proteinase-activated receptor that is a translation product of the human F2R gene or a 1:1 ortholog thereof. It is activated by thrombin, which cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity.
has db xref: PMID:1672265
has db xref: PRO:WCB

Axiom
annotated source: proteinase-activated receptor 1
annotated property: hasExactSynonym
annotated target: F2R
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: proteinase-activated receptor 1
annotated property: hasRelatedSynonym
annotated target: CF2R
has synonym type: Gene-based

Axiom
annotated source: proteinase-activated receptor 1
annotated property: hasRelatedSynonym
annotated target: PAR1
has synonym type: Gene-based

Axiom
annotated source: proteinase-activated receptor 1
annotated property: hasRelatedSynonym
annotated target: TR
has synonym type: Gene-based

thromboxane A2 receptor
type: Class
subclass of: prostanoid receptor
IAO_0000115: A prostanoid receptor that is a translation product of the human TBXA2R gene or a 1:1 ortholog thereof. The preferred ligand is thromboxane A2. This receptor is found mainly in vascular smooth muscle, where it mediates vasoconstriction, in platelets, where it mediates aggregation, and in airway smooth muscle.
has db xref: IUPHARobj:346
has exact synonym: TBXA2R
has exact synonym: TXA2-R
has exact synonym: prostanoid TP receptor
has OBO namespace: protein
id: PR:000001676
comment: Category=gene.

Axiom
annotated source: thromboxane A2 receptor
annotated property: IAO_0000115
annotated target: A prostanoid receptor that is a translation product of the human TBXA2R gene or a 1:1 ortholog thereof. The preferred ligand is thromboxane A2. This receptor is found mainly in vascular smooth muscle, where it mediates vasoconstriction, in platelets, where it mediates aggregation, and in airway smooth muscle.
has db xref: PMID:7938166
has db xref: PRO:WCB

Axiom
annotated source: thromboxane A2 receptor
annotated property: hasExactSynonym
annotated target: TBXA2R
has db xref: PRO:DNx
has synonym type: PRO-short-label

transcription factor NF-kappa-B subunit
type: Class
subclass of: protein
IAO_0000115: A protein that has a core domain composition consisting of a Rel homology domain (RHD) (Pfam:PF00554), an IPT/TIG domain (Pfam:PF01833), six copies of the Ankyrin repeat (Pfam:PF00023), a Death domain (Pfam:PF00531) and a C-terminal PEST region.
has db xref: PIRSF:PIRSF036310
has OBO namespace: protein
has related synonym: transcription factor NF-kappa-B
id: PR:000001753
comment: Category=family.

Axiom
annotated source: transcription factor NF-kappa-B subunit
annotated property: IAO_0000115
annotated target: A protein that has a core domain composition consisting of a Rel homology domain (RHD) (Pfam:PF00554), an IPT/TIG domain (Pfam:PF01833), six copies of the Ankyrin repeat (Pfam:PF00023), a Death domain (Pfam:PF00531) and a C-terminal PEST region.
has db xref: PRO:JAN

C/C-C motif small inducible chemokine
type: Class
subclass of: protein
IAO_0000115: A protein with core architecture consisting of a Small cytokines (intecrine/chemokine), interleukin-8 like (Pfam:PF00048) domain.
has db xref: PIRSF:PIRSF001950
has exact synonym: fam:C/C-C chemokine
has OBO namespace: protein
id: PR:000001808
comment: Category=family.

Axiom
annotated source: C/C-C motif small inducible chemokine
annotated property: IAO_0000115
annotated target: A protein with core architecture consisting of a Small cytokines (intecrine/chemokine), interleukin-8 like (Pfam:PF00048) domain.
has db xref: PRO:WCB

Axiom
annotated source: C/C-C motif small inducible chemokine
annotated property: hasExactSynonym
annotated target: fam:C/C-C chemokine
has db xref: PRO:DAN
has synonym type: PRO-short-label

CSF-1/PDGF receptor-type tyrosine-protein kinase
type: Class
subclass of: protein
IAO_0000115: A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (Pfam:PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. Pfam:PF00047 is most common, but other members of the Ig domain clan, Pfam:PF07679 and Pfam:PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines.
has db xref: PIRSF:PIRSF000615
has OBO namespace: protein
id: PR:000001810
comment: Category=family.

Axiom
annotated source: CSF-1/PDGF receptor-type tyrosine-protein kinase
annotated property: IAO_0000115
annotated target: A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (Pfam:PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. Pfam:PF00047 is most common, but other members of the Ig domain clan, Pfam:PF07679 and Pfam:PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines.
has db xref: PRO:WCB

EGF receptor type tyrosine-protein kinase
type: Class
subclass of: protein
IAO_0000115: A protein with core architecture consisting of a signal sequence, a Receptor L domain (Pfam:PF01030), a Furin-like cysteine rich region (Pfam:PF00757), another Receptor L domain, a transmembrane domain, and a Protein tyrosine kinase domain (Pfam:PF07714), that may be followed by up to two YLP motifs (Pfam:PF02757).
has db xref: PIRSF:PIRSF000619
has OBO namespace: protein
id: PR:000001812
comment: Category=family.

Axiom
annotated source: EGF receptor type tyrosine-protein kinase
annotated property: IAO_0000115
annotated target: A protein with core architecture consisting of a signal sequence, a Receptor L domain (Pfam:PF01030), a Furin-like cysteine rich region (Pfam:PF00757), another Receptor L domain, a transmembrane domain, and a Protein tyrosine kinase domain (Pfam:PF07714), that may be followed by up to two YLP motifs (Pfam:PF02757).
has db xref: PRO:WCB

HGF/MSP receptor type tyrosine-protein kinase
type: Class
subclass of: protein
IAO_0000115: A protein with core architecture consisting of a signal sequence, followed by a Sema domain (Pfam:PF01403), three IPT/TIG domains (Pfam:PF01833), a transmembrane region, and a Protein tyrosine kinase domain (Pfam:PF07714).
has db xref: PIRSF:PIRSF000617
has OBO namespace: protein
id: PR:000001816
comment: Category=family.

Axiom
annotated source: HGF/MSP receptor type tyrosine-protein kinase
annotated property: IAO_0000115
annotated target: A protein with core architecture consisting of a signal sequence, followed by a Sema domain (Pfam:PF01403), three IPT/TIG domains (Pfam:PF01833), a transmembrane region, and a Protein tyrosine kinase domain (Pfam:PF07714).
has db xref: PRO:WCB

leukemia inhibitory factor receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human LIFR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1713
has exact synonym: CD118
has exact synonym: D-factor/LIF receptor
has exact synonym: LIF receptor
has exact synonym: LIF-R
has exact synonym: LIFR
has OBO namespace: protein
id: PR:000001876
comment: Category=gene.

Axiom
annotated source: leukemia inhibitory factor receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human LIFR gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: leukemia inhibitory factor receptor
annotated property: hasExactSynonym
annotated target: LIFR
has db xref: PRO:DNx
has synonym type: PRO-short-label

melanotransferrin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human MELTF gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF500685
has exact synonym: CD228
has exact synonym: MELTF
has exact synonym: MTf
has exact synonym: melanoma-associated antigen p97
has exact synonym: membrane-bound transferrin-like protein p97
has OBO namespace: protein
has related synonym: MAP97
has related synonym: MFI2
id: PR:000001887
comment: Category=gene.

Axiom
annotated source: melanotransferrin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human MELTF gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: melanotransferrin
annotated property: hasExactSynonym
annotated target: MELTF
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: melanotransferrin
annotated property: hasRelatedSynonym
annotated target: MAP97
has synonym type: Gene-based

Axiom
annotated source: melanotransferrin
annotated property: hasRelatedSynonym
annotated target: MFI2
has synonym type: Gene-based

nuclear receptor ROR-gamma
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human RORC gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:600
has exact synonym: RAR-related orphan receptor C
has exact synonym: RORC
has exact synonym: TOR
has exact synonym: nuclear receptor RZR-gamma
has exact synonym: nuclear receptor subfamily 1 group F member 3
has exact synonym: retinoid-related orphan receptor-gamma
has exact synonym: thymus orphan receptor
has OBO namespace: protein
has related synonym: NR1F3
has related synonym: RORG
has related synonym: RZRG
has related synonym: Thor
id: PR:000001902
comment: Category=gene.

Axiom
annotated source: nuclear receptor ROR-gamma
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human RORC gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: nuclear receptor ROR-gamma
annotated property: hasExactSynonym
annotated target: RORC
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: nuclear receptor ROR-gamma
annotated property: hasRelatedSynonym
annotated target: NR1F3
has synonym type: Gene-based

Axiom
annotated source: nuclear receptor ROR-gamma
annotated property: hasRelatedSynonym
annotated target: RORG
has synonym type: Gene-based

Axiom
annotated source: nuclear receptor ROR-gamma
annotated property: hasRelatedSynonym
annotated target: RZRG
has synonym type: Gene-based

Axiom
annotated source: nuclear receptor ROR-gamma
annotated property: hasRelatedSynonym
annotated target: Thor
has synonym type: Gene-based

semaphorin
type: Class
subclass of: protein
IAO_0000115: A protein with core architecture consisting of a signal sequence,a Sema domain (Pfam:PF01403), a Plexin repeat (Pfam:PF01437), and an Ig-like domain (Pfam:PF00047, Pfam:PF07686, or Pfam:PF07679).
has db xref: PIRSF:PIRSF005526
has OBO namespace: protein
id: PR:000001926
comment: Category=family.

Axiom
annotated source: semaphorin
annotated property: IAO_0000115
annotated target: A protein with core architecture consisting of a signal sequence,a Sema domain (Pfam:PF01403), a Plexin repeat (Pfam:PF01437), and an Ig-like domain (Pfam:PF00047, Pfam:PF07686, or Pfam:PF07679).
has db xref: PRO:WCB

tumor necrosis factor ligand superfamily member 10/11
type: Class
subclass of: protein
IAO_0000115: A protein with core architecture consisting of a fairly small cytoplasmic region, a transmembrane domain, and an extracellular domain containing a TNF(Tumour Necrosis Factor) family domain (Pfam:PF00229).
has db xref: PIRSF:PIRSF038013
has OBO namespace: protein
id: PR:000001946
comment: Category=family.

Axiom
annotated source: tumor necrosis factor ligand superfamily member 10/11
annotated property: IAO_0000115
annotated target: A protein with core architecture consisting of a fairly small cytoplasmic region, a transmembrane domain, and an extracellular domain containing a TNF(Tumour Necrosis Factor) family domain (Pfam:PF00229).
has db xref: PRO:WCB

vascular endothelial growth factor receptor
type: Class
subclass of: protein
IAO_0000115: A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain.
has db xref: PIRSF:PIRSF038502
has OBO namespace: protein
id: PR:000001971
comment: Category=family.

Axiom
annotated source: vascular endothelial growth factor receptor
annotated property: IAO_0000115
annotated target: A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain.
has db xref: PRO:WCB

C-C motif chemokine 19
type: Class
subclass of: C/C-C motif small inducible chemokine
IAO_0000115: A C/C-C motif small inducible chemokine that is a translation product of the human CCL19 gene or a 1:1 ortholog thereof.
has exact synonym: CCL19
has exact synonym: CK beta-11
has exact synonym: EBI1 ligand chemokine
has exact synonym: MIP-3-beta
has exact synonym: beta chemokine exodus-3
has exact synonym: epstein-Barr virus-induced molecule 1 ligand chemokine
has exact synonym: macrophage inflammatory protein 3 beta
has exact synonym: small-inducible cytokine A19
has OBO namespace: protein
has related synonym: ELC
has related synonym: MIP3B
has related synonym: SCYA19
id: PR:000001991
comment: Category=gene.

Axiom
annotated source: C-C motif chemokine 19
annotated property: IAO_0000115
annotated target: A C/C-C motif small inducible chemokine that is a translation product of the human CCL19 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: C-C motif chemokine 19
annotated property: hasExactSynonym
annotated target: CCL19
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: C-C motif chemokine 19
annotated property: hasRelatedSynonym
annotated target: ELC
has synonym type: Gene-based

Axiom
annotated source: C-C motif chemokine 19
annotated property: hasRelatedSynonym
annotated target: MIP3B
has synonym type: Gene-based

Axiom
annotated source: C-C motif chemokine 19
annotated property: hasRelatedSynonym
annotated target: SCYA19
has synonym type: Gene-based

C-C motif chemokine 21
type: Class
subclass of: C/C-C motif small inducible chemokine
IAO_0000115: A C/C-C motif small inducible chemokine that is a translation product of the human CCL21 gene or a 1:1 ortholog thereof.
has broad synonym: 6Ckine
has broad synonym: TCA4
has broad synonym: small-inducible cytokine A21a
has broad synonym: small-inducible cytokine A21b
has broad synonym: small-inducible cytokine A21c
has broad synonym: thymus-derived chemotactic agent 4
has exact synonym: CCL21
has exact synonym: SLC
has exact synonym: beta chemokine exodus-2
has exact synonym: secondary lymphoid-tissue chemokine
has exact synonym: small-inducible cytokine A21
has OBO namespace: protein
has related synonym: Ccl21b
has related synonym: Ccl21c
has related synonym: SCYA21
has related synonym: Scya21b
has related synonym: Scya21c
has related synonym: UNQ784/PRO1600
id: PR:000001993
comment: Category=gene. Three genes code for CCL21 in mouse. Ccl21b and Ccl21c genes encode identical proteins while the protein encoded by Ccl21a differs at only one position.

Axiom
annotated source: C-C motif chemokine 21
annotated property: IAO_0000115
annotated target: A C/C-C motif small inducible chemokine that is a translation product of the human CCL21 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: C-C motif chemokine 21
annotated property: hasBroadSynonym
annotated target: 6Ckine
has db xref: PRO:DNx

Axiom
annotated source: C-C motif chemokine 21
annotated property: hasBroadSynonym
annotated target: TCA4
has db xref: PRO:DNx

Axiom
annotated source: C-C motif chemokine 21
annotated property: hasBroadSynonym
annotated target: small-inducible cytokine A21a
has db xref: PRO:DNx

Axiom
annotated source: C-C motif chemokine 21
annotated property: hasBroadSynonym
annotated target: small-inducible cytokine A21b
has db xref: PRO:DNx

Axiom
annotated source: C-C motif chemokine 21
annotated property: hasBroadSynonym
annotated target: small-inducible cytokine A21c
has db xref: PRO:DNx

Axiom
annotated source: C-C motif chemokine 21
annotated property: hasBroadSynonym
annotated target: thymus-derived chemotactic agent 4
has db xref: PRO:DNx

Axiom
annotated source: C-C motif chemokine 21
annotated property: hasExactSynonym
annotated target: CCL21
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: C-C motif chemokine 21
annotated property: hasRelatedSynonym
annotated target: SCYA21
has synonym type: Gene-based

Axiom
annotated source: C-C motif chemokine 21
annotated property: hasRelatedSynonym
annotated target: UNQ784/PRO1600
has synonym type: Gene-based

eotaxin-like cytokine
type: Class
subclass of: C/C-C motif small inducible chemokine
IAO_0000115: A C/C-C motif small inducible chemokine that is a member of a subfamily that includes eotaxin.
has db xref: PIRSF:PIRSF500572
has OBO namespace: protein
id: PR:000002038
comment: Category=family.

Axiom
annotated source: eotaxin-like cytokine
annotated property: IAO_0000115
annotated target: A C/C-C motif small inducible chemokine that is a member of a subfamily that includes eotaxin.
has db xref: PRO:WCB

mast/stem cell growth factor receptor
type: Class
subclass of: CSF-1/PDGF receptor-type tyrosine-protein kinase
IAO_0000115: A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1805
has db xref: PIRSF:PIRSF500951
has exact synonym: CD117
has exact synonym: KIT
has exact synonym: proto-oncogene c-Kit
has exact synonym: tyrosine-protein kinase Kit
has OBO namespace: protein
has related synonym: SCFR
has related synonym: Sl
id: PR:000002065
comment: Category=gene. Requested by=CL.

Axiom
annotated source: mast/stem cell growth factor receptor
annotated property: IAO_0000115
annotated target: A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: mast/stem cell growth factor receptor
annotated property: hasExactSynonym
annotated target: KIT
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: mast/stem cell growth factor receptor
annotated property: hasRelatedSynonym
annotated target: SCFR
has synonym type: Gene-based

Axiom
annotated source: mast/stem cell growth factor receptor
annotated property: hasRelatedSynonym
annotated target: Sl
has synonym type: Gene-based

C-C motif chemokine 5
type: Class
subclass of: C/C-C motif small inducible chemokine
IAO_0000115: A C/C-C motif small inducible chemokine that is a translation product of the human CCL5 gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF500570
has exact synonym: CCL5
has exact synonym: EoCP
has exact synonym: RANTES
has exact synonym: SIS-delta
has exact synonym: T cell-specific protein P228
has exact synonym: T-cell-specific protein RANTES
has exact synonym: TCP228
has exact synonym: small inducible cytokine A5
has exact synonym: small-inducible cytokine A5
has OBO namespace: protein
has related synonym: D17S136E
has related synonym: SCYA5
has related synonym: eosinophil chemotactic cytokine
id: PR:000002094
comment: Category=gene.

Axiom
annotated source: C-C motif chemokine 5
annotated property: IAO_0000115
annotated target: A C/C-C motif small inducible chemokine that is a translation product of the human CCL5 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: C-C motif chemokine 5
annotated property: hasExactSynonym
annotated target: CCL5
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: C-C motif chemokine 5
annotated property: hasRelatedSynonym
annotated target: D17S136E
has synonym type: Gene-based

Axiom
annotated source: C-C motif chemokine 5
annotated property: hasRelatedSynonym
annotated target: SCYA5
has synonym type: Gene-based

tumor necrosis factor ligand superfamily member 10
type: Class
subclass of: tumor necrosis factor ligand superfamily member 10/11
IAO_0000115: A tumor necrosis factor ligand superfamily member 10/11 that is a translation product of the human TNFSF10 gene or a 1:1 ortholog thereof.
has exact synonym: CD253
has exact synonym: TNF-related apoptosis-inducing ligand
has exact synonym: TNFSF10
has exact synonym: apo-2 ligand
has exact synonym: apo-2L
has exact synonym: protein TRAIL
has OBO namespace: protein
has related synonym: APO2L
has related synonym: TRAIL
id: PR:000002106
comment: Category=gene.

Axiom
annotated source: tumor necrosis factor ligand superfamily member 10
annotated property: IAO_0000115
annotated target: A tumor necrosis factor ligand superfamily member 10/11 that is a translation product of the human TNFSF10 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: tumor necrosis factor ligand superfamily member 10
annotated property: hasExactSynonym
annotated target: TNFSF10
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: tumor necrosis factor ligand superfamily member 10
annotated property: hasRelatedSynonym
annotated target: APO2L
has synonym type: Gene-based

Axiom
annotated source: tumor necrosis factor ligand superfamily member 10
annotated property: hasRelatedSynonym
annotated target: TRAIL
has synonym type: Gene-based

tumor necrosis factor ligand superfamily member 11
type: Class
subclass of: tumor necrosis factor ligand superfamily member 10/11
IAO_0000115: A tumor necrosis factor ligand superfamily member 10/11 that is a translation product of the human TNFSF11 gene or a 1:1 ortholog thereof.
has exact synonym: CD254
has exact synonym: ODF
has exact synonym: TNF-related activation-induced cytokine
has exact synonym: TNFSF11
has exact synonym: osteoclast differentiation factor
has exact synonym: osteoprotegerin ligand
has exact synonym: receptor activator of nuclear factor kappa-B ligand
has OBO namespace: protein
has related synonym: OPGL
has related synonym: RANKL
has related synonym: TRANCE
id: PR:000002107
comment: Category=gene.

Axiom
annotated source: tumor necrosis factor ligand superfamily member 11
annotated property: IAO_0000115
annotated target: A tumor necrosis factor ligand superfamily member 10/11 that is a translation product of the human TNFSF11 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: tumor necrosis factor ligand superfamily member 11
annotated property: hasExactSynonym
annotated target: TNFSF11
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: tumor necrosis factor ligand superfamily member 11
annotated property: hasRelatedSynonym
annotated target: OPGL
has synonym type: Gene-based

Axiom
annotated source: tumor necrosis factor ligand superfamily member 11
annotated property: hasRelatedSynonym
annotated target: RANKL
has synonym type: Gene-based

Axiom
annotated source: tumor necrosis factor ligand superfamily member 11
annotated property: hasRelatedSynonym
annotated target: TRANCE
has synonym type: Gene-based

vascular endothelial growth factor receptor 2
type: Class
subclass of: vascular endothelial growth factor receptor
IAO_0000115: A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1813
has exact synonym: CD309
has exact synonym: FLK-1
has exact synonym: KDR
has exact synonym: VEGFR-2
has exact synonym: fetal liver kinase 1
has exact synonym: kinase NYK
has exact synonym: kinase insert domain receptor
has exact synonym: protein-tyrosine kinase receptor flk-1
has OBO namespace: protein
has related synonym: FLK1
has related synonym: VEGFR2
id: PR:000002112
comment: Category=gene. Requested by=CL.

Axiom
annotated source: vascular endothelial growth factor receptor 2
annotated property: IAO_0000115
annotated target: A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: vascular endothelial growth factor receptor 2
annotated property: hasExactSynonym
annotated target: KDR
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: vascular endothelial growth factor receptor 2
annotated property: hasRelatedSynonym
annotated target: FLK1
has synonym type: Gene-based

Axiom
annotated source: vascular endothelial growth factor receptor 2
annotated property: hasRelatedSynonym
annotated target: VEGFR2
has synonym type: Gene-based

C-C motif chemokine 2
type: Class
subclass of: eotaxin-like cytokine
IAO_0000115: An eotaxin-like cytokine that is a translation product of the human CCL2 gene or a 1:1 ortholog thereof.
has broad synonym: MCP-1
has exact synonym: CCL2
has exact synonym: HC11
has exact synonym: MCAF
has exact synonym: monocyte chemoattractant protein 1
has exact synonym: monocyte chemotactic and activating factor
has exact synonym: monocyte chemotactic protein 1
has exact synonym: monocyte secretory protein JE
has exact synonym: platelet-derived growth factor-inducible protein JE
has exact synonym: small-inducible cytokine A2
has OBO namespace: protein
has related synonym: Je
has related synonym: MCP1
has related synonym: SCYA2
id: PR:000002122
comment: Category=gene.

Axiom
annotated source: C-C motif chemokine 2
annotated property: IAO_0000115
annotated target: An eotaxin-like cytokine that is a translation product of the human CCL2 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: C-C motif chemokine 2
annotated property: hasBroadSynonym
annotated target: MCP-1
has db xref: PRO:DAN

Axiom
annotated source: C-C motif chemokine 2
annotated property: hasExactSynonym
annotated target: CCL2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: C-C motif chemokine 2
annotated property: hasRelatedSynonym
annotated target: Je
has synonym type: Gene-based

Axiom
annotated source: C-C motif chemokine 2
annotated property: hasRelatedSynonym
annotated target: MCP1
has synonym type: Gene-based

Axiom
annotated source: C-C motif chemokine 2
annotated property: hasRelatedSynonym
annotated target: SCYA2
has synonym type: Gene-based

C-C motif chemokine 7
type: Class
subclass of: eotaxin-like cytokine
IAO_0000115: An eotaxin-like cytokine that is a translation product of the human CCL7 gene or a 1:1 ortholog thereof.
has exact synonym: CCL7
has exact synonym: MCP-3
has exact synonym: NC28
has exact synonym: intercrine/chemokine MARC
has exact synonym: monocyte chemoattractant protein 3
has exact synonym: monocyte chemotactic protein 3
has exact synonym: protein FIC
has exact synonym: small-inducible cytokine A7
has OBO namespace: protein
has related synonym: Fic
has related synonym: MCP3
has related synonym: SCYA6
has related synonym: SCYA7
id: PR:000002125
comment: Category=gene.

Axiom
annotated source: C-C motif chemokine 7
annotated property: IAO_0000115
annotated target: An eotaxin-like cytokine that is a translation product of the human CCL7 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: C-C motif chemokine 7
annotated property: hasExactSynonym
annotated target: CCL7
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: C-C motif chemokine 7
annotated property: hasRelatedSynonym
annotated target: Fic
has synonym type: Gene-based

Axiom
annotated source: C-C motif chemokine 7
annotated property: hasRelatedSynonym
annotated target: MCP3
has synonym type: Gene-based

Axiom
annotated source: C-C motif chemokine 7
annotated property: hasRelatedSynonym
annotated target: SCYA6
has synonym type: Gene-based

Axiom
annotated source: C-C motif chemokine 7
annotated property: hasRelatedSynonym
annotated target: SCYA7
has synonym type: Gene-based

RAC-alpha serine/threonine-protein kinase
type: Class
subclass of: AKT kinase
IAO_0000115: An AKT kinase that is a translation product of the human AKT1 gene or a 1:1 ortholog thereof.
has broad synonym: PKB
has db xref: IUPHARobj:1479
has exact synonym: AKT1
has exact synonym: AKT1 kinase
has exact synonym: PKB alpha
has exact synonym: RAC-PK-alpha
has exact synonym: protein kinase B
has exact synonym: protein kinase B alpha
has exact synonym: proto-oncogene c-Akt
has exact synonym: thymoma viral proto-oncogene
has OBO namespace: protein
has related synonym: Akt
has related synonym: RAC
id: PR:000002190
comment: Category=gene.

Axiom
annotated source: RAC-alpha serine/threonine-protein kinase
annotated property: IAO_0000115
annotated target: An AKT kinase that is a translation product of the human AKT1 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: RAC-alpha serine/threonine-protein kinase
annotated property: hasBroadSynonym
annotated target: PKB
has db xref: PRO:DNx
has synonym type: Gene-based

Axiom
annotated source: RAC-alpha serine/threonine-protein kinase
annotated property: hasExactSynonym
annotated target: AKT1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: RAC-alpha serine/threonine-protein kinase
annotated property: hasRelatedSynonym
annotated target: Akt
has synonym type: Gene-based

Axiom
annotated source: RAC-alpha serine/threonine-protein kinase
annotated property: hasRelatedSynonym
annotated target: RAC
has synonym type: Gene-based

catenin beta-1
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human CTNNB1 gene or a 1:1 ortholog thereof.
has exact synonym: CTNNB1
has exact synonym: beta-catenin
has OBO namespace: protein
has related synonym: CTNNB
has related synonym: Catnb
has related synonym: OK/SW-cl.35
has related synonym: PRO2286
id: PR:000002198
comment: Category=gene.

Axiom
annotated source: catenin beta-1
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human CTNNB1 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: catenin beta-1
annotated property: hasExactSynonym
annotated target: CTNNB1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: catenin beta-1
annotated property: hasRelatedSynonym
annotated target: CTNNB
has synonym type: Gene-based

Axiom
annotated source: catenin beta-1
annotated property: hasRelatedSynonym
annotated target: Catnb
has synonym type: Gene-based

Axiom
annotated source: catenin beta-1
annotated property: hasRelatedSynonym
annotated target: OK/SW-cl.35
has synonym type: Gene-based

Axiom
annotated source: catenin beta-1
annotated property: hasRelatedSynonym
annotated target: PRO2286
has synonym type: Gene-based

dynein light chain
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human DYNLL1 or DYNLL2 genes, or 1:1 orthologs thereof. The protein is small (89 residues in human and mouse) with core architecture consisting of a Dynein light chain type 1 domain (Pfam:PF01221).
has db xref: PIRSF:PIRSF005695
has OBO namespace: protein
id: PR:000002201
comment: Category=family.

Axiom
annotated source: dynein light chain
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human DYNLL1 or DYNLL2 genes, or 1:1 orthologs thereof. The protein is small (89 residues in human and mouse) with core architecture consisting of a Dynein light chain type 1 domain (Pfam:PF01221).
has db xref: PRO:WCB

lymphotoxin-alpha
type: Class
subclass of: lymphotoxin
IAO_0000115: A lymphotoxin that is a translation product of the human LTA gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF500469
has exact synonym: LT-alpha
has exact synonym: LTA
has exact synonym: TNF-beta
has exact synonym: tumor necrosis factor B
has exact synonym: tumor necrosis factor ligand superfamily member 1
has OBO namespace: protein
has related synonym: TNFB
has related synonym: TNFSF1
id: PR:000002204
comment: Category=gene.

Axiom
annotated source: lymphotoxin-alpha
annotated property: IAO_0000115
annotated target: A lymphotoxin that is a translation product of the human LTA gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: lymphotoxin-alpha
annotated property: hasExactSynonym
annotated target: LTA
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: lymphotoxin-alpha
annotated property: hasExactSynonym
annotated target: tumor necrosis factor B
has db xref: PRO:DAN

Axiom
annotated source: lymphotoxin-alpha
annotated property: hasRelatedSynonym
annotated target: TNFB
has synonym type: Gene-based

Axiom
annotated source: lymphotoxin-alpha
annotated property: hasRelatedSynonym
annotated target: TNFSF1
has synonym type: Gene-based

cellular tumor antigen p53
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human TP53 gene or a 1:1 ortholog thereof.
has db xref: PIRSF:PIRSF002089
has exact synonym: TP53
has exact synonym: antigen NY-CO-13
has exact synonym: phosphoprotein p53
has exact synonym: tumor suppressor p53
has OBO namespace: protein
has related synonym: P53
has related synonym: Trp53
id: PR:000003035
comment: Category=gene.

Axiom
annotated source: cellular tumor antigen p53
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human TP53 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: cellular tumor antigen p53
annotated property: hasExactSynonym
annotated target: TP53
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: cellular tumor antigen p53
annotated property: hasRelatedSynonym
annotated target: P53
has synonym type: Gene-based

Axiom
annotated source: cellular tumor antigen p53
annotated property: hasRelatedSynonym
annotated target: Trp53
has synonym type: Gene-based

NFAT protein
type: Class
subclass of: protein
IAO_0000115: A protein that contains a Rel homology domain (RHD) (Pfam:PF00554) followed by an IPT/TIG domain (Pfam:PF01833).
has OBO namespace: protein
id: PR:000003112
comment: Category=family.

Axiom
annotated source: NFAT protein
annotated property: IAO_0000115
annotated target: A protein that contains a Rel homology domain (RHD) (Pfam:PF00554) followed by an IPT/TIG domain (Pfam:PF01833).
has db xref: PRO:WCB

nuclear factor of activated T-cells, cytoplasmic 1
type: Class
subclass of: NFAT protein
IAO_0000115: An NFAT protein that is a translation product of the human NFATC1 gene or a 1:1 ortholog thereof.
has exact synonym: NF-ATc
has exact synonym: NF-ATc1
has exact synonym: NFAT transcription complex cytosolic component
has exact synonym: NFATC1
has exact synonym: NFATc
has exact synonym: NFATc1
has OBO namespace: protein
has related synonym: NFAT2
has related synonym: NFATC
id: PR:000003113
comment: Category=gene.

Axiom
annotated source: nuclear factor of activated T-cells, cytoplasmic 1
annotated property: IAO_0000115
annotated target: An NFAT protein that is a translation product of the human NFATC1 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: nuclear factor of activated T-cells, cytoplasmic 1
annotated property: hasExactSynonym
annotated target: NFATC1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: nuclear factor of activated T-cells, cytoplasmic 1
annotated property: hasRelatedSynonym
annotated target: NFAT2
has synonym type: Gene-based

Axiom
annotated source: nuclear factor of activated T-cells, cytoplasmic 1
annotated property: hasRelatedSynonym
annotated target: NFATC
has synonym type: Gene-based

14-3-3 protein
type: Class
subclass of: protein
IAO_0000115: A protein that is a stand alone version of the 14-3-3 protein (Pfam:PF00244) domain.
has db xref: PIRSF:PIRSF000868
has exact synonym: fam:14-3-3
has OBO namespace: protein
id: PR:000003237
comment: Category=family.

Axiom
annotated source: 14-3-3 protein
annotated property: IAO_0000115
annotated target: A protein that is a stand alone version of the 14-3-3 protein (Pfam:PF00244) domain.
has db xref: PRO:CNA

Axiom
annotated source: 14-3-3 protein
annotated property: hasExactSynonym
annotated target: fam:14-3-3
has db xref: PRO:DAN
has synonym type: PRO-short-label

Hsp70 family chaperone
type: Class
subclass of: protein
IAO_0000115: A protein that is a stand alone version of the Hsp70 protein (Pfam:PF00012) domain, which comprises two major regions: an N-terminal ATP-binding domain and a C-terminal substrate-binding domain.
has OBO namespace: protein
id: PR:000003425
comment: Category=family.

Axiom
annotated source: Hsp70 family chaperone
annotated property: IAO_0000115
annotated target: A protein that is a stand alone version of the Hsp70 protein (Pfam:PF00012) domain, which comprises two major regions: an N-terminal ATP-binding domain and a C-terminal substrate-binding domain.
has db xref: PRO:CNA
has db xref: Pfam:PF00012

acrosin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human ACR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:2327
has exact synonym: ACR
has OBO namespace: protein
has related synonym: ACRS
id: PR:000003652
comment: Category=gene.

Axiom
annotated source: acrosin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human ACR gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: acrosin
annotated property: hasExactSynonym
annotated target: ACR
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: acrosin
annotated property: hasRelatedSynonym
annotated target: ACRS
has synonym type: Gene-based

pituitary adenylate cyclase-activating polypeptide
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human ADCYAP1 gene or a 1:1 ortholog thereof.
has exact synonym: ADCYAP1
has OBO namespace: protein
has related synonym: PACAP
id: PR:000003761
comment: Category=gene.

Axiom
annotated source: pituitary adenylate cyclase-activating polypeptide
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human ADCYAP1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: pituitary adenylate cyclase-activating polypeptide
annotated property: hasExactSynonym
annotated target: ADCYAP1
has db xref: PRO:DNx
has synonym type: PRO-short-label

adiponectin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof.
has exact synonym: 30 kDa adipocyte complement-related protein
has exact synonym: ADIPOQ
has exact synonym: adipocyte complement-related 30 kDa protein
has exact synonym: adipocyte, C1q and collagen domain-containing protein
has exact synonym: adipocyte-specific protein AdipoQ
has exact synonym: adipose most abundant gene transcript 1 protein
has exact synonym: apM-1
has exact synonym: gelatin-binding protein
has OBO namespace: protein
has related synonym: ACDC
has related synonym: ACRP30
has related synonym: APM1
has related synonym: GBP28
id: PR:000003777
comment: Category=gene.

Axiom
annotated source: adiponectin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: adiponectin
annotated property: hasExactSynonym
annotated target: ADIPOQ
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: adiponectin
annotated property: hasRelatedSynonym
annotated target: ACDC
has synonym type: Gene-based

Axiom
annotated source: adiponectin
annotated property: hasRelatedSynonym
annotated target: ACRP30
has synonym type: Gene-based

Axiom
annotated source: adiponectin
annotated property: hasRelatedSynonym
annotated target: APM1
has synonym type: Gene-based

Axiom
annotated source: adiponectin
annotated property: hasRelatedSynonym
annotated target: GBP28
has synonym type: Gene-based

aryl hydrocarbon receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human AHR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:2951
has exact synonym: AHR
has exact synonym: Ah receptor
has exact synonym: AhR
has exact synonym: bHLHe76
has exact synonym: class E basic helix-loop-helix protein 76
has OBO namespace: protein
has related synonym: BHLHE76
id: PR:000003858
comment: Category=gene.

Axiom
annotated source: aryl hydrocarbon receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human AHR gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: aryl hydrocarbon receptor
annotated property: hasExactSynonym
annotated target: AHR
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: aryl hydrocarbon receptor
annotated property: hasRelatedSynonym
annotated target: BHLHE76
has synonym type: Gene-based

apelin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human APLN gene or a 1:1 ortholog thereof.
has exact synonym: APJ endogenous ligand
has exact synonym: APLN
has OBO namespace: protein
has related synonym: APEL
id: PR:000004135
comment: Category=gene.

Axiom
annotated source: apelin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human APLN gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: apelin
annotated property: hasExactSynonym
annotated target: APLN
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: apelin
annotated property: hasRelatedSynonym
annotated target: APEL
has synonym type: Gene-based

apolipoprotein A-I
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human APOA1 gene or a 1:1 ortholog thereof.
has exact synonym: APOA1
has exact synonym: ApoA-I
has exact synonym: apo-AI
has exact synonym: apolipoprotein A1
has OBO namespace: protein
id: PR:000004140
comment: Category=gene.

Axiom
annotated source: apolipoprotein A-I
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human APOA1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: apolipoprotein A-I
annotated property: hasExactSynonym
annotated target: APOA1
has db xref: PRO:DNx
has synonym type: PRO-short-label

amyloid-beta precursor protein
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human APP gene or a 1:1 ortholog thereof.
has exact synonym: ABPP
has exact synonym: AG
has exact synonym: APP
has exact synonym: APPI
has exact synonym: CVAP
has exact synonym: PN-II
has exact synonym: PreA4
has exact synonym: alzheimer disease amyloid A4 protein homolog
has exact synonym: alzheimer disease amyloid protein
has exact synonym: amyloid beta A4 protein
has exact synonym: amyloid precursor protein
has exact synonym: amyloid-beta (A4) precursor protein
has exact synonym: amyloid-beta A4 protein
has exact synonym: amyloidogenic glycoprotein
has exact synonym: cerebral vascular amyloid peptide
has exact synonym: protease nexin-II
has OBO namespace: protein
has related synonym: A4
has related synonym: AD1
id: PR:000004168
comment: Category=gene. Requested by=Alzforum.

Axiom
annotated source: amyloid-beta precursor protein
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human APP gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: amyloid-beta precursor protein
annotated property: hasExactSynonym
annotated target: APP
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: amyloid-beta precursor protein
annotated property: hasRelatedSynonym
annotated target: A4
has synonym type: Gene-based

Axiom
annotated source: amyloid-beta precursor protein
annotated property: hasRelatedSynonym
annotated target: AD1
has synonym type: Gene-based

androgen receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human AR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:628
has exact synonym: AR
has exact synonym: dihydrotestosterone receptor
has exact synonym: nuclear receptor subfamily 3 group C member 4
has OBO namespace: protein
has related synonym: DHTR
has related synonym: NR3C4
id: PR:000004191
comment: Category=gene.

Axiom
annotated source: androgen receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human AR gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: androgen receptor
annotated property: hasExactSynonym
annotated target: AR
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: androgen receptor
annotated property: hasRelatedSynonym
annotated target: DHTR
has synonym type: Gene-based

Axiom
annotated source: androgen receptor
annotated property: hasRelatedSynonym
annotated target: NR3C4
has synonym type: Gene-based

beta-2-microglobulin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human B2M gene or a 1:1 ortholog thereof.
has exact synonym: B2M
has OBO namespace: protein
has related synonym: CDABP0092
has related synonym: HDCMA22P
id: PR:000004580
comment: Category=gene.

Axiom
annotated source: beta-2-microglobulin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human B2M gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: beta-2-microglobulin
annotated property: hasExactSynonym
annotated target: B2M
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: beta-2-microglobulin
annotated property: hasRelatedSynonym
annotated target: CDABP0092
has synonym type: Gene-based

Axiom
annotated source: beta-2-microglobulin
annotated property: hasRelatedSynonym
annotated target: HDCMA22P
has synonym type: Gene-based

neurotrophic factor BDNF precursor form
type: Class
subclass of: neurotrophin
IAO_0000115: A neurotrophin that is a translation product of the human BDNF gene or a 1:1 ortholog thereof.
has exact synonym: BDNF
has exact synonym: abrineurin
has exact synonym: brain-derived neurotrophic factor
has exact synonym: proBDNF
has OBO namespace: protein
id: PR:000004716
comment: Category=gene.

Axiom
annotated source: neurotrophic factor BDNF precursor form
annotated property: IAO_0000115
annotated target: A neurotrophin that is a translation product of the human BDNF gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: neurotrophic factor BDNF precursor form
annotated property: hasExactSynonym
annotated target: BDNF
has db xref: PRO:DNx
has synonym type: PRO-short-label

calcitonin receptor
type: Class
subclass of: calcitonin receptor protein
IAO_0000115: A calcitonin receptor protein that is a translation product of the human CALCR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:43
has exact synonym: CALCR
has exact synonym: CT-R
has OBO namespace: protein
id: PR:000004972
comment: Category=gene.

Axiom
annotated source: calcitonin receptor
annotated property: IAO_0000115
annotated target: A calcitonin receptor protein that is a translation product of the human CALCR gene or a 1:1 ortholog thereof.
has db xref: PRO:DAN

Axiom
annotated source: calcitonin receptor
annotated property: hasExactSynonym
annotated target: CALCR
has db xref: PRO:DNx
has synonym type: PRO-short-label

calmodulin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human CALM1, CALM2, or CALM3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has exact synonym: CALM
has exact synonym: CaM
has narrow synonym: CAM3
has OBO namespace: protein
has related synonym: CALML2
has related synonym: CAMC
has related synonym: CAMIII
id: PR:000004978
comment: Category=gene. Note: The human CALM1, CALM2, and CALM3 genes encode identical proteins.

Axiom
annotated source: calmodulin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human CALM1, CALM2, or CALM3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PRO:DAN

Axiom
annotated source: calmodulin
annotated property: hasExactSynonym
annotated target: CALM
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: calmodulin
annotated property: hasNarrowSynonym
annotated target: CAM3
has db xref: PRO:DAN

cholecystokinin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human CCK gene or a 1:1 ortholog thereof.
has exact synonym: CCK
has OBO namespace: protein
id: PR:000005110
comment: Category=gene.

Axiom
annotated source: cholecystokinin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human CCK gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: cholecystokinin
annotated property: hasExactSynonym
annotated target: CCK
has db xref: PRO:DNx
has synonym type: PRO-short-label

glycoprotein hormones alpha chain
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human CGA gene or a 1:1 ortholog thereof.
has exact synonym: CG-alpha
has exact synonym: CGA
has exact synonym: FSH-alpha
has exact synonym: LSH-alpha
has exact synonym: TSH-alpha
has exact synonym: anterior pituitary glycoprotein hormones common subunit alpha
has exact synonym: choriogonadotropin alpha chain
has exact synonym: chorionic gonadotrophin subunit alpha
has exact synonym: follicle-stimulating hormone alpha chain
has exact synonym: follitropin alpha chain
has exact synonym: luteinizing hormone alpha chain
has exact synonym: lutropin alpha chain
has exact synonym: thyroid-stimulating hormone alpha chain
has exact synonym: thyrotropin alpha chain
has OBO namespace: protein
id: PR:000005388
comment: Category=gene.

Axiom
annotated source: glycoprotein hormones alpha chain
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human CGA gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: glycoprotein hormones alpha chain
annotated property: hasExactSynonym
annotated target: CGA
has db xref: PRO:DNx
has synonym type: PRO-short-label

ciliary neurotrophic factor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human CNTF gene or a 1:1 ortholog thereof.
has exact synonym: CNTF
has OBO namespace: protein
id: PR:000005663
comment: Category=gene.

Axiom
annotated source: ciliary neurotrophic factor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human CNTF gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: ciliary neurotrophic factor
annotated property: hasExactSynonym
annotated target: CNTF
has db xref: PRO:DNx
has synonym type: PRO-short-label

corticotropin-releasing factor receptor 1
type: Class
subclass of: corticotropin-releasing factor receptor
IAO_0000115: A corticotropin-releasing factor receptor that is a translation product of the human CRHR1 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:212
has exact synonym: CRF-R-1
has exact synonym: CRF-R1
has exact synonym: CRFR-1
has exact synonym: CRH-R-1
has exact synonym: CRH-R1
has exact synonym: CRHR1
has exact synonym: corticotropin-releasing hormone receptor 1
has OBO namespace: protein
has related synonym: CRFR
has related synonym: CRFR1
has related synonym: CRHR
id: PR:000005869
comment: Category=gene.

Axiom
annotated source: corticotropin-releasing factor receptor 1
annotated property: IAO_0000115
annotated target: A corticotropin-releasing factor receptor that is a translation product of the human CRHR1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DAN

Axiom
annotated source: corticotropin-releasing factor receptor 1
annotated property: hasExactSynonym
annotated target: CRHR1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: corticotropin-releasing factor receptor 1
annotated property: hasRelatedSynonym
annotated target: CRFR
has synonym type: Gene-based

Axiom
annotated source: corticotropin-releasing factor receptor 1
annotated property: hasRelatedSynonym
annotated target: CRFR1
has synonym type: Gene-based

Axiom
annotated source: corticotropin-releasing factor receptor 1
annotated property: hasRelatedSynonym
annotated target: CRHR
has synonym type: Gene-based

corticotropin-releasing factor receptor 2
type: Class
subclass of: corticotropin-releasing factor receptor
IAO_0000115: A corticotropin-releasing factor receptor that is a translation product of the human CRHR2 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:213
has exact synonym: CRF-R-2
has exact synonym: CRF-R2
has exact synonym: CRF-RB
has exact synonym: CRFR-2
has exact synonym: CRH-R-2
has exact synonym: CRH-R2
has exact synonym: CRHR2
has exact synonym: corticotropin-releasing hormone receptor 2
has OBO namespace: protein
has related synonym: CRF2R
has related synonym: CRH2R
id: PR:000005870
comment: Category=gene.

Axiom
annotated source: corticotropin-releasing factor receptor 2
annotated property: IAO_0000115
annotated target: A corticotropin-releasing factor receptor that is a translation product of the human CRHR2 gene or a 1:1 ortholog thereof.
has db xref: PRO:DAN

Axiom
annotated source: corticotropin-releasing factor receptor 2
annotated property: hasExactSynonym
annotated target: CRHR2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: corticotropin-releasing factor receptor 2
annotated property: hasRelatedSynonym
annotated target: CRF2R
has synonym type: Gene-based

Axiom
annotated source: corticotropin-releasing factor receptor 2
annotated property: hasRelatedSynonym
annotated target: CRH2R
has synonym type: Gene-based

granulocyte-macrophage colony-stimulating factor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human CSF2 gene or a 1:1 ortholog thereof.
has exact synonym: CSF
has exact synonym: CSF2
has exact synonym: GM-CSF
has exact synonym: colony-stimulating factor
has exact synonym: molgramostin
has exact synonym: sargramostim
has OBO namespace: protein
has related synonym: Csfgm
has related synonym: GMCSF
id: PR:000005931
comment: Category=gene.

Axiom
annotated source: granulocyte-macrophage colony-stimulating factor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human CSF2 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: granulocyte-macrophage colony-stimulating factor
annotated property: hasExactSynonym
annotated target: CSF2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: granulocyte-macrophage colony-stimulating factor
annotated property: hasRelatedSynonym
annotated target: Csfgm
has synonym type: Gene-based

Axiom
annotated source: granulocyte-macrophage colony-stimulating factor
annotated property: hasRelatedSynonym
annotated target: GMCSF
has synonym type: Gene-based

granulocyte colony-stimulating factor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human CSF3 gene or a 1:1 ortholog thereof.
has exact synonym: CSF3
has exact synonym: G-CSF
has exact synonym: filgrastim
has exact synonym: lenograstim
has exact synonym: pluripoietin
has OBO namespace: protein
has related synonym: C17orf33
has related synonym: Csfg
has related synonym: GCSF
id: PR:000005932
comment: Category=gene.

Axiom
annotated source: granulocyte colony-stimulating factor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human CSF3 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: granulocyte colony-stimulating factor
annotated property: hasExactSynonym
annotated target: CSF3
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: granulocyte colony-stimulating factor
annotated property: hasRelatedSynonym
annotated target: C17orf33
has synonym type: Gene-based

Axiom
annotated source: granulocyte colony-stimulating factor
annotated property: hasRelatedSynonym
annotated target: Csfg
has synonym type: Gene-based

Axiom
annotated source: granulocyte colony-stimulating factor
annotated property: hasRelatedSynonym
annotated target: GCSF
has synonym type: Gene-based

catenin delta-2
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human CTNND2 gene or a 1:1 ortholog thereof.
has exact synonym: CTNND2
has exact synonym: GT24
has exact synonym: delta-catenin
has exact synonym: neural plakophilin-related ARM-repeat protein
has exact synonym: neurojungin
has OBO namespace: protein
has related synonym: Catnd2
has related synonym: NPRAP
id: PR:000006013
comment: Category=gene.

Axiom
annotated source: catenin delta-2
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human CTNND2 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: catenin delta-2
annotated property: hasExactSynonym
annotated target: CTNND2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: catenin delta-2
annotated property: hasRelatedSynonym
annotated target: Catnd2
has synonym type: Gene-based

Axiom
annotated source: catenin delta-2
annotated property: hasRelatedSynonym
annotated target: NPRAP
has synonym type: Gene-based

C-C motif chemokine 12
type: Class
subclass of: eotaxin-like cytokine
IAO_0000115: An eotaxin-like cytokine that is a translation product of the mouse Ccl12 gene or a 1:1 ortholog thereof.
has broad synonym: MCP-5
has exact synonym: Ccl12
has exact synonym: MCP-1-related chemokine
has exact synonym: monocyte chemoattractant protein 5
has exact synonym: monocyte chemotactic protein 5
has exact synonym: small-inducible cytokine A12
has OBO namespace: protein
has related synonym: Mcp5
has related synonym: Scya12
id: PR:000006165
comment: Category=gene.

Axiom
annotated source: C-C motif chemokine 12
annotated property: IAO_0000115
annotated target: An eotaxin-like cytokine that is a translation product of the mouse Ccl12 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: C-C motif chemokine 12
annotated property: hasBroadSynonym
annotated target: MCP-5
has db xref: PRO:DAN

Axiom
annotated source: C-C motif chemokine 12
annotated property: hasExactSynonym
annotated target: Ccl12
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: C-C motif chemokine 12
annotated property: hasRelatedSynonym
annotated target: Mcp5
has synonym type: Gene-based

Axiom
annotated source: C-C motif chemokine 12
annotated property: hasRelatedSynonym
annotated target: Scya12
has synonym type: Gene-based

dystroglycan 1
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human DAG1 gene or a 1:1 ortholog thereof.
has exact synonym: DAG1
has exact synonym: dystroglycan
has exact synonym: dystrophin-associated glycoprotein 1
has OBO namespace: protein
has related synonym: Dag-1
id: PR:000006267
comment: Category=gene.

Axiom
annotated source: dystroglycan 1
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human DAG1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: dystroglycan 1
annotated property: hasExactSynonym
annotated target: DAG1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: dystroglycan 1
annotated property: hasRelatedSynonym
annotated target: Dag-1
has synonym type: Gene-based

elongation factor 2
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human EEF2 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:2756
has exact synonym: EEF2
has exact synonym: EF-2
has OBO namespace: protein
has related synonym: EF2
id: PR:000006909
comment: Category=gene.

Axiom
annotated source: elongation factor 2
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human EEF2 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: elongation factor 2
annotated property: hasExactSynonym
annotated target: EEF2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: elongation factor 2
annotated property: hasRelatedSynonym
annotated target: EF2
has synonym type: Gene-based

pre-pro-epidermal growth factor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human EGF gene or a 1:1 ortholog thereof.
has exact synonym: pre-pro-EGF
has OBO namespace: protein
has related synonym: EGF
has related synonym: epidermal growth factor
has related synonym: pro-epidermal growth factor
id: PR:000006928
comment: Category=gene.

Axiom
annotated source: pre-pro-epidermal growth factor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human EGF gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: pre-pro-epidermal growth factor
annotated property: hasExactSynonym
annotated target: pre-pro-EGF
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: pre-pro-epidermal growth factor
annotated property: hasRelatedSynonym
annotated target: EGF
has synonym type: Gene-based

Axiom
annotated source: pre-pro-epidermal growth factor
annotated property: hasRelatedSynonym
annotated target: epidermal growth factor
has db xref: PRO:DAN

Axiom
annotated source: pre-pro-epidermal growth factor
annotated property: hasRelatedSynonym
annotated target: pro-epidermal growth factor
has db xref: PRO:DAN

epidermal growth factor receptor
type: Class
subclass of: EGF receptor type tyrosine-protein kinase
IAO_0000115: An EGF receptor type tyrosine-protein kinase that is a translation product of the human EGFR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1797
has exact synonym: EGFR
has exact synonym: proto-oncogene c-ErbB-1
has exact synonym: receptor tyrosine-protein kinase erbB-1
has OBO namespace: protein
has related synonym: ERBB
has related synonym: ERBB1
has related synonym: HER1
id: PR:000006933
comment: Category=gene.

Axiom
annotated source: epidermal growth factor receptor
annotated property: IAO_0000115
annotated target: An EGF receptor type tyrosine-protein kinase that is a translation product of the human EGFR gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: epidermal growth factor receptor
annotated property: hasExactSynonym
annotated target: EGFR
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: epidermal growth factor receptor
annotated property: hasRelatedSynonym
annotated target: ERBB
has synonym type: Gene-based

Axiom
annotated source: epidermal growth factor receptor
annotated property: hasRelatedSynonym
annotated target: ERBB1
has synonym type: Gene-based

Axiom
annotated source: epidermal growth factor receptor
annotated property: hasRelatedSynonym
annotated target: HER1
has synonym type: Gene-based

eukaryotic translation initiation factor 4E
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human EIF4E gene or a 1:1 ortholog thereof.
has exact synonym: EIF4E
has exact synonym: eIF-4E
has exact synonym: eIF-4F 25 kDa subunit
has exact synonym: eIF4E
has exact synonym: mRNA cap-binding protein
has OBO namespace: protein
has related synonym: EIF4EL1
has related synonym: EIF4F
id: PR:000006990
comment: Category=gene.

Axiom
annotated source: eukaryotic translation initiation factor 4E
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human EIF4E gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: eukaryotic translation initiation factor 4E
annotated property: hasExactSynonym
annotated target: EIF4E
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: eukaryotic translation initiation factor 4E
annotated property: hasRelatedSynonym
annotated target: EIF4EL1
has synonym type: Gene-based

Axiom
annotated source: eukaryotic translation initiation factor 4E
annotated property: hasRelatedSynonym
annotated target: EIF4F
has synonym type: Gene-based

erythropoietin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human EPO gene or a 1:1 ortholog thereof.
has exact synonym: EPO
has exact synonym: epoetin
has OBO namespace: protein
id: PR:000007141
comment: Category=gene.

Axiom
annotated source: erythropoietin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human EPO gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: erythropoietin
annotated property: hasExactSynonym
annotated target: EPO
has db xref: PRO:DNx
has synonym type: PRO-short-label

erythropoietin receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human EPOR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1718
has exact synonym: EPO-R
has exact synonym: EPOR
has OBO namespace: protein
id: PR:000007142
comment: Category=gene.

Axiom
annotated source: erythropoietin receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human EPOR gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: erythropoietin receptor
annotated property: hasExactSynonym
annotated target: EPOR
has db xref: PRO:DNx
has synonym type: PRO-short-label

estrogen receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human ESR1 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:620
has exact synonym: ER
has exact synonym: ER-alpha
has exact synonym: ESR1
has exact synonym: estradiol receptor
has exact synonym: nuclear receptor subfamily 3 group A member 1
has OBO namespace: protein
has related synonym: ESR
has related synonym: Estr
has related synonym: Estra
has related synonym: NR3A1
id: PR:000007204
comment: Category=gene.

Axiom
annotated source: estrogen receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human ESR1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: estrogen receptor
annotated property: hasExactSynonym
annotated target: ESR1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: estrogen receptor
annotated property: hasRelatedSynonym
annotated target: ESR
has synonym type: Gene-based

Axiom
annotated source: estrogen receptor
annotated property: hasRelatedSynonym
annotated target: Estr
has synonym type: Gene-based

Axiom
annotated source: estrogen receptor
annotated property: hasRelatedSynonym
annotated target: Estra
has synonym type: Gene-based

Axiom
annotated source: estrogen receptor
annotated property: hasRelatedSynonym
annotated target: NR3A1
has synonym type: Gene-based

fibroblast growth factor 3
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human FGF3 gene or a 1:1 ortholog thereof.
has exact synonym: FGF-3
has exact synonym: FGF3
has exact synonym: HBGF-3
has exact synonym: INT-2 proto-oncogene protein
has exact synonym: heparin-binding growth factor 3
has exact synonym: proto-oncogene Int-2
has OBO namespace: protein
has related synonym: INT2
has related synonym: Int-2
id: PR:000007494
comment: Category=gene.

Axiom
annotated source: fibroblast growth factor 3
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human FGF3 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: fibroblast growth factor 3
annotated property: hasExactSynonym
annotated target: FGF3
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: fibroblast growth factor 3
annotated property: hasRelatedSynonym
annotated target: INT2
has synonym type: Gene-based

Axiom
annotated source: fibroblast growth factor 3
annotated property: hasRelatedSynonym
annotated target: Int-2
has synonym type: Gene-based

fibroblast growth factor 4
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human FGF4 gene or a 1:1 ortholog thereof.
has broad synonym: HST
has exact synonym: FGF-4
has exact synonym: FGF4
has exact synonym: HBGF-4
has exact synonym: HST-1
has exact synonym: HSTF-1
has exact synonym: K-fibroblast growth factor
has exact synonym: heparin secretory-transforming protein 1
has exact synonym: heparin-binding growth factor 4
has exact synonym: transforming protein KS3
has OBO namespace: protein
has related synonym: HSTF1
has related synonym: KS3
has related synonym: Kfgf
id: PR:000007495
comment: Category=gene.

Axiom
annotated source: fibroblast growth factor 4
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human FGF4 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: fibroblast growth factor 4
annotated property: hasBroadSynonym
annotated target: HST
has db xref: PRO:DNx
has synonym type: Gene-based

Axiom
annotated source: fibroblast growth factor 4
annotated property: hasExactSynonym
annotated target: FGF4
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: fibroblast growth factor 4
annotated property: hasRelatedSynonym
annotated target: HSTF1
has synonym type: Gene-based

Axiom
annotated source: fibroblast growth factor 4
annotated property: hasRelatedSynonym
annotated target: KS3
has synonym type: Gene-based

Axiom
annotated source: fibroblast growth factor 4
annotated property: hasRelatedSynonym
annotated target: Kfgf
has synonym type: Gene-based

fibroblast growth factor 5
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human FGF5 gene or a 1:1 ortholog thereof.
has exact synonym: FGF-5
has exact synonym: FGF5
has exact synonym: HBGF-5
has exact synonym: Smag-82
has exact synonym: heparin-binding growth factor 5
has OBO namespace: protein
id: PR:000007496
comment: Category=gene.

Axiom
annotated source: fibroblast growth factor 5
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human FGF5 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: fibroblast growth factor 5
annotated property: hasExactSynonym
annotated target: FGF5
has db xref: PRO:DNx
has synonym type: PRO-short-label

fibroblast growth factor 6
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human FGF6 gene or a 1:1 ortholog thereof.
has exact synonym: FGF-6
has exact synonym: FGF6
has exact synonym: HBGF-6
has exact synonym: HST-2
has exact synonym: HSTF-2
has exact synonym: heparin secretory-transforming protein 2
has exact synonym: heparin-binding growth factor 6
has OBO namespace: protein
has related synonym: HST2
has related synonym: HSTF2
id: PR:000007497
comment: Category=gene.

Axiom
annotated source: fibroblast growth factor 6
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human FGF6 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: fibroblast growth factor 6
annotated property: hasExactSynonym
annotated target: FGF6
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: fibroblast growth factor 6
annotated property: hasRelatedSynonym
annotated target: HST2
has synonym type: Gene-based

Axiom
annotated source: fibroblast growth factor 6
annotated property: hasRelatedSynonym
annotated target: HSTF2
has synonym type: Gene-based

filamin-A
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human FLNA gene or a 1:1 ortholog thereof.
has exact synonym: ABP-280
has exact synonym: FLN-A
has exact synonym: FLNA
has exact synonym: actin-binding protein 280
has exact synonym: alpha-filamin
has exact synonym: endothelial actin-binding protein
has exact synonym: filamin-1
has exact synonym: non-muscle filamin
has OBO namespace: protein
has related synonym: FLN
has related synonym: FLN1
id: PR:000007555
comment: Category=gene.

Axiom
annotated source: filamin-A
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human FLNA gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: filamin-A
annotated property: hasExactSynonym
annotated target: FLNA
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: filamin-A
annotated property: hasRelatedSynonym
annotated target: FLN
has synonym type: Gene-based

Axiom
annotated source: filamin-A
annotated property: hasRelatedSynonym
annotated target: FLN1
has synonym type: Gene-based

filamin-B
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human FLNB gene or a 1:1 ortholog thereof.
has broad synonym: actin-binding-like protein
has exact synonym: ABP-278
has exact synonym: ABP-280 homolog
has exact synonym: FLN-B
has exact synonym: FLNB
has exact synonym: Fh1
has exact synonym: beta-filamin
has exact synonym: filamin homolog 1
has exact synonym: filamin-3
has exact synonym: thyroid autoantigen
has exact synonym: truncated ABP
has exact synonym: truncated actin-binding protein
has OBO namespace: protein
has related synonym: ABP-280-like protein
has related synonym: FLN1L
has related synonym: FLN3
has related synonym: TABP
has related synonym: TAP
id: PR:000007556
comment: Category=gene.

Axiom
annotated source: filamin-B
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human FLNB gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: filamin-B
annotated property: hasBroadSynonym
annotated target: actin-binding-like protein
has db xref: PRO:DNx

Axiom
annotated source: filamin-B
annotated property: hasExactSynonym
annotated target: FLNB
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: filamin-B
annotated property: hasRelatedSynonym
annotated target: FLN1L
has synonym type: Gene-based

Axiom
annotated source: filamin-B
annotated property: hasRelatedSynonym
annotated target: FLN3
has synonym type: Gene-based

Axiom
annotated source: filamin-B
annotated property: hasRelatedSynonym
annotated target: TABP
has synonym type: Gene-based

Axiom
annotated source: filamin-B
annotated property: hasRelatedSynonym
annotated target: TAP
has synonym type: Gene-based

filamin-C
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human FLNC gene or a 1:1 ortholog thereof.
has broad synonym: actin-binding-like protein
has exact synonym: ABP-L
has exact synonym: FLN-C
has exact synonym: FLNC
has exact synonym: FLNc
has exact synonym: filamin-2
has exact synonym: gamma-filamin
has OBO namespace: protein
has related synonym: ABP-280-like protein
has related synonym: ABPL
has related synonym: FLN2
id: PR:000007557
comment: Category=gene.

Axiom
annotated source: filamin-C
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human FLNC gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: filamin-C
annotated property: hasBroadSynonym
annotated target: actin-binding-like protein
has db xref: PRO:DNx

Axiom
annotated source: filamin-C
annotated property: hasExactSynonym
annotated target: FLNC
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: filamin-C
annotated property: hasRelatedSynonym
annotated target: ABPL
has synonym type: Gene-based

Axiom
annotated source: filamin-C
annotated property: hasRelatedSynonym
annotated target: FLN2
has synonym type: Gene-based

vascular endothelial growth factor receptor 1
type: Class
subclass of: vascular endothelial growth factor receptor
IAO_0000115: A vascular endothelial growth factor receptor that is a translation product of the human FLT1 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1812
has exact synonym: FLT-1
has exact synonym: FLT1
has exact synonym: Fms-like tyrosine kinase 1
has exact synonym: VEGFR-1
has exact synonym: embryonic receptor kinase 2
has exact synonym: tyrosine-protein kinase FRT
has exact synonym: tyrosine-protein kinase receptor FLT
has exact synonym: vascular permeability factor receptor
has OBO namespace: protein
has related synonym: Emrk2
has related synonym: FLT
has related synonym: FRT
has related synonym: VEGFR1
id: PR:000007563
comment: Category=gene.

Axiom
annotated source: vascular endothelial growth factor receptor 1
annotated property: IAO_0000115
annotated target: A vascular endothelial growth factor receptor that is a translation product of the human FLT1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: vascular endothelial growth factor receptor 1
annotated property: hasExactSynonym
annotated target: FLT1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: vascular endothelial growth factor receptor 1
annotated property: hasRelatedSynonym
annotated target: Emrk2
has synonym type: Gene-based

Axiom
annotated source: vascular endothelial growth factor receptor 1
annotated property: hasRelatedSynonym
annotated target: FLT
has synonym type: Gene-based

Axiom
annotated source: vascular endothelial growth factor receptor 1
annotated property: hasRelatedSynonym
annotated target: FRT
has synonym type: Gene-based

Axiom
annotated source: vascular endothelial growth factor receptor 1
annotated property: hasRelatedSynonym
annotated target: VEGFR1
has synonym type: Gene-based

vascular endothelial growth factor receptor 3
type: Class
subclass of: vascular endothelial growth factor receptor
IAO_0000115: A vascular endothelial growth factor receptor that is a translation product of the human FLT4 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1814
has exact synonym: FLT-4
has exact synonym: FLT4
has exact synonym: Fms-like tyrosine kinase 4
has exact synonym: VEGFR-3
has exact synonym: tyrosine-protein kinase receptor FLT4
has OBO namespace: protein
has related synonym: VEGFR3
id: PR:000007565
comment: Category=gene.

Axiom
annotated source: vascular endothelial growth factor receptor 3
annotated property: IAO_0000115
annotated target: A vascular endothelial growth factor receptor that is a translation product of the human FLT4 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: vascular endothelial growth factor receptor 3
annotated property: hasExactSynonym
annotated target: FLT4
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: vascular endothelial growth factor receptor 3
annotated property: hasRelatedSynonym
annotated target: VEGFR3
has synonym type: Gene-based

fibronectin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human FN1 gene or a 1:1 ortholog thereof.
has exact synonym: CIG
has exact synonym: FN1
has exact synonym: cold-insoluble globulin
has OBO namespace: protein
has related synonym: FN
id: PR:000007581
comment: Category=gene.

Axiom
annotated source: fibronectin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human FN1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: fibronectin
annotated property: hasExactSynonym
annotated target: FN1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: fibronectin
annotated property: hasRelatedSynonym
annotated target: FN
has synonym type: Gene-based

galanin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human GAL gene or a 1:1 ortholog thereof.
has exact synonym: GAL
has OBO namespace: protein
has related synonym: GAL1
has related synonym: GALN
has related synonym: GLNN
id: PR:000007806
comment: Category=gene.

Axiom
annotated source: galanin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human GAL gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: galanin
annotated property: hasExactSynonym
annotated target: GAL
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: galanin
annotated property: hasRelatedSynonym
annotated target: GAL1
has synonym type: Gene-based

Axiom
annotated source: galanin
annotated property: hasRelatedSynonym
annotated target: GALN
has synonym type: Gene-based

Axiom
annotated source: galanin
annotated property: hasRelatedSynonym
annotated target: GLNN
has synonym type: Gene-based

gastrin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human GAST gene or a 1:1 ortholog thereof.
has exact synonym: GAST
has OBO namespace: protein
has related synonym: GAS
id: PR:000007856
comment: Category=gene.

Axiom
annotated source: gastrin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human GAST gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: gastrin
annotated property: hasExactSynonym
annotated target: GAST
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: gastrin
annotated property: hasRelatedSynonym
annotated target: GAS
has synonym type: Gene-based

glucagon receptor
type: Class
subclass of: glucagon-like receptor
IAO_0000115: A glucagon-like receptor that is a translation product of the human GCGR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:251
has exact synonym: GCGR
has exact synonym: GL-R
has OBO namespace: protein
id: PR:000007892
comment: Category=gene.

Axiom
annotated source: glucagon receptor
annotated property: IAO_0000115
annotated target: A glucagon-like receptor that is a translation product of the human GCGR gene or a 1:1 ortholog thereof.
has db xref: PRO:DAN

Axiom
annotated source: glucagon receptor
annotated property: hasExactSynonym
annotated target: GCGR
has db xref: PRO:DNx
has synonym type: PRO-short-label

GTP cyclohydrolase 1
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human GCH1 gene or a 1:1 ortholog thereof.
has broad synonym: GTP cyclohydrolase I
has broad synonym: GTP-CH-I
has exact synonym: GCH1
has OBO namespace: protein
has related synonym: DYT5
has related synonym: GCH
id: PR:000007893
comment: Category=gene.

Axiom
annotated source: GTP cyclohydrolase 1
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human GCH1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: GTP cyclohydrolase 1
annotated property: hasBroadSynonym
annotated target: GTP cyclohydrolase I
has db xref: PRO:DNx

Axiom
annotated source: GTP cyclohydrolase 1
annotated property: hasBroadSynonym
annotated target: GTP-CH-I
has db xref: PRO:DNx

Axiom
annotated source: GTP cyclohydrolase 1
annotated property: hasExactSynonym
annotated target: GCH1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: GTP cyclohydrolase 1
annotated property: hasRelatedSynonym
annotated target: DYT5
has synonym type: Gene-based

Axiom
annotated source: GTP cyclohydrolase 1
annotated property: hasRelatedSynonym
annotated target: GCH
has synonym type: Gene-based

glial cell line-derived neurotrophic factor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human GDNF gene or a 1:1 ortholog thereof.
has exact synonym: ATF
has exact synonym: GDNF
has exact synonym: astrocyte-derived trophic factor
has OBO namespace: protein
id: PR:000007928
comment: Category=gene.

Axiom
annotated source: glial cell line-derived neurotrophic factor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human GDNF gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: glial cell line-derived neurotrophic factor
annotated property: hasExactSynonym
annotated target: GDNF
has db xref: PRO:DNx
has synonym type: PRO-short-label

growth hormone receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human GHR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1720
has exact synonym: GH receptor
has exact synonym: GHR
has exact synonym: somatotropin receptor
has OBO namespace: protein
id: PR:000007970
comment: Category=gene.

Axiom
annotated source: growth hormone receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human GHR gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: growth hormone receptor
annotated property: hasExactSynonym
annotated target: GHR
has db xref: PRO:DNx
has synonym type: PRO-short-label

somatoliberin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human GHRH gene or a 1:1 ortholog thereof.
has exact synonym: GHRH
has exact synonym: GRF
has exact synonym: growth hormone-releasing factor
has exact synonym: growth hormone-releasing hormone
has exact synonym: sermorelin
has exact synonym: somatocrinin
has exact synonym: somatorelin
has OBO namespace: protein
has related synonym: GHRF
id: PR:000007971
comment: Category=gene.

Axiom
annotated source: somatoliberin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human GHRH gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: somatoliberin
annotated property: hasExactSynonym
annotated target: GHRH
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: somatoliberin
annotated property: hasRelatedSynonym
annotated target: GHRF
has synonym type: Gene-based

growth hormone-releasing hormone receptor
type: Class
subclass of: glucagon-like receptor
IAO_0000115: A glucagon-like receptor that is a translation product of the human GHRHR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:247
has exact synonym: GHRH receptor
has exact synonym: GHRHR
has exact synonym: GRF receptor
has exact synonym: GRFR
has exact synonym: growth hormone-releasing factor receptor
has OBO namespace: protein
id: PR:000007972
comment: Category=gene.

Axiom
annotated source: growth hormone-releasing hormone receptor
annotated property: IAO_0000115
annotated target: A glucagon-like receptor that is a translation product of the human GHRHR gene or a 1:1 ortholog thereof.
has db xref: PRO:DAN

Axiom
annotated source: growth hormone-releasing hormone receptor
annotated property: hasExactSynonym
annotated target: GHRHR
has db xref: PRO:DNx
has synonym type: PRO-short-label

appetite-regulating hormone
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human GHRL gene or a 1:1 ortholog thereof.
has exact synonym: GHRL
has exact synonym: growth hormone secretagogue
has exact synonym: growth hormone-releasing peptide
has exact synonym: motilin-related peptide
has exact synonym: protein M46
has OBO namespace: protein
has related synonym: MTLRP
has related synonym: UNQ524/PRO1066
id: PR:000007973
comment: Category=gene.

Axiom
annotated source: appetite-regulating hormone
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human GHRL gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: appetite-regulating hormone
annotated property: hasExactSynonym
annotated target: GHRL
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: appetite-regulating hormone
annotated property: hasRelatedSynonym
annotated target: MTLRP
has synonym type: Gene-based

Axiom
annotated source: appetite-regulating hormone
annotated property: hasRelatedSynonym
annotated target: UNQ524/PRO1066
has synonym type: Gene-based

gastric inhibitory polypeptide receptor
type: Class
subclass of: glucagon-like receptor
IAO_0000115: A glucagon-like receptor that is a translation product of the human GIPR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:248
has exact synonym: GIP-R
has exact synonym: GIPR
has exact synonym: glucose-dependent insulinotropic polypeptide receptor
has OBO namespace: protein
id: PR:000007988
comment: Category=gene.

Axiom
annotated source: gastric inhibitory polypeptide receptor
annotated property: IAO_0000115
annotated target: A glucagon-like receptor that is a translation product of the human GIPR gene or a 1:1 ortholog thereof.
has db xref: PRO:DAN

Axiom
annotated source: gastric inhibitory polypeptide receptor
annotated property: hasExactSynonym
annotated target: GIPR
has db xref: PRO:DNx
has synonym type: PRO-short-label

hypocretin neuropeptide precursor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human HCRT gene or a 1:1 ortholog thereof.
has exact synonym: HCRT
has exact synonym: Hcrt
has exact synonym: hypocretin
has exact synonym: orexin
has exact synonym: orexin precursor
has exact synonym: prepro-orexin
has exact synonym: preprohypocretin
has OBO namespace: protein
has related synonym: OX
has related synonym: PPORX
has related synonym: PPOX
id: PR:000008476
comment: Category=gene.

Axiom
annotated source: hypocretin neuropeptide precursor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human HCRT gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: hypocretin neuropeptide precursor
annotated property: hasExactSynonym
annotated target: HCRT
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: hypocretin neuropeptide precursor
annotated property: hasRelatedSynonym
annotated target: OX
has synonym type: Gene-based

Axiom
annotated source: hypocretin neuropeptide precursor
annotated property: hasRelatedSynonym
annotated target: PPORX
has synonym type: Gene-based

Axiom
annotated source: hypocretin neuropeptide precursor
annotated property: hasRelatedSynonym
annotated target: PPOX
has synonym type: Gene-based

hepatocyte growth factor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human HGF gene or a 1:1 ortholog thereof.
has exact synonym: HGF
has exact synonym: SF
has exact synonym: hepatopoeitin-A
has exact synonym: hepatopoietin-A
has exact synonym: scatter factor
has OBO namespace: protein
has related synonym: HPTA
id: PR:000008534
comment: Category=gene.

Axiom
annotated source: hepatocyte growth factor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human HGF gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: hepatocyte growth factor
annotated property: hasExactSynonym
annotated target: HGF
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: hepatocyte growth factor
annotated property: hasRelatedSynonym
annotated target: HPTA
has synonym type: Gene-based

high mobility group protein B1
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human HMGB1 gene or a 1:1 ortholog thereof.
has exact synonym: HMG-1
has exact synonym: HMGB1
has exact synonym: high mobility group protein 1
has OBO namespace: protein
has related synonym: HMG1
id: PR:000008630
comment: Category=gene.

Axiom
annotated source: high mobility group protein B1
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human HMGB1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: high mobility group protein B1
annotated property: hasExactSynonym
annotated target: HMGB1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: high mobility group protein B1
annotated property: hasRelatedSynonym
annotated target: HMG1
has synonym type: Gene-based

3-hydroxy-3-methylglutaryl-coenzyme A reductase
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human HMGCR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:639
has exact synonym: HMG-CoA reductase
has exact synonym: HMGCR
has OBO namespace: protein
id: PR:000008636
comment: Category=gene.

Axiom
annotated source: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human HMGCR gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
annotated property: hasExactSynonym
annotated target: HMGCR
has db xref: PRO:DNx
has synonym type: PRO-short-label

haptoglobin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human HP gene or a 1:1 ortholog thereof.
has exact synonym: HP
has OBO namespace: protein
id: PR:000008725
comment: Category=gene.

Axiom
annotated source: haptoglobin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human HP gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: haptoglobin
annotated property: hasExactSynonym
annotated target: HP
has db xref: PRO:DNx
has synonym type: PRO-short-label

islet amyloid polypeptide
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IAPP gene or a 1:1 ortholog thereof.
has broad synonym: DAP
has exact synonym: IAPP
has exact synonym: amylin
has exact synonym: diabetes-associated peptide
has exact synonym: insulinoma amyloid peptide
has OBO namespace: protein
id: PR:000008875
comment: Category=gene.

Axiom
annotated source: islet amyloid polypeptide
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IAPP gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: islet amyloid polypeptide
annotated property: hasBroadSynonym
annotated target: DAP
has db xref: PRO:DNx

Axiom
annotated source: islet amyloid polypeptide
annotated property: hasExactSynonym
annotated target: IAPP
has db xref: PRO:DNx
has synonym type: PRO-short-label

integrin-binding sialoprotein
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IBSP gene or a 1:1 ortholog thereof.
has exact synonym: BSP II
has exact synonym: IBSP
has exact synonym: bone sialoprotein 2
has exact synonym: bone sialoprotein II
has exact synonym: cell-binding sialoprotein
has OBO namespace: protein
has related synonym: BNSP
id: PR:000008878
comment: Category=gene.

Axiom
annotated source: integrin-binding sialoprotein
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IBSP gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: integrin-binding sialoprotein
annotated property: hasExactSynonym
annotated target: IBSP
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: integrin-binding sialoprotein
annotated property: hasRelatedSynonym
annotated target: BNSP
has synonym type: Gene-based

isocitrate dehydrogenase [NADP], mitochondrial
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IDH2 gene or a 1:1 ortholog thereof.
has broad synonym: IDH
has broad synonym: IDP
has broad synonym: NADP(+)-specific ICDH
has broad synonym: oxalosuccinate decarboxylase
has db xref: IUPHARobj:2885
has exact synonym: ICD-M
has exact synonym: IDH2nadp
has OBO namespace: protein
has related synonym: IDH2
id: PR:000008888
comment: Category=gene.

Axiom
annotated source: isocitrate dehydrogenase [NADP], mitochondrial
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IDH2 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: isocitrate dehydrogenase [NADP], mitochondrial
annotated property: hasBroadSynonym
annotated target: IDH
has db xref: PRO:DNx

Axiom
annotated source: isocitrate dehydrogenase [NADP], mitochondrial
annotated property: hasBroadSynonym
annotated target: IDP
has db xref: PRO:DNx

Axiom
annotated source: isocitrate dehydrogenase [NADP], mitochondrial
annotated property: hasBroadSynonym
annotated target: NADP(+)-specific ICDH
has db xref: PRO:DNx

Axiom
annotated source: isocitrate dehydrogenase [NADP], mitochondrial
annotated property: hasBroadSynonym
annotated target: oxalosuccinate decarboxylase
has db xref: PRO:DNx

Axiom
annotated source: isocitrate dehydrogenase [NADP], mitochondrial
annotated property: hasExactSynonym
annotated target: IDH2nadp
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: isocitrate dehydrogenase [NADP], mitochondrial
annotated property: hasRelatedSynonym
annotated target: IDH2
has synonym type: Gene-based

interferon-induced helicase C domain-containing protein 1
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IFIH1 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:2921
has exact synonym: IFIH1
has exact synonym: MDA-5
has exact synonym: RIG-I-like receptor 2
has exact synonym: RLR-2
has exact synonym: RNA helicase-DEAD box protein 116
has exact synonym: helicard
has exact synonym: helicase with 2 CARD domains
has exact synonym: interferon induced with helicase C domain protein 1
has exact synonym: interferon-induced with helicase C domain protein 1
has exact synonym: melanoma differentiation-associated protein 5
has exact synonym: murabutide down-regulated protein
has OBO namespace: protein
has related synonym: MDA5
has related synonym: RH116
id: PR:000008910
comment: Category=gene.

Axiom
annotated source: interferon-induced helicase C domain-containing protein 1
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IFIH1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: interferon-induced helicase C domain-containing protein 1
annotated property: hasExactSynonym
annotated target: IFIH1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interferon-induced helicase C domain-containing protein 1
annotated property: hasRelatedSynonym
annotated target: MDA5
has synonym type: Gene-based

Axiom
annotated source: interferon-induced helicase C domain-containing protein 1
annotated property: hasRelatedSynonym
annotated target: RH116
has synonym type: Gene-based

insulin-like growth factor 2
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IGF2 gene or a 1:1 ortholog thereof.
has exact synonym: IGF-II
has exact synonym: IGF2
has exact synonym: insulin-like growth factor II
has exact synonym: multiplication-stimulating polypeptide
has exact synonym: somatomedin-A
has OBO namespace: protein
has related synonym: Igf-2
has related synonym: PP1446
id: PR:000008942
comment: Category=gene.

Axiom
annotated source: insulin-like growth factor 2
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IGF2 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: insulin-like growth factor 2
annotated property: hasExactSynonym
annotated target: IGF2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: insulin-like growth factor 2
annotated property: hasRelatedSynonym
annotated target: Igf-2
has synonym type: Gene-based

Axiom
annotated source: insulin-like growth factor 2
annotated property: hasRelatedSynonym
annotated target: PP1446
has synonym type: Gene-based

interleukin-21 receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL21R gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1703
has exact synonym: CD360
has exact synonym: IL-21 receptor
has exact synonym: IL-21R
has exact synonym: IL21R
has exact synonym: LR-beta
has exact synonym: NR8
has exact synonym: lymphocyte receptor beta
has exact synonym: novel cytokine receptor 8
has exact synonym: novel interleukin receptor
has OBO namespace: protein
has related synonym: NILR
has related synonym: UNQ3121/PRO10273
id: PR:000008998
comment: Category=gene.

Axiom
annotated source: interleukin-21 receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL21R gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: interleukin-21 receptor
annotated property: hasExactSynonym
annotated target: CD360
has db xref: ImmPort:DSD

Axiom
annotated source: interleukin-21 receptor
annotated property: hasExactSynonym
annotated target: IL21R
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: interleukin-21 receptor
annotated property: hasRelatedSynonym
annotated target: NILR
has synonym type: Gene-based

Axiom
annotated source: interleukin-21 receptor
annotated property: hasRelatedSynonym
annotated target: UNQ3121/PRO10273
has synonym type: Gene-based

interleukin-23 receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IL23R gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1717
has exact synonym: IL-23 receptor
has exact synonym: IL-23R
has exact synonym: IL23R
has OBO namespace: protein
id: PR:000009001
comment: Category=gene.

Axiom
annotated source: interleukin-23 receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IL23R gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: interleukin-23 receptor
annotated property: hasExactSynonym
annotated target: IL23R
has db xref: PRO:DNx
has synonym type: PRO-short-label

preproinsulin
type: Class
subclass of: insulin family protein
IAO_0000115: An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof.
has exact synonym: INS
has OBO namespace: protein
id: PR:000009054
comment: Category=gene.

Axiom
annotated source: preproinsulin
annotated property: IAO_0000115
annotated target: An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: preproinsulin
annotated property: hasExactSynonym
annotated target: INS
has db xref: PRO:DNx
has synonym type: PRO-short-label

insulin receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human INSR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1800
has exact synonym: CD220
has exact synonym: INSR
has exact synonym: IR
has OBO namespace: protein
id: PR:000009064
comment: Category=gene.

Axiom
annotated source: insulin receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human INSR gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: insulin receptor
annotated property: hasExactSynonym
annotated target: INSR
has db xref: PRO:DNx
has synonym type: PRO-short-label

insulin-like growth factor 1
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human IGF1 gene or a 1:1 ortholog thereof.
has broad synonym: IGF-I
has broad synonym: MGF
has exact synonym: IGF1
has exact synonym: insulin-like growth factor I
has exact synonym: mechano growth factor
has exact synonym: somatomedin
has exact synonym: somatomedin-C
has OBO namespace: protein
has related synonym: IBP1
has related synonym: Igf-1
id: PR:000009182
comment: Category=gene.

Axiom
annotated source: insulin-like growth factor 1
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human IGF1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: insulin-like growth factor 1
annotated property: hasBroadSynonym
annotated target: IGF-I
has db xref: PRO:DNx

Axiom
annotated source: insulin-like growth factor 1
annotated property: hasBroadSynonym
annotated target: MGF
has db xref: PRO:DNx

Axiom
annotated source: insulin-like growth factor 1
annotated property: hasExactSynonym
annotated target: IGF1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: insulin-like growth factor 1
annotated property: hasRelatedSynonym
annotated target: IBP1
has synonym type: Gene-based

Axiom
annotated source: insulin-like growth factor 1
annotated property: hasRelatedSynonym
annotated target: Igf-1
has synonym type: Gene-based

kit ligand
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human KITLG gene or a 1:1 ortholog thereof.
has broad synonym: MGF
has exact synonym: KITLG
has exact synonym: c-Kit ligand
has exact synonym: hematopoietic growth factor KL
has exact synonym: steel factor
has exact synonym: stem cell factor
has OBO namespace: protein
has related synonym: Kitl
has related synonym: SCF
has related synonym: Sl
has related synonym: Slf
has related synonym: mast cell growth factor
id: PR:000009345
comment: Category=gene.

Axiom
annotated source: kit ligand
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human KITLG gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: kit ligand
annotated property: hasBroadSynonym
annotated target: MGF
has db xref: PRO:DNx
has synonym type: Gene-based

Axiom
annotated source: kit ligand
annotated property: hasExactSynonym
annotated target: KITLG
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: kit ligand
annotated property: hasRelatedSynonym
annotated target: Kitl
has synonym type: Gene-based

Axiom
annotated source: kit ligand
annotated property: hasRelatedSynonym
annotated target: SCF
has synonym type: Gene-based

Axiom
annotated source: kit ligand
annotated property: hasRelatedSynonym
annotated target: Sl
has synonym type: Gene-based

Axiom
annotated source: kit ligand
annotated property: hasRelatedSynonym
annotated target: Slf
has synonym type: Gene-based

leukemia inhibitory factor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human LIF gene or a 1:1 ortholog thereof.
has exact synonym: D factor
has exact synonym: LIF
has exact synonym: MLPLI
has exact synonym: differentiation-stimulating factor
has exact synonym: emfilermin
has exact synonym: melanoma-derived LPL inhibitor
has OBO namespace: protein
has related synonym: HILDA
id: PR:000009799
comment: Category=gene.

Axiom
annotated source: leukemia inhibitory factor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human LIF gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: leukemia inhibitory factor
annotated property: hasExactSynonym
annotated target: LIF
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: leukemia inhibitory factor
annotated property: hasRelatedSynonym
annotated target: HILDA
has synonym type: Gene-based

lactotransferrin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof.
has exact synonym: LTF
has exact synonym: lactoferrin
has exact synonym: talalactoferrin
has OBO namespace: protein
has related synonym: GIG12
has related synonym: LF
id: PR:000009978
comment: Category=gene. Requested by=CL.

Axiom
annotated source: lactotransferrin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: lactotransferrin
annotated property: hasExactSynonym
annotated target: LTF
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: lactotransferrin
annotated property: hasRelatedSynonym
annotated target: GIG12
has synonym type: Gene-based

Axiom
annotated source: lactotransferrin
annotated property: hasRelatedSynonym
annotated target: LF
has synonym type: Gene-based

hepatocyte growth factor receptor
type: Class
subclass of: HGF/MSP receptor type tyrosine-protein kinase
IAO_0000115: An HGF/MSP receptor type tyrosine-protein kinase that is a translation product of the human MET gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1815
has exact synonym: HGF receptor
has exact synonym: HGF/SF receptor
has exact synonym: MET
has exact synonym: SF receptor
has exact synonym: proto-oncogene c-Met
has exact synonym: scatter factor receptor
has exact synonym: tyrosine-protein kinase Met
has OBO namespace: protein
id: PR:000010335
comment: Category=gene.

Axiom
annotated source: hepatocyte growth factor receptor
annotated property: IAO_0000115
annotated target: An HGF/MSP receptor type tyrosine-protein kinase that is a translation product of the human MET gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: hepatocyte growth factor receptor
annotated property: hasExactSynonym
annotated target: MET
has db xref: PRO:DNx
has synonym type: PRO-short-label

macrophage migration inhibitory factor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human MIF gene or a 1:1 ortholog thereof.
has exact synonym: DER6
has exact synonym: L-dopachrome isomerase
has exact synonym: MIF
has exact synonym: delayed early response protein 6
has exact synonym: glycosylation-inhibiting factor
has exact synonym: phenylpyruvate tautomerase
has OBO namespace: protein
has related synonym: GIF
has related synonym: GLIF
has related synonym: L-dopachrome tautomerase
has related synonym: MMIF
id: PR:000010413
comment: Category=gene.

Axiom
annotated source: macrophage migration inhibitory factor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human MIF gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: macrophage migration inhibitory factor
annotated property: hasExactSynonym
annotated target: MIF
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: macrophage migration inhibitory factor
annotated property: hasRelatedSynonym
annotated target: GLIF
has synonym type: Gene-based

Axiom
annotated source: macrophage migration inhibitory factor
annotated property: hasRelatedSynonym
annotated target: MMIF
has synonym type: Gene-based

mitogen-activated protein kinase kinase kinase 21
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human MAP3K21 gene or a 1:1 ortholog thereof.
has exact synonym: MAP3K21
has exact synonym: mitogen-activated protein kinase kinase kinase MLK4
has exact synonym: mixed lineage kinase 4
has OBO namespace: protein
has related synonym: KIAA1804
has related synonym: MLK4
id: PR:000010444
comment: Category=gene.

Axiom
annotated source: mitogen-activated protein kinase kinase kinase 21
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human MAP3K21 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: mitogen-activated protein kinase kinase kinase 21
annotated property: hasExactSynonym
annotated target: MAP3K21
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: mitogen-activated protein kinase kinase kinase 21
annotated property: hasRelatedSynonym
annotated target: KIAA1804
has synonym type: Gene-based

Axiom
annotated source: mitogen-activated protein kinase kinase kinase 21
annotated property: hasRelatedSynonym
annotated target: MLK4
has db xref: PRO:DNx
has synonym type: Gene-based

myogenic factor 5
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human MYF5 gene or a 1:1 ortholog thereof.
has exact synonym: MYF5
has exact synonym: bHLHc2
has exact synonym: class C basic helix-loop-helix protein 2
has OBO namespace: protein
has related synonym: BHLHC2
has related synonym: Myf-5
id: PR:000010818
comment: Category=gene.

Axiom
annotated source: myogenic factor 5
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human MYF5 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: myogenic factor 5
annotated property: hasExactSynonym
annotated target: MYF5
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: myogenic factor 5
annotated property: hasRelatedSynonym
annotated target: BHLHC2
has synonym type: Gene-based

Axiom
annotated source: myogenic factor 5
annotated property: hasRelatedSynonym
annotated target: Myf-5
has synonym type: Gene-based

myosin-Ia
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human MYO1A gene or a 1:1 ortholog thereof.
has exact synonym: BBM-I
has exact synonym: BBMI
has exact synonym: MIHC
has exact synonym: MYO1A
has exact synonym: brush border myosin I
has exact synonym: myosin I heavy chain
has OBO namespace: protein
has related synonym: MYHL
id: PR:000010855
comment: Category=gene.

Axiom
annotated source: myosin-Ia
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human MYO1A gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: myosin-Ia
annotated property: hasExactSynonym
annotated target: MYO1A
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: myosin-Ia
annotated property: hasRelatedSynonym
annotated target: MYHL
has synonym type: Gene-based

myogenin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human MYOG gene or a 1:1 ortholog thereof.
has exact synonym: MYOD1-related protein
has exact synonym: MYOG
has exact synonym: Myf-4
has exact synonym: bHLHc3
has exact synonym: class C basic helix-loop-helix protein 3
has exact synonym: myogenic factor 4
has OBO namespace: protein
has related synonym: BHLHC3
has related synonym: MYF4
id: PR:000010877
comment: Category=gene.

Axiom
annotated source: myogenin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human MYOG gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: myogenin
annotated property: hasExactSynonym
annotated target: MYOG
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: myogenin
annotated property: hasRelatedSynonym
annotated target: BHLHC3
has synonym type: Gene-based

Axiom
annotated source: myogenin
annotated property: hasRelatedSynonym
annotated target: MYF4
has synonym type: Gene-based

myozenin-1
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human MYOZ1 gene or a 1:1 ortholog thereof.
has exact synonym: MYOZ1
has exact synonym: calsarcin-2
has exact synonym: filamin-, actinin- and telethonin-binding protein
has exact synonym: protein FATZ
has OBO namespace: protein
has related synonym: MYOZ
id: PR:000010882
comment: Category=gene.

Axiom
annotated source: myozenin-1
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human MYOZ1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: myozenin-1
annotated property: hasExactSynonym
annotated target: MYOZ1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: myozenin-1
annotated property: hasRelatedSynonym
annotated target: MYOZ
has synonym type: Gene-based

ubiquitin-like protein NEDD8
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human NEDD8 gene or a 1:1 ortholog thereof.
has exact synonym: NEDD-8
has exact synonym: NEDD8
has exact synonym: NEDD8 protein
has exact synonym: neddylin
has exact synonym: neural precursor cell expressed developmentally down-regulated protein 8
has exact synonym: ubiquitin-like protein Nedd8
has OBO namespace: protein
id: PR:000011116
comment: Category=gene.

Axiom
annotated source: ubiquitin-like protein NEDD8
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human NEDD8 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: ubiquitin-like protein NEDD8
annotated property: hasExactSynonym
annotated target: NEDD8
has db xref: PRO:DNx
has synonym type: PRO-short-label

nuclear factor of activated T-cells, cytoplasmic 2
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human NFATC2 gene or a 1:1 ortholog thereof.
has exact synonym: NF-ATc2
has exact synonym: NF-ATp
has exact synonym: NFAT pre-existing subunit
has exact synonym: NFATC2
has exact synonym: NFATc2
has exact synonym: T-cell transcription factor NFAT1
has OBO namespace: protein
has related synonym: NFAT1
has related synonym: NFATP
id: PR:000011164
comment: Category=gene.

Axiom
annotated source: nuclear factor of activated T-cells, cytoplasmic 2
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human NFATC2 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: nuclear factor of activated T-cells, cytoplasmic 2
annotated property: hasExactSynonym
annotated target: NFATC2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: nuclear factor of activated T-cells, cytoplasmic 2
annotated property: hasRelatedSynonym
annotated target: NFAT1
has synonym type: Gene-based

Axiom
annotated source: nuclear factor of activated T-cells, cytoplasmic 2
annotated property: hasRelatedSynonym
annotated target: NFATP
has synonym type: Gene-based

nuclear factor of activated T-cells, cytoplasmic 3
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human NFATC3 gene or a 1:1 ortholog thereof.
has exact synonym: NF-AT4
has exact synonym: NF-ATc3
has exact synonym: NFATC3
has exact synonym: NFATc3
has exact synonym: NFATx
has exact synonym: T-cell transcription factor NFAT4
has OBO namespace: protein
has related synonym: NFAT4
id: PR:000011166
comment: Category=gene.

Axiom
annotated source: nuclear factor of activated T-cells, cytoplasmic 3
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human NFATC3 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: nuclear factor of activated T-cells, cytoplasmic 3
annotated property: hasExactSynonym
annotated target: NFATC3
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: nuclear factor of activated T-cells, cytoplasmic 3
annotated property: hasRelatedSynonym
annotated target: NFAT4
has synonym type: Gene-based

nuclear factor of activated T-cells, cytoplasmic 4
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human NFATC4 gene or a 1:1 ortholog thereof.
has exact synonym: NF-AT3
has exact synonym: NF-ATc4
has exact synonym: NFATC4
has exact synonym: NFATc4
has exact synonym: T-cell transcription factor NFAT3
has OBO namespace: protein
has related synonym: NFAT3
id: PR:000011167
comment: Category=gene.

Axiom
annotated source: nuclear factor of activated T-cells, cytoplasmic 4
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human NFATC4 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: nuclear factor of activated T-cells, cytoplasmic 4
annotated property: hasExactSynonym
annotated target: NFATC4
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: nuclear factor of activated T-cells, cytoplasmic 4
annotated property: hasRelatedSynonym
annotated target: NFAT3
has synonym type: Gene-based

beta-nerve growth factor
type: Class
subclass of: neurotrophin
IAO_0000115: A neurotrophin that is a translation product of the human NGF gene or a 1:1 ortholog thereof.
has exact synonym: NGF
has exact synonym: beta-NGF
has OBO namespace: protein
has related synonym: NGFB
id: PR:000011194
comment: Category=gene.

Axiom
annotated source: beta-nerve growth factor
annotated property: IAO_0000115
annotated target: A neurotrophin that is a translation product of the human NGF gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: beta-nerve growth factor
annotated property: hasExactSynonym
annotated target: NGF
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: beta-nerve growth factor
annotated property: hasRelatedSynonym
annotated target: NGFB
has synonym type: Gene-based

atrial natriuretic factor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human NPPA gene or a 1:1 ortholog thereof.
has exact synonym: ANF
has exact synonym: CDD
has exact synonym: CDD-ANF
has exact synonym: NPPA
has exact synonym: atrial natriuretic factor prohormone
has exact synonym: atrial natriuretic peptide
has exact synonym: atrial natriuretic peptide prohormone
has exact synonym: atriopeptigen
has exact synonym: cardiodilatin
has exact synonym: preproANP
has exact synonym: preproCDD-ANF
has exact synonym: prepronatriodilatin
has exact synonym: proANF
has exact synonym: proANP
has OBO namespace: protein
has related synonym: ANP
has related synonym: PND
id: PR:000011374
comment: Category=gene.

Axiom
annotated source: atrial natriuretic factor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human NPPA gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: atrial natriuretic factor
annotated property: hasExactSynonym
annotated target: NPPA
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: atrial natriuretic factor
annotated property: hasRelatedSynonym
annotated target: ANP
has synonym type: Gene-based

Axiom
annotated source: atrial natriuretic factor
annotated property: hasRelatedSynonym
annotated target: PND
has synonym type: Gene-based

neuropeptide Y
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human NPY gene or a 1:1 ortholog thereof.
has exact synonym: NPY
has OBO namespace: protein
id: PR:000011387
comment: Category=gene.

Axiom
annotated source: neuropeptide Y
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human NPY gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: neuropeptide Y
annotated property: hasExactSynonym
annotated target: NPY
has db xref: PRO:DNx
has synonym type: PRO-short-label

glucocorticoid receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human NR3C1 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:625
has exact synonym: NR3C1
has exact synonym: nuclear receptor subfamily 3 group C member 1
has OBO namespace: protein
has related synonym: GR
has related synonym: GRL
has related synonym: Grl1
id: PR:000011406
comment: Category=gene.

Axiom
annotated source: glucocorticoid receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human NR3C1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: glucocorticoid receptor
annotated property: hasExactSynonym
annotated target: NR3C1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: glucocorticoid receptor
annotated property: hasRelatedSynonym
annotated target: GRL
has synonym type: Gene-based

Axiom
annotated source: glucocorticoid receptor
annotated property: hasRelatedSynonym
annotated target: Grl1
has synonym type: Gene-based

mineralocorticoid receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human NR3C2 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:626
has exact synonym: MR
has exact synonym: NR3C2
has exact synonym: nuclear receptor subfamily 3 group C member 2
has OBO namespace: protein
has related synonym: MCR
has related synonym: MLR
id: PR:000011407
comment: Category=gene.

Axiom
annotated source: mineralocorticoid receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human NR3C2 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: mineralocorticoid receptor
annotated property: hasExactSynonym
annotated target: NR3C2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: mineralocorticoid receptor
annotated property: hasRelatedSynonym
annotated target: MCR
has synonym type: Gene-based

Axiom
annotated source: mineralocorticoid receptor
annotated property: hasRelatedSynonym
annotated target: MLR
has synonym type: Gene-based

neurotrophin-3
type: Class
subclass of: neurotrophin
IAO_0000115: A neurotrophin that is a translation product of the human NTF3 gene or a 1:1 ortholog thereof.
has exact synonym: HDNF
has exact synonym: NGF-2
has exact synonym: NT-3
has exact synonym: NTF3
has exact synonym: nerve growth factor 2
has exact synonym: neurotrophic factor
has OBO namespace: protein
has related synonym: Ntf-3
id: PR:000011459
comment: Category=gene.

Axiom
annotated source: neurotrophin-3
annotated property: IAO_0000115
annotated target: A neurotrophin that is a translation product of the human NTF3 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: neurotrophin-3
annotated property: hasExactSynonym
annotated target: NTF3
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: neurotrophin-3
annotated property: hasRelatedSynonym
annotated target: Ntf-3
has synonym type: Gene-based

oncostatin-M
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human OSM gene or a 1:1 ortholog thereof.
has exact synonym: OSM
has OBO namespace: protein
id: PR:000012059
comment: Category=gene.

Axiom
annotated source: oncostatin-M
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human OSM gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: oncostatin-M
annotated property: hasExactSynonym
annotated target: OSM
has db xref: PRO:DNx
has synonym type: PRO-short-label

proliferating cell nuclear antigen
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human PCNA gene or a 1:1 ortholog thereof.
has exact synonym: PCNA
has exact synonym: cyclin
has OBO namespace: protein
id: PR:000012421
comment: Category=gene.

Axiom
annotated source: proliferating cell nuclear antigen
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human PCNA gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: proliferating cell nuclear antigen
annotated property: hasExactSynonym
annotated target: PCNA
has db xref: PRO:DNx
has synonym type: PRO-short-label

progesterone receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human PGR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:627
has exact synonym: PGR
has exact synonym: PR
has exact synonym: nuclear receptor subfamily 3 group C member 3
has OBO namespace: protein
has related synonym: NR3C3
id: PR:000012621
comment: Category=gene.

Axiom
annotated source: progesterone receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human PGR gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: progesterone receptor
annotated property: hasExactSynonym
annotated target: PGR
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: progesterone receptor
annotated property: hasRelatedSynonym
annotated target: NR3C3
has synonym type: Gene-based

polymeric immunoglobulin receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human PIGR gene or a 1:1 ortholog thereof.
has exact synonym: PIGR
has exact synonym: PIgR
has exact synonym: hepatocellular carcinoma-associated protein TB6
has exact synonym: poly-Ig receptor
has OBO namespace: protein
id: PR:000012705
comment: Category=gene.

Axiom
annotated source: polymeric immunoglobulin receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human PIGR gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: polymeric immunoglobulin receptor
annotated property: hasExactSynonym
annotated target: PIGR
has db xref: PRO:DNx
has synonym type: PRO-short-label

urokinase-type plasminogen activator
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human PLAU gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:2393
has exact synonym: PLAU
has exact synonym: U-plasminogen activator
has exact synonym: uPA
has OBO namespace: protein
id: PR:000012826
comment: Category=gene.

Axiom
annotated source: urokinase-type plasminogen activator
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human PLAU gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: urokinase-type plasminogen activator
annotated property: hasExactSynonym
annotated target: PLAU
has db xref: PRO:DNx
has synonym type: PRO-short-label

pancreatic polypeptide prohormone
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human PPY gene or a 1:1 ortholog thereof.
has exact synonym: PP
has exact synonym: PPY
has exact synonym: obinepitide
has exact synonym: pancreatic polypeptide
has exact synonym: pancreatic prohormone
has OBO namespace: protein
has related synonym: PNP
id: PR:000013164
comment: Category=gene.

Axiom
annotated source: pancreatic polypeptide prohormone
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human PPY gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: pancreatic polypeptide prohormone
annotated property: hasExactSynonym
annotated target: PPY
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: pancreatic polypeptide prohormone
annotated property: hasRelatedSynonym
annotated target: PNP
has synonym type: Gene-based

prolactin
type: Class
subclass of: somatotropin hormone family member
IAO_0000115: A somatotropin hormone family member that is a translation product of the human PRL gene or a 1:1 ortholog thereof.
has exact synonym: PRL
has OBO namespace: protein
id: PR:000013246
comment: Category=gene.

Axiom
annotated source: prolactin
annotated property: IAO_0000115
annotated target: A somatotropin hormone family member that is a translation product of the human PRL gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: prolactin
annotated property: hasExactSynonym
annotated target: PRL
has db xref: PRO:DNx
has synonym type: PRO-short-label

prolactin receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human PRLR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1721
has exact synonym: PRL-R
has exact synonym: PRLR
has OBO namespace: protein
id: PR:000013248
comment: Category=gene.

Axiom
annotated source: prolactin receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human PRLR gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: prolactin receptor
annotated property: hasExactSynonym
annotated target: PRLR
has db xref: PRO:DNx
has synonym type: PRO-short-label

parathyroid hormone
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human PTH gene or a 1:1 ortholog thereof.
has exact synonym: PTH
has exact synonym: parathormone
has exact synonym: parathyrin
has OBO namespace: protein
id: PR:000013429
comment: Category=gene.

Axiom
annotated source: parathyroid hormone
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human PTH gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: parathyroid hormone
annotated property: hasExactSynonym
annotated target: PTH
has db xref: PRO:DNx
has synonym type: PRO-short-label

peptide YY
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human PYY gene or a 1:1 ortholog thereof.
has exact synonym: PYY
has exact synonym: PYY-I
has exact synonym: peptide tyrosine tyrosine
has OBO namespace: protein
id: PR:000013526
comment: Category=gene.

Axiom
annotated source: peptide YY
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human PYY gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: peptide YY
annotated property: hasExactSynonym
annotated target: PYY
has db xref: PRO:DNx
has synonym type: PRO-short-label

Ras GTPase-activating protein 1
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human RASA1 gene or a 1:1 ortholog thereof.
has broad synonym: GAP
has exact synonym: GTPase-activating protein
has exact synonym: RASA1
has exact synonym: RasGAP
has exact synonym: p120GAP
has exact synonym: ras p21 protein activator
has OBO namespace: protein
has related synonym: RASA
id: PR:000013743
comment: Category=gene.

Axiom
annotated source: Ras GTPase-activating protein 1
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human RASA1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: Ras GTPase-activating protein 1
annotated property: hasBroadSynonym
annotated target: GAP
has db xref: PRO:DNx
has synonym type: Gene-based

Axiom
annotated source: Ras GTPase-activating protein 1
annotated property: hasExactSynonym
annotated target: RASA1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: Ras GTPase-activating protein 1
annotated property: hasRelatedSynonym
annotated target: RASA
has synonym type: Gene-based

renin
type: Class
subclass of: angiotensinogenase
IAO_0000115: An angiotensinogenase that is a translation product of the human REN gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:2413
has exact synonym: REN
has OBO namespace: protein
has related synonym: angiotensinogenase
id: PR:000013883
comment: Category=gene.

Axiom
annotated source: renin
annotated property: IAO_0000115
annotated target: An angiotensinogenase that is a translation product of the human REN gene or a 1:1 ortholog thereof.
has db xref: PRO:DAN

Axiom
annotated source: renin
annotated property: hasExactSynonym
annotated target: REN
has db xref: PRO:DNx
has synonym type: PRO-short-label

ubiquitin-ribosomal protein eS31 fusion protein
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human RPS27A gene or a 1:1 ortholog thereof.
has exact synonym: RPS27A
has exact synonym: ubiquitin carboxyl extension protein 80
has exact synonym: ubiquitin-40S ribosomal protein S27a
has OBO namespace: protein
has related synonym: 40S ribosomal protein S27a
has related synonym: UBA80
has related synonym: UBCEP1
id: PR:000014271
comment: Category=gene.

Axiom
annotated source: ubiquitin-ribosomal protein eS31 fusion protein
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human RPS27A gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: ubiquitin-ribosomal protein eS31 fusion protein
annotated property: hasExactSynonym
annotated target: RPS27A
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: ubiquitin-ribosomal protein eS31 fusion protein
annotated property: hasExactSynonym
annotated target: ubiquitin-40S ribosomal protein S27a
has db xref: PRO:DAN

Axiom
annotated source: ubiquitin-ribosomal protein eS31 fusion protein
annotated property: hasRelatedSynonym
annotated target: UBA80
has synonym type: Gene-based

Axiom
annotated source: ubiquitin-ribosomal protein eS31 fusion protein
annotated property: hasRelatedSynonym
annotated target: UBCEP1
has synonym type: Gene-based

secretin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human SCT gene or a 1:1 ortholog thereof.
has exact synonym: SCT
has OBO namespace: protein
id: PR:000014543
comment: Category=gene.

Axiom
annotated source: secretin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human SCT gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: secretin
annotated property: hasExactSynonym
annotated target: SCT
has db xref: PRO:DNx
has synonym type: PRO-short-label

secretin receptor
type: Class
subclass of: glucagon-like receptor
IAO_0000115: A glucagon-like receptor that is a translation product of the human SCTR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:252
has exact synonym: SCT-R
has exact synonym: SCTR
has OBO namespace: protein
id: PR:000014544
comment: Category=gene.

Axiom
annotated source: secretin receptor
annotated property: IAO_0000115
annotated target: A glucagon-like receptor that is a translation product of the human SCTR gene or a 1:1 ortholog thereof.
has db xref: PRO:DAN

Axiom
annotated source: secretin receptor
annotated property: hasExactSynonym
annotated target: SCTR
has db xref: PRO:DNx
has synonym type: PRO-short-label

protein SET
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human SET gene or a 1:1 ortholog thereof.
has exact synonym: I-2PP2A
has exact synonym: IGAAD
has exact synonym: PHAPII
has exact synonym: SET
has exact synonym: TAF-I
has exact synonym: inhibitor of granzyme A-activated DNase
has exact synonym: phosphatase 2A inhibitor I2PP2A
has exact synonym: template-activating factor I
has narrow synonym: HLA-DR-associated protein II
has OBO namespace: protein
id: PR:000014717
comment: Category=gene.

Axiom
annotated source: protein SET
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human SET gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: protein SET
annotated property: hasExactSynonym
annotated target: SET
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: protein SET
annotated property: hasNarrowSynonym
annotated target: HLA-DR-associated protein II
has db xref: PRO:DAN

protein smoothened
type: Class
subclass of: frizzled-like G-protein coupled receptor
IAO_0000115: A frizzled-like G-protein coupled receptor that is a translation product of the human SMO gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:239
has exact synonym: SMO
has exact synonym: protein Gx
has OBO namespace: protein
has related synonym: SMOH
id: PR:000015288
comment: Category=gene.

Axiom
annotated source: protein smoothened
annotated property: IAO_0000115
annotated target: A frizzled-like G-protein coupled receptor that is a translation product of the human SMO gene or a 1:1 ortholog thereof.
has db xref: PRO:DAN

Axiom
annotated source: protein smoothened
annotated property: hasExactSynonym
annotated target: SMO
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: protein smoothened
annotated property: hasRelatedSynonym
annotated target: SMOH
has synonym type: Gene-based

syntaxin-2
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human STX2 gene or a 1:1 ortholog thereof.
has exact synonym: STX2
has exact synonym: epimorphin
has OBO namespace: protein
has related synonym: EPIM
has related synonym: STX2A
has related synonym: STX2B
has related synonym: STX2C
id: PR:000015794
comment: Category=gene.

Axiom
annotated source: syntaxin-2
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human STX2 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: syntaxin-2
annotated property: hasExactSynonym
annotated target: STX2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: syntaxin-2
annotated property: hasRelatedSynonym
annotated target: EPIM
has synonym type: Gene-based

Axiom
annotated source: syntaxin-2
annotated property: hasRelatedSynonym
annotated target: STX2A
has synonym type: Gene-based

Axiom
annotated source: syntaxin-2
annotated property: hasRelatedSynonym
annotated target: STX2B
has synonym type: Gene-based

Axiom
annotated source: syntaxin-2
annotated property: hasRelatedSynonym
annotated target: STX2C
has synonym type: Gene-based

syntaxin-3
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human STX3 gene or a 1:1 ortholog thereof.
has exact synonym: STX3
has OBO namespace: protein
has related synonym: STX3A
id: PR:000015795
comment: Category=gene.

Axiom
annotated source: syntaxin-3
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human STX3 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: syntaxin-3
annotated property: hasExactSynonym
annotated target: STX3
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: syntaxin-3
annotated property: hasRelatedSynonym
annotated target: STX3A
has synonym type: Gene-based

syntaxin-5
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human STX5 gene or a 1:1 ortholog thereof.
has exact synonym: STX5
has OBO namespace: protein
has related synonym: STX5A
id: PR:000015797
comment: Category=gene.

Axiom
annotated source: syntaxin-5
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human STX5 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: syntaxin-5
annotated property: hasExactSynonym
annotated target: STX5
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: syntaxin-5
annotated property: hasRelatedSynonym
annotated target: STX5A
has synonym type: Gene-based

syntaxin-6
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human STX6 gene or a 1:1 ortholog thereof.
has exact synonym: STX6
has OBO namespace: protein
id: PR:000015798
comment: Category=gene.

Axiom
annotated source: syntaxin-6
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human STX6 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: syntaxin-6
annotated property: hasExactSynonym
annotated target: STX6
has db xref: PRO:DNx
has synonym type: PRO-short-label

antigen peptide transporter 1
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human TAP1 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:769
has exact synonym: APT1
has exact synonym: ATP-binding cassette sub-family B member 2
has exact synonym: PSF-1
has exact synonym: TAP1
has exact synonym: histocompatibility antigen modifier 1
has exact synonym: peptide supply factor 1
has exact synonym: peptide transporter PSF1
has exact synonym: peptide transporter TAP1
has exact synonym: peptide transporter involved in antigen processing 1
has exact synonym: really interesting new gene 4 protein
has OBO namespace: protein
has related synonym: ABCB2
has related synonym: Ham-1
has related synonym: Ham1
has related synonym: PSF1
has related synonym: RING4
has related synonym: Y3
id: PR:000016051
comment: Category=gene.

Axiom
annotated source: antigen peptide transporter 1
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human TAP1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: antigen peptide transporter 1
annotated property: hasExactSynonym
annotated target: TAP1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: antigen peptide transporter 1
annotated property: hasRelatedSynonym
annotated target: ABCB2
has synonym type: Gene-based

Axiom
annotated source: antigen peptide transporter 1
annotated property: hasRelatedSynonym
annotated target: Ham-1
has synonym type: Gene-based

Axiom
annotated source: antigen peptide transporter 1
annotated property: hasRelatedSynonym
annotated target: Ham1
has synonym type: Gene-based

Axiom
annotated source: antigen peptide transporter 1
annotated property: hasRelatedSynonym
annotated target: PSF1
has synonym type: Gene-based

Axiom
annotated source: antigen peptide transporter 1
annotated property: hasRelatedSynonym
annotated target: RING4
has synonym type: Gene-based

Axiom
annotated source: antigen peptide transporter 1
annotated property: hasRelatedSynonym
annotated target: Y3
has synonym type: Gene-based

antigen peptide transporter 2
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human TAP2 gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:770
has exact synonym: APT2
has exact synonym: ATP-binding cassette sub-family B member 3
has exact synonym: PSF-2
has exact synonym: TAP2
has exact synonym: histocompatibility antigen modifier 2
has exact synonym: peptide supply factor 2
has exact synonym: peptide transporter PSF2
has exact synonym: peptide transporter TAP2
has exact synonym: peptide transporter involved in antigen processing 2
has exact synonym: really interesting new gene 11 protein
has OBO namespace: protein
has related synonym: ABCB3
has related synonym: Ham-2
has related synonym: Ham2
has related synonym: PSF2
has related synonym: RING11
has related synonym: Y1
id: PR:000016052
comment: Category=gene.

Axiom
annotated source: antigen peptide transporter 2
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human TAP2 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: antigen peptide transporter 2
annotated property: hasExactSynonym
annotated target: TAP2
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: antigen peptide transporter 2
annotated property: hasRelatedSynonym
annotated target: ABCB3
has synonym type: Gene-based

Axiom
annotated source: antigen peptide transporter 2
annotated property: hasRelatedSynonym
annotated target: Ham-2
has synonym type: Gene-based

Axiom
annotated source: antigen peptide transporter 2
annotated property: hasRelatedSynonym
annotated target: Ham2
has synonym type: Gene-based

Axiom
annotated source: antigen peptide transporter 2
annotated property: hasRelatedSynonym
annotated target: PSF2
has synonym type: Gene-based

Axiom
annotated source: antigen peptide transporter 2
annotated property: hasRelatedSynonym
annotated target: RING11
has synonym type: Gene-based

Axiom
annotated source: antigen peptide transporter 2
annotated property: hasRelatedSynonym
annotated target: Y1
has synonym type: Gene-based

tapasin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human TAPBP gene or a 1:1 ortholog thereof.
has exact synonym: NGS-17
has exact synonym: TAP-associated protein
has exact synonym: TAP-binding protein
has exact synonym: TAPBP
has exact synonym: TPN
has exact synonym: TPSN
has OBO namespace: protein
has related synonym: NGS17
has related synonym: TAPA
id: PR:000016053
comment: Category=gene.

Axiom
annotated source: tapasin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human TAPBP gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: tapasin
annotated property: hasExactSynonym
annotated target: TAPBP
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: tapasin
annotated property: hasRelatedSynonym
annotated target: NGS17
has synonym type: Gene-based

Axiom
annotated source: tapasin
annotated property: hasRelatedSynonym
annotated target: TAPA
has synonym type: Gene-based

telethonin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human TCAP gene or a 1:1 ortholog thereof.
has exact synonym: TCAP
has exact synonym: titin cap protein
has OBO namespace: protein
id: PR:000016156
comment: Category=gene.

Axiom
annotated source: telethonin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human TCAP gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: telethonin
annotated property: hasExactSynonym
annotated target: TCAP
has db xref: PRO:DNx
has synonym type: PRO-short-label

serotransferrin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human TF gene or a 1:1 ortholog thereof.
has exact synonym: TF
has exact synonym: beta-1 metal-binding globulin
has exact synonym: siderophilin
has exact synonym: transferrin
has OBO namespace: protein
has related synonym: PRO1400
has related synonym: Trf
id: PR:000016261
comment: Category=gene.

Axiom
annotated source: serotransferrin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human TF gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: serotransferrin
annotated property: hasExactSynonym
annotated target: TF
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: serotransferrin
annotated property: hasRelatedSynonym
annotated target: PRO1400
has synonym type: Gene-based

Axiom
annotated source: serotransferrin
annotated property: hasRelatedSynonym
annotated target: Trf
has synonym type: Gene-based

tyrosine 3-monooxygenase
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human TH gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:1243
has exact synonym: TH
has exact synonym: tyrosine 3-hydroxylase
has OBO namespace: protein
has related synonym: TYH
id: PR:000016301
comment: Category=gene.

Axiom
annotated source: tyrosine 3-monooxygenase
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human TH gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: tyrosine 3-monooxygenase
annotated property: hasExactSynonym
annotated target: TH
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: tyrosine 3-monooxygenase
annotated property: hasRelatedSynonym
annotated target: TYH
has synonym type: Gene-based

type 1B DNA topoisomerase 1
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human TOP1 gene or a 1:1 ortholog thereof.
has broad synonym: DNA topoisomerase I
has db xref: IUPHARobj:2636
has exact synonym: TOP1
has OBO namespace: protein
has related synonym: Top-1
id: PR:000016542
comment: Category=gene.

Axiom
annotated source: type 1B DNA topoisomerase 1
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human TOP1 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: type 1B DNA topoisomerase 1
annotated property: hasBroadSynonym
annotated target: DNA topoisomerase I
has db xref: PRO:DNx

Axiom
annotated source: type 1B DNA topoisomerase 1
annotated property: hasExactSynonym
annotated target: TOP1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: type 1B DNA topoisomerase 1
annotated property: hasRelatedSynonym
annotated target: Top-1
has synonym type: Gene-based

thyrotropin subunit beta
type: Class
subclass of: glycoprotein hormone beta chain
IAO_0000115: A glycoprotein hormone beta chain that is a translation product of the human TSHB gene or a 1:1 ortholog thereof.
has exact synonym: TSH-B
has exact synonym: TSH-beta
has exact synonym: TSHB
has exact synonym: thyroid-stimulating hormone subunit beta
has exact synonym: thyrotropin alfa
has exact synonym: thyrotropin beta chain
has OBO namespace: protein
id: PR:000016724
comment: Category=gene.

Axiom
annotated source: thyrotropin subunit beta
annotated property: IAO_0000115
annotated target: A glycoprotein hormone beta chain that is a translation product of the human TSHB gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: thyrotropin subunit beta
annotated property: hasExactSynonym
annotated target: TSHB
has db xref: PRO:DNx
has synonym type: PRO-short-label

titin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human TTN gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:2265
has exact synonym: TTN
has exact synonym: connectin
has exact synonym: rhabdomyosarcoma antigen MU-RMS-40.14
has OBO namespace: protein
id: PR:000016798
comment: Category=gene.

Axiom
annotated source: titin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human TTN gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: titin
annotated property: hasExactSynonym
annotated target: TTN
has db xref: PRO:DNx
has synonym type: PRO-short-label

ubiquitin-ribosomal protein eL40 fusion protein
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human UBA52 gene or a 1:1 ortholog thereof.
has exact synonym: CEP52
has exact synonym: UBA52
has exact synonym: ubiquitin A-52 residue ribosomal protein fusion product 1
has OBO namespace: protein
has related synonym: 60S ribosomal protein L40
has related synonym: UBCEP2
id: PR:000016954
comment: Category=gene.

Axiom
annotated source: ubiquitin-ribosomal protein eL40 fusion protein
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human UBA52 gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: ubiquitin-ribosomal protein eL40 fusion protein
annotated property: hasExactSynonym
annotated target: UBA52
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: ubiquitin-ribosomal protein eL40 fusion protein
annotated property: hasRelatedSynonym
annotated target: UBCEP2
has synonym type: Gene-based

polyubiquitin-C
type: Class
subclass of: tandem-copy polyubiquitin
IAO_0000115: A tandem-copy polyubiquitin that is a translation product of the human UBC gene or a 1:1 ortholog thereof.
has exact synonym: UBC
has OBO namespace: protein
id: PR:000016963
comment: Category=gene.

Axiom
annotated source: polyubiquitin-C
annotated property: IAO_0000115
annotated target: A tandem-copy polyubiquitin that is a translation product of the human UBC gene or a 1:1 ortholog thereof.
has db xref: PRO:DAN

Axiom
annotated source: polyubiquitin-C
annotated property: hasExactSynonym
annotated target: UBC
has db xref: PRO:DNx
has synonym type: PRO-short-label

ubiquitin D
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human UBD gene or a 1:1 ortholog thereof.
has exact synonym: UBD
has exact synonym: diubiquitin
has exact synonym: ubiquitin-like protein FAT10
has OBO namespace: protein
has related synonym: FAT10
id: PR:000016964
comment: Category=gene.

Axiom
annotated source: ubiquitin D
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human UBD gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: ubiquitin D
annotated property: hasExactSynonym
annotated target: UBD
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: ubiquitin D
annotated property: hasRelatedSynonym
annotated target: FAT10
has synonym type: Gene-based

vinculin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human VCL gene or a 1:1 ortholog thereof.
has exact synonym: VCL
has exact synonym: metavinculin
has OBO namespace: protein
id: PR:000017272
comment: Category=gene.

Axiom
annotated source: vinculin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human VCL gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: vinculin
annotated property: hasExactSynonym
annotated target: VCL
has db xref: PRO:DNx
has synonym type: PRO-short-label

vitamin D3 receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human VDR gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:605
has exact synonym: 1,25-dihydroxyvitamin D3 receptor
has exact synonym: VDR
has exact synonym: nuclear receptor subfamily 1 group I member 1
has OBO namespace: protein
has related synonym: NR1I1
id: PR:000017283
comment: Category=gene.

Axiom
annotated source: vitamin D3 receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human VDR gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: vitamin D3 receptor
annotated property: hasExactSynonym
annotated target: VDR
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: vitamin D3 receptor
annotated property: hasRelatedSynonym
annotated target: NR1I1
has synonym type: Gene-based

amino acid chain
type: Class
subclass of: COB_0000013
subclass of: Restriction
  on property: has constituent monomer
  min qualified cardinality: 2
  on class: CHEBI_33708
IAO_0000115: A molecule that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds.
has narrow synonym: peptide
has narrow synonym: polypeptide
has OBO namespace: protein
id: PR:000018263
comment: Category=polymer.

Axiom
annotated source: amino acid chain
annotated property: IAO_0000115
annotated target: A molecule that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds.
has db xref: PRO:DAN
has db xref: PRO:JSG

Axiom
annotated source: amino acid chain
annotated property: hasNarrowSynonym
annotated target: peptide
has db xref: PRO:DAN

Axiom
annotated source: amino acid chain
annotated property: hasNarrowSynonym
annotated target: polypeptide
has db xref: PRO:DAN

proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: protein
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: protein
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A protein that is produced as the result of proteolytic processing of a longer protein.
has exact synonym: ClvPrd
has narrow synonym: peptide
has narrow synonym: polypeptide
has OBO namespace: protein
id: PR:000018264

Axiom
annotated source: proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A protein that is produced as the result of proteolytic processing of a longer protein.
has db xref: PRO:DAN

Axiom
annotated source: proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: ClvPrd
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: proteolytic cleavage product
annotated property: hasNarrowSynonym
annotated target: peptide
has db xref: PRO:DAN

Axiom
annotated source: proteolytic cleavage product
annotated property: hasNarrowSynonym
annotated target: polypeptide
has db xref: PRO:DAN

interferon gamma proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: interferon gamma
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: interferon gamma
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: An interferon gamma that has been processed by proteolytic cleavage.
has exact synonym: IFNG/ClvPrd
has OBO namespace: protein
id: PR:000018271
comment: Category=modification.

Axiom
annotated source: interferon gamma proteolytic cleavage product
annotated property: IAO_0000115
annotated target: An interferon gamma that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: interferon gamma proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: IFNG/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

pro-interleukin-16 proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: pro-interleukin-16
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: pro-interleukin-16
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A pro-interleukin-16 that has been processed by proteolytic cleavage.
has exact synonym: IL16/ClvPrd
has OBO namespace: protein
id: PR:000018435
comment: Category=modification.

Axiom
annotated source: pro-interleukin-16 proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A pro-interleukin-16 that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: pro-interleukin-16 proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: IL16/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

interleukin-18 proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: interleukin-18
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: interleukin-18
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: An interleukin-18 that has been processed by proteolytic cleavage.
has exact synonym: IL18/ClvPrd
has OBO namespace: protein
id: PR:000018438
comment: Category=modification.

Axiom
annotated source: interleukin-18 proteolytic cleavage product
annotated property: IAO_0000115
annotated target: An interleukin-18 that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: interleukin-18 proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: IL18/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

interleukin-8 proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: interleukin-8
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: interleukin-8
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: An interleukin-8 that has been processed by proteolytic cleavage.
has exact synonym: CXCL8/ClvPrd
has OBO namespace: protein
id: PR:000018461
comment: Category=modification.

Axiom
annotated source: interleukin-8 proteolytic cleavage product
annotated property: IAO_0000115
annotated target: An interleukin-8 that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: interleukin-8 proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: CXCL8/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

proteinase-activated receptor 1 proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: proteinase-activated receptor 1
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: proteinase-activated receptor 1
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A proteinase-activated receptor 1 that has been processed by proteolytic cleavage.
has exact synonym: F2R/ClvPrd
has OBO namespace: protein
id: PR:000018513
comment: Category=modification.

Axiom
annotated source: proteinase-activated receptor 1 proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A proteinase-activated receptor 1 that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: proteinase-activated receptor 1 proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: F2R/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

C-C motif chemokine 5 proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: C-C motif chemokine 5
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: C-C motif chemokine 5
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A C-C motif chemokine 5 that has been processed by proteolytic cleavage.
has exact synonym: CCL5/ClvPrd
has OBO namespace: protein
id: PR:000018718
comment: Category=modification.

Axiom
annotated source: C-C motif chemokine 5 proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A C-C motif chemokine 5 that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: C-C motif chemokine 5 proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: CCL5/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

tumor necrosis factor ligand superfamily member 11 proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: tumor necrosis factor ligand superfamily member 11
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: tumor necrosis factor ligand superfamily member 11
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A tumor necrosis factor ligand superfamily member 11 that has been processed by proteolytic cleavage.
has exact synonym: TNFSF11/ClvPrd
has OBO namespace: protein
id: PR:000018721
comment: Category=modification.

Axiom
annotated source: tumor necrosis factor ligand superfamily member 11 proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A tumor necrosis factor ligand superfamily member 11 that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: tumor necrosis factor ligand superfamily member 11 proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: TNFSF11/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

acrosin proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: acrosin
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: acrosin
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: An acrosin that has been processed by proteolytic cleavage.
has exact synonym: ACR/ClvPrd
has OBO namespace: protein
id: PR:000018880
comment: Category=modification.

Axiom
annotated source: acrosin proteolytic cleavage product
annotated property: IAO_0000115
annotated target: An acrosin that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: acrosin proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: ACR/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

pituitary adenylate cyclase-activating polypeptide proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: pituitary adenylate cyclase-activating polypeptide
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: pituitary adenylate cyclase-activating polypeptide
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A pituitary adenylate cyclase-activating polypeptide that has been processed by proteolytic cleavage.
has exact synonym: ADCYAP1/ClvPrd
has OBO namespace: protein
id: PR:000018902
comment: Category=modification.

Axiom
annotated source: pituitary adenylate cyclase-activating polypeptide proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A pituitary adenylate cyclase-activating polypeptide that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: pituitary adenylate cyclase-activating polypeptide proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: ADCYAP1/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

aryl hydrocarbon receptor proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: aryl hydrocarbon receptor
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: aryl hydrocarbon receptor
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: An aryl hydrocarbon receptor that has been processed by proteolytic cleavage.
has exact synonym: AHR/ClvPrd
has OBO namespace: protein
id: PR:000018934
comment: Category=modification.

Axiom
annotated source: aryl hydrocarbon receptor proteolytic cleavage product
annotated property: IAO_0000115
annotated target: An aryl hydrocarbon receptor that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: aryl hydrocarbon receptor proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: AHR/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

apolipoprotein A-I proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: apolipoprotein A-I
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: apolipoprotein A-I
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: An apolipoprotein A-I that has been processed by proteolytic cleavage.
has exact synonym: APOA1/ClvPrd
has OBO namespace: protein
id: PR:000019010
comment: Category=modification.

Axiom
annotated source: apolipoprotein A-I proteolytic cleavage product
annotated property: IAO_0000115
annotated target: An apolipoprotein A-I that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: apolipoprotein A-I proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: APOA1/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

amyloid-beta precursor protein proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: amyloid-beta precursor protein
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: amyloid-beta precursor protein
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: An amyloid-beta precursor protein that has been processed by proteolytic cleavage.
has exact synonym: APP/ClvPrd
has OBO namespace: protein
id: PR:000019036
comment: Category=modification. Requested by=Alzforum.

Axiom
annotated source: amyloid-beta precursor protein proteolytic cleavage product
annotated property: IAO_0000115
annotated target: An amyloid-beta precursor protein that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: amyloid-beta precursor protein proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: APP/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

beta-2-microglobulin proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: beta-2-microglobulin
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: beta-2-microglobulin
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A beta-2-microglobulin that has been processed by proteolytic cleavage.
has exact synonym: B2M/ClvPrd
has OBO namespace: protein
id: PR:000019110
comment: Category=modification.

Axiom
annotated source: beta-2-microglobulin proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A beta-2-microglobulin that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: beta-2-microglobulin proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: B2M/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

neurotrophic factor BDNF precursor form proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: neurotrophic factor BDNF precursor form
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: neurotrophic factor BDNF precursor form
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A neurotrophic factor BDNF precursor form that has been processed by proteolytic cleavage.
has exact synonym: BDNF/ClvPrd
has OBO namespace: protein
id: PR:000019130
comment: Category=modification.

Axiom
annotated source: neurotrophic factor BDNF precursor form proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A neurotrophic factor BDNF precursor form that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: neurotrophic factor BDNF precursor form proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: BDNF/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

cholecystokinin proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: cholecystokinin
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: cholecystokinin
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A cholecystokinin that has been processed by proteolytic cleavage.
has exact synonym: CCK/ClvPrd
has OBO namespace: protein
id: PR:000019255
comment: Category=modification.

Axiom
annotated source: cholecystokinin proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A cholecystokinin that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: cholecystokinin proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: CCK/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

dystroglycan 1 proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: dystroglycan 1
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: dystroglycan 1
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A dystroglycan 1 that has been processed by proteolytic cleavage.
has exact synonym: DAG1/ClvPrd
has OBO namespace: protein
id: PR:000019642
comment: Category=modification.

Axiom
annotated source: dystroglycan 1 proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A dystroglycan 1 that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: dystroglycan 1 proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: DAG1/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

erythropoietin proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: erythropoietin
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: erythropoietin
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: An erythropoietin that has been processed by proteolytic cleavage.
has exact synonym: EPO/ClvPrd
has OBO namespace: protein
id: PR:000019798
comment: Category=modification.

Axiom
annotated source: erythropoietin proteolytic cleavage product
annotated property: IAO_0000115
annotated target: An erythropoietin that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: erythropoietin proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: EPO/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

fibronectin proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: fibronectin
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: fibronectin
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A fibronectin that has been processed by proteolytic cleavage.
has exact synonym: FN1/ClvPrd
has OBO namespace: protein
id: PR:000019919
comment: Category=modification.

Axiom
annotated source: fibronectin proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A fibronectin that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: fibronectin proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: FN1/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

galanin proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: galanin
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: galanin
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A galanin that has been processed by proteolytic cleavage.
has exact synonym: GAL/ClvPrd
has OBO namespace: protein
id: PR:000019959
comment: Category=modification.

Axiom
annotated source: galanin proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A galanin that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: galanin proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: GAL/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

gastrin proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: gastrin
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: gastrin
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A gastrin that has been processed by proteolytic cleavage.
has exact synonym: GAST/ClvPrd
has OBO namespace: protein
id: PR:000019973
comment: Category=modification.

Axiom
annotated source: gastrin proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A gastrin that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: gastrin proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: GAST/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

growth hormone receptor proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: growth hormone receptor
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: growth hormone receptor
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A growth hormone receptor that has been processed by proteolytic cleavage.
has exact synonym: GHR/ClvPrd
has OBO namespace: protein
id: PR:000019995
comment: Category=modification.

Axiom
annotated source: growth hormone receptor proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A growth hormone receptor that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: growth hormone receptor proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: GHR/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

somatoliberin proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: somatoliberin
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: somatoliberin
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A somatoliberin that has been processed by proteolytic cleavage.
has exact synonym: GHRH/ClvPrd
has OBO namespace: protein
id: PR:000019996
comment: Category=modification.

Axiom
annotated source: somatoliberin proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A somatoliberin that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: somatoliberin proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: GHRH/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

appetite-regulating hormone proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: appetite-regulating hormone
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: appetite-regulating hormone
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: An appetite-regulating hormone that has been processed by proteolytic cleavage.
has exact synonym: GHRL/ClvPrd
has OBO namespace: protein
id: PR:000019999
comment: Category=modification.

Axiom
annotated source: appetite-regulating hormone proteolytic cleavage product
annotated property: IAO_0000115
annotated target: An appetite-regulating hormone that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: appetite-regulating hormone proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: GHRL/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

hypocretin neuropeptide precursor proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: hypocretin neuropeptide precursor
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: hypocretin neuropeptide precursor
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A hypocretin neuropeptide precursor that has been processed by proteolytic cleavage.
has exact synonym: HCRT/ClvPrd
has OBO namespace: protein
id: PR:000020124
comment: Category=modification.

Axiom
annotated source: hypocretin neuropeptide precursor proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A hypocretin neuropeptide precursor that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: hypocretin neuropeptide precursor proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: HCRT/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

hepatocyte growth factor proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: hepatocyte growth factor
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: hepatocyte growth factor
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A hepatocyte growth factor that has been processed by proteolytic cleavage.
has exact synonym: HGF/ClvPrd
has OBO namespace: protein
id: PR:000020135
comment: Category=modification.

Axiom
annotated source: hepatocyte growth factor proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A hepatocyte growth factor that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: hepatocyte growth factor proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: HGF/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

haptoglobin proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: haptoglobin
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: haptoglobin
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A haptoglobin that has been processed by proteolytic cleavage.
has exact synonym: HP/ClvPrd
has OBO namespace: protein
id: PR:000020180
comment: Category=modification.

Axiom
annotated source: haptoglobin proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A haptoglobin that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: haptoglobin proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: HP/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

islet amyloid polypeptide proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: islet amyloid polypeptide
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: islet amyloid polypeptide
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: An islet amyloid polypeptide that has been processed by proteolytic cleavage.
has exact synonym: IAPP/ClvPrd
has OBO namespace: protein
id: PR:000020226
comment: Category=modification.

Axiom
annotated source: islet amyloid polypeptide proteolytic cleavage product
annotated property: IAO_0000115
annotated target: An islet amyloid polypeptide that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: islet amyloid polypeptide proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: IAPP/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

insulin-like growth factor 2 proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: insulin-like growth factor 2
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: insulin-like growth factor 2
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: An insulin-like growth factor 2 that has been processed by proteolytic cleavage.
has exact synonym: IGF2/ClvPrd
has OBO namespace: protein
id: PR:000020267
comment: Category=modification.

Axiom
annotated source: insulin-like growth factor 2 proteolytic cleavage product
annotated property: IAO_0000115
annotated target: An insulin-like growth factor 2 that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: insulin-like growth factor 2 proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: IGF2/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

insulin receptor proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: insulin receptor
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: insulin receptor
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: An insulin receptor that has been processed by proteolytic cleavage.
has exact synonym: INSR/ClvPrd
has OBO namespace: protein
id: PR:000020320
comment: Category=modification.

Axiom
annotated source: insulin receptor proteolytic cleavage product
annotated property: IAO_0000115
annotated target: An insulin receptor that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: insulin receptor proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: INSR/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

insulin-like growth factor 1 proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: insulin-like growth factor 1
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: insulin-like growth factor 1
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: An insulin-like growth factor 1 that has been processed by proteolytic cleavage.
has exact synonym: IGF1/ClvPrd
has OBO namespace: protein
id: PR:000020357
comment: Category=modification.

Axiom
annotated source: insulin-like growth factor 1 proteolytic cleavage product
annotated property: IAO_0000115
annotated target: An insulin-like growth factor 1 that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: insulin-like growth factor 1 proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: IGF1/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

lactotransferrin proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: lactotransferrin
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: lactotransferrin
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A lactotransferrin that has been processed by proteolytic cleavage.
has exact synonym: LTF/ClvPrd
has OBO namespace: protein
id: PR:000020497
comment: Category=modification.

Axiom
annotated source: lactotransferrin proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A lactotransferrin that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: lactotransferrin proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: LTF/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

ubiquitin-like protein NEDD8 proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: ubiquitin-like protein NEDD8
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: ubiquitin-like protein NEDD8
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A ubiquitin-like protein NEDD8 that has been processed by proteolytic cleavage.
has exact synonym: NEDD8/ClvPrd
has OBO namespace: protein
id: PR:000020722
comment: Category=modification.

Axiom
annotated source: ubiquitin-like protein NEDD8 proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A ubiquitin-like protein NEDD8 that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: ubiquitin-like protein NEDD8 proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: NEDD8/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

beta-nerve growth factor proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: beta-nerve growth factor
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: beta-nerve growth factor
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A beta-nerve growth factor that has been processed by proteolytic cleavage.
has exact synonym: NGF/ClvPrd
has OBO namespace: protein
id: PR:000020737
comment: Category=modification.

Axiom
annotated source: beta-nerve growth factor proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A beta-nerve growth factor that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: beta-nerve growth factor proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: NGF/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

atrial natriuretic factor proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: atrial natriuretic factor
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: atrial natriuretic factor
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: An atrial natriuretic factor that has been processed by proteolytic cleavage.
has exact synonym: NPPA/ClvPrd
has OBO namespace: protein
id: PR:000020775
comment: Category=modification.

Axiom
annotated source: atrial natriuretic factor proteolytic cleavage product
annotated property: IAO_0000115
annotated target: An atrial natriuretic factor that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: atrial natriuretic factor proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: NPPA/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

neuropeptide Y proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: neuropeptide Y
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: neuropeptide Y
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A neuropeptide Y that has been processed by proteolytic cleavage.
has exact synonym: NPY/ClvPrd
has OBO namespace: protein
id: PR:000020789
comment: Category=modification.

Axiom
annotated source: neuropeptide Y proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A neuropeptide Y that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: neuropeptide Y proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: NPY/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

neurotrophin-3 proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: neurotrophin-3
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: neurotrophin-3
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A neurotrophin-3 that has been processed by proteolytic cleavage.
has exact synonym: NTF3/ClvPrd
has OBO namespace: protein
id: PR:000020795
comment: Category=modification.

Axiom
annotated source: neurotrophin-3 proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A neurotrophin-3 that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: neurotrophin-3 proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: NTF3/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

oncostatin-M proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: oncostatin-M
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: oncostatin-M
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: An oncostatin-M that has been processed by proteolytic cleavage.
has exact synonym: OSM/ClvPrd
has OBO namespace: protein
id: PR:000020841
comment: Category=modification.

Axiom
annotated source: oncostatin-M proteolytic cleavage product
annotated property: IAO_0000115
annotated target: An oncostatin-M that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: oncostatin-M proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: OSM/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

polymeric immunoglobulin receptor proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: polymeric immunoglobulin receptor
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: polymeric immunoglobulin receptor
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A polymeric immunoglobulin receptor that has been processed by proteolytic cleavage.
has exact synonym: PIGR/ClvPrd
has OBO namespace: protein
id: PR:000020966
comment: Category=modification.

Axiom
annotated source: polymeric immunoglobulin receptor proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A polymeric immunoglobulin receptor that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: polymeric immunoglobulin receptor proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: PIGR/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

urokinase-type plasminogen activator proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: urokinase-type plasminogen activator
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: urokinase-type plasminogen activator
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A urokinase-type plasminogen activator that has been processed by proteolytic cleavage.
has exact synonym: PLAU/ClvPrd
has OBO namespace: protein
id: PR:000021003
comment: Category=modification.

Axiom
annotated source: urokinase-type plasminogen activator proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A urokinase-type plasminogen activator that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: urokinase-type plasminogen activator proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: PLAU/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

pancreatic polypeptide prohormone proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: pancreatic polypeptide prohormone
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: pancreatic polypeptide prohormone
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A pancreatic polypeptide prohormone that has been processed by proteolytic cleavage.
has exact synonym: PPY/ClvPrd
has OBO namespace: protein
id: PR:000021066
comment: Category=modification.

Axiom
annotated source: pancreatic polypeptide prohormone proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A pancreatic polypeptide prohormone that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: pancreatic polypeptide prohormone proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: PPY/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

parathyroid hormone proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: parathyroid hormone
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: parathyroid hormone
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A parathyroid hormone that has been processed by proteolytic cleavage.
has exact synonym: PTH/ClvPrd
has OBO namespace: protein
id: PR:000021170
comment: Category=modification.

Axiom
annotated source: parathyroid hormone proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A parathyroid hormone that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: parathyroid hormone proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: PTH/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

peptide YY proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: peptide YY
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: peptide YY
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A peptide YY that has been processed by proteolytic cleavage.
has exact synonym: PYY/ClvPrd
has OBO namespace: protein
id: PR:000021195
comment: Category=modification.

Axiom
annotated source: peptide YY proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A peptide YY that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: peptide YY proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: PYY/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

secretin proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: secretin
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: secretin
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A secretin that has been processed by proteolytic cleavage.
has exact synonym: SCT/ClvPrd
has OBO namespace: protein
id: PR:000021385
comment: Category=modification.

Axiom
annotated source: secretin proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A secretin that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: secretin proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: SCT/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

thyrotropin subunit beta proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: thyrotropin subunit beta
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: thyrotropin subunit beta
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A thyrotropin subunit beta that has been processed by proteolytic cleavage.
has exact synonym: TSHB/ClvPrd
has OBO namespace: protein
id: PR:000021742
comment: Category=modification.

Axiom
annotated source: thyrotropin subunit beta proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A thyrotropin subunit beta that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: thyrotropin subunit beta proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: TSHB/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

neurotrophin
type: Class
subclass of: protein
IAO_0000115: A protein that is a neurotrophic polypeptide factor that regulates neuronal differentiation and is essential for neuronal survival, neurite growth and plasticity. It contains a signal peptide, a propeptide, and a C-terminal Nerve growth factor family (Pfam:PF00243) domain.
has db xref: PIRSF:PIRSF001789
has OBO namespace: protein
id: PR:000021998
comment: Category=family.

Axiom
annotated source: neurotrophin
annotated property: IAO_0000115
annotated target: A protein that is a neurotrophic polypeptide factor that regulates neuronal differentiation and is essential for neuronal survival, neurite growth and plasticity. It contains a signal peptide, a propeptide, and a C-terminal Nerve growth factor family (Pfam:PF00243) domain.
has db xref: PMID:10388563

death receptor
type: Class
subclass of: protein
IAO_0000115: A protein that contains multiple TNFR/NGFR cysteine-rich region (Pfam:PF00020) within the extracellular ligand-binding domain, a type I (single pass) transmembrane domain, and a cytoplasmic Death domain (Pfam:PF00531) required for intracellular signaling.
has OBO namespace: protein
id: PR:000021999
comment: Category=family.

Axiom
annotated source: death receptor
annotated property: IAO_0000115
annotated target: A protein that contains multiple TNFR/NGFR cysteine-rich region (Pfam:PF00020) within the extracellular ligand-binding domain, a type I (single pass) transmembrane domain, and a cytoplasmic Death domain (Pfam:PF00531) required for intracellular signaling.
has db xref: PMID:12655292

adenylate cyclase
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the Escherichia coli K-12 cyaA gene or a 1:1 ortholog thereof.
has exact synonym: ATP pyrophosphate-lyase
has exact synonym: adenylyl cyclase
has exact synonym: cyaA
has OBO namespace: protein
has related synonym: cya
id: PR:000022358
comment: Category=gene.

Axiom
annotated source: adenylate cyclase
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the Escherichia coli K-12 cyaA gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: adenylate cyclase
annotated property: hasExactSynonym
annotated target: cyaA
has db xref: PRO:DNx
has synonym type: PRO-short-label

methyl-accepting chemotaxis protein IV
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the Escherichia coli K-12 tap gene or a 1:1 ortholog thereof.
has exact synonym: MCP-IV
has exact synonym: dipeptide chemoreceptor protein
has exact synonym: tap
has OBO namespace: protein
id: PR:000024025
comment: Category=gene.

Axiom
annotated source: methyl-accepting chemotaxis protein IV
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the Escherichia coli K-12 tap gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: methyl-accepting chemotaxis protein IV
annotated property: hasExactSynonym
annotated target: tap
has db xref: PRO:DNx
has synonym type: PRO-short-label

homoserine kinase
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the Escherichia coli K-12 thrB gene or a 1:1 ortholog thereof.
has exact synonym: HK
has exact synonym: HSK
has exact synonym: thrB
has OBO namespace: protein
id: PR:000024067
comment: Category=gene.

Axiom
annotated source: homoserine kinase
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the Escherichia coli K-12 thrB gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: homoserine kinase
annotated property: hasExactSynonym
annotated target: thrB
has db xref: PRO:DNx
has synonym type: PRO-short-label

type II interferon
type: Class
subclass of: protein
IAO_0000115: A protein that binds to a specific cell surface receptor complex known as the IFN-gamma receptor (IFNGR), a complex of two IFNGR1 and two IFNGR2 chains.
has exact synonym: IFN type II
has exact synonym: interferon type II
has OBO namespace: protein
has related synonym: interferon gamma
id: PR:000024990
comment: Category=family. Note: Some references consider 'gamma' and 'type II' to be synonyms. This is likely because gamma is the only type II interferon identified. However, the classification criteria for each nomenclature system differ.

Axiom
annotated source: type II interferon
annotated property: IAO_0000115
annotated target: A protein that binds to a specific cell surface receptor complex known as the IFN-gamma receptor (IFNGR), a complex of two IFNGR1 and two IFNGR2 chains.
has db xref: PMID:9607096
has db xref: PRO:DAN
has db xref: PRO:MSY

HSPC protein
type: Class
subclass of: Hsp70 family chaperone
IAO_0000115: An Hsp70 family chaperone that contains an ATPase and HSP90 domains.
has exact synonym: HSP90
has OBO namespace: protein
id: PR:000025350
comment: Category=family.

Axiom
annotated source: HSPC protein
annotated property: IAO_0000115
annotated target: An Hsp70 family chaperone that contains an ATPase and HSP90 domains.
has db xref: PMID:18663603
has db xref: PRO:DAN

nodal protein proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: nodal protein
  intersection of: Restriction
    on property: RO_0002353
    some values from: GO_0016485
subclass of: nodal protein
subclass of: proteolytic cleavage product
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A nodal protein that has been processed by proteolytic cleavage.
has exact synonym: NODAL/ClvPrd
has OBO namespace: protein
id: PR:000025433
comment: Category=modification.

Axiom
annotated source: nodal protein proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A nodal protein that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: nodal protein proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: NODAL/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

ephrin receptor
type: Class
subclass of: protein
IAO_0000115: A protein that consists of an Ephrin receptor ligand binding domain (Pfam:PF01404), two copies of the Fibronectin type III domain (Pfam:PF00041), and a copy of either type of SAM domain (Sterile alpha motif) (Pfam:PF00536 or Pfam:PF07647).
has OBO namespace: protein
id: PR:000025845
comment: Category=family.

Axiom
annotated source: ephrin receptor
annotated property: IAO_0000115
annotated target: A protein that consists of an Ephrin receptor ligand binding domain (Pfam:PF01404), two copies of the Fibronectin type III domain (Pfam:PF00041), and a copy of either type of SAM domain (Sterile alpha motif) (Pfam:PF00536 or Pfam:PF07647).
has db xref: PRO:DAN

type I interferon
type: Class
subclass of: protein
IAO_0000115: A protein that consists solely of an Interferon alpha/beta domain (Pfam:PF00143) and which binds to a specific cell surface receptor complex known as the IFN-alpha receptor (IFNAR), a heterodimer of IFNAR1 and IFNAR2 chains.
has exact synonym: IFN type I
has exact synonym: interferon type I
has OBO namespace: protein
id: PR:000025848
comment: Category=family.

Axiom
annotated source: type I interferon
annotated property: IAO_0000115
annotated target: A protein that consists solely of an Interferon alpha/beta domain (Pfam:PF00143) and which binds to a specific cell surface receptor complex known as the IFN-alpha receptor (IFNAR), a heterodimer of IFNAR1 and IFNAR2 chains.
has db xref: PMID:15233997
has db xref: PMID:9607096
has db xref: PRO:DAN
has db xref: PRO:MSY

type III interferon
type: Class
subclass of: class 2 cytokine, IL-10 type
IAO_0000115: A class 2 cytokine, IL-10 type that binds to a specific cell surface receptor complex known as the IFN type III receptor, a heterodimer consisting of IFNLR1 and IL-10R2.
has exact synonym: IFN type III
has exact synonym: interferon type III
has OBO namespace: protein
has related synonym: interferon lambda
id: PR:000028205
comment: Category=family. Note: Some references consider 'lambda' and 'type III' to be synonyms. This is likely because lambda is the only type III interferon identified. However, the classification criteria for each nomenclature system differ.

Axiom
annotated source: type III interferon
annotated property: IAO_0000115
annotated target: A class 2 cytokine, IL-10 type that binds to a specific cell surface receptor complex known as the IFN type III receptor, a heterodimer consisting of IFNLR1 and IL-10R2.
has db xref: PMID:9607096

thyroid stimulating hormone
type: Class
subclass of: GO_0032991
subclass of: Restriction
  on property: RO_0002180
  qualified cardinality: 1
  on class: glycoprotein hormones alpha chain
subclass of: Restriction
  on property: RO_0002180
  qualified cardinality: 1
  on class: thyrotropin subunit beta
IAO_0000115: A protein-containing complex that is a heterodimer of an alpha subunit (CGA) common to several glycoprotein hormones and a beta subunit (TSHB) unique to thyroid stimulating hormone.
has exact synonym: TSH
has exact synonym: thyrotropin
has OBO namespace: protein
id: PR:000028269
comment: Category=complex. Requested by=GOC.

Axiom
annotated source: thyroid stimulating hormone
annotated property: IAO_0000115
annotated target: A protein-containing complex that is a heterodimer of an alpha subunit (CGA) common to several glycoprotein hormones and a beta subunit (TSHB) unique to thyroid stimulating hormone.
has db xref: PRO:MSY

AKT kinase
type: Class
subclass of: protein
IAO_0000115: A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites.
has broad synonym: PKB
has exact synonym: AKT
has exact synonym: serine-threonine kinase Akt
has OBO namespace: protein
id: PR:000029189
comment: Category=family.

Axiom
annotated source: AKT kinase
annotated property: IAO_0000115
annotated target: A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites.
has db xref: PMID:9736715
has db xref: PRO:CNA

Axiom
annotated source: AKT kinase
annotated property: hasBroadSynonym
annotated target: PKB
has db xref: PRO:DNx

antiviral innate immune response receptor RIG-I
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human RIGI gene or a 1:1 ortholog thereof.
has db xref: IUPHARobj:2920
has exact synonym: ATP-dependent RNA helicase DDX58
has exact synonym: DEAD box protein 58
has exact synonym: RIG-1
has exact synonym: RIG-I
has exact synonym: RIG-I-like receptor 1
has exact synonym: RIGI
has exact synonym: RLR-1
has exact synonym: RNA sensor RIG-I
has exact synonym: probable ATP-dependent RNA helicase DDX58
has exact synonym: retinoic acid-inducible gene 1 protein
has exact synonym: retinoic acid-inducible gene I protein
has OBO namespace: protein
has related synonym: DDX58
id: PR:000029394
comment: Category=gene.

Axiom
annotated source: antiviral innate immune response receptor RIG-I
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human RIGI gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: antiviral innate immune response receptor RIG-I
annotated property: hasExactSynonym
annotated target: RIGI
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: antiviral innate immune response receptor RIG-I
annotated property: hasRelatedSynonym
annotated target: DDX58
has synonym type: Gene-based

somatotropin hormone family member
type: Class
subclass of: protein
IAO_0000115: A protein that is a standalone version of the Hormone_1 domain (Pfam:PF00103). In the immature form, the domain is preceded by a signal peptide.
has exact synonym: fam:GH1
has OBO namespace: protein
id: PR:000029968
comment: Category=family.

Axiom
annotated source: somatotropin hormone family member
annotated property: IAO_0000115
annotated target: A protein that is a standalone version of the Hormone_1 domain (Pfam:PF00103). In the immature form, the domain is preceded by a signal peptide.
has db xref: PRO:DAN

Axiom
annotated source: somatotropin hormone family member
annotated property: hasExactSynonym
annotated target: fam:GH1
has db xref: PRO:DNx
has synonym type: PRO-short-label

G-protein coupled receptor
type: Class
equivalent class: Class
  intersection of: protein
  intersection of: Restriction
    on property: RO_0002215
    some values from: GO_0004930
subclass of: protein
subclass of: Restriction
  on property: RO_0002215
  some values from: GO_0004930
IAO_0000115: A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit.
has broad synonym: 7TM receptor
has broad synonym: seven-transmembrane receptor
has db xref: IUPHARfam:694
has exact synonym: fam:GPCR
has OBO namespace: protein
id: PR:000030035
comment: Category=family. Classification based on GRAFS system. [PMID:12761335]

Axiom
annotated source: G-protein coupled receptor
annotated property: IAO_0000115
annotated target: A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit.
has db xref: IUPHARfam:694
has db xref: PRO:DAN
has db xref: Wikipedia:GPCR

Axiom
annotated source: G-protein coupled receptor
annotated property: hasBroadSynonym
annotated target: 7TM receptor
has db xref: IUPHARfam:694

Axiom
annotated source: G-protein coupled receptor
annotated property: hasBroadSynonym
annotated target: seven-transmembrane receptor
has db xref: IUPHARfam:694

Axiom
annotated source: G-protein coupled receptor
annotated property: hasExactSynonym
annotated target: fam:GPCR
has db xref: PRO:DAN
has synonym type: PRO-short-label

polyubiquitin-B
type: Class
subclass of: tandem-copy polyubiquitin
IAO_0000115: A tandem-copy polyubiquitin that is a translation product of the human UBB gene or a 1:1 ortholog thereof.
has exact synonym: UBB
has OBO namespace: protein
id: PR:000030443
comment: Category=gene.

Axiom
annotated source: polyubiquitin-B
annotated property: IAO_0000115
annotated target: A tandem-copy polyubiquitin that is a translation product of the human UBB gene or a 1:1 ortholog thereof.
has db xref: PRO:DAN

Axiom
annotated source: polyubiquitin-B
annotated property: hasExactSynonym
annotated target: UBB
has db xref: PRO:DNx
has synonym type: PRO-short-label

ubiquitin (RPS27A)
type: Class
subclass of: ubiquitin-ribosomal protein eS31 fusion protein
subclass of: ubiquitin
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A ubiquitin-ribosomal protein eS31 fusion protein that has been processed by proteolytic cleavage. This form is the N-terminal region consisting of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P62979, 1-76.
has exact synonym: RPS27A/Clv:ubiq
has OBO namespace: protein
id: PR:000035716
comment: Category=modification.

Axiom
annotated source: ubiquitin (RPS27A)
annotated property: IAO_0000115
annotated target: A ubiquitin-ribosomal protein eS31 fusion protein that has been processed by proteolytic cleavage. This form is the N-terminal region consisting of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P62979, 1-76.
has db xref: PMID:124018
has db xref: PRO:CNA

Axiom
annotated source: ubiquitin (RPS27A)
annotated property: hasExactSynonym
annotated target: RPS27A/Clv:ubiq
has db xref: PRO:DAN
has synonym type: PRO-short-label

ubiquitin (UBC)
type: Class
subclass of: polyubiquitin-C
subclass of: ubiquitin
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A polyubiquitin-C that has been processed by proteolytic cleavage to produce a protein consisting of a Ubiquitin (Pfam:PF00240) domain. There are nine copies of ubiquitin in polyubiquitin C. Example: UniProtKB:P0CG48, (1-76) or (77-152) or (153-228) or (229-304) or (305-380) or (381-456) or (457-532) or (533-608) or (609-684).
has exact synonym: UBC/Clv:ubiq
has OBO namespace: protein
id: PR:000035720
comment: Category=modification.

Axiom
annotated source: ubiquitin (UBC)
annotated property: IAO_0000115
annotated target: A polyubiquitin-C that has been processed by proteolytic cleavage to produce a protein consisting of a Ubiquitin (Pfam:PF00240) domain. There are nine copies of ubiquitin in polyubiquitin C. Example: UniProtKB:P0CG48, (1-76) or (77-152) or (153-228) or (229-304) or (305-380) or (381-456) or (457-532) or (533-608) or (609-684).
has db xref: PRO:CNA

Axiom
annotated source: ubiquitin (UBC)
annotated property: hasExactSynonym
annotated target: UBC/Clv:ubiq
has db xref: PRO:DAN
has synonym type: PRO-short-label

ubiquitin (UBA52)
type: Class
subclass of: ubiquitin-ribosomal protein eL40 fusion protein
subclass of: ubiquitin
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A ubiquitin-ribosomal protein eL40 fusion protein that has been processed by proteolytic cleavage. This form is the N-terminal region consisting of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P62987, 1-76.
has exact synonym: UBA52/Clv:ubiq
has OBO namespace: protein
id: PR:000035722
comment: Category=modification.

Axiom
annotated source: ubiquitin (UBA52)
annotated property: IAO_0000115
annotated target: A ubiquitin-ribosomal protein eL40 fusion protein that has been processed by proteolytic cleavage. This form is the N-terminal region consisting of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P62987, 1-76.
has db xref: PRO:CNA

Axiom
annotated source: ubiquitin (UBA52)
annotated property: hasExactSynonym
annotated target: UBA52/Clv:ubiq
has db xref: PRO:DAN
has synonym type: PRO-short-label

ubiquitin (UBB)
type: Class
subclass of: polyubiquitin-B
subclass of: ubiquitin
subclass of: Restriction
  on property: RO_0002353
  some values from: GO_0016485
IAO_0000115: A polyubiquitin-B that has been processed by proteolytic cleavage to produce a protein consisting of a Ubiquitin (Pfam:PF00240) domain. There are three copies of ubiquitin in polyubiquitin B. Example: UniProtKB:P0CG47, (1-76) or (77-152) or (153-228).
has exact synonym: UBB/Clv:ubiq
has OBO namespace: protein
id: PR:000035726
comment: Category=modification.

Axiom
annotated source: ubiquitin (UBB)
annotated property: IAO_0000115
annotated target: A polyubiquitin-B that has been processed by proteolytic cleavage to produce a protein consisting of a Ubiquitin (Pfam:PF00240) domain. There are three copies of ubiquitin in polyubiquitin B. Example: UniProtKB:P0CG47, (1-76) or (77-152) or (153-228).
has db xref: PRO:CNA

Axiom
annotated source: ubiquitin (UBB)
annotated property: hasExactSynonym
annotated target: UBB/Clv:ubiq
has db xref: PRO:DAN
has synonym type: PRO-short-label

ubiquitin
type: Class
equivalent class: Class
  union of: ubiquitin (RPS27A)
  union of: ubiquitin (UBC)
  union of: ubiquitin (UBA52)
  union of: ubiquitin (UBB)
subclass of: proteolytic cleavage product
IAO_0000115: A proteolytic cleavage product that gives rise to a protein that corresponds to the stand-alone version of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P0CG48, 1-76.
has exact synonym: Ubiq
has OBO namespace: protein
id: PR:000035728
comment: Category=union.

Axiom
annotated source: ubiquitin
annotated property: IAO_0000115
annotated target: A proteolytic cleavage product that gives rise to a protein that corresponds to the stand-alone version of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P0CG48, 1-76.
has db xref: Pfam:PF00240

Axiom
annotated source: ubiquitin
annotated property: hasExactSynonym
annotated target: Ubiq
has db xref: PRO:DAN
has synonym type: PRO-short-label

eukaryotic protein
type: Class
equivalent class: Class
  intersection of: protein
  intersection of: Restriction
    on property: RO_0002160
    some values from: NCBITaxon 2759
subclass of: protein
subclass of: Restriction
  on property: RO_0002160
  some values from: NCBITaxon 2759
IAO_0000115: A protein that is encoded in the genome of some Eukaryota.
has exact synonym: Eukaryota protein
has OBO namespace: protein
id: PR:000036194

Axiom
annotated source: eukaryotic protein
annotated property: IAO_0000115
annotated target: A protein that is encoded in the genome of some Eukaryota.
has db xref: PRO:DAN

Axiom
annotated source: eukaryotic protein
annotated property: hasExactSynonym
annotated target: Eukaryota protein
has db xref: PRO:DAN

tandem-copy polyubiquitin
type: Class
subclass of: protein
IAO_0000115: A protein that contains multiple tandem copies of the Ubiquitin (Pfam:PF00240) domain within a single amino acid chain.
has exact synonym: fam:tandemUb
has OBO namespace: protein
id: PR:000036929
comment: Category=family.

Axiom
annotated source: tandem-copy polyubiquitin
annotated property: IAO_0000115
annotated target: A protein that contains multiple tandem copies of the Ubiquitin (Pfam:PF00240) domain within a single amino acid chain.
has db xref: PRO:DAN

Axiom
annotated source: tandem-copy polyubiquitin
annotated property: hasExactSynonym
annotated target: fam:tandemUb
has db xref: PRO:DAN
has synonym type: PRO-short-label

phosphoprotein
type: Class
equivalent class: Class
  intersection of: protein
  intersection of: Restriction
    on property: BFO_0000051
    some values from: MOD_00696
subclass of: protein
subclass of: Restriction
  on property: BFO_0000051
  some values from: MOD_00696
IAO_0000115: A protein that includes at least one phosphorylated residue.
has exact synonym: Prot/PhosRes+
has exact synonym: phosphorylated protein
has OBO namespace: protein
id: PR:000037070
comment: Category=modification.

Axiom
annotated source: phosphoprotein
annotated property: IAO_0000115
annotated target: A protein that includes at least one phosphorylated residue.
has db xref: PRO:DAN

Axiom
annotated source: phosphoprotein
annotated property: hasExactSynonym
annotated target: Prot/PhosRes+
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: phosphoprotein
annotated property: hasExactSynonym
annotated target: phosphorylated protein
has db xref: PRO:DAN

corticotropin-releasing factor receptor
type: Class
subclass of: secretin-like G-protein coupled receptor
IAO_0000115: A secretin-like G-protein coupled receptor that is a translation product of the human CRHR1 or CRHR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: IUPHARfam:19
has OBO namespace: protein
id: PR:000044630
comment: Category=family.

Axiom
annotated source: corticotropin-releasing factor receptor
annotated property: IAO_0000115
annotated target: A secretin-like G-protein coupled receptor that is a translation product of the human CRHR1 or CRHR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PRO:XQ

adrenoceptor protein
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, or ADRB3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: IUPHARfam:4
has OBO namespace: protein
id: PR:000044631
comment: Category=family.

Axiom
annotated source: adrenoceptor protein
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, or ADRB3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PRO:XQ

calcitonin receptor protein
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human CALCR or CALCRL genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: IUPHARfam:11
has OBO namespace: protein
id: PR:000044637
comment: Category=family.

Axiom
annotated source: calcitonin receptor protein
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human CALCR or CALCRL genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PRO:XQ

complement peptide receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human C3AR1, C5AR1, or C5AR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: IUPHARfam:5
has OBO namespace: protein
id: PR:000044643
comment: Category=family.

Axiom
annotated source: complement peptide receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human C3AR1, C5AR1, or C5AR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PRO:XQ

glycoprotein hormone beta chain
type: Class
subclass of: protein
IAO_0000115: A protein that has a core domain composition consisting of a signal peptide followed by a single copy of the Cys_knot (Pfam:PF00007) domain. The Cysteine knot is a protein structural motif containing three disulfide bridges.
has OBO namespace: protein
id: PR:000044813
comment: Category=family.

Axiom
annotated source: glycoprotein hormone beta chain
annotated property: IAO_0000115
annotated target: A protein that has a core domain composition consisting of a signal peptide followed by a single copy of the Cys_knot (Pfam:PF00007) domain. The Cysteine knot is a protein structural motif containing three disulfide bridges.
has db xref: PRO:CNA
has db xref: Pfam:PF00007

insulin family protein
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide.
has exact synonym: fam:INS
has OBO namespace: protein
id: PR:000045358
comment: Category=family.

Axiom
annotated source: insulin family protein
annotated property: IAO_0000115
annotated target: A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide.
has db xref: PRO:DAN

Axiom
annotated source: insulin family protein
annotated property: hasExactSynonym
annotated target: fam:INS
has db xref: PRO:DAN
has synonym type: PRO-short-label

glucagon-like receptor
type: Class
subclass of: secretin-like G-protein coupled receptor
IAO_0000115: A secretin-like G-protein coupled receptor that is a translation product of the human GHRHR, GIPR, GLP1R, GLP2R, GCGR, or SCTR genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has broad synonym: glucagon receptor
has db xref: IUPHARfam:29
has OBO namespace: protein
id: PR:000049989
comment: Category=family.

Axiom
annotated source: glucagon-like receptor
annotated property: IAO_0000115
annotated target: A secretin-like G-protein coupled receptor that is a translation product of the human GHRHR, GIPR, GLP1R, GLP2R, GCGR, or SCTR genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PRO:XQ

Axiom
annotated source: glucagon-like receptor
annotated property: hasBroadSynonym
annotated target: glucagon receptor
has db xref: IUPHARfam:29
has db xref: PRO:DAN

histamine receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human HRH1 to HRH4 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: IUPHARfam:33
has OBO namespace: protein
id: PR:000049994
comment: Category=family.

Axiom
annotated source: histamine receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human HRH1 to HRH4 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PRO:XQ

leukotriene receptor
type: Class
subclass of: rhodopsin-like G-protein coupled receptor
IAO_0000115: A rhodopsin-like G-protein coupled receptor that is a translation product of the human LTB4R, LTB4R2, CYSLTR1, CYSLTR2, or OXER1 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: IUPHARfam:35
has OBO namespace: protein
id: PR:000049997
comment: Category=family.

Axiom
annotated source: leukotriene receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that is a translation product of the human LTB4R, LTB4R2, CYSLTR1, CYSLTR2, or OXER1 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PRO:XQ

angiotensinogenase
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the mouse Ren1 or Ren2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has exact synonym: fam:angiotensinogenase
has OBO namespace: protein
id: PR:000050025
comment: Category=family.

Axiom
annotated source: angiotensinogenase
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the mouse Ren1 or Ren2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PRO:DAN

Axiom
annotated source: angiotensinogenase
annotated property: hasExactSynonym
annotated target: fam:angiotensinogenase
has db xref: PRO:DAN
has synonym type: PRO-short-label

thyrotropin-releasing hormone receptor
type: Class
equivalent class: Class
  intersection of: rhodopsin-like G-protein coupled receptor
  intersection of: Restriction
    on property: RO_0002215
    some values from: GO_0004997
subclass of: rhodopsin-like G-protein coupled receptor
subclass of: Restriction
  on property: RO_0002215
  some values from: GO_0004997
IAO_0000115: A rhodopsin-like G-protein coupled receptor that has thyrotropin-releasing hormone receptor activity.
has db xref: IUPHARfam:63
has OBO namespace: protein
id: PR:000050029
comment: Category=family.

Axiom
annotated source: thyrotropin-releasing hormone receptor
annotated property: IAO_0000115
annotated target: A rhodopsin-like G-protein coupled receptor that has thyrotropin-releasing hormone receptor activity.
has db xref: GO:0004997
has db xref: PRO:XQ

lymphotoxin
type: Class
subclass of: tumor necrosis factor, TNF-like
IAO_0000115: A tumor necrosis factor, TNF-like that is a translation product of the human LTA or LTB genes, or 1:1 orthologs thereof.
has exact synonym: fam:LT
has OBO namespace: protein
id: PR:000050043
comment: Category=family. Requested by=CRAFT.

Axiom
annotated source: lymphotoxin
annotated property: IAO_0000115
annotated target: A tumor necrosis factor, TNF-like that is a translation product of the human LTA or LTB genes, or 1:1 orthologs thereof.
has db xref: PRO:DAN

Axiom
annotated source: lymphotoxin
annotated property: hasExactSynonym
annotated target: fam:LT
has db xref: PRO:DAN
has synonym type: PRO-short-label

monoubiquitin
type: Class
equivalent class: Class
  intersection of: ubiquitin
  intersection of: Restriction
    on property: has constituent monomer
    qualified cardinality: 1
    on class: ubiquitin
subclass of: Restriction
  on property: has constituent monomer
  qualified cardinality: 1
  on class: ubiquitin
IAO_0000115: A ubiquitin that is a monomer.
has exact synonym: monoUbiq
has OBO namespace: protein
id: PR:000060228
comment: Category=polymer. Requested by=Reactome.

Axiom
annotated source: monoubiquitin
annotated property: IAO_0000115
annotated target: A ubiquitin that is a monomer.
has db xref: PRO:DAN

Axiom
annotated source: monoubiquitin
annotated property: hasExactSynonym
annotated target: monoUbiq
has db xref: PRO:DAN
has synonym type: PRO-short-label