goslim yeast.owl
type: Ontology
version IRI: goslim yeast.owl
version info: 2026-08-11

definition
type: AnnotationProperty

term tracker item
type: AnnotationProperty
database_cross_reference: IAO:0000233
has_obo_namespace: external
id: term_tracker_item
is class level: true
is metadata tag: true
shorthand: term_tracker_item

has ontology root term
type: AnnotationProperty
database_cross_reference: IAO:0000700
has_obo_namespace: external
id: has_ontology_root_term
is class level: true
is metadata tag: true
shorthand: has_ontology_root_term

term replaced by
type: AnnotationProperty

chebi ph7 3
type: AnnotationProperty
comment: Rhea list of ChEBI terms representing the major species at pH 7.3.
sub property of: subset_property

gocheck do not annotate
type: AnnotationProperty
comment: Term not to be used for direct annotation
sub property of: subset_property

gocheck obsoletion candidate
type: AnnotationProperty
comment: Terms planned for obsoletion
sub property of: subset_property

goslim agr
type: AnnotationProperty
comment: AGR slim
sub property of: subset_property

goslim aspergillus
type: AnnotationProperty
comment: Aspergillus GO slim
sub property of: subset_property

goslim candida
type: AnnotationProperty
comment: Candida GO slim
sub property of: subset_property

goslim chembl
type: AnnotationProperty
comment: ChEMBL protein targets summary
sub property of: subset_property

goslim drosophila
type: AnnotationProperty
comment: Drosophila GO slim
sub property of: subset_property

goslim euk cellular processes ribbon
type: AnnotationProperty
comment: GO ribbon for eukaroytic cellular processes
sub property of: subset_property

goslim flybase ribbon
type: AnnotationProperty
comment: Insecta GO ribbon slim
sub property of: subset_property

goslim generic
type: AnnotationProperty
comment: Generic GO slim
sub property of: subset_property

goslim metagenomics
type: AnnotationProperty
comment: Metagenomics GO slim
sub property of: subset_property

goslim mouse
type: AnnotationProperty
comment: Mouse GO slim
sub property of: subset_property

goslim pir
type: AnnotationProperty
comment: PIR GO slim
sub property of: subset_property

goslim plant
type: AnnotationProperty
comment: Plant GO slim
sub property of: subset_property

goslim plant ribbon
type: AnnotationProperty
comment: Plant GO ribbon
sub property of: subset_property

goslim pombe
type: AnnotationProperty
comment: Fission yeast GO slim
sub property of: subset_property

goslim prokaryote
type: AnnotationProperty
comment: GO subset for prokaryotes
sub property of: subset_property

goslim prokaryote ribbon
type: AnnotationProperty
comment: Prokaryote GO ribbon slim
sub property of: subset_property

goslim synapse
type: AnnotationProperty
comment: synapse GO slim
sub property of: subset_property

goslim virus
type: AnnotationProperty
comment: GO subset for viruses
sub property of: subset_property

goslim yeast
type: AnnotationProperty
comment: Yeast GO slim
sub property of: subset_property

label approved by the SynGO project
type: AnnotationProperty
sub property of: synonym_type_property

Systematic synonym
type: AnnotationProperty
has_scope: has_exact_synonym
sub property of: synonym_type_property

subset_property
type: AnnotationProperty

synonym_type_property
type: AnnotationProperty

consider
type: AnnotationProperty

created by
type: AnnotationProperty

creation date
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_format_version
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

has_scope
type: AnnotationProperty

has_synonym_type
type: AnnotationProperty

id
type: AnnotationProperty

in_subset
type: AnnotationProperty

shorthand
type: AnnotationProperty

part of
type: ObjectProperty
inverse of: has part
type: TransitiveProperty
database_cross_reference: BFO:0000050
has_obo_namespace: external
id: part_of
shorthand: part_of

has part
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: BFO:0000051
has_obo_namespace: external
id: has_part
shorthand: has_part

occurs in
type: ObjectProperty
property chain axiom: part of
database_cross_reference: BFO:0000066
has_obo_namespace: external
id: occurs_in
shorthand: occurs_in

starts during
type: ObjectProperty
database_cross_reference: RO:0002091
has_obo_namespace: external
id: starts_during
shorthand: starts_during

happens during
type: ObjectProperty
sub property of: ends during
type: TransitiveProperty
database_cross_reference: RO:0002092
has_obo_namespace: external
id: happens_during
shorthand: happens_during

ends during
type: ObjectProperty
database_cross_reference: RO:0002093
has_obo_namespace: external
id: ends_during
shorthand: ends_during

regulates
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002211
has_obo_namespace: external
id: regulates
shorthand: regulates

negatively regulates
type: ObjectProperty
sub property of: regulates
database_cross_reference: RO:0002212
has_obo_namespace: external
id: negatively_regulates
shorthand: negatively_regulates

positively regulates
type: ObjectProperty
sub property of: regulates
property chain axiom: negatively regulates
database_cross_reference: RO:0002213
has_obo_namespace: external
id: positively_regulates
shorthand: positively_regulates

ribosomal subunit export from nucleus
type: Class
subclass of: nuclear transport
definition: The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.
has_exact_synonym: ribosomal subunit export from cell nucleus
has_exact_synonym: ribosomal subunit export out of nucleus
has_exact_synonym: ribosomal subunit transport from nucleus to cytoplasm
has_exact_synonym: ribosomal subunit-nucleus export
has_obo_namespace: biological_process
has_related_synonym: ribosome export from nucleus
id: GO:0000054
in_subset: goslim yeast

Axiom
annotated source: ribosomal subunit export from nucleus
annotated property: has_related_synonym
annotated target: ribosome export from nucleus
database_cross_reference: GOC:mah
database_cross_reference: GOC:rb

Axiom
annotated source: ribosomal subunit export from nucleus
annotated property: definition
annotated target: The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.
database_cross_reference: GOC:ai

Axiom
annotated source: ribosomal subunit export from nucleus
annotated property: has_exact_synonym
annotated target: ribosomal subunit export from cell nucleus
database_cross_reference: GOC:mah

Axiom
annotated source: ribosomal subunit export from nucleus
annotated property: has_exact_synonym
annotated target: ribosomal subunit export out of nucleus
database_cross_reference: GOC:mah

Axiom
annotated source: ribosomal subunit export from nucleus
annotated property: has_exact_synonym
annotated target: ribosomal subunit transport from nucleus to cytoplasm
database_cross_reference: GOC:mah

Axiom
annotated source: ribosomal subunit export from nucleus
annotated property: has_exact_synonym
annotated target: ribosomal subunit-nucleus export
database_cross_reference: GOC:mah

mitotic cell cycle
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: has part
  some values from: organelle fission
definition: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
has_alternative_id: GO:0007067
database_cross_reference: Reactome:R-HSA-69278
database_cross_reference: Wikipedia:Mitosis
has_obo_namespace: biological_process
has_related_synonym: mitosis
id: GO:0000278
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim yeast
comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.

Axiom
annotated source: mitotic cell cycle
annotated property: definition
annotated target: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194

Cell Cycle, Mitotic
type: Axiom
annotated source: mitotic cell cycle
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-69278

conjugation with cellular fusion
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: has part
  some values from: biological_process
definition: A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae.
has_alternative_id: GO:0007322
has_alternative_id: GO:0007333
has_alternative_id: GO:0030461
has_alternative_id: GO:0030477
database_cross_reference: Wikipedia:Conjugation
has_obo_namespace: biological_process
has_related_synonym: cell fusion
has_related_synonym: mating
id: GO:0000747
in_subset: goslim candida
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: conjugation with cellular fusion
annotated property: definition
annotated target: A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae.
database_cross_reference: GOC:elh

cell morphogenesis
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: The developmental process in which the size or shape of a cell is generated and organized.
has_alternative_id: GO:0007148
has_alternative_id: GO:0045790
has_alternative_id: GO:0045791
has_exact_synonym: cellular morphogenesis
has_obo_namespace: biological_process
id: GO:0000902
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: cell morphogenesis
annotated property: definition
annotated target: The developmental process in which the size or shape of a cell is generated and organized.
database_cross_reference: GOC:clt
database_cross_reference: GOC:curators
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

cytokinesis
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
subclass of: Restriction
  on property: has part
  some values from: biological_process
definition: The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
has_alternative_id: GO:0007104
has_alternative_id: GO:0016288
has_alternative_id: GO:0033205
database_cross_reference: Wikipedia:Cytokinesis
has_exact_synonym: cell cycle cytokinesis
has_exact_synonym: cytokinesis involved in cell cycle
has_obo_namespace: biological_process
id: GO:0000910
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: Note that this term should not be used for direct annotation. When annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other.

Axiom
annotated source: cytokinesis
annotated property: definition
annotated target: The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
database_cross_reference: GOC:mtg_cell_cycle

Axiom
annotated source: cytokinesis
annotated property: has_exact_synonym
annotated target: cytokinesis involved in cell cycle
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

invasive growth in response to glucose limitation
type: Class
subclass of: biological_process
definition: A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae.
has_obo_namespace: biological_process
has_related_synonym: colony morphology
id: GO:0001403
in_subset: goslim yeast
comment: Note that this term should not be used to describe the invasion of host tissues by pathogenic organisms, which is described by the biological process term 'entry into host ; GO:0044409', nor should it be used to describe growth of diseased cells of an organism into the surrounding normal tissue, which is outside of the scope of GO.

Axiom
annotated source: invasive growth in response to glucose limitation
annotated property: definition
annotated target: A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae.
database_cross_reference: GOC:mcc
database_cross_reference: PMID:9728395

cytoplasmic translation
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
subclass of: Restriction
  on property: has part
  some values from: translational initiation
subclass of: Restriction
  on property: has part
  some values from: translational elongation
subclass of: Restriction
  on property: has part
  some values from: transferase activity
definition: The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
created by: hjd
creation date: 2011-06-09T03:11:53Z
has_obo_namespace: biological_process
id: GO:0002181
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim yeast
comment: Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms.

Axiom
annotated source: cytoplasmic translation
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
database_cross_reference: GOC:hjd

molecular_function
type: Class
definition: A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
has_alternative_id: GO:0005554
has_exact_synonym: molecular function
has_obo_namespace: molecular_function
id: GO:0003674
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex.

Axiom
annotated source: molecular_function
annotated property: definition
annotated target: A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
database_cross_reference: GOC:pdt

DNA binding
type: Class
subclass of: molecular_function
definition: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
has_alternative_id: GO:0043566
has_narrow_synonym: plasmid binding
has_obo_namespace: molecular_function
has_related_synonym: microtubule/chromatin interaction
has_related_synonym: structure specific DNA binding
has_related_synonym: structure-specific DNA binding
id: GO:0003677
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: DNA binding
annotated property: definition
annotated target: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb
database_cross_reference: GOC:vw

chromatin binding
type: Class
subclass of: molecular_function
definition: Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
has_narrow_synonym: lamin/chromatin binding
has_narrow_synonym: microtubule/chromatin interaction
has_narrow_synonym: nuclear membrane vesicle binding to chromatin
has_obo_namespace: molecular_function
id: GO:0003682
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: chromatin binding
annotated property: definition
annotated target: Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:20404130

DNA-binding transcription factor activity
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: part of
  some values from: biological_process
subclass of: Restriction
  on property: has part
  some values from: DNA binding
definition: A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
term tracker item: https://github.com/geneontology/go-ontology/issues/15704
term tracker item: https://github.com/geneontology/go-ontology/issues/16534
term tracker item: https://github.com/geneontology/go-ontology/issues/20253
created by: krc
creation date: 2010-10-21T04:37:54Z
has_alternative_id: GO:0000130
has_alternative_id: GO:0001071
has_alternative_id: GO:0001130
has_alternative_id: GO:0001131
has_alternative_id: GO:0001151
has_alternative_id: GO:0001199
has_alternative_id: GO:0001204
has_broad_synonym: nucleic acid binding transcription factor activity
has_broad_synonym: transcription factor activity
has_exact_synonym: DNA binding transcription factor activity
has_exact_synonym: gene-specific transcription factor activity
has_exact_synonym: sequence-specific DNA binding transcription factor activity
has_narrow_synonym: bacterial-type DNA binding transcription factor activity
has_narrow_synonym: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
has_narrow_synonym: bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity
has_narrow_synonym: bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
has_narrow_synonym: bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
has_narrow_synonym: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
has_narrow_synonym: metal ion regulated sequence-specific DNA binding transcription factor activity
has_narrow_synonym: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
has_narrow_synonym: transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
has_narrow_synonym: transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
has_narrow_synonym: transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding
has_narrow_synonym: transcription factor activity, metal ion regulated sequence-specific DNA binding
has_obo_namespace: molecular_function
id: GO:0003700
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim yeast
comment: Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions.

Axiom
annotated source: DNA-binding transcription factor activity
annotated property: definition
annotated target: A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
database_cross_reference: GOC:txnOH-2018

RNA binding
type: Class
subclass of: molecular_function
definition: Binding to an RNA molecule or a portion thereof.
has_alternative_id: GO:0000498
has_alternative_id: GO:0044822
database_cross_reference: Reactome:R-HSA-203922
has_narrow_synonym: base pairing with RNA
has_obo_namespace: molecular_function
has_related_synonym: poly(A) RNA binding
has_related_synonym: poly(A)-RNA binding
has_related_synonym: poly-A RNA binding
id: GO:0003723
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: RNA binding
annotated property: definition
annotated target: Binding to an RNA molecule or a portion thereof.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Exportin-5 recognizes 3' overhang of pre-miRNA
type: Axiom
annotated source: RNA binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203922

mRNA binding
type: Class
subclass of: RNA binding
definition: Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
has_alternative_id: GO:0000499
has_narrow_synonym: base pairing with mRNA
has_obo_namespace: molecular_function
id: GO:0003729
in_subset: goslim chembl
in_subset: goslim yeast

Axiom
annotated source: mRNA binding
annotated property: definition
annotated target: Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
database_cross_reference: GOC:kmv
database_cross_reference: GOC:pr
database_cross_reference: SO:0000234

structural constituent of ribosome
type: Class
equivalent class: Class
  intersection of: structural molecule activity
  intersection of: Restriction
    on property: occurs in
    some values from: ribosome
subclass of: structural molecule activity
subclass of: Restriction
  on property: occurs in
  some values from: ribosome
definition: The action of a molecule that contributes to the structural integrity of the ribosome.
has_alternative_id: GO:0003736
has_alternative_id: GO:0003737
has_alternative_id: GO:0003738
has_alternative_id: GO:0003739
has_alternative_id: GO:0003740
has_alternative_id: GO:0003741
has_alternative_id: GO:0003742
has_broad_synonym: ribosomal protein
has_obo_namespace: molecular_function
has_related_synonym: ribosomal RNA
id: GO:0003735
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim yeast
comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins.

Axiom
annotated source: structural constituent of ribosome
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of the ribosome.
database_cross_reference: GOC:mah

GTPase activity
type: Class
subclass of: hydrolase activity
definition: Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
term tracker item: https://github.com/geneontology/go-ontology/issues/19078
term tracker item: https://github.com/geneontology/go-ontology/issues/26014
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
created by: dph
creation date: 2015-11-11T12:47:56Z
has_alternative_id: GO:0061745
has_broad_synonym: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
database_cross_reference: MetaCyc:RXN0-5462
database_cross_reference: RHEA:19669
database_cross_reference: Reactome:R-HSA-1445143
database_cross_reference: Reactome:R-HSA-1458485
database_cross_reference: Reactome:R-HSA-156923
database_cross_reference: Reactome:R-HSA-164381
database_cross_reference: Reactome:R-HSA-165055
database_cross_reference: Reactome:R-HSA-167415
database_cross_reference: Reactome:R-HSA-170666
database_cross_reference: Reactome:R-HSA-170685
database_cross_reference: Reactome:R-HSA-170686
database_cross_reference: Reactome:R-HSA-177501
database_cross_reference: Reactome:R-HSA-203973
database_cross_reference: Reactome:R-HSA-2130641
database_cross_reference: Reactome:R-HSA-2130725
database_cross_reference: Reactome:R-HSA-2584246
database_cross_reference: Reactome:R-HSA-380979
database_cross_reference: Reactome:R-HSA-392133
database_cross_reference: Reactome:R-HSA-392212
database_cross_reference: Reactome:R-HSA-418574
database_cross_reference: Reactome:R-HSA-418582
database_cross_reference: Reactome:R-HSA-421835
database_cross_reference: Reactome:R-HSA-428941
database_cross_reference: Reactome:R-HSA-432707
database_cross_reference: Reactome:R-HSA-5333615
database_cross_reference: Reactome:R-HSA-5389839
database_cross_reference: Reactome:R-HSA-5389842
database_cross_reference: Reactome:R-HSA-5419273
database_cross_reference: Reactome:R-HSA-5419279
database_cross_reference: Reactome:R-HSA-555065
database_cross_reference: Reactome:R-HSA-5623513
database_cross_reference: Reactome:R-HSA-5638006
database_cross_reference: Reactome:R-HSA-5658231
database_cross_reference: Reactome:R-HSA-5665809
database_cross_reference: Reactome:R-HSA-5672017
database_cross_reference: Reactome:R-HSA-5694527
database_cross_reference: Reactome:R-HSA-6807877
database_cross_reference: Reactome:R-HSA-6814833
database_cross_reference: Reactome:R-HSA-8847534
database_cross_reference: Reactome:R-HSA-8847883
database_cross_reference: Reactome:R-HSA-8849082
database_cross_reference: Reactome:R-HSA-8854173
database_cross_reference: Reactome:R-HSA-8854255
database_cross_reference: Reactome:R-HSA-8854329
database_cross_reference: Reactome:R-HSA-8854604
database_cross_reference: Reactome:R-HSA-8854612
database_cross_reference: Reactome:R-HSA-8868661
database_cross_reference: Reactome:R-HSA-8981353
database_cross_reference: Reactome:R-HSA-8982020
database_cross_reference: Reactome:R-HSA-8982021
database_cross_reference: Reactome:R-HSA-8982025
database_cross_reference: Reactome:R-HSA-9018814
database_cross_reference: Reactome:R-HSA-9018826
database_cross_reference: Reactome:R-HSA-9640195
database_cross_reference: Reactome:R-HSA-9645598
database_cross_reference: Reactome:R-HSA-9649736
database_cross_reference: Reactome:R-HSA-983422
database_cross_reference: Reactome:R-HSA-9947842
database_cross_reference: Reactome:R-HSA-9954919
has_narrow_synonym: ARF small monomeric GTPase activity
has_narrow_synonym: RHEB small monomeric GTPase activity
has_narrow_synonym: Rab small monomeric GTPase activity
has_narrow_synonym: Ran small monomeric GTPase activity
has_narrow_synonym: Ras small monomeric GTPase activity
has_narrow_synonym: Rho small monomeric GTPase activity
has_narrow_synonym: Sar small monomeric GTPase activity
has_narrow_synonym: dynamin GTPase activity
has_narrow_synonym: heterotrimeric G-protein GTPase activity
has_narrow_synonym: protein-synthesizing GTPase activity
has_narrow_synonym: protein-synthesizing GTPase activity, elongation

ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9954919

Axiom
annotated source: GTPase activity
annotated property: definition
annotated target: Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
database_cross_reference: PMID:26832457
database_cross_reference: PMID:27218782

RAB8A,10,13,14 hydrolyze GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1445143

RALA hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1458485

Hydrolysis of eEF1A:GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-156923

G alpha (s) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-164381

Hydrolysis of Ran:GTP to Ran:GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-165055

G-protein alpha subunit is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-167415

Adenylate cyclase increases the GTPase activity of G alpha-olf
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170666

Adenylaye cyclase increases the GTPase activity of G alpha-olf
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170685

Adenylate cyclase increases the GTPase activity of Gi alpha
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170686

Endocytosis (internalization) of clathrin-coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-177501

Vesicle budding
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203973

Translocation of TGN-lysosome vesicle to lysosome
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2130641

Internalization of MHC II:Ii clathrin coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2130725

GNAT1-GTP hydrolyses its bound GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2584246

RHEB in mTORC1:RHEB:GTP hydrolyses GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-380979

G alpha (z) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392133

G alpha (i) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392212

G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418574

G alpha (q) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418582

trans-Golgi Network Vesicle Scission
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-421835

P2Y purinoceptor 1 activates MAP kinase p38 alpha
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-428941

trans-Golgi Network Lysosomal Vesicle Scission
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-432707

80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5333615

39S subunit binds 28S subunit:mRNA:fMet-tRNA
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5389839

TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5389842

Hydrolysis of GTP and dissociation of 28S and 39S subunits
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5419273

Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5419279

Formation of clathrin coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-555065

ASAP1 stimulates GTPase activity of ARF4
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5623513

ARL3 hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5638006

RAS GAPs stimulate RAS GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5658231

SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5665809

Rheb in the MTORC1 complex hydrolyses GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5672017

Loss of SAR1B GTPase
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694527

ARFGAPs stimulate ARF GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6807877

TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6814833

RAB43 hydrolyses GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8847534

CYTH proteins stimulate ARF1 GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8847883

ARHGAP35 stimulates RHOA GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8849082

TBC RabGAPs accelerate GTP hydrolysis by RAB35
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854173

TBC1D2A accelerates GTP hydrolysis by RAB7
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854255

TBC1D15 accelerates GTP hydrolysis by RAB7
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854329

TBC1D16 accelerates GTP hydrolysis by RAB4A
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854604

TBC1D25 accelerates GTP hydrolysis by RAB33B
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854612

Dynamin-mediated GTP hydrolysis promotes vesicle scission
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8868661

RASA1 stimulates RAS GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8981353

G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982020

G alpha (z) in G alpha (z):RGS complex is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982021

G alpha (q) in G (q):RGS complex is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982025

RHOT1 hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018814

RHOT2 hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018826

RRAGA,B hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9640195

RRAGC,D hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9645598

RAS intrinsic GTPase activity hydrolyzes GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9649736

Disassembly of COPII coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-983422

GBP1 hydrolyzes GTP forming GBP1 oligomers
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9947842

helicase activity
type: Class
subclass of: isomerase activity
subclass of: ATP-dependent activity
definition: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
term tracker item: https://github.com/geneontology/go-ontology/issues/21393
term tracker item: https://github.com/geneontology/go-ontology/issues/29690
has_alternative_id: GO:0008026
database_cross_reference: Reactome:R-HSA-169461
database_cross_reference: Reactome:R-HSA-169468
database_cross_reference: Reactome:R-HSA-5686410
database_cross_reference: Reactome:R-HSA-5690996
database_cross_reference: Reactome:R-HSA-9922957
database_cross_reference: Reactome:R-HSA-9923073
has_exact_synonym: ATP-dependent helicase activity
has_obo_namespace: molecular_function
id: GO:0004386
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim pir
in_subset: goslim yeast
comment: Note that most helicases catalyze processive duplex unwinding.

Axiom
annotated source: helicase activity
annotated property: definition
annotated target: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
database_cross_reference: GOC:jl

MCM8 mediated fork unwinding
type: Axiom
annotated source: helicase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-169461

MCM2-7 mediated fork unwinding
type: Axiom
annotated source: helicase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-169468

BLM mediates dissolution of double Holliday junction
type: Axiom
annotated source: helicase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5686410

ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA
type: Axiom
annotated source: helicase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5690996

NS3 melts (+)-RNA secondary structures
type: Axiom
annotated source: helicase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9922957

NS3 unwinds dsRNA secondary structures
type: Axiom
annotated source: helicase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9923073

nuclease activity
type: Class
subclass of: molecular_function
definition: Catalysis of the cleavage of ester linkages within nucleic acids.
term tracker item: https://github.com/geneontology/go-ontology/issues/24408
has_obo_namespace: molecular_function
id: GO:0004518
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim plant
in_subset: goslim yeast
comment: Most nucleases are classed as hydrolases, though a minority are classed as lyases.

Axiom
annotated source: nuclease activity
annotated property: definition
annotated target: Catalysis of the cleavage of ester linkages within nucleic acids.
database_cross_reference: ISBN:0198547684

guanyl-nucleotide exchange factor activity
type: Class
subclass of: enzyme regulator activity
definition: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
term tracker item: https://github.com/geneontology/go-ontology/issues/18749
term tracker item: https://github.com/geneontology/go-ontology/issues/18750
term tracker item: https://github.com/geneontology/go-ontology/issues/27684
has_alternative_id: GO:0005086
has_alternative_id: GO:0005087
has_alternative_id: GO:0005088
has_alternative_id: GO:0005089
has_alternative_id: GO:0005090
has_alternative_id: GO:0008321
has_alternative_id: GO:0008433
has_alternative_id: GO:0016219
has_alternative_id: GO:0016220
has_alternative_id: GO:0017034
has_alternative_id: GO:0017112
has_alternative_id: GO:0017132
has_alternative_id: GO:0019839
has_alternative_id: GO:0030676
database_cross_reference: Reactome:R-HSA-109807
database_cross_reference: Reactome:R-HSA-109817
database_cross_reference: Reactome:R-HSA-114544
database_cross_reference: Reactome:R-HSA-1168636
database_cross_reference: Reactome:R-HSA-1225951
database_cross_reference: Reactome:R-HSA-1225957
database_cross_reference: Reactome:R-HSA-1250383
database_cross_reference: Reactome:R-HSA-1250463
database_cross_reference: Reactome:R-HSA-1250498
database_cross_reference: Reactome:R-HSA-1306972
database_cross_reference: Reactome:R-HSA-1433415
database_cross_reference: Reactome:R-HSA-1433471
database_cross_reference: Reactome:R-HSA-156913
database_cross_reference: Reactome:R-HSA-169904
database_cross_reference: Reactome:R-HSA-170979
database_cross_reference: Reactome:R-HSA-171026
database_cross_reference: Reactome:R-HSA-177938
database_cross_reference: Reactome:R-HSA-177945
database_cross_reference: Reactome:R-HSA-180687
database_cross_reference: Reactome:R-HSA-186834
database_cross_reference: Reactome:R-HSA-187746
database_cross_reference: Reactome:R-HSA-194518
database_cross_reference: Reactome:R-HSA-2029445
database_cross_reference: Reactome:R-HSA-2029451
database_cross_reference: Reactome:R-HSA-2029467
database_cross_reference: Reactome:R-HSA-203977
database_cross_reference: Reactome:R-HSA-205039
database_cross_reference: Reactome:R-HSA-210977
database_cross_reference: Reactome:R-HSA-2179407
database_cross_reference: Reactome:R-HSA-2424476
database_cross_reference: Reactome:R-HSA-2424477
database_cross_reference: Reactome:R-HSA-2485180
database_cross_reference: Reactome:R-HSA-2730840
database_cross_reference: Reactome:R-HSA-350769
database_cross_reference: Reactome:R-HSA-354173
database_cross_reference: Reactome:R-HSA-379044
database_cross_reference: Reactome:R-HSA-379048
database_cross_reference: Reactome:R-HSA-380073
database_cross_reference: Reactome:R-HSA-381727
database_cross_reference: Reactome:R-HSA-389348
database_cross_reference: Reactome:R-HSA-389350
database_cross_reference: Reactome:R-HSA-392054
database_cross_reference: Reactome:R-HSA-392195
database_cross_reference: Reactome:R-HSA-3928592
database_cross_reference: Reactome:R-HSA-3928612
database_cross_reference: Reactome:R-HSA-3928628
database_cross_reference: Reactome:R-HSA-3928632
database_cross_reference: Reactome:R-HSA-3928633
database_cross_reference: Reactome:R-HSA-3928642
database_cross_reference: Reactome:R-HSA-3928651
database_cross_reference: Reactome:R-HSA-392870
database_cross_reference: Reactome:R-HSA-3965444
database_cross_reference: Reactome:R-HSA-399938
database_cross_reference: Reactome:R-HSA-399995
database_cross_reference: Reactome:R-HSA-400037
database_cross_reference: Reactome:R-HSA-400092
database_cross_reference: Reactome:R-HSA-4093336
database_cross_reference: Reactome:R-HSA-416530
database_cross_reference: Reactome:R-HSA-416588
database_cross_reference: Reactome:R-HSA-418579

Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: definition
annotated target: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
database_cross_reference: GOC:kd
database_cross_reference: GOC:mah
database_cross_reference: PMID:23303910
database_cross_reference: PMID:27218782

GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-109807

GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-109817

p115-RhoGEF activation of RHOA
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-114544

p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1168636

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1225951

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1225957

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1250383

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1250463

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1250498

RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1306972

Activation of RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1433415

Activation of RAS by p-KIT bound SOS1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1433471

Regeneration of eEF1A:GTP by eEF1B activity
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-156913

C3G stimulates nucleotide exchange on Rap1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-169904

(Frs2)C3G stimulates nucleotide exchange on Rap1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170979

Guanine nucleotide exchange on RAL
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-171026

SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-177938

SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-177945

Conversion of Ran-GDP to Ran-GTP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-180687

SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-186834

RIT/RIN are activated
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-187746

RhoA is activated by nucleotide exchange and inhibits axonal growth
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-194518

An unknown GEF exchanges GTP for GDP on CDC42:GDP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029445

Activation of RAC1 by VAV
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029451

Activation of RAC1 by CRKII:DOCK180:ELMO
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029467

SAR1 Activation And Membrane Binding
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203977

p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-205039

Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-210977

SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2179407

Activation of RAC1 by VAV2/3
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2424476

SOS mediated nucleotide exchange of RAS (SHC)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2424477

MII catalyses GDP/GTP exchange on Gt
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2485180

Activation of RAC1 by VAV
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2730840

trans-Golgi Network Coat Activation
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-350769

Activation of Rap1 by cytosolic GEFs
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-354173

Liganded Gs-activating GPCR acts as a GEF for Gs
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-379044

Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-379048

Liganded Gi-activating GPCR acts as a GEF for Gi
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-380073

RAP1A exchanges GDP for GTP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-381727

Activation of Rac1 by pVav1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-389348

Activation of Cdc42 by pVav1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-389350

NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392054

Gi activation by P2Y purinoceptor 12
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392195

p190RhoGEF exchanges GTP for GDP on RHOA, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928592

KALRN exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928612

VAV exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928628

ITSN1 exchanges GTP for GDP on CDC42, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928632

bPIX exchanges GTP for GDP on RAC, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928633

TIAM1 exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928642

NGEF exchanges GTP for GDP on RHOA
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928651

Gs activation by prostacyclin receptor
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392870

WNT:FZD complex promotes G-protein nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3965444

Activation of Rac1 by FARP2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-399938

Muscarinic Acetylcholine Receptor M3 activates Gq
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-399995

Gi,Go Heterotrimeric G-protein complex dissociates
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-400037

Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-400092

p-TIAM1 exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-4093336

FFAR1:FFAR1 ligands activate Gq
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-416530

Activation of Rho by LARG and PDZ-RhoGEF
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-416588

Gq activation by P2Y purinoceptor 1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418579

Activation of Cdc42
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418850

Activation of Rac1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418856

GEFs activate RhoA,B,C
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-419166

Opsins act as GEFs for G alpha-t
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-420883

Activation of RAC1 by SOS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-428535

Gq activation by TP receptor
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-428750

G13 activation by TP receptor
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-428917

VAV1 is a GEF for Rho/Rac family GTPases
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-442273

VAV2 is a GEF for Rho/Rac family kinases
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-442291

VAV3 is a GEF for Rho/Rac family kinases
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-442314

NMDA-activated RASGRF1 activates RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-442732

Activation of Rac1 by VAV2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-445064

VEGF induces CDC42 activation by unknown mechanism
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5218829

DOCK180:ELMO exchanges GTP for GDP, activating RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5218839

VAV exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5218850

RAB3IP stimulates nucleotide exchange on RAB8A
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5617816

GBF1 stimulates nucleotide exchange on ARF4
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5623508

RAB3IP stimulates nucleotide exchange on RAB8A
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5623521

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5637806

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5637808

Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654392

Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654402

Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654413

Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654426

Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654600

Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654618

Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654647

Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654663

Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655241

Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655277

Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655326

Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655347

RAS GEFs promote RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5672965

GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5686071

GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5686318

Nucleotide exchange on RAB1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694409

GBF1 stimulates ARF nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6807868

GBF1 stimulates nucleotide exchange on ARF
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6811414

ARFGAPs stimulate ARF GTPase activity at the Golgi membrane
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6811418

RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6811429

Liganded Gz-activating GPCR acts as a GEF for Gz
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-749453

Liganded G12/13-activating GPCR acts as a GEF for G12/13
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-751029

Glucagon:GCGR mediates GTP-GDP exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-825631

Activation of RAC1 by the PXN:CRK complex
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8848618

RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8850041

RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8851827

RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8851877

RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8851899

RAB3 GEFs exchange GTP for GDP on RAB3A
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8875318

RAB5 GEFs exchange GTP for GDP on RAB5
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8875320

RAPGEF1 activates RAP1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8875568

DOCK7 activates RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8875591

DENND4s exchange GTP for GDP on RAB10
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876188

RAB8 GEFs exchange GTP for GDP on RAB8
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876190

RAB9 GEFs exchange GTP for GDP on RAB9
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876191

RIC1-RGP1 exchanges GTP for GDP on RAB6
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876193

DENND3 exchanges GTP for GDP on RAB12
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876454

RAB13 GEFs exchange GTP for GDP on RAB13
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876615

DENND6A,B exchange GTP for GDP on RAB14
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876616

RAB21 GEFs exchange GTP for GDP on RAB21
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876837

MADD exchanges GTP for GDP on RAB27
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877308

RAB31 GEFs exchange GTP for GDP on RAB31
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877311

MON1:CCZ1 exchanges GTP for GDP on RAB7
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877451

TRAPPC complexes exchange GTP for GDP on RAB1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877475

DENND1s exchange GTP for GDP on RAB35
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877612

HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877760

DENND5A,B exchange GTP for GDP on RAB39
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877813

RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877998

CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8964604

RHOA GEFs activate RHOA
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8980691

Opsins binds G alpha-t
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982637

G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982640

RHOB GEFs activate RHOB
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013023

RHOC GEFs activate RHOC
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013109

RAC1 GEFs activate RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013143

CDC42 GEFs activate CDC42
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013159

RHOD auto-activates
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013435

RAC2 GEFs activate RAC2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9014296

RHOG GEFs activate RHOG
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9014433

RHOJ GEFs activate RHOJ
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9017491

RHOQ GEFs activate RHOQ
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018747

RHOU auto-activates
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018768

RAC3 GEFs activate RAC3
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018804

RHOT1 GEFs activate RHOT1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018817

RHOT2 GEFs activate RHOT2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018825

NTRK2 activates RAS signaling through SHC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026891

EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9029158

NTRK2 activates RAS signaling through FRS2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9032067

DOCK3 activates RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9032798

NTRK2 and CDK5 promote activation of RAC1 by TIAM1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9033292

ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9036301

Activation of Rap1 by membrane-associated GEFs
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-939265

SOS1-mediated nucleotide exchange of RAS downstream of FLT3
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9607304

p-S516-ARHGEF7 activates RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9619803

RCC1 stimulates GDP to GTP exchange on RAN
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9624845

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9634418

RRAGC,D exchanges GTP for GDP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9639286

RRAGA,B exchanges GDP for GTP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9640167

ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9660824

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9664991

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9665009

RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9665404

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9665408

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9665700

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9665707

DOCK180 exchanges GTP for GDP on RAC1:GDP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9666428

p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9666430

p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9670436

SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9672163

SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9672170

CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9680385

RHOF auto-activates
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9693111

FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9695853

SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9703441

p-VAV1,2,3 exchange 6TGTP for GDP on RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9751201

SRC-phosphorylated RAC1,(CDC42) GEFs activate RAC1,(CDC42)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9970163

structural molecule activity
type: Class
subclass of: molecular_function
definition: The action of a molecule that contributes to the structural integrity of a complex.
term tracker item: https://github.com/geneontology/go-ontology/issues/24130
has_obo_namespace: molecular_function
id: GO:0005198
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: structural molecule activity
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of a complex.
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw

cellular_component
type: Class
definition: A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
term tracker item: https://github.com/geneontology/go-ontology/issues/17729
has_alternative_id: GO:0008372
database_cross_reference: NIF_Subcellular:sao1337158144
has_exact_synonym: cell or subcellular entity
has_exact_synonym: cellular component
has_obo_namespace: cellular_component
has_related_synonym: subcellular entity
id: GO:0005575
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.

Axiom
annotated source: cellular_component
annotated property: definition
annotated target: A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
database_cross_reference: GOC:pdt

Axiom
annotated source: cellular_component
annotated property: has_related_synonym
annotated target: subcellular entity
database_cross_reference: NIF_Subcellular:nlx_subcell_100315

extracellular region
type: Class
subclass of: cellular_component
definition: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
term tracker item: https://github.com/geneontology/go-ontology/issues/31545
database_cross_reference: Wikipedia:Extracellular
has_exact_synonym: extracellular
has_obo_namespace: cellular_component
id: GO:0005576
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products at the cell surface, consider annotating to external side of plasma membrane ; GO:0009897.

Axiom
annotated source: extracellular region
annotated property: definition
annotated target: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
database_cross_reference: GOC:curators

cell wall
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: extracellular region
definition: The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
term tracker item: https://github.com/geneontology/go-ontology/issues/21669
database_cross_reference: Wikipedia:Cell_wall
has_obo_namespace: cellular_component
id: GO:0005618
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Not to be used for manual annotation. Please choose a more specific term: for bacteria, annotate to GO:0009274; peptidoglycan-based cell wall, for plants: annotate to GO:0009505 ; plant-type cell wall, for fungi: GO:0009277 ; fungal-type cell wall, and for archae, use GO:0030115 S-layer (see PMID:31214995).

Axiom
annotated source: cell wall
annotated property: definition
annotated target: The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
database_cross_reference: GOC:giardia
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:15134259
database_cross_reference: Wikipedia:Microbial_cyst

nucleus
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cellular_component
subclass of: Restriction
  on property: has part
  some values from: membrane
definition: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
database_cross_reference: NIF_Subcellular:sao1702920020
database_cross_reference: Wikipedia:Cell_nucleus
has_exact_synonym: cell nucleus
has_narrow_synonym: horsetail nucleus
has_obo_namespace: cellular_component
id: GO:0005634
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: nucleus
annotated property: definition
annotated target: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
database_cross_reference: GOC:curators

Axiom
annotated source: nucleus
annotated property: has_narrow_synonym
annotated target: horsetail nucleus
database_cross_reference: GOC:al
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw
database_cross_reference: PMID:15030757

chromosome
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cellular_component
definition: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
database_cross_reference: Wikipedia:Chromosome
has_narrow_synonym: interphase chromosome
has_narrow_synonym: prophase chromosome
has_obo_namespace: cellular_component
has_related_synonym: chromatid
id: GO:0005694
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.

Axiom
annotated source: chromosome
annotated property: definition
annotated target: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
database_cross_reference: ISBN:0198547684

nucleolus
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: nucleus
definition: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
database_cross_reference: NIF_Subcellular:sao1820400233
database_cross_reference: Wikipedia:Nucleolus
has_obo_namespace: cellular_component
id: GO:0005730
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: nucleolus
annotated property: definition
annotated target: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
database_cross_reference: ISBN:0198506732

cytoplasm
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cellular_component
definition: The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
term tracker item: https://github.com/geneontology/go-ontology/issues/23023
database_cross_reference: Wikipedia:Cytoplasm
has_obo_namespace: cellular_component
id: GO:0005737
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: cytoplasm
annotated property: definition
annotated target: The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
database_cross_reference: ISBN:0198547684

mitochondrion
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: has part
  some values from: membrane
definition: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: NIF_Subcellular:sao1860313010
database_cross_reference: Wikipedia:Mitochondrion
has_exact_synonym: mitochondria
has_obo_namespace: cellular_component
id: GO:0005739
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.)

Axiom
annotated source: mitochondrion
annotated property: definition
annotated target: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: GOC:giardia
database_cross_reference: ISBN:0198506732

mitochondrial envelope
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: mitochondrion
definition: The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
has_obo_namespace: cellular_component
id: GO:0005740
in_subset: goslim candida
in_subset: goslim yeast

Axiom
annotated source: mitochondrial envelope
annotated property: definition
annotated target: The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
database_cross_reference: GOC:ai
database_cross_reference: GOC:pz

vacuole
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: has part
  some values from: membrane
definition: A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
database_cross_reference: Wikipedia:Vacuole
has_obo_namespace: cellular_component
has_related_synonym: vacuolar carboxypeptidase Y
id: GO:0005773
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: vacuole
annotated property: definition
annotated target: A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0198506732

peroxisome
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: has part
  some values from: membrane
definition: A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
has_alternative_id: GO:0019818
has_broad_synonym: peroxisome vesicle
database_cross_reference: NIF_Subcellular:sao499555322
database_cross_reference: Wikipedia:Peroxisome
has_obo_namespace: cellular_component
has_related_synonym: peroxisomal
id: GO:0005777
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: peroxisome
annotated property: definition
annotated target: A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
database_cross_reference: GOC:pm
database_cross_reference: PMID:9302272
database_cross_reference: UniProtKB-KW:KW-0576

endoplasmic reticulum
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: part of
  some values from: endomembrane system
subclass of: Restriction
  on property: has part
  some values from: membrane
definition: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: NIF_Subcellular:sao1036339110
database_cross_reference: Wikipedia:Endoplasmic_reticulum
has_exact_synonym: ER
has_obo_namespace: cellular_component
id: GO:0005783
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: endoplasmic reticulum
annotated property: definition
annotated target: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: ISBN:0198506732

Golgi apparatus
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: part of
  some values from: endomembrane system
subclass of: Restriction
  on property: has part
  some values from: membrane
definition: A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
term tracker item: https://github.com/geneontology/go-ontology/issues/14798
has_broad_synonym: Golgi
database_cross_reference: NIF_Subcellular:sao451912436
database_cross_reference: Wikipedia:Golgi_apparatus
has_exact_synonym: Golgi complex
has_narrow_synonym: Golgi ribbon
has_obo_namespace: cellular_component
id: GO:0005794
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.

Axiom
annotated source: Golgi apparatus
annotated property: definition
annotated target: A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:9695800

microtubule organizing center
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cytoskeleton
definition: An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
database_cross_reference: Wikipedia:Microtubule_organizing_center
has_exact_synonym: MTOC
has_exact_synonym: microtubule organising centre
has_obo_namespace: cellular_component
id: GO:0005815
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim yeast

Axiom
annotated source: microtubule organizing center
annotated property: definition
annotated target: An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
database_cross_reference: GOC:vw
database_cross_reference: ISBN:0815316194
database_cross_reference: PMID:17072892
database_cross_reference: PMID:17245416
database_cross_reference: Wikipedia:Microtubule_organizing_center

ribosome
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cellular_component
definition: An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
term tracker item: https://github.com/geneontology/go-ontology/issues/17777
has_alternative_id: GO:0033279
database_cross_reference: NIF_Subcellular:sao1429207766
database_cross_reference: Wikipedia:Ribosome
has_narrow_synonym: free ribosome
has_narrow_synonym: membrane bound ribosome
has_obo_namespace: cellular_component
has_related_synonym: ribosomal RNA
id: GO:0005840
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: ribosome
annotated property: definition
annotated target: An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
database_cross_reference: ISBN:0198506732

Axiom
annotated source: ribosome
annotated property: has_narrow_synonym
annotated target: free ribosome
database_cross_reference: NIF_Subcellular:sao1139385046

Axiom
annotated source: ribosome
annotated property: has_narrow_synonym
annotated target: membrane bound ribosome
database_cross_reference: NIF_Subcellular:sao1291545653

cytoskeleton
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cellular_component
definition: A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: Wikipedia:Cytoskeleton
has_obo_namespace: cellular_component
id: GO:0005856
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeleton
annotated property: definition
annotated target: A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: GOC:mah
database_cross_reference: PMID:16959967
database_cross_reference: PMID:27419875

plasma membrane
type: Class
subclass of: membrane
subclass of: Restriction
  on property: part of
  some values from: cellular_component
definition: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
has_alternative_id: GO:0005887
has_alternative_id: GO:0005904
has_broad_synonym: juxtamembrane
database_cross_reference: NIF_Subcellular:sao1663586795
database_cross_reference: Wikipedia:Cell_membrane
has_exact_synonym: cell membrane
has_exact_synonym: cellular membrane
has_exact_synonym: cytoplasmic membrane
has_exact_synonym: plasmalemma
has_narrow_synonym: bacterial inner membrane
has_narrow_synonym: inner endospore membrane
has_narrow_synonym: integral component of plasma membrane
has_narrow_synonym: integral to plasma membrane
has_narrow_synonym: plasma membrane lipid bilayer
has_obo_namespace: cellular_component
id: GO:0005886
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: plasma membrane
annotated property: definition
annotated target: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
database_cross_reference: ISBN:0716731363

Axiom
annotated source: plasma membrane
annotated property: has_exact_synonym
annotated target: cellular membrane
database_cross_reference: NIF_Subcellular:sao6433132645

Axiom
annotated source: plasma membrane
annotated property: has_narrow_synonym
annotated target: plasma membrane lipid bilayer
database_cross_reference: GOC:mah

cellular bud
type: Class
subclass of: cellular_component
definition: A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated.
has_obo_namespace: cellular_component
id: GO:0005933
in_subset: goslim candida
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: cellular bud
annotated property: definition
annotated target: A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated.
database_cross_reference: GOC:sgd_curators

cell cortex
type: Class
subclass of: cytoplasm
definition: The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
term tracker item: https://github.com/geneontology/go-ontology/issues/26298
database_cross_reference: Wikipedia:Cell_cortex
has_narrow_synonym: ectoplasm
has_obo_namespace: cellular_component
has_related_synonym: cell periphery
has_related_synonym: peripheral cytoplasm
id: GO:0005938
in_subset: goslim candida
in_subset: goslim yeast

Axiom
annotated source: cell cortex
annotated property: definition
annotated target: The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194

carbohydrate metabolic process
type: Class
subclass of: biological_process
definition: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
term tracker item: https://github.com/geneontology/go-ontology/issues/22880
created by: jl
creation date: 2012-10-23T15:40:34Z
has_alternative_id: GO:0044261
has_alternative_id: GO:0044723
database_cross_reference: Wikipedia:Carbohydrate_metabolism
has_exact_synonym: carbohydrate metabolism
has_obo_namespace: biological_process
id: GO:0005975
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: carbohydrate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

generation of precursor metabolites and energy
type: Class
subclass of: biological_process
definition: The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
has_broad_synonym: energy pathways
has_obo_namespace: biological_process
has_related_synonym: intermediary metabolism
has_related_synonym: metabolic energy generation
id: GO:0006091
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: generation of precursor metabolites and energy
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
database_cross_reference: GOC:jl

Axiom
annotated source: generation of precursor metabolites and energy
annotated property: has_related_synonym
annotated target: intermediary metabolism
database_cross_reference: GOC:mah

DNA replication
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: has part
  some values from: biological_process
definition: The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
term tracker item: https://github.com/geneontology/go-ontology/issues/10596
has_alternative_id: GO:0055133
database_cross_reference: Reactome:R-HSA-176187
database_cross_reference: Reactome:R-HSA-69239
database_cross_reference: Wikipedia:DNA_replication
has_obo_namespace: biological_process
id: GO:0006260
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: DNA biosynthesis is only part of this process. See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'.

Axiom
annotated source: DNA replication
annotated property: definition
annotated target: The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
database_cross_reference: GOC:mah

Activation of ATR in response to replication stress
type: Axiom
annotated source: DNA replication
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-176187

Synthesis of DNA
type: Axiom
annotated source: DNA replication
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-69239

DNA repair
type: Class
subclass of: DNA damage response
definition: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
database_cross_reference: Reactome:R-HSA-73894
database_cross_reference: Wikipedia:DNA_repair
has_obo_namespace: biological_process
id: GO:0006281
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: DNA repair
annotated property: definition
annotated target: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
database_cross_reference: PMID:11563486

DNA Repair
type: Axiom
annotated source: DNA repair
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-73894

DNA recombination
type: Class
subclass of: biological_process
definition: Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
has_obo_namespace: biological_process
id: GO:0006310
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: DNA recombination
annotated property: definition
annotated target: Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
database_cross_reference: ISBN:0198506732

chromatin organization
type: Class
subclass of: biological_process
definition: The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
term tracker item: https://github.com/geneontology/go-ontology/issues/22130
term tracker item: https://github.com/geneontology/go-ontology/issues/23549
has_alternative_id: GO:0006333
has_alternative_id: GO:0006336
has_alternative_id: GO:0016568
has_alternative_id: GO:0031497
has_alternative_id: GO:0034724
has_broad_synonym: chromatin maintenance
database_cross_reference: Reactome:R-HSA-4839726
has_exact_synonym: chromatin organisation
has_exact_synonym: establishment of chromatin architecture
has_exact_synonym: establishment or maintenance of chromatin architecture
has_narrow_synonym: DNA replication-independent chromatin assembly
has_narrow_synonym: DNA replication-independent chromatin organization
has_narrow_synonym: DNA replication-independent nucleosome organisation
has_narrow_synonym: DNA replication-independent nuclesome assembly
has_narrow_synonym: chromatin assembly
has_narrow_synonym: transcription-coupled nucleosome assembly
has_obo_namespace: biological_process
has_related_synonym: chromatin assembly or disassembly
has_related_synonym: chromatin assembly/disassembly
has_related_synonym: chromatin modification
id: GO:0006325
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: chromatin organization
annotated property: definition
annotated target: The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
database_cross_reference: PMID:20404130

Chromatin organization
type: Axiom
annotated source: chromatin organization
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-4839726

Axiom
annotated source: chromatin organization
annotated property: has_exact_synonym
annotated target: chromatin organisation
database_cross_reference: GOC:mah

Axiom
annotated source: chromatin organization
annotated property: has_exact_synonym
annotated target: establishment of chromatin architecture
database_cross_reference: GOC:mah

Axiom
annotated source: chromatin organization
annotated property: has_exact_synonym
annotated target: establishment or maintenance of chromatin architecture
database_cross_reference: GOC:mah

DNA-templated transcription initiation
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.
term tracker item: https://github.com/geneontology/go-ontology/issues/23386
has_alternative_id: GO:0001123
has_exact_synonym: DNA-dependent RNA polymerase complex assembly at promoter
has_exact_synonym: DNA-dependent transcription, initiation
has_exact_synonym: DNA-templated transcription, initiation
has_exact_synonym: initiation of DNA-dependent transcription
has_exact_synonym: initiation of transcription, DNA-dependent
has_narrow_synonym: transcription initiation from bacterial-type RNA polymerase promoter
has_obo_namespace: biological_process
has_related_synonym: transcription initiation factor activity
has_related_synonym: transcription initiation, DNA-dependent
id: GO:0006352
in_subset: goslim yeast
comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation.

Axiom
annotated source: DNA-templated transcription initiation
annotated property: definition
annotated target: The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.
database_cross_reference: GOC:jid
database_cross_reference: GOC:txnOH
database_cross_reference: PMID:18280161

Axiom
annotated source: DNA-templated transcription initiation
annotated property: has_exact_synonym
annotated target: DNA-dependent transcription, initiation
database_cross_reference: GOC:txnOH

Axiom
annotated source: DNA-templated transcription initiation
annotated property: has_exact_synonym
annotated target: initiation of DNA-dependent transcription
database_cross_reference: GOC:jh2

Axiom
annotated source: DNA-templated transcription initiation
annotated property: has_exact_synonym
annotated target: initiation of transcription, DNA-dependent
database_cross_reference: GOC:mah

Axiom
annotated source: DNA-templated transcription initiation
annotated property: has_related_synonym
annotated target: transcription initiation, DNA-dependent
database_cross_reference: GOC:jh2

DNA-templated transcription termination
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template.
term tracker item: https://github.com/geneontology/go-ontology/issues/23386
has_alternative_id: GO:0001125
has_broad_synonym: transcriptional complex disassembly
has_exact_synonym: DNA-dependent transcription, termination
has_exact_synonym: DNA-templated transcription, termination
has_exact_synonym: termination of DNA-dependent transcription
has_exact_synonym: termination of transcription, DNA-dependent
has_narrow_synonym: transcription termination from bacterial-type RNA polymerase promoter
has_obo_namespace: biological_process
has_related_synonym: transcription termination factor activity
has_related_synonym: transcription termination, DNA-dependent
id: GO:0006353
in_subset: goslim yeast

Axiom
annotated source: DNA-templated transcription termination
annotated property: definition
annotated target: The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template.
database_cross_reference: GOC:txnOH
database_cross_reference: PMID:15020047
database_cross_reference: PMID:18280161
database_cross_reference: PMID:30978344

Axiom
annotated source: DNA-templated transcription termination
annotated property: has_exact_synonym
annotated target: DNA-dependent transcription, termination
database_cross_reference: GOC:txnOH

Axiom
annotated source: DNA-templated transcription termination
annotated property: has_exact_synonym
annotated target: termination of DNA-dependent transcription
database_cross_reference: GOC:jh2

Axiom
annotated source: DNA-templated transcription termination
annotated property: has_exact_synonym
annotated target: termination of transcription, DNA-dependent
database_cross_reference: GOC:mah

Axiom
annotated source: DNA-templated transcription termination
annotated property: has_related_synonym
annotated target: transcription termination, DNA-dependent
database_cross_reference: GOC:jh2

DNA-templated transcription elongation
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.
term tracker item: https://github.com/geneontology/go-ontology/issues/23386
has_alternative_id: GO:0001124
has_broad_synonym: RNA elongation
has_exact_synonym: DNA-dependent transcription, elongation
has_exact_synonym: DNA-templated transcription, elongation
has_exact_synonym: transcription elongation, DNA-dependent
has_exact_synonym: transcriptional elongation, DNA-dependent
has_narrow_synonym: RNA elongation from bacterial-type RNA polymerase promoter
has_narrow_synonym: transcription elongation from bacterial-type RNA polymerase promoter
has_obo_namespace: biological_process
id: GO:0006354
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: DNA-templated transcription elongation
annotated property: definition
annotated target: The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.
database_cross_reference: GOC:mah
database_cross_reference: GOC:txnOH
database_cross_reference: PMID:15020047
database_cross_reference: PMID:18280161

Axiom
annotated source: DNA-templated transcription elongation
annotated property: has_exact_synonym
annotated target: DNA-dependent transcription, elongation
database_cross_reference: GOC:txnOH

Axiom
annotated source: DNA-templated transcription elongation
annotated property: has_exact_synonym
annotated target: transcription elongation, DNA-dependent
database_cross_reference: GOC:jh2

transcription by RNA polymerase I
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.
term tracker item: https://github.com/geneontology/go-ontology/issues/14854
database_cross_reference: Reactome:R-HSA-73864
has_exact_synonym: transcription from Pol I promoter
has_exact_synonym: transcription from RNA polymerase I promoter
has_obo_namespace: biological_process
has_related_synonym: RNA polymerase I transcription factor activity
id: GO:0006360
in_subset: goslim yeast

Axiom
annotated source: transcription by RNA polymerase I
annotated property: definition
annotated target: The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.
database_cross_reference: GOC:jl
database_cross_reference: GOC:txnOH

RNA Polymerase I Transcription
type: Axiom
annotated source: transcription by RNA polymerase I
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-73864

rRNA processing
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
has_alternative_id: GO:0006365
database_cross_reference: Reactome:R-HSA-72312
has_narrow_synonym: 35S primary transcript processing
has_obo_namespace: biological_process
id: GO:0006364
in_subset: goslim yeast

Axiom
annotated source: rRNA processing
annotated property: definition
annotated target: Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
database_cross_reference: GOC:curators

rRNA processing
type: Axiom
annotated source: rRNA processing
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-72312

transcription by RNA polymerase II
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
term tracker item: https://github.com/geneontology/go-ontology/issues/14854
has_alternative_id: GO:0032568
has_alternative_id: GO:0032569
database_cross_reference: Reactome:R-HSA-73857
has_exact_synonym: transcription from Pol II promoter
has_exact_synonym: transcription from RNA polymerase II promoter
has_obo_namespace: biological_process
has_related_synonym: RNA polymerase II transcription factor activity
has_related_synonym: gene-specific transcription from RNA polymerase II promoter
has_related_synonym: general transcription from RNA polymerase II promoter
has_related_synonym: specific transcription from RNA polymerase II promoter
id: GO:0006366
in_subset: goslim yeast

Axiom
annotated source: transcription by RNA polymerase II
annotated property: definition
annotated target: The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
database_cross_reference: GOC:jl
database_cross_reference: GOC:txnOH
database_cross_reference: ISBN:0321000382

RNA Polymerase II Transcription
type: Axiom
annotated source: transcription by RNA polymerase II
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-73857

Axiom
annotated source: transcription by RNA polymerase II
annotated property: has_related_synonym
annotated target: specific transcription from RNA polymerase II promoter
database_cross_reference: GOC:mah

transcription by RNA polymerase III
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
term tracker item: https://github.com/geneontology/go-ontology/issues/14854
term tracker item: https://github.com/geneontology/go-ontology/issues/9617
created by: krc
creation date: 2010-08-18T06:37:56Z
has_alternative_id: GO:0001009
has_alternative_id: GO:0001035
has_alternative_id: GO:0001041
database_cross_reference: Reactome:R-HSA-74158
has_exact_synonym: transcription from Pol III promoter
has_exact_synonym: transcription from RNA polymerase III promoter
has_narrow_synonym: U2 snRNA transcription (S. cerevisiae)
has_narrow_synonym: U6 snRNA transcription (mammalian)
has_narrow_synonym: transcription from RNA polymerase III type 2 promoter
has_narrow_synonym: transcription from RNA polymerase III type 3 promoter
has_narrow_synonym: transcription from a RNA polymerase III hybrid type promoter
has_obo_namespace: biological_process
has_related_synonym: RNA polymerase III transcription factor activity
id: GO:0006383
in_subset: goslim yeast

Axiom
annotated source: transcription by RNA polymerase III
annotated property: definition
annotated target: The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
database_cross_reference: GOC:jl
database_cross_reference: GOC:txnOH
database_cross_reference: PMID:12381659

RNA Polymerase III Transcription
type: Axiom
annotated source: transcription by RNA polymerase III
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-74158

mRNA processing
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
has_obo_namespace: biological_process
has_related_synonym: mRNA maturation
id: GO:0006397
in_subset: goslim chembl
in_subset: goslim yeast

Axiom
annotated source: mRNA processing
annotated property: definition
annotated target: Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
database_cross_reference: GOC:mah

RNA catabolic process
type: Class
subclass of: biological_process
definition: The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
database_cross_reference: Reactome:R-HSA-9930044
has_exact_synonym: RNA breakdown
has_exact_synonym: RNA catabolism
has_exact_synonym: RNA degradation
has_obo_namespace: biological_process
id: GO:0006401
in_subset: goslim yeast

Axiom
annotated source: RNA catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
database_cross_reference: ISBN:0198506732

Nuclear RNA decay
type: Axiom
annotated source: RNA catabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9930044

translational initiation
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
subclass of: Restriction
  on property: has part
  some values from: biological_process
definition: The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
has_alternative_id: GO:0006440
has_alternative_id: GO:0006454
has_broad_synonym: biopolymerisation
has_broad_synonym: biopolymerization
has_broad_synonym: protein synthesis initiation
database_cross_reference: Reactome:R-HSA-72613
has_exact_synonym: translation initiation
has_obo_namespace: biological_process
id: GO:0006413
in_subset: goslim yeast

Axiom
annotated source: translational initiation
annotated property: definition
annotated target: The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
database_cross_reference: ISBN:019879276X

Eukaryotic Translation Initiation
type: Axiom
annotated source: translational initiation
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-72613

translational elongation
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.
has_alternative_id: GO:0006442
has_alternative_id: GO:0006455
has_broad_synonym: protein synthesis elongation
database_cross_reference: Reactome:R-HSA-156842
has_exact_synonym: translation elongation
has_obo_namespace: biological_process
id: GO:0006414
in_subset: goslim yeast

Axiom
annotated source: translational elongation
annotated property: definition
annotated target: The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.
database_cross_reference: GOC:ems

Eukaryotic Translation Elongation
type: Axiom
annotated source: translational elongation
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-156842

regulation of translation
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: regulates
  some values from: biological_process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
has_alternative_id: GO:0006445
has_exact_synonym: regulation of protein anabolism
has_exact_synonym: regulation of protein biosynthesis
has_exact_synonym: regulation of protein formation
has_exact_synonym: regulation of protein synthesis
has_obo_namespace: biological_process
id: GO:0006417
in_subset: goslim yeast

Axiom
annotated source: regulation of translation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
database_cross_reference: GOC:isa_complete

tRNA aminoacylation for protein translation
type: Class
subclass of: amino acid metabolic process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis.
database_cross_reference: MetaCyc:TRNA-CHARGING-PWY
database_cross_reference: Reactome:R-HSA-379724
has_narrow_synonym: tRNA charging
has_obo_namespace: biological_process
id: GO:0006418
in_subset: goslim yeast

Axiom
annotated source: tRNA aminoacylation for protein translation
annotated property: definition
annotated target: The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis.
database_cross_reference: GOC:ma

tRNA Aminoacylation
type: Axiom
annotated source: tRNA aminoacylation for protein translation
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-379724

protein folding
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: protein maturation
definition: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
term tracker item: https://github.com/geneontology/go-ontology/issues/25673
has_alternative_id: GO:0007022
has_alternative_id: GO:0007024
has_alternative_id: GO:0007025
database_cross_reference: Reactome:R-HSA-389960
database_cross_reference: Reactome:R-HSA-390450
database_cross_reference: Reactome:R-HSA-390466
database_cross_reference: Reactome:R-HSA-532668
database_cross_reference: Wikipedia:Protein_folding
has_narrow_synonym: alpha-tubulin folding
has_narrow_synonym: beta-tubulin folding
has_narrow_synonym: chaperonin-mediated tubulin folding
has_obo_namespace: biological_process
has_related_synonym: chaperone activity
has_related_synonym: chaperonin ATPase activity
has_related_synonym: co-chaperone activity
has_related_synonym: co-chaperonin activity
has_related_synonym: glycoprotein-specific chaperone activity
has_related_synonym: non-chaperonin molecular chaperone ATPase activity
has_related_synonym: protein complex assembly, multichaperone pathway
id: GO:0006457
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: protein folding
annotated property: definition
annotated target: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
database_cross_reference: GOC:curators
database_cross_reference: GOC:rb

Formation of tubulin folding intermediates by CCT/TriC
type: Axiom
annotated source: protein folding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-389960

Folding of actin by CCT/TriC
type: Axiom
annotated source: protein folding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390450

Chaperonin-mediated protein folding
type: Axiom
annotated source: protein folding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390466

N-glycan trimming in the ER and Calnexin/Calreticulin cycle
type: Axiom
annotated source: protein folding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-532668

Axiom
annotated source: protein folding
annotated property: has_narrow_synonym
annotated target: alpha-tubulin folding
database_cross_reference: GOC:mah

Axiom
annotated source: protein folding
annotated property: has_narrow_synonym
annotated target: beta-tubulin folding
database_cross_reference: GOC:mah

Axiom
annotated source: protein folding
annotated property: has_narrow_synonym
annotated target: chaperonin-mediated tubulin folding
database_cross_reference: GOC:mah

amino acid metabolic process
type: Class
subclass of: biological_process
definition: The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
term tracker item: https://github.com/geneontology/go-ontology/issues/17904
has_alternative_id: GO:0006519
has_exact_synonym: cellular amino acid metabolic process
has_exact_synonym: cellular amino acid metabolism
has_obo_namespace: biological_process
has_related_synonym: amino acid and derivative metabolism
has_related_synonym: cellular amino acid and derivative metabolic process
id: GO:0006520
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: amino acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
database_cross_reference: ISBN:0198506732

protein targeting
type: Class
subclass of: biological_process
definition: The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
term tracker item: https://github.com/geneontology/go-ontology/issues/26248
database_cross_reference: Wikipedia:Protein_targeting
has_narrow_synonym: protein sorting along secretory pathway
has_obo_namespace: biological_process
has_related_synonym: nascent polypeptide association
id: GO:0006605
in_subset: goslim chembl
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: protein targeting
annotated property: definition
annotated target: The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
database_cross_reference: GOC:ma

lipid metabolic process
type: Class
subclass of: biological_process
definition: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
database_cross_reference: Reactome:R-HSA-556833
database_cross_reference: Wikipedia:Lipid_metabolism
has_exact_synonym: lipid metabolism
has_obo_namespace: biological_process
id: GO:0006629
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: lipid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
database_cross_reference: GOC:ma

Metabolism of lipids
type: Axiom
annotated source: lipid metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-556833

vitamin metabolic process
type: Class
subclass of: biological_process
definition: The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
database_cross_reference: Reactome:R-HSA-211916
has_exact_synonym: vitamin metabolism
has_obo_namespace: biological_process
id: GO:0006766
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: vitamin metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
database_cross_reference: GOC:ai

Vitamins
type: Axiom
annotated source: vitamin metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-211916

monoatomic ion transport
type: Class
subclass of: biological_process
definition: The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
has_broad_synonym: ion transport
has_obo_namespace: biological_process
id: GO:0006811
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: monoatomic ion transport
annotated property: definition
annotated target: The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
database_cross_reference: GOC:ai

amino acid transport
type: Class
subclass of: biological_process
definition: The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_alternative_id: GO:0006866
database_cross_reference: Reactome:R-HSA-9958863
has_obo_namespace: biological_process
id: GO:0006865
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: amino acid transport
annotated property: definition
annotated target: The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai

SLC-mediated transport of amino acids
type: Axiom
annotated source: amino acid transport
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9958863

lipid transport
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
database_cross_reference: Reactome:R-HSA-1369062
has_obo_namespace: biological_process
id: GO:0006869
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: lipid transport
annotated property: definition
annotated target: The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
database_cross_reference: ISBN:0198506732

ABC transporters in lipid homeostasis
type: Axiom
annotated source: lipid transport
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1369062

intracellular monoatomic ion homeostasis
type: Class
subclass of: biological_process
definition: A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
term tracker item: https://github.com/geneontology/go-ontology/issues/24455
has_broad_synonym: cellular ion homeostasis
has_exact_synonym: cellular monoatomic ion homeostasis
has_obo_namespace: biological_process
id: GO:0006873
in_subset: goslim yeast

Axiom
annotated source: intracellular monoatomic ion homeostasis
annotated property: definition
annotated target: A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
database_cross_reference: GOC:mah

exocytosis
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: has part
  some values from: vesicle organization
subclass of: Restriction
  on property: has part
  some values from: organelle fusion
subclass of: Restriction
  on property: has part
  some values from: membrane fusion
definition: A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
has_alternative_id: GO:0016194
has_alternative_id: GO:0016195
database_cross_reference: Wikipedia:Exocytosis
has_exact_synonym: vesicle exocytosis
has_obo_namespace: biological_process
has_related_synonym: nonselective vesicle exocytosis
id: GO:0006887
in_subset: goslim yeast

Axiom
annotated source: exocytosis
annotated property: definition
annotated target: A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0716731363
database_cross_reference: PMID:22323285

endocytosis
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: has part
  some values from: vesicle organization
definition: A cellular process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle.
term tracker item: https://github.com/geneontology/go-ontology/issues/24907
term tracker item: https://github.com/geneontology/go-ontology/issues/25268
term tracker item: https://github.com/geneontology/go-ontology/issues/30667
has_alternative_id: GO:0016193
has_alternative_id: GO:0016196
has_alternative_id: GO:0098701
database_cross_reference: Wikipedia:Endocytosis
has_exact_synonym: endocytic import into cell
has_exact_synonym: vesicle endocytosis
has_narrow_synonym: plasma membrane invagination
has_obo_namespace: biological_process
has_related_synonym: nonselective vesicle endocytosis
id: GO:0006897
in_subset: goslim yeast

Axiom
annotated source: endocytosis
annotated property: definition
annotated target: A cellular process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732
database_cross_reference: ISBN:0716731363
database_cross_reference: Wikipedia:Endocytosis

response to osmotic stress
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
has_exact_synonym: osmotic response
has_exact_synonym: osmotic stress response
has_obo_namespace: biological_process
id: GO:0006970
in_subset: goslim yeast

Axiom
annotated source: response to osmotic stress
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
database_cross_reference: GOC:jl

DNA damage response
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
term tracker item: https://github.com/geneontology/go-ontology/issues/24775
has_alternative_id: GO:0034984
has_broad_synonym: response to DNA damage stimulus
has_exact_synonym: cellular DNA damage response
has_exact_synonym: cellular response to DNA damage stimulus
has_exact_synonym: response to genotoxic stress
has_obo_namespace: biological_process
id: GO:0006974
in_subset: goslim yeast

Axiom
annotated source: DNA damage response
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
database_cross_reference: GOC:curators

response to oxidative stress
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
has_obo_namespace: biological_process
id: GO:0006979
in_subset: goslim yeast

Axiom
annotated source: response to oxidative stress
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
database_cross_reference: GOC:jl
database_cross_reference: PMID:12115731

nucleus organization
type: Class
subclass of: biological_process
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
has_alternative_id: GO:0048287
has_exact_synonym: nuclear organisation
has_exact_synonym: nuclear organization
has_obo_namespace: biological_process
has_related_synonym: nuclear morphology
has_related_synonym: nuclear organization and biogenesis
has_related_synonym: nucleus organization and biogenesis
id: GO:0006997
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: nucleus organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
database_cross_reference: GOC:dph
database_cross_reference: GOC:ems
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: nucleus organization
annotated property: has_related_synonym
annotated target: nuclear organization and biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: nucleus organization
annotated property: has_related_synonym
annotated target: nucleus organization and biogenesis
database_cross_reference: GOC:mah

mitochondrion organization
type: Class
subclass of: biological_process
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
database_cross_reference: Reactome:R-HSA-1592230
has_exact_synonym: mitochondria organization
has_exact_synonym: mitochondrial biogenesis
has_exact_synonym: mitochondrial organization
has_exact_synonym: mitochondrion biogenesis
has_exact_synonym: mitochondrion organisation
has_obo_namespace: biological_process
has_related_synonym: mitochondrion morphogenesis
has_related_synonym: mitochondrion organization and biogenesis
id: GO:0007005
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: mitochondrion organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: GOC:sgd_curators
database_cross_reference: PMID:9786946

Mitochondrial biogenesis
type: Axiom
annotated source: mitochondrion organization
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1592230

Axiom
annotated source: mitochondrion organization
annotated property: has_exact_synonym
annotated target: mitochondria organization
database_cross_reference: GOC:mah

Axiom
annotated source: mitochondrion organization
annotated property: has_exact_synonym
annotated target: mitochondrion organisation
database_cross_reference: GOC:mah

cytoskeleton organization
type: Class
subclass of: biological_process
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
has_exact_synonym: cytoskeleton organisation
has_obo_namespace: biological_process
has_related_synonym: cytoskeletal organization and biogenesis
has_related_synonym: cytoskeletal regulator activity
has_related_synonym: cytoskeleton organization and biogenesis
id: GO:0007010
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeleton organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: cytoskeleton organization
annotated property: has_related_synonym
annotated target: cytoskeletal organization and biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cytoskeleton organization
annotated property: has_related_synonym
annotated target: cytoskeleton organization and biogenesis
database_cross_reference: GOC:mah

peroxisome organization
type: Class
subclass of: biological_process
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
has_exact_synonym: peroxisome organisation
has_obo_namespace: biological_process
has_related_synonym: peroxisome organization and biogenesis
id: GO:0007031
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: peroxisome organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
database_cross_reference: GOC:mah

Axiom
annotated source: peroxisome organization
annotated property: has_related_synonym
annotated target: peroxisome organization and biogenesis
database_cross_reference: GOC:mah

vacuole organization
type: Class
subclass of: biological_process
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.
has_alternative_id: GO:0044086
has_exact_synonym: vacuole organisation
has_narrow_synonym: vacuolar assembly
has_obo_namespace: biological_process
has_related_synonym: vacuole biogenesis
has_related_synonym: vacuole organization and biogenesis
id: GO:0007033
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: vacuole organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.
database_cross_reference: GOC:mah

Axiom
annotated source: vacuole organization
annotated property: has_narrow_synonym
annotated target: vacuolar assembly
database_cross_reference: GOC:mah

Axiom
annotated source: vacuole organization
annotated property: has_related_synonym
annotated target: vacuole biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: vacuole organization
annotated property: has_related_synonym
annotated target: vacuole organization and biogenesis
database_cross_reference: GOC:mah

chromosome segregation
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
database_cross_reference: Wikipedia:Chromosome_segregation
has_exact_synonym: chromosome division
has_obo_namespace: biological_process
has_related_synonym: chromosome transmission
id: GO:0007059
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: chromosome segregation
annotated property: definition
annotated target: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: GOC:vw

cell budding
type: Class
subclass of: biological_process
definition: A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell.
has_broad_synonym: budding
has_obo_namespace: biological_process
id: GO:0007114
in_subset: goslim candida
in_subset: goslim yeast

Axiom
annotated source: cell budding
annotated property: definition
annotated target: A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell.
database_cross_reference: ISBN:0198506732

pseudohyphal growth
type: Class
subclass of: biological_process
definition: The process in which cells grow as a chain of physically attached, elongated cells in response to an environmental stimulus or stimuli.
has_obo_namespace: biological_process
id: GO:0007124
in_subset: goslim candida
in_subset: goslim yeast

Axiom
annotated source: pseudohyphal growth
annotated property: definition
annotated target: The process in which cells grow as a chain of physically attached, elongated cells in response to an environmental stimulus or stimuli.
database_cross_reference: GOC:krc
database_cross_reference: PMID:11104818
database_cross_reference: PMID:19347739
database_cross_reference: PMID:24710476

tRNA processing
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
database_cross_reference: Reactome:R-HSA-72306
has_exact_synonym: tRNA maturation
has_obo_namespace: biological_process
id: GO:0008033
in_subset: goslim yeast

Axiom
annotated source: tRNA processing
annotated property: definition
annotated target: The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
database_cross_reference: GOC:jl
database_cross_reference: PMID:12533506

tRNA processing
type: Axiom
annotated source: tRNA processing
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-72306

Axiom
annotated source: tRNA processing
annotated property: has_exact_synonym
annotated target: tRNA maturation
database_cross_reference: GOC:vw

cytoskeletal protein binding
type: Class
subclass of: molecular_function
definition: Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
has_obo_namespace: molecular_function
id: GO:0008092
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeletal protein binding
annotated property: definition
annotated target: Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
database_cross_reference: GOC:mah

transcription factor binding
type: Class
subclass of: molecular_function
definition: Binding to a transcription factor, a protein required to initiate or regulate transcription.
term tracker item: https://github.com/geneontology/go-ontology/issues/19354
has_exact_synonym: TF binding
has_obo_namespace: molecular_function
has_related_synonym: transcription regulator binding
id: GO:0008134
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim yeast
comment: Note that this term should not be used for direct annotation. Please consider one of the more specific descendants, GO:0140297 ; DNA-binding transcription factor binding, GO:0140296 ; general transcription initiation factor binding or GO:0001221 ; transcription coregulator binding.

Axiom
annotated source: transcription factor binding
annotated property: definition
annotated target: Binding to a transcription factor, a protein required to initiate or regulate transcription.
database_cross_reference: ISBN:0198506732

translation factor activity, RNA binding
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: part of
  some values from: biological_process
subclass of: Restriction
  on property: has part
  some values from: RNA binding
definition: Functions during translation by binding to RNA during polypeptide synthesis at the ribosome.
has_broad_synonym: translation factor activity, nucleic acid binding
has_obo_namespace: molecular_function
id: GO:0008135
in_subset: goslim chembl
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: translation factor activity, RNA binding
annotated property: definition
annotated target: Functions during translation by binding to RNA during polypeptide synthesis at the ribosome.
database_cross_reference: GOC:ai
database_cross_reference: GOC:vw

Axiom
annotated source: translation factor activity, RNA binding
annotated property: has_broad_synonym
annotated target: translation factor activity, nucleic acid binding
database_cross_reference: GOC:mah

biological_process
type: Class
definition: A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
term tracker item: https://github.com/geneontology/go-ontology/issues/24968
created by: jl
creation date: 2012-09-19T15:05:24Z
has_alternative_id: GO:0000004
has_alternative_id: GO:0007582
has_alternative_id: GO:0044699
database_cross_reference: Wikipedia:Biological_process
has_exact_synonym: biological process
has_exact_synonym: physiological process
has_obo_namespace: biological_process
has_related_synonym: single organism process
has_related_synonym: single-organism process
id: GO:0008150
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim pombe
in_subset: goslim yeast
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.

Axiom
annotated source: biological_process
annotated property: definition
annotated target: A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
database_cross_reference: GOC:pdt

methyltransferase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of a methyl group to an acceptor molecule.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0004480
has_broad_synonym: methylase
database_cross_reference: EC:2.1.1.-
database_cross_reference: Reactome:R-HSA-212269
database_cross_reference: Reactome:R-HSA-379387
database_cross_reference: Reactome:R-HSA-379464
database_cross_reference: Reactome:R-HSA-5333608
database_cross_reference: Reactome:R-HSA-6800149
database_cross_reference: Reactome:R-HSA-71286
database_cross_reference: Reactome:R-HSA-9710490
has_obo_namespace: molecular_function
id: GO:0008168
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: methyltransferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a methyl group to an acceptor molecule.
database_cross_reference: ISBN:0198506732

DNMT1,3A,3B:PRC2 methylates cytosine and histone H3
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-212269

COMT transfers Met to DA to form 3MT
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-379387

COMT transfers Met to DOPAC to form HVA
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-379464

GSSebGalNac is reduced and methylated to MeSebGalNac
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5333608

N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6800149

guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-71286

The GSDME gene promoter is hypermethylated
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9710490

peptidase activity
type: Class
subclass of: hydrolase activity
definition: Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0070010
has_alternative_id: GO:0070011
database_cross_reference: EC:3.4.-.-
database_cross_reference: Reactome:R-HSA-205112
database_cross_reference: Reactome:R-HSA-3000243
database_cross_reference: Reactome:R-HSA-3000263
database_cross_reference: Reactome:R-HSA-3065958
database_cross_reference: Reactome:R-HSA-3065959
database_cross_reference: Reactome:R-HSA-3139027
database_cross_reference: Reactome:R-HSA-376149
database_cross_reference: Reactome:R-HSA-4167501
database_cross_reference: Reactome:R-HSA-448678
database_cross_reference: Reactome:R-HSA-5655483
database_cross_reference: Reactome:R-HSA-5684864
database_cross_reference: Reactome:R-HSA-5685902
database_cross_reference: Reactome:R-HSA-6803060
database_cross_reference: Reactome:R-HSA-9935547
has_exact_synonym: hydrolase, acting on peptide bonds
has_exact_synonym: peptide hydrolase activity
has_exact_synonym: protease activity
has_narrow_synonym: peptidase activity, acting on D-amino acid peptides
has_narrow_synonym: peptidase activity, acting on L-amino acid peptides
has_narrow_synonym: proteinase activity
has_obo_namespace: molecular_function
id: GO:0008233
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: peptidase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
database_cross_reference: EC:3.4.-.-
database_cross_reference: GOC:jl

gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-205112

Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3000243

TCN2:RCbl is degraded to release RCbl
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3000263

An unknown protease degrades ACACA
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3065958

An unknown protease degrades hCBXs
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3065959

Maturation of HIV Virion
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3139027

Proteolytic processing of SLIT
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-376149

An unknown protease degrades ACACB
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-4167501

CTSG cleaves CASP1(1-404)
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-448678

USP1 autocleavage
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655483

NAPSA, CTSH, PGA3-5 cleave pro-SFTPB
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5684864

NAPSA, CTSH, PGA3-5 cleave pro-SFTPC
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5685902

DCD(63-110) is processed to DCD(63-109)
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6803060

Lysosomal degradation of ubiquitinated CDH1
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9935547

lipid binding
type: Class
subclass of: molecular_function
definition: Binding to a lipid.
has_obo_namespace: molecular_function
id: GO:0008289
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: lipid binding
annotated property: definition
annotated target: Binding to a lipid.
database_cross_reference: GOC:ai

RNA splicing
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
has_alternative_id: GO:0006395
database_cross_reference: Reactome:R-HSA-72172
database_cross_reference: Wikipedia:RNA_splicing
has_obo_namespace: biological_process
has_related_synonym: pre-mRNA splicing factor activity
id: GO:0008380
in_subset: goslim yeast

Axiom
annotated source: RNA splicing
annotated property: definition
annotated target: The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
database_cross_reference: GOC:krc
database_cross_reference: GOC:mah

mRNA Splicing
type: Axiom
annotated source: RNA splicing
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-72172

carbohydrate transport
type: Class
subclass of: biological_process
definition: The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.
has_alternative_id: GO:0006861
has_alternative_id: GO:0008644
has_narrow_synonym: sugar transport
has_obo_namespace: biological_process
id: GO:0008643
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: carbohydrate transport
annotated property: definition
annotated target: The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.
database_cross_reference: GOC:ai

glycoprotein biosynthetic process
type: Class
subclass of: biological_process
definition: The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
has_exact_synonym: glycoprotein anabolism
has_exact_synonym: glycoprotein biosynthesis
has_exact_synonym: glycoprotein formation
has_exact_synonym: glycoprotein synthesis
has_obo_namespace: biological_process
id: GO:0009101
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: glycoprotein biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
database_cross_reference: PMID:35536965

oligosaccharide metabolic process
type: Class
subclass of: carbohydrate metabolic process
definition: The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.
has_alternative_id: GO:0051690
has_exact_synonym: oligosaccharide metabolism
has_narrow_synonym: multicellular organismal oligosaccharide metabolic process
has_obo_namespace: biological_process
id: GO:0009311
in_subset: goslim yeast

Axiom
annotated source: oligosaccharide metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.
database_cross_reference: ISBN:0198506732

response to heat
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
has_alternative_id: GO:0006951
has_narrow_synonym: response to heat shock
has_obo_namespace: biological_process
id: GO:0009408
in_subset: goslim yeast

Axiom
annotated source: response to heat
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
database_cross_reference: GOC:lr

RNA modification
type: Class
subclass of: biological_process
definition: The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically.
has_alternative_id: GO:0016547
database_cross_reference: Wikipedia:RNA_editing
has_narrow_synonym: RNA editing
has_obo_namespace: biological_process
id: GO:0009451
in_subset: goslim yeast
comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing.

Axiom
annotated source: RNA modification
annotated property: definition
annotated target: The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically.
database_cross_reference: GOC:curators
database_cross_reference: ISBN:1555811337

Axiom
annotated source: RNA modification
annotated property: has_narrow_synonym
annotated target: RNA editing
database_cross_reference: GOC:hjd

endomembrane system
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: has part
  some values from: vacuole
subclass of: Restriction
  on property: has part
  some values from: plasma membrane
definition: A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
database_cross_reference: Wikipedia:Endomembrane_system
has_obo_namespace: cellular_component
id: GO:0012505
in_subset: goslim candida
in_subset: goslim flybase ribbon
in_subset: goslim yeast

Axiom
annotated source: endomembrane system
annotated property: definition
annotated target: A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
database_cross_reference: GOC:lh

protein transport
type: Class
subclass of: biological_process
definition: The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_alternative_id: GO:0015831
has_narrow_synonym: enzyme transport
has_obo_namespace: biological_process
id: GO:0015031
in_subset: goslim chembl
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: protein transport
annotated property: definition
annotated target: The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai

nucleobase-containing compound transport
type: Class
subclass of: biological_process
definition: The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
has_related_synonym: nucleobase, nucleoside, nucleotide and nucleic acid transport
id: GO:0015931
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: nucleobase-containing compound transport
annotated property: definition
annotated target: The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai

Axiom
annotated source: nucleobase-containing compound transport
annotated property: has_related_synonym
annotated target: nucleobase, nucleoside, nucleotide and nucleic acid transport
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

membrane
type: Class
subclass of: cellular_component
definition: A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
creation date: 2014-03-06T11:37:54Z
has_alternative_id: GO:0016021
has_alternative_id: GO:0098589
has_alternative_id: GO:0098805
database_cross_reference: Wikipedia:Biological_membrane
database_cross_reference: Wikipedia:Transmembrane_protein
has_narrow_synonym: integral component of membrane
has_narrow_synonym: integral to membrane
has_narrow_synonym: membrane region
has_narrow_synonym: region of membrane
has_narrow_synonym: whole membrane
has_obo_namespace: cellular_component
has_related_synonym: transmembrane
id: GO:0016020
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: membrane
annotated property: definition
annotated target: A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
database_cross_reference: GOC:dos
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194

Axiom
annotated source: membrane
annotated property: has_related_synonym
annotated target: transmembrane
database_cross_reference: GOC:mah

vesicle organization
type: Class
subclass of: biological_process
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.
has_exact_synonym: vesicle organisation
has_obo_namespace: biological_process
has_related_synonym: vesicle organization and biogenesis
id: GO:0016050
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: vesicle organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.
database_cross_reference: GOC:mah

Axiom
annotated source: vesicle organization
annotated property: has_related_synonym
annotated target: vesicle organization and biogenesis
database_cross_reference: GOC:mah

endosomal transport
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
subclass of: Restriction
  on property: occurs in
  some values from: cellular_component
definition: The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
has_alternative_id: GO:0032439
database_cross_reference: Reactome:R-HSA-917729
has_exact_synonym: endosome localisation
has_obo_namespace: biological_process
has_related_synonym: endosome localization
has_related_synonym: endosome transport
id: GO:0016197
in_subset: goslim yeast

Axiom
annotated source: endosomal transport
annotated property: definition
annotated target: The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
database_cross_reference: ISBN:0198506732

Endosomal Sorting Complex Required For Transport (ESCRT)
type: Axiom
annotated source: endosomal transport
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-917729

Axiom
annotated source: endosomal transport
annotated property: has_exact_synonym
annotated target: endosome localisation
database_cross_reference: GOC:mah

Axiom
annotated source: endosomal transport
annotated property: has_related_synonym
annotated target: endosome transport
database_cross_reference: GOC:bf

kinase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
database_cross_reference: Reactome:R-HSA-6788855
database_cross_reference: Reactome:R-HSA-6788867
has_exact_synonym: phosphokinase activity
has_obo_namespace: molecular_function
id: GO:0016301
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term.

Axiom
annotated source: kinase activity
annotated property: definition
annotated target: Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
database_cross_reference: ISBN:0198506732

FN3KRP phosphorylates PsiAm, RibAm
type: Axiom
annotated source: kinase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788855

FN3K phosphorylates ketosamines
type: Axiom
annotated source: kinase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788867

oxidoreductase activity
type: Class
subclass of: molecular_function
definition: Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:1.-.-.-
database_cross_reference: Reactome:R-HSA-1614362
database_cross_reference: Reactome:R-HSA-2161612
database_cross_reference: Reactome:R-HSA-265296
database_cross_reference: Reactome:R-HSA-266051
database_cross_reference: Reactome:R-HSA-390425
database_cross_reference: Reactome:R-HSA-390438
database_cross_reference: Reactome:R-HSA-8936442
database_cross_reference: Reactome:R-HSA-9020249
database_cross_reference: Reactome:R-HSA-9020260
database_cross_reference: Reactome:R-HSA-9024624
database_cross_reference: Reactome:R-HSA-9024630
database_cross_reference: Reactome:R-HSA-9025007
database_cross_reference: Reactome:R-HSA-9026001
database_cross_reference: Reactome:R-HSA-9026917
database_cross_reference: Reactome:R-HSA-9027033
database_cross_reference: Reactome:R-HSA-9693722
database_cross_reference: Reactome:R-HSA-9759549
has_exact_synonym: redox activity
has_narrow_synonym: oxidoreductase activity, acting on other substrates
has_obo_namespace: molecular_function
id: GO:0016491
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: oxidoreductase activity
annotated property: definition
annotated target: Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
database_cross_reference: EC:1.-.-.-

SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1614362

PGH2 is reduced to PGF2a by FAM213B
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2161612

Arachidonate is oxidised to 5S-HpETE by ALOX5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-265296

5S-HpETE is dehydrated to LTA4 by ALOX5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-266051

FAR1 reduces PalmCoA to HXOL
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390425

FAR2 reduces PalmCoA to HXOL
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390438

MARC1,MARC2 reduce N-hydroxylated compounds
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8936442

Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020249

Hydroperoxy reductase reduces 7(S)-Hp-17(S)-HDHA to RvD5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020260

Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9024624

Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9024630

Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9025007

Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026001

Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026917

Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9027033

Unknown sepiapterin synthase transforms PTHP to sepiapterin
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9693722

Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9759549

transferase activity
type: Class
subclass of: molecular_function
definition: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:2.-.-.-
database_cross_reference: Reactome:R-HSA-1483089
database_cross_reference: Reactome:R-HSA-1483186
database_cross_reference: Reactome:R-HSA-5333607
database_cross_reference: Reactome:R-HSA-5668414
database_cross_reference: Reactome:R-HSA-8868783
has_obo_namespace: molecular_function
id: GO:0016740
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: transferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: EC:2.-.-.-

PE is converted to PS by PTDSS2
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483089

PC is converted to PS by PTDSS1
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483186

GSSeH combines with bGalNAc derivative to form GSSebGalNac
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5333607

TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5668414

TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8868783

glycosyltransferase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0016932
database_cross_reference: EC:2.4.-.-
database_cross_reference: Reactome:R-HSA-5173005
database_cross_reference: Reactome:R-HSA-6785565
has_exact_synonym: transferase activity, transferring glycosyl groups
has_exact_synonym: transglycosidase activity
has_exact_synonym: transglycosylase activity
has_narrow_synonym: transferase activity, transferring other glycosyl groups
has_obo_namespace: molecular_function
id: GO:0016757
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: glycosyltransferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

B3GALTL transfers glucose to O-fucosyl-proteins
type: Axiom
annotated source: glycosyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5173005

Defective B3GALTL does not transfer glucose to O-fucosyl-proteins
type: Axiom
annotated source: glycosyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6785565

nucleotidyltransferase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:2.7.7.-
database_cross_reference: Reactome:R-HSA-6782434
has_obo_namespace: molecular_function
id: GO:0016779
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim yeast

Axiom
annotated source: nucleotidyltransferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
database_cross_reference: EC:2.7.7.-

THG1L transfers GMP to 5' end of tRNA(His)
type: Axiom
annotated source: nucleotidyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6782434

hydrolase activity
type: Class
subclass of: molecular_function
definition: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.-.-.-
database_cross_reference: Reactome:R-HSA-1236938
database_cross_reference: Reactome:R-HSA-2029475
database_cross_reference: Reactome:R-HSA-5694583
database_cross_reference: Reactome:R-HSA-5695964
database_cross_reference: Reactome:R-HSA-6786190
database_cross_reference: Reactome:R-HSA-6788295
database_cross_reference: Reactome:R-HSA-8938314
database_cross_reference: Reactome:R-HSA-8952137
database_cross_reference: Reactome:R-HSA-9942295
has_obo_namespace: molecular_function
id: GO:0016787
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: hydrolase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
database_cross_reference: ISBN:0198506732

Partial proteolysis of antigen in phagolysosomes
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1236938

Production of AA by iPLA2 upon FCGR activation
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029475

ABHD4 hydrolyses NAPE
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694583

ABHD14B hydrolyses PNPB
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5695964

CMBL hydrolyses OM to OLMS
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6786190

HDHD1:Mg2+ dephosphorylates PURIDP
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788295

ENPPs hydrolyse CoA-SH to PPANT, PAP
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8938314

Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8952137

QNG1 hydrolyzes queuosine 5'-monophosphate yielding queuine and ribose 5'-monophosphate
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9942295

phosphatase activity
type: Class
subclass of: hydrolase activity
definition: Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.
term tracker item: https://github.com/geneontology/go-ontology/issues/25755
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0003869
has_alternative_id: GO:0016302
database_cross_reference: EC:3.1.3.-
database_cross_reference: Reactome:R-HSA-4419986
database_cross_reference: Reactome:R-HSA-9636457
database_cross_reference: Reactome:R-HSA-9837419
database_cross_reference: Reactome:R-HSA-9940993
has_exact_synonym: phosphoric monoester hydrolase activity
has_obo_namespace: molecular_function
has_related_synonym: phosphatase
id: GO:0016791
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim yeast

Axiom
annotated source: phosphatase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.
database_cross_reference: GOC:curators

Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL
type: Axiom
annotated source: phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-4419986

SapM dephosphorylates PI3P
type: Axiom
annotated source: phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9636457

PANK4 hydrolyzes PPANT to pantetheine
type: Axiom
annotated source: phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9837419

PXYLP1 dephosphorylates Xyl moiety
type: Axiom
annotated source: phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9940993

hydrolase activity, acting on glycosyl bonds
type: Class
subclass of: hydrolase activity
definition: Catalysis of the hydrolysis of any glycosyl bond.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.2.-.-
database_cross_reference: Reactome:R-HSA-1793176
database_cross_reference: Reactome:R-HSA-2065233
database_cross_reference: Reactome:R-HSA-5333609
has_exact_synonym: glycosidase activity
has_narrow_synonym: N-glycosylase
has_narrow_synonym: glycosylase
has_obo_namespace: molecular_function
id: GO:0016798
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: hydrolase activity, acting on glycosyl bonds
annotated property: definition
annotated target: Catalysis of the hydrolysis of any glycosyl bond.
database_cross_reference: GOC:jl

DS is cleaved from its proteoglycan
type: Axiom
annotated source: hydrolase activity, acting on glycosyl bonds
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1793176

CS is cleaved from its proteoglycan
type: Axiom
annotated source: hydrolase activity, acting on glycosyl bonds
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2065233

MeSebGalNac is hydrolysed to MeSeH and bGalNac
type: Axiom
annotated source: hydrolase activity, acting on glycosyl bonds
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5333609

lyase activity
type: Class
subclass of: molecular_function
definition: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:4.-.-.-
database_cross_reference: Reactome:R-HSA-5696408
database_cross_reference: Reactome:R-HSA-6782895
has_obo_namespace: molecular_function
id: GO:0016829
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: lyase activity
annotated property: definition
annotated target: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
database_cross_reference: EC:4.-.-.-

PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
type: Axiom
annotated source: lyase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5696408

TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)
type: Axiom
annotated source: lyase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6782895

isomerase activity
type: Class
subclass of: molecular_function
definition: Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:5.-.-.-
database_cross_reference: Reactome:R-HSA-2161666
database_cross_reference: Reactome:R-HSA-2161735
database_cross_reference: Reactome:R-HSA-6787623
has_narrow_synonym: other isomerase activity
has_obo_namespace: molecular_function
id: GO:0016853
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: isomerase activity
annotated property: definition
annotated target: Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
database_cross_reference: ISBN:0198506732

PGA2 is isomerised to PGC2
type: Axiom
annotated source: isomerase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2161666

PGC2 is isomerised to PGB2
type: Axiom
annotated source: isomerase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2161735

GFUS dimer epimerises GDP-DHDMan to GDP-KDGal
type: Axiom
annotated source: isomerase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6787623

ligase activity
type: Class
subclass of: molecular_function
definition: Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
term tracker item: https://github.com/geneontology/go-ontology/issues/19380
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:6.-.-.-
has_exact_synonym: synthetase activity
has_obo_namespace: molecular_function
id: GO:0016874
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: ligase activity
annotated property: definition
annotated target: Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
database_cross_reference: EC:6.-.-.-

Axiom
annotated source: ligase activity
annotated property: has_exact_synonym
annotated target: synthetase activity
database_cross_reference: GOC:jh2

rRNA binding
type: Class
subclass of: RNA binding
definition: Binding to a ribosomal RNA.
has_alternative_id: GO:0000944
has_narrow_synonym: base pairing with rRNA
has_obo_namespace: molecular_function
id: GO:0019843
in_subset: goslim chembl
in_subset: goslim yeast

Axiom
annotated source: rRNA binding
annotated property: definition
annotated target: Binding to a ribosomal RNA.
database_cross_reference: GOC:jl

enzyme binding
type: Class
subclass of: molecular_function
definition: Binding to an enzyme, a protein with catalytic activity.
has_obo_namespace: molecular_function
id: GO:0019899
in_subset: goslim chembl
in_subset: goslim yeast

Axiom
annotated source: enzyme binding
annotated property: definition
annotated target: Binding to an enzyme, a protein with catalytic activity.
database_cross_reference: GOC:jl

transmembrane transporter activity
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: part of
  some values from: transmembrane transport
definition: Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
has_alternative_id: GO:0005386
has_alternative_id: GO:0015563
has_alternative_id: GO:0015646
has_alternative_id: GO:0022891
has_alternative_id: GO:0022892
database_cross_reference: Reactome:R-HSA-1236947
database_cross_reference: Reactome:R-HSA-2142859
database_cross_reference: Reactome:R-HSA-2161500
database_cross_reference: Reactome:R-HSA-429036
database_cross_reference: Reactome:R-HSA-434650
database_cross_reference: Reactome:R-HSA-549129
database_cross_reference: Reactome:R-HSA-549279
database_cross_reference: Reactome:R-HSA-549304
database_cross_reference: Reactome:R-HSA-549322
database_cross_reference: Reactome:R-HSA-561041
database_cross_reference: Reactome:R-HSA-561054
database_cross_reference: Reactome:R-HSA-561072
database_cross_reference: Reactome:R-HSA-5638209
database_cross_reference: Reactome:R-HSA-5671707
database_cross_reference: Reactome:R-HSA-6784434
database_cross_reference: Reactome:R-HSA-6784436
database_cross_reference: Reactome:R-HSA-8954513
database_cross_reference: Reactome:R-HSA-9794270
database_cross_reference: Reactome:R-HSA-9794523
database_cross_reference: Reactome:R-HSA-9794830
database_cross_reference: Reactome:R-HSA-9795207
has_obo_namespace: molecular_function
has_related_synonym: substrate-specific transmembrane transporter activity
has_related_synonym: substrate-specific transporter activity
has_related_synonym: uptake permease activity
has_related_synonym: uptake transmembrane transporter activity
id: GO:0022857
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: transmembrane transporter activity
annotated property: definition
annotated target: Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
database_cross_reference: GOC:jid
database_cross_reference: GOC:mtg_transport
database_cross_reference: ISBN:0815340729

Egress of internalized antigen to the cytosol via sec61
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1236947

Growing HA is extruded from the cell by ABCC5
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2142859

abacavir [extracellular] => abacavir [cytosol]
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2161500

SLC2A9 transports Fru, Glc, urate
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-429036

MATEs mediate extrusion of xenobiotics
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-434650

OCT1 transports organic cations into hepatic cells
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-549129

OCT2 mediates tubular uptake of organic cations in the kidney
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-549279

OCT3 mediates renal clearance of organic cations
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-549304

OCT1 transports organic cations out of hepatic cells
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-549322

OAT1,2,3 transport organic anions with antiport of dicarboxylic acids
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-561041

OCT2 mediates tubular secretion of organic cations in the kidney
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-561054

OCT3 mediates renal uptake of organic cations
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-561072

Defective SLC2A9 does not transport Fru, Glc, urate
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5638209

Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5671707

An unknown carrier transports cytosolic glyoxylate to the peroxisome
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6784434

An unknown carrier transports mitochondrial glyoxylate to the cytosol
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6784436

NAASP translocates from mitochondrial matrix to cytosol
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8954513

SLCO1A2 transports Cipro(1+) into the cytosol
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9794270

SLC22A1 transports Cipro into renal cell
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9794523

SLC22A8 transports Cipro into renal cell
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9794830

SLC22A1 transports Cipro into hepatic cell
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9795207

signaling
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: regulates
  some values from: biological_process
definition: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
created by: jl
creation date: 2010-02-16T09:30:50Z
has_alternative_id: GO:0023046
has_alternative_id: GO:0044700
has_exact_synonym: biological signaling
has_exact_synonym: signaling process
has_exact_synonym: signalling
has_obo_namespace: biological_process
has_related_synonym: signalling process
has_related_synonym: single organism signaling
id: GO:0023052
in_subset: goslim agr
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.

Axiom
annotated source: signaling
annotated property: definition
annotated target: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
database_cross_reference: GOC:mtg_signal
database_cross_reference: GOC:mtg_signaling_feb11
database_cross_reference: GOC:signaling

Axiom
annotated source: signaling
annotated property: has_related_synonym
annotated target: signalling process
database_cross_reference: GOC:mah

protein catabolic process
type: Class
subclass of: biological_process
definition: The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
term tracker item: https://github.com/geneontology/go-ontology/issues/23112
has_alternative_id: GO:0044254
has_alternative_id: GO:0044257
database_cross_reference: Wikipedia:Protein_catabolism
has_exact_synonym: cellular protein breakdown
has_exact_synonym: cellular protein catabolic process
has_exact_synonym: cellular protein catabolism
has_exact_synonym: cellular protein degradation
has_exact_synonym: protein breakdown
has_exact_synonym: protein catabolism
has_exact_synonym: protein degradation
has_narrow_synonym: multicellular organismal protein catabolic process
has_obo_namespace: biological_process
has_related_synonym: pheromone catabolic process
has_related_synonym: pheromone catabolism
id: GO:0030163
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children.

Axiom
annotated source: protein catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
database_cross_reference: GOC:mah

enzyme regulator activity
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: has part
  some values from: molecular_function
subclass of: Restriction
  on property: regulates
  some values from: molecular_function
definition: A molecular function regulator that modulates a catalytic activity.
has_alternative_id: GO:0010576
has_exact_synonym: catalytic regulator activity
has_exact_synonym: enzyme modulator
has_narrow_synonym: metalloenzyme regulator activity
has_obo_namespace: molecular_function
id: GO:0030234
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: This term should only be used in cases when the regulator directly interacts with the enzyme, but does not result in a covalent modification.

Axiom
annotated source: enzyme regulator activity
annotated property: definition
annotated target: A molecular function regulator that modulates a catalytic activity.
database_cross_reference: GOC:pdt

Axiom
annotated source: enzyme regulator activity
annotated property: has_exact_synonym
annotated target: catalytic regulator activity
database_cross_reference: GOC:dph

site of polarized growth
type: Class
subclass of: cellular_component
definition: Any part of a cell where non-isotropic growth takes place.
has_alternative_id: GO:0000134
has_alternative_id: GO:0030483
has_obo_namespace: cellular_component
id: GO:0030427
in_subset: goslim candida
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: site of polarized growth
annotated property: definition
annotated target: Any part of a cell where non-isotropic growth takes place.
database_cross_reference: GOC:mah

triplet codon-amino acid adaptor activity
type: Class
subclass of: mRNA binding
subclass of: Restriction
  on property: part of
  some values from: biological_process
subclass of: Restriction
  on property: has part
  some values from: molecular_function
definition: The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis.
has_obo_namespace: molecular_function
has_related_synonym: tRNA
has_related_synonym: transfer RNA
id: GO:0030533
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim yeast
comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'.

Axiom
annotated source: triplet codon-amino acid adaptor activity
annotated property: definition
annotated target: The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis.
database_cross_reference: GOC:hjd
database_cross_reference: GOC:mtg_MIT_16mar07
database_cross_reference: ISBN:0198506732

RNA modification guide activity
type: Class
subclass of: RNA binding
definition: Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue.
has_obo_namespace: molecular_function
id: GO:0030555
in_subset: goslim yeast
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.

Axiom
annotated source: RNA modification guide activity
annotated property: definition
annotated target: Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue.
database_cross_reference: GOC:mah
database_cross_reference: PMID:12457565

protein-macromolecule adaptor activity
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: has part
  some values from: molecular_function
definition: An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
term tracker item: https://github.com/geneontology/go-ontology/issues/18655
term tracker item: https://github.com/geneontology/go-ontology/issues/19409
term tracker item: https://github.com/geneontology/go-ontology/issues/22925
term tracker item: https://github.com/geneontology/go-ontology/issues/31444
database_cross_reference: Reactome:R-HSA-3780997
database_cross_reference: Reactome:R-HSA-3781001
database_cross_reference: Reactome:R-HSA-3781021
database_cross_reference: Reactome:R-HSA-3781023
database_cross_reference: Reactome:R-HSA-8871366
database_cross_reference: Reactome:R-HSA-8871376
has_exact_synonym: protein binding, bridging
has_narrow_synonym: protein-protein adaptor
has_obo_namespace: molecular_function
has_related_synonym: protein recruiting activity
id: GO:0030674
in_subset: goslim chembl
in_subset: goslim yeast
comment: Note that protein complex scaffolds should use GO:0140378 protein complex scaffold activity.

Axiom
annotated source: protein-macromolecule adaptor activity
annotated property: definition
annotated target: An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
database_cross_reference: GOC:bf
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw

PPP1R3C binds to glycogen:GYG2:GYS2
type: Axiom
annotated source: protein-macromolecule adaptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3780997

EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex
type: Axiom
annotated source: protein-macromolecule adaptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3781001

EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex
type: Axiom
annotated source: protein-macromolecule adaptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3781021

PPP1R3C binds to glycogen:GYG1:GYS1
type: Axiom
annotated source: protein-macromolecule adaptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3781023

p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP
type: Axiom
annotated source: protein-macromolecule adaptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8871366

p-Y389,400-RUFY1 binds PI3P
type: Axiom
annotated source: protein-macromolecule adaptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8871376

cytoplasmic vesicle
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: has part
  some values from: membrane
definition: A vesicle found in the cytoplasm of a cell.
has_alternative_id: GO:0016023
database_cross_reference: NIF_Subcellular:sao180601769
has_obo_namespace: cellular_component
has_related_synonym: cytoplasmic membrane bounded vesicle
has_related_synonym: cytoplasmic membrane-enclosed vesicle
has_related_synonym: cytoplasmic, membrane-bounded vesicle
id: GO:0031410
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim yeast

Axiom
annotated source: cytoplasmic vesicle
annotated property: definition
annotated target: A vesicle found in the cytoplasm of a cell.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah
database_cross_reference: GOC:vesicles

ubiquitin-like protein binding
type: Class
subclass of: molecular_function
definition: Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein.
has_exact_synonym: small conjugating protein binding
has_obo_namespace: molecular_function
id: GO:0032182
in_subset: goslim chembl
in_subset: goslim yeast

Axiom
annotated source: ubiquitin-like protein binding
annotated property: definition
annotated target: Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein.
database_cross_reference: GOC:mah

Axiom
annotated source: ubiquitin-like protein binding
annotated property: has_exact_synonym
annotated target: small conjugating protein binding
database_cross_reference: GOC:dph

transposition
type: Class
subclass of: biological_process
definition: Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites. For elements that are transcribed as the first step of transposition, the process starts with the transcription of the transposable element, its translation and maturation, and ending with integration into DNA. For elements that are cut out, the process starts with the excision of the donor DNA and integrated into another site.
database_cross_reference: Wikipedia:Transposon
has_obo_namespace: biological_process
id: GO:0032196
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: transposition
annotated property: definition
annotated target: Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites. For elements that are transcribed as the first step of transposition, the process starts with the transcription of the transposable element, its translation and maturation, and ending with integration into DNA. For elements that are cut out, the process starts with the excision of the donor DNA and integrated into another site.
database_cross_reference: ISBN:1555812090
database_cross_reference: PMID:14682279
database_cross_reference: PMID:25893143

telomere organization
type: Class
subclass of: biological_process
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins.
has_exact_synonym: chromosome organization, telomeric
has_exact_synonym: organization of chromosome, telomeric region
has_exact_synonym: telomere organisation
has_obo_namespace: biological_process
has_related_synonym: telomere organization and biogenesis
id: GO:0032200
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: telomere organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: telomere organization
annotated property: has_exact_synonym
annotated target: telomere organisation
database_cross_reference: GOC:mah

Axiom
annotated source: telomere organization
annotated property: has_related_synonym
annotated target: telomere organization and biogenesis
database_cross_reference: GOC:mah

mitochondrial translation
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
subclass of: Restriction
  on property: has part
  some values from: translational initiation
subclass of: Restriction
  on property: has part
  some values from: translational elongation
subclass of: Restriction
  on property: has part
  some values from: transferase activity
subclass of: Restriction
  on property: occurs in
  some values from: cytoplasm
subclass of: Restriction
  on property: occurs in
  some values from: mitochondrion
definition: The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.
database_cross_reference: Reactome:R-HSA-5368287
has_exact_synonym: mitochondrial protein anabolism
has_exact_synonym: mitochondrial protein biosynthesis
has_exact_synonym: mitochondrial protein formation
has_exact_synonym: mitochondrial protein synthesis
has_exact_synonym: mitochondrial protein translation
has_obo_namespace: biological_process
id: GO:0032543
in_subset: goslim yeast

Axiom
annotated source: mitochondrial translation
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.
database_cross_reference: GOC:curators

Mitochondrial translation
type: Axiom
annotated source: mitochondrial translation
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5368287

monocarboxylic acid metabolic process
type: Class
subclass of: biological_process
definition: The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).
has_exact_synonym: monocarboxylate metabolic process
has_exact_synonym: monocarboxylic acid metabolism
has_obo_namespace: biological_process
id: GO:0032787
in_subset: goslim yeast

Axiom
annotated source: monocarboxylic acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).
database_cross_reference: GOC:vk

regulation of organelle organization
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: regulates
  some values from: biological_process
definition: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
has_exact_synonym: regulation of organelle organisation
has_obo_namespace: biological_process
has_related_synonym: regulation of organelle organization and biogenesis
id: GO:0033043
in_subset: gocheck do not annotate
in_subset: goslim yeast

Axiom
annotated source: regulation of organelle organization
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of organelle organization
annotated property: has_exact_synonym
annotated target: regulation of organelle organisation
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of organelle organization
annotated property: has_related_synonym
annotated target: regulation of organelle organization and biogenesis
database_cross_reference: GOC:mah

response to chemical
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
has_exact_synonym: response to chemical stimulus
has_exact_synonym: response to chemical substance
has_obo_namespace: biological_process
id: GO:0042221
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to chemical
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
database_cross_reference: GOC:jl

Axiom
annotated source: response to chemical
annotated property: has_exact_synonym
annotated target: response to chemical stimulus
database_cross_reference: GOC:dos

ribosome assembly
type: Class
subclass of: organelle assembly
definition: The aggregation, arrangement and bonding together of the mature ribosome and of its subunits.
has_alternative_id: GO:0042257
has_narrow_synonym: ribosomal subunit assembly
has_obo_namespace: biological_process
id: GO:0042255
in_subset: goslim yeast

Axiom
annotated source: ribosome assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of the mature ribosome and of its subunits.
database_cross_reference: GOC:ma
database_cross_reference: PMID:30467428

Axiom
annotated source: ribosome assembly
annotated property: has_narrow_synonym
annotated target: ribosomal subunit assembly
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw

ribosomal large subunit biogenesis
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
has_exact_synonym: ribosomal large subunit biogenesis and assembly
has_obo_namespace: biological_process
id: GO:0042273
in_subset: goslim yeast

Axiom
annotated source: ribosomal large subunit biogenesis
annotated property: definition
annotated target: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
database_cross_reference: GOC:jl

ribosomal small subunit biogenesis
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
has_exact_synonym: ribosomal small subunit biogenesis and assembly
has_obo_namespace: biological_process
id: GO:0042274
in_subset: goslim yeast

Axiom
annotated source: ribosomal small subunit biogenesis
annotated property: definition
annotated target: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
database_cross_reference: GOC:jl

histone binding
type: Class
subclass of: molecular_function
definition: Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
term tracker item: https://github.com/geneontology/go-ontology/issues/23106
has_obo_namespace: molecular_function
has_related_synonym: histone-specific chaperone activity
id: GO:0042393
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: histone binding
annotated property: definition
annotated target: Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
database_cross_reference: GOC:jl
database_cross_reference: PMID:16209651
database_cross_reference: PMID:30212449
database_cross_reference: PMID:9305837

response to starvation
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
has_obo_namespace: biological_process
id: GO:0042594
in_subset: goslim yeast

Axiom
annotated source: response to starvation
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
database_cross_reference: GOC:curators

sno(s)RNA processing
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: Any process involved in the conversion of a primary snoRNA family RNA transcript into a mature snoRNA (eukaryota) or sRNA (archaea).
term tracker item: https://github.com/geneontology/go-ontology/issues/20416
has_obo_namespace: biological_process
id: GO:0043144
in_subset: goslim yeast

Axiom
annotated source: sno(s)RNA processing
annotated property: definition
annotated target: Any process involved in the conversion of a primary snoRNA family RNA transcript into a mature snoRNA (eukaryota) or sRNA (archaea).
database_cross_reference: GOC:curators
database_cross_reference: GOC:krc
database_cross_reference: PMID:12773397

ion binding
type: Class
subclass of: molecular_function
definition: Binding to an ion, a charged atoms or groups of atoms.
term tracker item: https://github.com/geneontology/go-ontology/issues/26424
has_obo_namespace: molecular_function
has_related_synonym: atom binding
id: GO:0043167
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: ion binding
annotated property: definition
annotated target: Binding to an ion, a charged atoms or groups of atoms.
database_cross_reference: GOC:jl

sporulation
type: Class
subclass of: biological_process
definition: The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction.
database_cross_reference: Wikipedia:Spore
has_obo_namespace: biological_process
id: GO:0043934
in_subset: goslim metagenomics
in_subset: goslim yeast

Axiom
annotated source: sporulation
annotated property: definition
annotated target: The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction.
database_cross_reference: GOC:pamgo_curators

cellular respiration
type: Class
subclass of: generation of precursor metabolites and energy
definition: The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).
has_broad_synonym: respiration
database_cross_reference: Wikipedia:Cellular_respiration
has_exact_synonym: oxidative metabolic process
has_exact_synonym: oxidative metabolism
has_obo_namespace: biological_process
id: GO:0045333
in_subset: goslim candida
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: cellular respiration
annotated property: definition
annotated target: The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).
database_cross_reference: GOC:das
database_cross_reference: ISBN:0140513590
database_cross_reference: ISBN:0198506732

Golgi vesicle transport
type: Class
subclass of: biological_process
definition: The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
has_obo_namespace: biological_process
has_related_synonym: Golgi-derived vesicle transport
id: GO:0048193
in_subset: goslim yeast

Axiom
annotated source: Golgi vesicle transport
annotated property: definition
annotated target: The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
database_cross_reference: GOC:jid
database_cross_reference: ISBN:0716731363
database_cross_reference: PMID:10219233

organelle fusion
type: Class
subclass of: biological_process
definition: The creation of a single organelle from two or more organelles.
has_obo_namespace: biological_process
id: GO:0048284
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: organelle fusion
annotated property: definition
annotated target: The creation of a single organelle from two or more organelles.
database_cross_reference: GOC:jid

organelle fission
type: Class
subclass of: biological_process
definition: The creation of two or more organelles by division of one organelle.
has_obo_namespace: biological_process
id: GO:0048285
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: organelle fission
annotated property: definition
annotated target: The creation of two or more organelles by division of one organelle.
database_cross_reference: GOC:jid

organelle inheritance
type: Class
subclass of: biological_process
definition: The partitioning of organelles between daughter cells at cell division.
has_obo_namespace: biological_process
id: GO:0048308
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: organelle inheritance
annotated property: definition
annotated target: The partitioning of organelles between daughter cells at cell division.
database_cross_reference: GOC:jid

regulation of transport
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: regulates
  some values from: biological_process
definition: Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
id: GO:0051049
in_subset: goslim yeast

Axiom
annotated source: regulation of transport
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai

regulation of DNA metabolic process
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: regulates
  some values from: biological_process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.
has_exact_synonym: regulation of DNA metabolism
has_obo_namespace: biological_process
id: GO:0051052
in_subset: goslim yeast

Axiom
annotated source: regulation of DNA metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.
database_cross_reference: GOC:ai

nuclear transport
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
subclass of: Restriction
  on property: occurs in
  some values from: cellular_component
definition: The directed movement of substances into, out of, or within the nucleus.
database_cross_reference: Wikipedia:Nuclear_transport
has_exact_synonym: nucleus transport
has_obo_namespace: biological_process
id: GO:0051169
in_subset: goslim yeast

Axiom
annotated source: nuclear transport
annotated property: definition
annotated target: The directed movement of substances into, out of, or within the nucleus.
database_cross_reference: GOC:ai

meiotic cell cycle
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
subclass of: Restriction
  on property: has part
  some values from: organelle fission
definition: Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
term tracker item: https://github.com/geneontology/go-ontology/issues/24599
has_alternative_id: GO:0007126
database_cross_reference: Wikipedia:Meiosis
has_obo_namespace: biological_process
has_related_synonym: meiosis
id: GO:0051321
in_subset: goslim drosophila
in_subset: goslim yeast
comment: Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.

Axiom
annotated source: meiotic cell cycle
annotated property: definition
annotated target: Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
database_cross_reference: GOC:ai

protein maturation
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: Any process leading to the attainment of the full functional capacity of a protein.
database_cross_reference: Reactome:R-HSA-9918432
has_obo_namespace: biological_process
id: GO:0051604
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: protein maturation
annotated property: definition
annotated target: Any process leading to the attainment of the full functional capacity of a protein.
database_cross_reference: GOC:ai

Maturation of DENV proteins
type: Axiom
annotated source: protein maturation
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9918432

regulation of cell cycle
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: regulates
  some values from: biological_process
definition: Any process that modulates the rate or extent of progression through the cell cycle.
has_alternative_id: GO:0000074
has_alternative_id: GO:0007050
has_alternative_id: GO:0071156
has_alternative_id: GO:0071157
has_alternative_id: GO:0071158
has_alternative_id: GO:0071850
database_cross_reference: Reactome:R-HSA-156711
database_cross_reference: Reactome:R-HSA-380972
has_exact_synonym: cell cycle modulation
has_exact_synonym: cell cycle regulation
has_exact_synonym: control of cell cycle progression
has_exact_synonym: modulation of cell cycle progression
has_exact_synonym: regulation of cell cycle progression
has_exact_synonym: regulation of progression through cell cycle
has_narrow_synonym: arrest of mitotic cell cycle progression
has_narrow_synonym: cell cycle arrest
has_narrow_synonym: mitotic cell cycle arrest
has_narrow_synonym: negative regulation of cell cycle arrest
has_narrow_synonym: positive regulation of cell cycle arrest
has_narrow_synonym: regulation of cell cycle arrest
has_obo_namespace: biological_process
has_related_synonym: cell cycle regulator
has_related_synonym: tumor suppressor
id: GO:0051726
in_subset: goslim yeast

Axiom
annotated source: regulation of cell cycle
annotated property: definition
annotated target: Any process that modulates the rate or extent of progression through the cell cycle.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Polo-like kinase mediated events
type: Axiom
annotated source: regulation of cell cycle
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-156711

Energy dependent regulation of mTOR by LKB1-AMPK
type: Axiom
annotated source: regulation of cell cycle
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-380972

Axiom
annotated source: regulation of cell cycle
annotated property: has_narrow_synonym
annotated target: arrest of mitotic cell cycle progression
database_cross_reference: GOC:mah

transmembrane transport
type: Class
subclass of: biological_process
definition: The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
created by: tb
creation date: 2015-10-21T13:22:47Z
has_alternative_id: GO:0090662
database_cross_reference: Reactome:R-HSA-382556
database_cross_reference: Reactome:R-HSA-425407
database_cross_reference: Reactome:R-HSA-5223345
has_exact_synonym: membrane transport
has_narrow_synonym: ATP hydrolysis coupled transmembrane transport
has_obo_namespace: biological_process
id: GO:0055085
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim yeast
comment: Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes.

Axiom
annotated source: transmembrane transport
annotated property: definition
annotated target: The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid

ABC-family protein mediated transport
type: Axiom
annotated source: transmembrane transport
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-382556

SLC-mediated transmembrane transport
type: Axiom
annotated source: transmembrane transport
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-425407

Miscellaneous transport and binding events
type: Axiom
annotated source: transmembrane transport
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5223345

nucleobase-containing small molecule metabolic process
type: Class
subclass of: biological_process
definition: The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
database_cross_reference: Reactome:R-HSA-15869
database_cross_reference: Reactome:R-HSA-2393930
has_exact_synonym: nucleobase, nucleoside and nucleotide metabolism
has_obo_namespace: biological_process
has_related_synonym: nucleobase, nucleoside and nucleotide metabolic process
id: GO:0055086
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: nucleobase-containing small molecule metabolic process
annotated property: definition
annotated target: The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
database_cross_reference: GOC:vw

Metabolism of nucleotides
type: Axiom
annotated source: nucleobase-containing small molecule metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-15869

Phosphate bond hydrolysis by NUDT proteins
type: Axiom
annotated source: nucleobase-containing small molecule metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2393930

membrane fusion
type: Class
subclass of: biological_process
definition: The membrane organization process that joins two lipid bilayers to form a single membrane.
created by: jl
creation date: 2010-02-08T02:48:06Z
has_alternative_id: GO:0006944
has_alternative_id: GO:0044801
database_cross_reference: Wikipedia:Lipid_bilayer_fusion
has_exact_synonym: cellular membrane fusion
has_obo_namespace: biological_process
has_related_synonym: single-organism membrane fusion
id: GO:0061025
in_subset: goslim yeast

Axiom
annotated source: membrane fusion
annotated property: definition
annotated target: The membrane organization process that joins two lipid bilayers to form a single membrane.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

protein modification by small protein conjugation or removal
type: Class
subclass of: biological_process
definition: A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.
created by: mah
creation date: 2009-05-11T02:54:03Z
has_obo_namespace: biological_process
id: GO:0070647
in_subset: goslim drosophila
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: protein modification by small protein conjugation or removal
annotated property: definition
annotated target: A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.
database_cross_reference: GOC:mah

organelle assembly
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
created by: mah
creation date: 2009-09-15T03:00:51Z
has_obo_namespace: biological_process
id: GO:0070925
in_subset: gocheck do not annotate
in_subset: goslim yeast

Axiom
annotated source: organelle assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
database_cross_reference: GOC:mah

cell wall organization or biogenesis
type: Class
subclass of: biological_process
definition: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall.
created by: mah
creation date: 2010-01-13T03:19:38Z
has_alternative_id: GO:0070882
has_exact_synonym: cell wall organisation or biogenesis
has_exact_synonym: cell wall organization or biogenesis at cellular level
has_exact_synonym: cellular cell wall organisation or biogenesis
has_exact_synonym: cellular cell wall organization or biogenesis
has_obo_namespace: biological_process
id: GO:0071554
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: cell wall organization or biogenesis
annotated property: definition
annotated target: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall.
database_cross_reference: GOC:mah

Axiom
annotated source: cell wall organization or biogenesis
annotated property: has_exact_synonym
annotated target: cell wall organisation or biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cell wall organization or biogenesis
annotated property: has_exact_synonym
annotated target: cell wall organization or biogenesis at cellular level
database_cross_reference: GOC:mah

Axiom
annotated source: cell wall organization or biogenesis
annotated property: has_exact_synonym
annotated target: cellular cell wall organisation or biogenesis
database_cross_reference: GOC:mah

ATP-dependent activity
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: has part
  some values from: hydrolase activity
definition: A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.
term tracker item: https://github.com/geneontology/go-ontology/issues/21612
term tracker item: https://github.com/geneontology/go-ontology/issues/22371
created by: pg
creation date: 2021-06-15T07:35:06Z
has_exact_synonym: ATP hydrolysis-dependent activity
has_exact_synonym: ATPase activity
has_exact_synonym: ATPase activity, coupled
has_exact_synonym: ATPase-dependent activity
has_obo_namespace: molecular_function
id: GO:0140657
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'.

Axiom
annotated source: ATP-dependent activity
annotated property: definition
annotated target: A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.
database_cross_reference: PMID:24878343
database_cross_reference: PMID:25750732
database_cross_reference: PMID:32933017
database_cross_reference: PMID:33818025
database_cross_reference: PMID:33873056
database_cross_reference: PMID:33988324