a ; "Isa http://purl.obolibrary.org/obo/PR_P30530" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-Y779,Y821-AXL" ; "https://reactome.org/content/detail/R-HSA-5357460" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 779 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 894 ; ] ; [ a ; [ a ; 26 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 821 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5357460" , "http://purl.obolibrary.org/obo/PR_000046450" ; "p-Y779,Y821-AXL" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "ibudilast" ; "https://reactome.org/content/detail/R-ALL-9705548" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9705548" ; "ibudilast" . a ; "Isa http://purl.obolibrary.org/obo/PR_000016052" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TAP2" ; "https://reactome.org/content/detail/R-HSA-8863947" ; ; [ a ; [ a ; [ a ; 686 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q03519" , "Reactome:R-HSA-8863947" ; "TAP2_HUMAN" , "Antigen peptide transporter 2" , "TAP2" . a ; "Unspecified modification type. Comment: [Replacement of residues 292 to 303 by RGASPRAAPREH]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TP53 K292Rfs*13" ; "https://reactome.org/content/detail/R-HSA-9719684" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 303 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9719684" ; "TP53 K292Rfs*13" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "E2F1/3:DP1/2" ; "https://reactome.org/content/detail/R-HSA-2248825" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2248825" ; "E2F1/3:DP1/2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MeR25,27-CNBP" ; "https://reactome.org/content/detail/R-HSA-9759641" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 27 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 177 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 25 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9759641" ; "CCHC-type zinc finger nucleic acid binding protein" , "MeR25,27-CNBP" , "MeR25,27-ZNF9" , "MeR25,27-RNF163" , "Cellular nucleic acid-binding protein" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Alpha-3(V) -N propeptides" ; "https://reactome.org/content/detail/R-HSA-2268849" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-2268849" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ] ] ; "Alpha-3(V) -N propeptides" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Influenza A Viral Particle" ; "https://reactome.org/content/detail/R-FLU-189171" ; ; [ a ; ; ; "3000"^^ ] ; [ a ; ; ; "165"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-FLU-189171" ; "Influenza A Viral Particle" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "IGFBP5(164-272)" ; "https://reactome.org/content/detail/R-HSA-381478" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 272 ; ] ; [ a ; [ a ; 164 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-381478" ; "IGFBP-5 (164-272 fragment)" , "IGFBP5(164-272)" . a ; "Isa http://purl.obolibrary.org/obo/PR_000013486" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PTTG1" ; "https://reactome.org/content/detail/R-HSA-174190" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 202 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-174190" , "http://purl.obolibrary.org/obo/PR_O95997" ; "Securin" , "PTTG1" , "Pituitary tumor-transforming gene 1 protein" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_Q05655" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "nPKC-delta" ; "https://reactome.org/content/detail/R-HSA-5218734" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 664 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 676 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 507 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 645 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5218734" , "http://purl.obolibrary.org/obo/PR_000048917" ; "nPKC-delta" , "p-T507,S645,S664-PRKCD" , "Phospho-Protein kinase C-delta" . a ; "Isa http://purl.obolibrary.org/obo/PR_Q5QNW6" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "AcK16-HIST2H2BF" ; "https://reactome.org/content/detail/R-HSA-4568725" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 16 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 126 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-4568725" , "http://purl.obolibrary.org/obo/PR_000047852" ; "AcK16-HIST2H2BF" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_A8TX70" ; "COL6A5" ; "https://reactome.org/content/detail/R-HSA-2023510" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 2615 ; ] ; [ a ; [ a ; 19 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2023510" , "http://purl.obolibrary.org/obo/PR_000046973" ; "Collagen alpha-5(VI) chain" , "COL6A5" , "COL29A1" , "CO6A5_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "OR52B6:eugenol" ; "https://reactome.org/content/detail/R-HSA-9737270" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9737270" ; "OR52B6:eugenol" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-S1330-ROBO3.1:AKAP5" ; "https://reactome.org/content/detail/R-HSA-9010776" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9010776" ; "p-S1330-ROBO3.1:AKAP5" . a ; "Isa http://purl.obolibrary.org/obo/PR_000012982" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "POLR1A" ; "https://reactome.org/content/detail/R-HSA-63494" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1720 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-63494" , "http://purl.obolibrary.org/obo/PR_O95602" ; "POLR1A" , "RNA polymerase I 194 kDa subunit" , "RPA194" , "DNA-directed RNA polymerase I largest subunit" . a ; "Unspecified modification type. Comment: [Insertion of residues 429 to 822 at 340 from UniProt:P11362 FGFR1]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CUX1-p-2Y-FGFR1 fusion" ; "https://reactome.org/content/detail/R-HSA-1838991" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 766 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 339 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-1838991" ; "t(7;8) CUX1-p-FGFR1 fusion" , "CUX1-p-2Y-FGFR1 fusion" , "CUX1(1-339)-p-FGFR1(429-822) fusion" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "CLPXP" ; "https://reactome.org/content/detail/R-HSA-9838085" ; ; [ a ; ; ; "14"^^ ] ; [ a ; ; ] ; [ a ; ; ; "12"^^ ] ; ; "Reactome:R-HSA-9838085" ; "CLPXP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HBD-4" ; "https://reactome.org/content/detail/R-HSA-1467188" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 72 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1467188" ; "D104A_HUMAN" , "DEFB104A(1-72)" , "HBD-4" , "Pre-pro-beta-defensin 104" , "Beta defensin-4" , "DEFB104A" . a ; "Isa http://purl.obolibrary.org/obo/PR_Q13153" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-S144,T423-PAK1" ; "https://reactome.org/content/detail/R-HSA-3928472" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 545 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 144 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 423 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-3928472" , "http://purl.obolibrary.org/obo/PR_000048688" ; "p-S144,T423-PAK1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "RUNX2-P1:CBFB" ; "https://reactome.org/content/detail/R-HSA-9016495" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9016495" ; "RUNX2-P1:CBFB" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SGLT1" ; "https://reactome.org/content/detail/R-HSA-5656362" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 28 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 664 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5656362" ; "SGLT1" , "SLC5A1 D28N" , "Sodium/glucose cotransporter 1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CENPE" ; "https://reactome.org/content/detail/R-HSA-376245" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 2698 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-376245" ; "CENP-E" , "CENPE" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "cholesterol ester" ; "https://reactome.org/content/detail/R-ALL-171061" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-171061" ; "cholesterol ester" , "cholesteryl ester" , "cholesterol esters" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "IN (Integrase) (P04585) protein" ; "https://reactome.org/content/detail/R-HIV-175288" ; ; [ a ; [ a ; [ a ; 1435 ; ] ; [ a ; [ a ; 1148 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HIV-175288" ; "IN (Integrase) (P04585) protein" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "M1" ; "https://reactome.org/content/detail/R-FLU-195782" ; ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-FLU-195782" ; "M1" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_P08603" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CFH" ; "https://reactome.org/content/detail/R-HSA-976788" ; ; [ a ; [ a ; [ a ; 1231 ; ] ; [ a ; [ a ; 19 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000046694" , "Reactome:R-HSA-976788" ; "CFH" , "CFAH_HUMAN" , "Complement factor H" . a ; "Isa http://purl.obolibrary.org/obo/PR_000008809" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HSPA4L" ; "https://reactome.org/content/detail/R-HSA-5252053" ; ; [ a ; [ a ; [ a ; 839 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5252053" , "http://purl.obolibrary.org/obo/PR_O95757" ; "Heat shock 70 kDa protein 4L" , "HSPA4L" , "HS74L_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "STAT6 upregulated plasma membrane protein genes" ; "https://reactome.org/content/detail/R-HSA-6793996" ; ; [ a ; ; ] ; "ENSEMBL:ENSG00000116329" , "ENSEMBL:ENSG00000104921" , "ENSEMBL:ENSG00000112038" , "ENSEMBL:ENSG00000077238" ; "Reactome:R-HSA-6793996" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "STAT6 upregulated plasma membrane protein genes" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ERK2" ; "https://reactome.org/content/detail/R-HSA-9652806" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 58 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 187 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 360 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 185 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9652806" ; "ERT1" , "Mitogen-activated protein kinase 2" , "Mitogen-activated protein kinase 1 (EC 2.7.1.-) (Extracellular signal- regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1)" , "Extracellular signal-regulated kinase 2" , "MAP kinase 2" , "MAPK 2" , "ERK2" , "ERK-2" , "p-T185,Y187 MAPK1 P58L" , "Mitogen-activated protein kinase 1" , "p42-MAPK" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "TGFB1:TGFBR2:TGFBR1" ; "https://reactome.org/content/detail/R-HSA-170840" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-170840" ; "TGF-beta 1:type II receptor:type I receptor complex" , "TGFB1:TGFBR2:TGFBR1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "TNF-α:TNFR1:TRADD:RIPK1:TRAF2" ; "https://reactome.org/content/detail/R-HSA-140946" ; ; [ a ; ; ; "3"^^ ] ; [ a ; ; ; "3"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000028432" , "Reactome:R-HSA-140946" ; "TNF-α:TNFR1:TRADD:RIPK1:TRAF2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "NCAN" ; "https://reactome.org/content/detail/R-HSA-2064055" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1321 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2064055" ; "NCAN" , "Neurocan" , "Gal-Xyl-NCAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "PolyUb-Misfolded Proteins" ; "https://reactome.org/content/detail/R-HSA-9660006" ; ; [ a ; ; ] ; , , , , , ; "Reactome:R-HSA-9660006" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "PolyUb-Misfolded Proteins" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MASP-2" ; "https://reactome.org/content/detail/R-HSA-166689" ; ; [ a ; [ a ; [ a ; 686 ; ] ; [ a ; [ a ; 16 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-166689" ; "MASP2-1" , "MASP-2" , "MASP2 isoform 1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "FAS Gene" ; "https://reactome.org/content/detail/R-HSA-6799817" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000026103" ; "ENSEMBL:ENSG00000026103" , "Reactome:R-HSA-6799817" ; "FAS Gene" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "P0DTC5" ; "https://reactome.org/content/detail/R-COV-9694738" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 5 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 221 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-COV-9694738" ; "P0DTC5" , "N-glycan M" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "FTMT 24mer" ; "https://reactome.org/content/detail/R-HSA-5691188" ; ; [ a ; ; ; "24"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5691188" ; "FTMT 24mer" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KMT2D K4768*" ; "https://reactome.org/content/detail/R-HSA-9951090" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 4768 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 4767 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9951090" ; "KMT2D K4768*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NBN:KPNA2" ; "https://reactome.org/content/detail/R-HSA-5684011" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5684011" ; "NBN:KPNA2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "hZIP4" ; "https://reactome.org/content/detail/R-HSA-5654117" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 330 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 647 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5654117" ; "Zinc transporter ZIP4" , "hZIP4" , "SLC39A4 G330D" , "S39A4_HUMAN" . a ; "Isa http://purl.obolibrary.org/obo/PR_000001950" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TNFSF5" ; "https://reactome.org/content/detail/R-HSA-198113" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 261 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-198113" , "http://purl.obolibrary.org/obo/PR_P29965" ; "TNF5_HUMAN" , "Tumor necrosis factor ligand superfamily member 5" , "TNFSF5" , "CD40LG(1-261)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-S195-CD274" ; "https://reactome.org/content/detail/R-HSA-9931259" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 195 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9931259" ; "p-S195-CD274" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "cilazapril" ; "https://reactome.org/content/detail/R-ALL-9619030" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9619030" ; "cilazapril" . a ; "Unspecified modification type. Comment: [Replacement of residues 206 to 246 by FWMTETLFDIVWWCPMSRLRLALTVPPSTTTTCVTVPAWAA]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TP53 L206Ffs*42" ; "https://reactome.org/content/detail/R-HSA-9721187" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 246 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9721187" ; "TP53 L206Ffs*42" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1" ; "https://reactome.org/content/detail/R-HSA-5682997" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5682997" ; "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000011951" ; "OR5T1" ; "https://reactome.org/content/detail/R-HSA-422183" ; ; [ a ; [ a ; [ a ; 326 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-422183" , "http://purl.obolibrary.org/obo/PR_Q8NG75" ; "OR5T1" , "OR5T1_HUMAN" , "Olfactory receptor 5T1" . a ; "Unspecified modification type. Comment: [Replacement of residues 322 to 325 by KTLL]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HEXB" ; "https://reactome.org/content/detail/R-HSA-3700889" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 325 ; ] ; [ a ; [ a ; 122 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-3700889" ; "Beta-hexosaminidase subunit beta B" , "HEXB" , "HEXB_HUMAN" , "HEXBB" , "HEXB I322Kfs*5" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "CD209:ManLAM" ; "https://reactome.org/content/detail/R-HSA-5621611" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5621611" ; "CD209:ManLAM" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_000016066" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TAS2R14" ; "https://reactome.org/content/detail/R-HSA-3299618" ; ; [ a ; [ a ; [ a ; 317 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-3299618" , "http://purl.obolibrary.org/obo/PR_Q9NYV8" ; "T2R14_HUMAN" , "Taste receptor type 2 member 14" , "TAS2R14" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-S357-RIP1" ; "https://reactome.org/content/detail/R-HSA-9819116" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 671 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 357 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9819116" ; "Receptor-interacting serine/threonine-protein kinase 1" , "p-S357-RIPK1" , "receptor interacting protein 1 kinase" , "p-S357-RIP1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SLC27A2" ; "https://reactome.org/content/detail/R-HSA-9033090" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 620 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9033090" ; "Very long-chain acyl-CoA synthetase" , "SLC27A2" , "S27A2_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "vWF S1731L" ; "https://reactome.org/content/detail/R-HSA-9823681" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1731 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 2813 ; ] ; [ a ; [ a ; 764 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9823681" ; "von Willebrand factor" , "VWF S1731L (764-2813)" , "vWF S1731L" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "ligands of SLC43A1,2" ; "https://reactome.org/content/detail/R-ALL-352101" ; ; [ a ; ; ] ; , , , , ; "Reactome:R-ALL-352101" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ; "ligands of SLC43A1,2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "DNA with RNA Polymerase III Type 3 Open Promoter" ; "https://reactome.org/content/detail/R-ALL-112135" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-112135" ; "DNA with RNA Polymerase III Type 3 Open Promoter" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Rna" ; "m7GpppG-N mRNA" ; "https://reactome.org/content/detail/R-RSY-9833949" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:KT992094" ; "NCBI NucleotideKT992094" , "Reactome:R-RSY-9833949" ; "m7GpppG-N mRNA" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "OLA1" ; "https://reactome.org/content/detail/R-HSA-8862978" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 396 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8862978" ; "OLA1" , "fullName evidence=\"3\"Obg-like ATPase 1" , "OLA1_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "glnA" ; "https://reactome.org/content/detail/R-HSA-198629" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 157 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 198 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-198629" ; "glnA" , "GLNA_LACDE" , "Phospho-p27Kip1" , "p-T157-CDKN1B" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "OR6N2" ; "https://reactome.org/content/detail/R-HSA-9751597" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 317 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9751597" ; "Olfactory receptor 6N2" , "OR6N2" , "OR6N2_HUMAN" . a ; "Isa http://purl.obolibrary.org/obo/PR_000032733" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "USP17L5" ; "https://reactome.org/content/detail/R-HSA-8848673" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 530 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_A8MUK1" , "Reactome:R-HSA-8848673" ; "U17L5_HUMAN" , "USP17L5" , "Ubiquitin carboxyl-terminal hydrolase 17-like protein 5 ecNumber3.4.19.12/ecNumber" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "cholesterol ester" ; "https://reactome.org/content/detail/R-ALL-2239439" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-2239439" ; "cholesteryl ester" , "cholesterol ester" , "cholesterol esters" . a ; "Unspecified modification type. Comment: [Replacement of residues 136 to 147 by STGQDLPCAAVG]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TP53 Q136Sfs*13" ; "https://reactome.org/content/detail/R-HSA-9718817" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 147 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9718817" ; "TP53 Q136Sfs*13" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "F9(227-461) I443T" ; "https://reactome.org/content/detail/R-HSA-9670908" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 461 ; ] ; [ a ; [ a ; 227 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 443 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9670908" ; "factor IXa heavy chain I443T" , "F9(227-461) I443T" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "IDS dimer" ; "https://reactome.org/content/detail/R-HSA-1678638" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1678638" ; "IDS dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "UBC(609-684)" ; "https://reactome.org/content/detail/R-HSA-939223" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 684 ; ] ; [ a ; [ a ; 609 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-939223" ; "ubiquitin (UBC 9)" , "UBC(609-684)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "STK-1" ; "https://reactome.org/content/detail/R-HSA-9682297" ; ; [ a ; [ a ; [ a ; 993 ; ] ; [ a ; [ a ; 27 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 835 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9682297" ; "FLT3 D835E" , "STK-1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "Globin genes" ; "https://reactome.org/content/detail/R-HSA-9605269" ; ; [ a ; ; ] ; "ENSEMBL:ENSG00000213934" , "ENSEMBL:ENSG00000213931" , "ENSEMBL:ENSG00000244734" , "ENSEMBL:ENSG00000223609" , "ENSEMBL:ENSG00000196565" ; "Reactome:R-HSA-9605269" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ; "Globin genes" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DEFA3" ; "https://reactome.org/content/detail/R-HSA-1470047" ; ; [ a ; [ a ; [ a ; 94 ; ] ; [ a ; [ a ; 65 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1470047" ; "DEFA3" , "DEF3_HUMAN" , "DEFA3(65-94)" , "Defensin alpha 3" , "Neutrophil defensin 3" . a ; "Isa http://purl.obolibrary.org/obo/PR_000003150" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "FURIN" ; "https://reactome.org/content/detail/R-HSA-448351" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 794 ; ] ; [ a ; [ a ; 108 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_000035903" , "Reactome:R-HSA-448351" ; "FURIN" , "furin" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GPI-MSLN" ; "https://reactome.org/content/detail/R-HSA-8941008" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 606 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 606 ; ] ; [ a ; [ a ; 37 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-8941008" ; "Mesothelin" , "cleaved GPI-MSLN" , "GPI-MSLN" , "MSLN_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "FCN2 trimer" ; "https://reactome.org/content/detail/R-HSA-2530460" ; ; [ a ; ; ] ; [ a ; ; ; "3"^^ ] ; ; "Reactome:R-HSA-2530460" ; "FCN2 trimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DCD peptides" ; "https://reactome.org/content/detail/R-HSA-6803037" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-6803037" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "DCD peptides" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ALKBH8:Fe2+" ; "https://reactome.org/content/detail/R-HSA-6786518" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-6786518" ; "ALKBH8:Fe2+" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000003754" ; "ADCY3" ; "https://reactome.org/content/detail/R-HSA-379051" ; ; [ a ; [ a ; [ a ; 1144 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-379051" , "http://purl.obolibrary.org/obo/PR_O60266" ; "ADCY3" , "Adenylate cyclase type 3" , "ADCY3_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PGAM monomers" ; "https://reactome.org/content/detail/R-HSA-9815664" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-9815664" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "PGAM monomers" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RB1 R334*" ; "https://reactome.org/content/detail/R-HSA-9688118" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 334 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 333 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9688118" ; "RB1 R334*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "PRC1 complex" ; "https://reactome.org/content/detail/R-HSA-389114" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-389114" ; "PRC1 complex" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000017877" ; "ZNF415" ; "https://reactome.org/content/detail/R-HSA-1247542" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 603 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q09FC8" , "Reactome:R-HSA-1247542" ; "ZN415_HUMAN" , "Zinc finger protein 415" , "ZNF415" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000029290" ; "ATP8A1" ; "https://reactome.org/content/detail/R-HSA-939739" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1164 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_Q9Y2Q0" , "Reactome:R-HSA-939739" ; "AT8A1_HUMAN" , "Probable phospholipid-transporting ATPase IA" , "ATP8A1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "OR10J5:ligand" ; "https://reactome.org/content/detail/R-HSA-9712179" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9712179" ; "OR10J5:ligand" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-STK4 dimer" ; "https://reactome.org/content/detail/R-HSA-2028260" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-2028260" ; "p-STK4 dimer" , "p-MST1 dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "pre-NS1" ; "https://reactome.org/content/detail/R-DVI-9918824" ; ; [ a ; [ a ; [ a ; 1127 ; ] ; [ a ; [ a ; 776 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-DVI-9918824" ; "pre-NS1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GLRA1,2,3" ; "https://reactome.org/content/detail/R-HSA-975405" ; ; [ a ; ; ] ; , , ; "Reactome:R-HSA-975405" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "GLRA1,2,3" , "Glycine receptor alpha subunits 1-4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SMAD4 E520*" ; "https://reactome.org/content/detail/R-HSA-9675636" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 520 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 519 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9675636" ; "SMAD4 E520TER" , "SMAD4 Glu520TER" , "SMAD4 E520*" , "SMAD4 Glu520*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "phospho-E proteins" ; "https://reactome.org/content/detail/R-HSA-448867" ; ; [ a ; ; ] ; , , ; "Reactome:R-HSA-448867" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "phospho-E proteins" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ubiquitin (UBC 6)" ; "https://reactome.org/content/detail/R-HSA-8852098" ; ; [ a ; [ a ; [ a ; 456 ; ] ; [ a ; [ a ; 381 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 456 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8852098" ; "ubiquitin (UBC 6)" , "adenylatedG456-UBC(381-456)" . a ; "Isa http://purl.obolibrary.org/obo/PR_000005541" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CLDN14" ; "https://reactome.org/content/detail/R-HSA-434615" ; ; [ a ; [ a ; [ a ; 239 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_O95500" , "Reactome:R-HSA-434615" ; "Claudin-14" , "CLDN14" , "CLD14_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HSP70" ; "https://reactome.org/content/detail/R-HSA-6792613" ; ; [ a ; [ a ; [ a ; 641 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6792613" ; "HSP70" , "HSPA1B" , "Heat shock 70 kDa protein 1B" , "Heat shock 70 kDa protein 2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P13473" ; "LAMP2" ; "https://reactome.org/content/detail/R-HSA-6800941" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 410 ; ] ; [ a ; [ a ; 29 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6800941" , "http://purl.obolibrary.org/obo/PR_000048165" ; "LAMP2_HUMAN" , "Lysosome-associated membrane glycoprotein 2" , "LAMP2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "EGF:p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2" ; "https://reactome.org/content/detail/R-HSA-8863840" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8863840" ; "EGF:p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2" . a ; "Isa http://purl.obolibrary.org/obo/PR_000004712" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "BCR" ; "https://reactome.org/content/detail/R-HSA-195200" ; ; [ a ; [ a ; [ a ; 1271 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_P11274" , "Reactome:R-HSA-195200" ; "Bcr" , "BCR" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "miR-106 RISC:PTEN mRNA" ; "https://reactome.org/content/detail/R-HSA-8944631" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8944631" ; "miR-106 RISC:PTEN mRNA" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "TeNT HC:LC dimer" ; "https://reactome.org/content/detail/R-CTE-5228384" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-CTE-5228384" ; "TeNT HC:LC dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "6xMCCC1:6xMCCC2" ; "https://reactome.org/content/detail/R-HSA-3323185" ; ; [ a ; ; ; "6"^^ ] ; [ a ; ; ; "6"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-3323185" ; "methylcrotonyl-CoA carboxylase complex" , "3-methylcrotonyl-CoA carboxylase complex" , "6xMCCC1:6xMCCC2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "COX6A1,2" ; "https://reactome.org/content/detail/R-HSA-5336166" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-5336166" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "COX6A1,2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GalHyl-COL1A1(162-1464)" ; "https://reactome.org/content/detail/R-HSA-2268742" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1464 ; ] ; [ a ; [ a ; 162 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2268742" ; "GalHyl-COL1A1(162-1464)" , "5-Gal-Hyl collagen alpha-1(I) -N propeptide" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "AK5 dimer" ; "https://reactome.org/content/detail/R-HSA-500061" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-500061" ; "AK5 dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TOMM20" ; "https://reactome.org/content/detail/R-HSA-9843313" ; ; [ a ; [ a ; [ a ; 145 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9843313" ; "TOMM20" , "Mitochondrial import receptor subunit TOM20 homolog" , "K63polyUb-TOMM20" , "TOM20_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "GGC-RAB21:GTP" ; "https://reactome.org/content/detail/R-HSA-8876838" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8876838" ; "GGC-RAB21:GTP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "Peptidyl-Cys-SH" ; "https://reactome.org/content/detail/R-ALL-6804015" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-6804015" ; "peptidyl-cysteine" , "Peptidyl-Cys-SH" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "RTP1S dimer" ; "https://reactome.org/content/detail/R-HSA-9752975" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-9752975" ; "RTP1S dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KRTAP4-11" ; "https://reactome.org/content/detail/R-HSA-6809960" ; ; [ a ; [ a ; [ a ; 195 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6809960" ; "KRTAP4-11" , "KR411_HUMAN" , "Keratin-associated protein 4-11" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "BACE1_HUMAN" ; "https://reactome.org/content/detail/R-HSA-5693105" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 501 ; ] ; [ a ; [ a ; 46 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5693105" ; "BACE1_HUMAN" , "Beta-secretase 1 ecNumber3.4.23.46/ecNumber" , "BACE1(46-501)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "OSMR:JAK1" ; "https://reactome.org/content/detail/R-HSA-8983748" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8983748" ; "OSMR:JAK1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "RUNX1:CBFB:YAP1" ; "https://reactome.org/content/detail/R-HSA-8956638" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8956638" ; "RUNX1:CBFB:YAP1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SST" ; "https://reactome.org/content/detail/R-HSA-374710" ; ; [ a ; [ a ; [ a ; 116 ; ] ; [ a ; [ a ; 89 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-374710" ; "Somatostatin-28" , "SST" , "SST(89-116)" , "SMS_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ACIN1" ; "https://reactome.org/content/detail/R-HSA-9770238" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1341 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9770238" ; "Apoptotic chromatin condensation inducer in the nucleus" , "ACINU_HUMAN" , "ACIN1" . a ; "Isa http://purl.obolibrary.org/obo/PR_P06727" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "APOA4" ; "https://reactome.org/content/detail/R-HSA-174701" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 396 ; ] ; [ a ; [ a ; 21 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000046355" , "Reactome:R-HSA-174701" ; "APOA4" , "apolipoprotein A-IV" , "apoA-IV" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "NPC1L1-1" ; "https://reactome.org/content/detail/R-HSA-265453" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1332 ; ] ; [ a ; [ a ; 22 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-265453" ; "NPC1L1 isoform 1" , "Niemann-Pick C1-like 1 protein" , "NPC1L1-1" . a ; "monohydroxylated lysine" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B" ; "https://reactome.org/content/detail/R-HSA-1458890" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-1458890" ; "WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "DNA with RNA Polymerase III Type 1 Closed Promoter" ; "https://reactome.org/content/detail/R-ALL-76050" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-76050" ; "DNA with RNA Polymerase III Type 1 Closed Promoter" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "tRNA(Gln,Glu,Lys) containing 2-thioU-34" ; "https://reactome.org/content/detail/R-HSA-6782249" ; ; [ a ; ; ] ; , , ; "Reactome:R-HSA-6782249" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "tRNA(Gln,Glu,Lys) containing 2-thioU-34" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RB1 W516*" ; "https://reactome.org/content/detail/R-HSA-9662660" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 515 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 516 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9662660" ; "RB1 Trp516TER" , "RB1 W516TER" , "RB1 W516*" , "RB1 Trp516*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "APC_HUMAN" ; "https://reactome.org/content/detail/R-HSA-9666951" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1408 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 1407 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9666951" ; "Adenomatous polyposis coli protein" , "APC E1408TER" , "APC E1408*" , "APC_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SPOP:SPOPL" ; "https://reactome.org/content/detail/R-HSA-5635068" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5635068" ; "SPOP:SPOPL" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KMT2D S510*" ; "https://reactome.org/content/detail/R-HSA-9950739" ; ; [ a ; [ a ; [ a ; 509 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 510 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9950739" ; "KMT2D S510*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PDIA1" ; "https://reactome.org/content/detail/R-HSA-3341287" ; ; [ a ; [ a ; [ a ; 508 ; ] ; [ a ; [ a ; 18 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 53 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-3341287" ; "Protein disulfide isomerase" , "HC53,56-P4HB" , "P4HB oxidized" , "PDIA1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "FOXO3,FOXO6,(FOXO1)" ; "https://reactome.org/content/detail/R-HSA-9622805" ; ; [ a ; ; ] ; , , ; "Reactome:R-HSA-9622805" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "FOXO3,FOXO6,(FOXO1)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "IGF1" ; "https://reactome.org/content/detail/R-HSA-2404178" ; ; [ a ; [ a ; [ a ; 118 ; ] ; [ a ; [ a ; 49 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2404178" ; "Insulin-like growth factor I" , "IGF1_HUMAN" , "IGF1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "OR56B1 gene" ; "https://reactome.org/content/detail/R-HSA-9752158" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000181023" ; "Reactome:R-HSA-9752158" , "ENSEMBL:ENSG00000181023" ; "OR56B1 gene" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_P25054" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "APC_HUMAN" ; "https://reactome.org/content/detail/R-HSA-5246690" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 2843 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5246690" , "http://purl.obolibrary.org/obo/PR_000046351" ; "K63polyUb-APC" , "Adenomatous polyposis coli protein" , "APC_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "L-Ala" ; "https://reactome.org/content/detail/R-ALL-29432" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-29432" ; "L-alanine zwitterion" , "L-alpha-Alanine" , "L-alanine" , "L-Ala" , "L-2-Aminopropionic acid" . a ; "Isa http://purl.obolibrary.org/obo/PR_000004485" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ATP6V1D" ; "https://reactome.org/content/detail/R-HSA-6799710" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 247 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q9Y5K8" , "Reactome:R-HSA-6799710" ; "ATP6V1D" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SULT1E1 dimer" ; "https://reactome.org/content/detail/R-HSA-176645" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-176645" ; "SULT1E1 dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "trans-2-hexacosenoyl-CoA" ; "https://reactome.org/content/detail/R-ALL-390249" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-390249" ; "trans-2-hexacosenoyl-CoA(4-)" , "trans-2,3-dehydrohexacosanoyl-CoA" , "trans-2-hexacosenoyl-CoA" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "FOXO1,FOXO3" ; "https://reactome.org/content/detail/R-HSA-9614686" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-9614686" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "FOXO1,FOXO3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "LFNG F188L" ; "https://reactome.org/content/detail/R-HSA-5137535" ; ; [ a ; [ a ; [ a ; 379 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 188 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5137535" ; "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" , "Lunatic fringe" , "Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe" , "LFNG F188L" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Multimerin 1" ; "https://reactome.org/content/detail/R-HSA-9935443" ; ; [ a ; [ a ; [ a ; 1228 ; ] ; [ a ; [ a ; 20 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9935443" ; "MMRN1(20-1228)" , "Multimerin 1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Activated PPARG:RXRA:PNPLA2 gene:nucleosomes" ; "https://reactome.org/content/detail/R-HSA-9864715" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9864715" ; "Activated PPARG:RXRA:PNPLA2 gene:nucleosomes" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CYR61" ; "https://reactome.org/content/detail/R-HSA-5173201" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 381 ; ] ; [ a ; [ a ; 25 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5173201" ; "CYR61_HUMAN" , "Protein CYR61" , "CYR61" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "APP" ; "https://reactome.org/content/detail/R-HSA-879340" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 713 ; ] ; [ a ; [ a ; 672 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-879340" ; "Amyloid beta A4 protein" , "A4_HUMAN" , "Beta-amyloid protein 42" , "APP(672-713)" , "APP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000017003" ; "UBN1" ; "https://reactome.org/content/detail/R-HSA-2532791" ; ; [ a ; [ a ; [ a ; 1134 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2532791" , "http://purl.obolibrary.org/obo/PR_Q9NPG3" ; "UBN1" , "Ubinuclein-1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Keratin filament units" ; "https://reactome.org/content/detail/R-HSA-6809659" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-6809659" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "Keratin filament units" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "MLT" ; "https://reactome.org/content/detail/R-ALL-209934" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-209934" ; "melatonin" , "MLT" . a ; "Isa http://purl.obolibrary.org/obo/PR_000013667" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RAD21" ; "https://reactome.org/content/detail/R-HSA-2466012" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 631 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_O60216" , "Reactome:R-HSA-2466012" ; "RAD21" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "aP2 gene" ; "https://reactome.org/content/detail/R-HSA-5640172" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000170323" ; "Reactome:R-HSA-5640172" , "ENSEMBL:ENSG00000170323" ; "aP2 gene" , "FABP4 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "ERBB2 heterodimers" ; "https://reactome.org/content/detail/R-HSA-1963573" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-1963573" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "ERBB2 heterodimers" . a ; "Isa http://purl.obolibrary.org/obo/PR_000011866" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "OR51E2" ; "https://reactome.org/content/detail/R-HSA-378598" ; ; [ a ; [ a ; [ a ; 320 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-378598" , "http://purl.obolibrary.org/obo/PR_Q9H255" ; "OR51E2" , "Olfactory receptor 51E2" , "O51E2_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "FLI1" ; "https://reactome.org/content/detail/R-HSA-9616216" ; ; [ a ; [ a ; [ a ; 452 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9616216" ; "Friend leukemia integration 1 transcription factor" , "FLI1" , "FLI1_HUMAN" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CETP" ; "https://reactome.org/content/detail/R-HSA-194231" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 493 ; ] ; [ a ; [ a ; 18 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-194231" ; "Cholesteryl ester transfer protein" , "CETP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "OR51F1" ; "https://reactome.org/content/detail/R-HSA-9751490" ; ; [ a ; [ a ; [ a ; 319 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9751490" ; "Olfactory receptor 51F1" , "O51F1_HUMAN" , "OR51F1" . a ; "Isa http://purl.obolibrary.org/obo/PR_000007172" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ERF" ; "https://reactome.org/content/detail/R-HSA-2534321" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 548 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2534321" , "http://purl.obolibrary.org/obo/PR_P50548" ; "ERF" , "PE-2" , "ETS domain-containing transcription factor ERF" , "Ets2 repressor factor" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "C5AR1 antagonists" ; "https://reactome.org/content/detail/R-ALL-9957436" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9957436" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "C5AR1 antagonists" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_Q96G03" ; "PGM2" ; "https://reactome.org/content/detail/R-HSA-6801502" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 612 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6801502" , "http://purl.obolibrary.org/obo/PR_000048758" ; "PGM2" , "Phosphoglucomutase-2" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "GATA4:ZFPM2" ; "https://reactome.org/content/detail/R-HSA-9692253" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9692253" ; "GATA4:ZFPM2" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "LIFR:JAKs,OSMR:JAKs" ; "https://reactome.org/content/detail/R-HSA-6783627" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-6783627" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "LIFR:JAKs,OSMR:JAKs" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "CDP-Cho" ; "https://reactome.org/content/detail/R-ALL-1524060" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-1524060" ; "CDP-Cho" , "CDP-choline" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "4xPALM-C-ABCA1 tetramer" ; "https://reactome.org/content/detail/R-HSA-5682073" ; ; [ a ; ; ] ; [ a ; ; ; "4"^^ ] ; ; "Reactome:R-HSA-5682073" ; "4xPALM-C-ABCA1 tetramer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000031459" ; "G0S2" ; "https://reactome.org/content/detail/R-HSA-1989741" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 103 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1989741" , "http://purl.obolibrary.org/obo/PR_P27469" ; "G0S2_HUMAN" , "G0S2" , "G0/G1 switch regulatory protein 2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_Q8IWL1" ; "SFTPA2" ; "https://reactome.org/content/detail/R-HSA-5686364" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 248 ; ] ; [ a ; [ a ; 21 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5686364" , "http://purl.obolibrary.org/obo/PR_000049219" ; "SFTA2_HUMAN" , "SFTPA2" , "Pulmonary surfactant-associated protein A2 (SP-A2)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RB1 L326*" ; "https://reactome.org/content/detail/R-HSA-9688011" ; ; [ a ; [ a ; [ a ; 325 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 326 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9688011" ; "RB1 L326*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SHH" ; "https://reactome.org/content/detail/R-HSA-5358430" ; ; [ a ; [ a ; [ a ; 462 ; ] ; [ a ; [ a ; 24 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 374 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5358430" ; "SHH" , "Sonic hedgehog protein precursor" , "SHH_HUMAN" , "SHH(24-462) H374R" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "PTGS2 gene" ; "https://reactome.org/content/detail/R-HSA-6785055" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000073756" ; "ENSEMBL:ENSG00000073756" , "Reactome:R-HSA-6785055" ; "PTGS2 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "SHC1 gene" ; "https://reactome.org/content/detail/R-HSA-5642218" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000160691" ; "Reactome:R-HSA-5642218" , "ENSEMBL:ENSG00000160691" ; "SHC1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "N-glycan pp1a-nsp3-4" ; "https://reactome.org/content/detail/R-COV-9684267" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 3240 ; ] ; [ a ; [ a ; 819 ; ] ; () ] ] ] ; ; "Reactome:R-COV-9684267" ; "N-glycan pp1a-nsp3-4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "AcK-HIST1H2BC" ; "https://reactome.org/content/detail/R-HSA-4549246" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 126 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-4549246" ; "Histone H2B type 1-C/E/F/G/I" , "AcK-HIST1H2BC" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ALK fusions:p-4Y PLCG1" ; "https://reactome.org/content/detail/R-HSA-9712072" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9712072" ; "ALK fusions:p-4Y PLCG1" . a ; "Unspecified modification type. Comment: [Replacement of residues 1081 to 1116 by RVRMEHMVERRKGASCLERVQGRDKIVHHLILRNIP]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ATRX K1081Rfs*37" ; "https://reactome.org/content/detail/R-HSA-9672745" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1116 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9672745" ; "ATRX K1081Rfs*37" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Rna" ; "CNOT6L mRNA" ; "https://reactome.org/content/detail/R-HSA-8945708" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENST00000264903" ; "ENSEMBLENST00000264903" , "Reactome:R-HSA-8945708" ; "CNOT6L mRNA" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PER3" ; "https://reactome.org/content/detail/R-HSA-400323" ; ; [ a ; [ a ; [ a ; 1201 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-400323" ; "PER3" , "Period circadian protein homolog 3" , "PER3_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "CACNA2D2a:CACNA2D2d" ; "https://reactome.org/content/detail/R-HSA-5577209" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5577209" ; "Voltage-dependent calcium channel subunit alpha-2-2:delta-2" , "CACNA2D2a:CACNA2D2d" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3" ; "https://reactome.org/content/detail/R-HSA-450241" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-450241" ; "p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3" . a ; . a ; "omega-N-methyl-L-arginine" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "B3GALT6 M1?" ; "https://reactome.org/content/detail/R-HSA-4420341" ; ; [ a ; [ a ; [ a ; 329 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-4420341" ; "B3GT6_HUMAN" , "B3GALT6 M1?" , "Beta-1,3-galactosyltransferase 6" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "cGMP:CNG channel" ; "https://reactome.org/content/detail/R-HSA-74011" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-74011" ; "cGMP:CNG channel" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "Unknown enzyme" ; "https://reactome.org/content/detail/R-HSA-9946782" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-9946782" ; "Unknown enzyme" . a ; "Unspecified modification type. Comment: [Replacement of residues 515 to 523 by ISMQVFQVI]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "BRCA2 T515Ifs*10" ; "https://reactome.org/content/detail/R-HSA-9712588" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 523 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9712588" ; "BRCA2 T515Ifs*10" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000026192" ; "pL1 (Y1176)" ; "https://reactome.org/content/detail/R-HSA-444985" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1176 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 1257 ; ] ; [ a ; [ a ; 20 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000026222" , "Reactome:R-HSA-444985" ; "p-Y1176-L1CAM" , "pL1 (Y1176)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PIK3CA Q546L" ; "https://reactome.org/content/detail/R-HSA-2362375" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 546 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1068 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2362375" ; "PIK3CA Q546L" , "PIK3CA Gln546Leu" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "LAP1" ; "https://reactome.org/content/detail/R-HSA-9736812" ; ; [ a ; [ a ; [ a ; 278 ; ] ; [ a ; [ a ; 30 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9736812" ; "Transforming Growth Factor beta 1 LAP" , "LAP1" , "TGFB1" , "TGFB1(30-278)" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CLARP2" ; "https://reactome.org/content/detail/R-HSA-3465357" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 221 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-3465357" ; "CASP8 and FADD-like apoptosis regulator Isoform 2" , "FLIP(S)" , "CASH beta" , "MRIT beta-1" , "CLARP2" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CRHR2-1" ; "https://reactome.org/content/detail/R-HSA-8937589" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 411 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8937589" ; "CRFR2_HUMAN" , "Corticotropin-releasing factor receptor 2" , "CRHR2-1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "ISCAL" ; "https://reactome.org/content/detail/R-ALL-193046" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-193046" ; "ISCAL" , "Isocaproic aldehyde" , "isocaproaldehyde" , "4-methylpentanal" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RS20_HUMAN" ; "https://reactome.org/content/detail/R-HSA-9948312" ; ; [ a ; [ a ; [ a ; 119 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 8 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9948312" ; "fullName evidence=\"10\"Small ribosomal subunit protein uS10" , "RS20_HUMAN" , "K63polyUb-K8-RPS20" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Rna" ; "tRNA Arg ACG 5' half" ; "https://reactome.org/content/detail/R-HSA-9708346" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:URS0000416E93_9606" ; "RNAcentralURS0000416E93_9606" , "Reactome:R-HSA-9708346" ; "tRNA Arg ACG 5' half" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DEFB108P1" ; "https://reactome.org/content/detail/R-HSA-8848265" ; ; [ a ; [ a ; [ a ; 73 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8848265" ; "DEFB108P1" , "Putative beta-defensin 108A" , "D108A_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000014241" ; "RPN2" ; "https://reactome.org/content/detail/R-HSA-6798741" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 953 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6798741" , "http://purl.obolibrary.org/obo/PR_P04844" ; "PSMD1" , "RPN2" , "26S proteasome non-ATPase regulatory subunit 1" , "26S proteasome regulatory subunit S1" , "26S proteasome subunit p112" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MAD2L1" ; "https://reactome.org/content/detail/R-HSA-141400" ; ; [ a ; [ a ; [ a ; 205 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-141400" ; "MAD2L1" , "HsMAD2" , "Mitotic spindle assembly checkpoint protein MAD2A (MAD2-like 1) (HsMAD2)" . a ; "Isa http://purl.obolibrary.org/obo/PR_000004397" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ATF1" ; "https://reactome.org/content/detail/R-HSA-199900" ; ; [ a ; [ a ; [ a ; 271 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-199900" , "http://purl.obolibrary.org/obo/PR_P18846" ; "ATF1_HUMAN" , "ATF1" , "Cyclic-AMP-dependent transcription factor ATF-1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC" ; "https://reactome.org/content/detail/R-HSA-5690214" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5690214" ; "GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_Q99715" ; "COL12A1" ; "https://reactome.org/content/detail/R-HSA-2192776" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 3063 ; ] ; [ a ; [ a ; 24 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000046779" , "Reactome:R-HSA-2192776" ; "COCA1_HUMAN" , "3x4Hyp-3Hyp-COL12A1" , "COL12A1" , "3,4-hydroxyprolyl-collagen alpha-1(XII) chain" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA)" ; "https://reactome.org/content/detail/R-HSA-9970140" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9970140" ; "Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "LMO1,LMO2" ; "https://reactome.org/content/detail/R-HSA-8956531" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-8956531" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "LMO1,LMO2" , "LMO1/LMO2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Cargo:AP-1:beta-Arrestin-1:Vamp Complex" ; "https://reactome.org/content/detail/R-HSA-432677" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-432677" ; "Cargo:AP-1:beta-Arrestin-1:Vamp Complex" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NCAM:pFyn-Y420" ; "https://reactome.org/content/detail/R-HSA-391843" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-391843" ; "NCAM:pFyn-Y420" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PTEN W274*" ; "https://reactome.org/content/detail/R-HSA-9659393" ; ; [ a ; [ a ; [ a ; 273 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 274 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9659393" ; "Pten Trp274*" , "PTEN W274*" , "PTEN Trp274TER" , "PTEN W274TER" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "FAD-SDHA:SDHB:2Fe-2S:3Fe-4S:4Fe-4S:SDHFA1:SDHFA3" ; "https://reactome.org/content/detail/R-HSA-9855213" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9855213" ; "FAD-SDHA:SDHB:2Fe-2S:3Fe-4S:4Fe-4S:SDHFA1:SDHFA3" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "m3G capped Spliceosomal snRNA" ; "https://reactome.org/content/detail/R-HSA-191834" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-191834" ; "m3G capped Spliceosomal snRNA" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ATM dimer:Ub-p-PEX5:SQSTM1:NBR1" ; "https://reactome.org/content/detail/R-HSA-9665165" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9665165" ; "ATM dimer:Ub-p-PEX5:SQSTM1:NBR1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "TC-NER incision complex" ; "https://reactome.org/content/detail/R-HSA-6782142" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6782142" ; "Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300:RPA:ERCC5:ERCC1:ERCC4" , "TC-NER incision complex" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "HGF:p-4Y-MET dimer:p-5Y-GAB1" ; "https://reactome.org/content/detail/R-HSA-8851941" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8851941" ; "HGF:p-4Y-MET dimer:p-5Y-GAB1" . a ; "Isa http://purl.obolibrary.org/obo/PR_Q9Y5X3" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SNX5" ; "https://reactome.org/content/detail/R-HSA-434207" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 404 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-434207" , "http://purl.obolibrary.org/obo/PR_000049317" ; "SNX5" , "Sorting nexin-5" , "SNX5_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Rna" ; "P1 mRNA" ; "https://reactome.org/content/detail/R-FLU-192977" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:J02151" ; "EMBLJ02151" , "Reactome:R-FLU-192977" ; "P1 mRNA" . a ; "Unspecified modification type. Comment: [Insertion of residues 1058 to 1620 at 959 from UniProt:Q9UM73 ALK]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "BIRC6_HUMAN" ; "https://reactome.org/content/detail/R-HSA-9713450" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 958 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9713450" ; "Baculoviral IAP repeat-containing protein 6 ecNumber evidence=\"9 11\"2.3.2.27/ecNumber" , "BIRC6_HUMAN" , "BIRC6(1-958)-ALK(1058-1620) fusion" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000007043" ; "ELP2" ; "https://reactome.org/content/detail/R-HSA-3318361" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 826 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q6IA86" , "Reactome:R-HSA-3318361" ; "ELP2_HUMAN" , "Elongator complex protein 2" , "ELP2" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DSG3" ; "https://reactome.org/content/detail/R-HSA-201590" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 999 ; ] ; [ a ; [ a ; 50 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-201590" ; "Desmoglein 3" , "DSG3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "HSO3-" ; "https://reactome.org/content/detail/R-ALL-9012724" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9012724" ; "HSO3-" , "hydrogensulfite" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PAK-2p34" ; "https://reactome.org/content/detail/R-HSA-211653" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 524 ; ] ; [ a ; [ a ; 213 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-211653" ; "PAK2(213-524)" , "PAK-2p34" . a ; "Isa http://purl.obolibrary.org/obo/PR_Q13797" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ITGA9" ; "https://reactome.org/content/detail/R-HSA-215944" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1035 ; ] ; [ a ; [ a ; 30 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000048065" , "Reactome:R-HSA-215944" ; "ITGA9" , "Integrin alpha-9" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "CCNA2:p-T14-CDK1" ; "https://reactome.org/content/detail/R-HSA-9929241" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9929241" ; "CCNA2:p-T14-CDK1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ATRX S797*" ; "https://reactome.org/content/detail/R-HSA-9671260" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 797 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 796 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9671260" ; "ATRX Ser797*" , "ATRX Ser797TER" , "ATRX S797*" , "ATRX S797TER" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "VAMP2,3,8" ; "https://reactome.org/content/detail/R-HSA-8869151" ; ; [ a ; ; ] ; , , ; "Reactome:R-HSA-8869151" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "VAMP2,3,8" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "guanidinium" ; "https://reactome.org/content/detail/R-ALL-9931161" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9931161" ; "guanidinium" . a ; "Isa http://purl.obolibrary.org/obo/PR_P25940" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "COL5A3" ; "https://reactome.org/content/detail/R-HSA-2022972" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1745 ; ] ; [ a ; [ a ; 30 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_000046959" , "Reactome:R-HSA-2022972" ; "COL5A3" , "3,4-Hyp 5-Hyl collagen alpha-3(V) propeptide" , "CO5A3_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "FP subcomplex" ; "https://reactome.org/content/detail/R-HSA-5689686" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5689686" ; "FlavoProtein fraction" , "FP subcomplex" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_000016346" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TIMM22" ; "https://reactome.org/content/detail/R-HSA-1267997" ; ; [ a ; [ a ; [ a ; 194 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1267997" , "http://purl.obolibrary.org/obo/PR_Q9Y584" ; "Mitochondrial import inner membrane translocase subunit Tim22" , "TIMM22" , "TIM22_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "FBXO32 gene" ; "https://reactome.org/content/detail/R-HSA-9624642" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000156804" ; "Reactome:R-HSA-9624642" , "ENSEMBL:ENSG00000156804" ; "FBXO32 gene" , "Atrogin-1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 257 to 340 by PVVIYWDGTALRCVFVPVLGETGAQRKRISARKGSLTTSCPQGALSEHCPTTPAPLPSQRRNHWMENISPFRSVGVSASRCSES]" ; "TP53 L257Pfs*85" ; "https://reactome.org/content/detail/R-HSA-9719685" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 340 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9719685" ; "TP53 L257Pfs*85" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Insertion of residues 381 to 766 at 511 from UniProt:P15056 BRAF]" ; "TRIM24(1-510)-BRAF(381-766) fusion" ; "https://reactome.org/content/detail/R-HSA-6802477" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 729 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 510 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 446 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6802477" ; "TRIM24(1-510)-BRAF(381-766) fusion" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-GFAP:EEF1A1" ; "https://reactome.org/content/detail/R-HSA-9626070" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9626070" ; "p-GFAP:EEF1A1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "XRCC5:XRCC6" ; "https://reactome.org/content/detail/R-HSA-75905" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-75905" ; "Ku70:Ku80 heterodimer" , "XRCC5:XRCC6" . a ; "Isa http://purl.obolibrary.org/obo/PR_000011329" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "NOSIP" ; "https://reactome.org/content/detail/R-HSA-203636" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 301 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-203636" , "http://purl.obolibrary.org/obo/PR_Q9Y314" ; "NOSIP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Influenza A Viral Envelope With An Inter-Membrane Spanning HA2" ; "https://reactome.org/content/detail/R-FLU-189172" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "60"^^ ] ; [ a ; ; ; "100"^^ ] ; [ a ; ; ; "500"^^ ] ; ; "Reactome:R-FLU-189172" ; "Influenza A Viral Envelope With An Inter-Membrane Spanning HA2" . a ; . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "phosphorylated anaphase promoting complex (APC/C)" ; "https://reactome.org/content/detail/R-HSA-174191" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-174191" ; "phosphorylated anaphase promoting complex (APC/C)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Opioid receptor:opioid ligand" ; "https://reactome.org/content/detail/R-HSA-374302" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-374302" ; "Opioid receptor:opioid ligand" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "C5AR2 ligands" ; "https://reactome.org/content/detail/R-HSA-964782" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-964782" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "C5AR2 ligands" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Ub,p-POLR2:damaged DNA template:nascent mRNA hybrid:TFIIH" ; "https://reactome.org/content/detail/R-HSA-6781990" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6781990" ; "Ub,p-POLR2:damaged DNA template:nascent mRNA hybrid:TFIIH" , "Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH" . a ; "Isa http://purl.obolibrary.org/obo/PR_A6NMZ7" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "COL6A6" ; "https://reactome.org/content/detail/R-HSA-2023511" ; ; [ a ; [ a ; [ a ; 2263 ; ] ; [ a ; [ a ; 20 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2023511" , "http://purl.obolibrary.org/obo/PR_000046979" ; "COL6A6" , "CO6A6_HUMAN" , "Collagen alpha-6(VI) chain" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-S28-PPP2R5A" ; "https://reactome.org/content/detail/R-HSA-9836658" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 28 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 486 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9836658" ; "PP2A- 56 kDa regulatory subunit, alpha isoform" , "p-S28-PPP2R5A" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "OR4C12:isovaleric acid" ; "https://reactome.org/content/detail/R-HSA-9737271" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9737271" ; "OR4C12:isovaleric acid" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NICD3:TACC3" ; "https://reactome.org/content/detail/R-HSA-9017852" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9017852" ; "NICD3:TACC3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_Q14653-1" ; "p-IRF3" ; "https://reactome.org/content/detail/R-HSA-936418" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 398 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 396 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 404 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 402 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 339 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 427 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 405 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_000045489" , "Reactome:R-HSA-936418" ; "p-6S-IRF3" , "p-IRF3" , "p-5S,T404-IRF3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "CUX1-p-FGFR1 fusion mutant dimer" ; "https://reactome.org/content/detail/R-HSA-1838992" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1838992" ; "CUX1-p-FGFR1 fusion mutant dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "3x4Hyp-3Hyp-5Hyl-COL4A3(1426-1670)" ; "https://reactome.org/content/detail/R-HSA-4085054" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1670 ; ] ; [ a ; [ a ; 1426 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-4085054" ; "3x4Hyp-3Hyp-5Hyl-COL4A3(1426-1670)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Complex of CD19, CD81, CD225 and CD21" ; "https://reactome.org/content/detail/R-HSA-198931" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-198931" ; "Complex of CD19, CD81, CD225 and CD21" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Edited GRIK2 (GluR6)" ; "https://reactome.org/content/detail/R-HSA-451318" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 621 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 571 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 908 ; ] ; [ a ; [ a ; 32 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 567 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-451318" ; "Edited GRIK2 (GluR6)" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_P07900" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HSP90" ; "https://reactome.org/content/detail/R-HSA-3221912" ; ; [ a ; [ a ; [ a ; 732 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000047909" , "Reactome:R-HSA-3221912" ; "HSP90" , "HSP90AA1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "B-WICH" ; "https://reactome.org/content/detail/R-HSA-5250626" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5250626" ; "B-WICH" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SEH1L-1" ; "https://reactome.org/content/detail/R-HSA-376246" ; ; [ a ; [ a ; [ a ; 360 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-376246" ; "SEH1L-1" , "SEH1L isoform 1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "MYB gene:hypophosphorylated RNA polymerase II:TFIIF" ; "https://reactome.org/content/detail/R-HSA-9012307" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9012307" ; "MYB gene:hypophosphorylated RNA polymerase II:TFIIF" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "dsDNA:ZBP1:pS-172-TBK:IRF3" ; "https://reactome.org/content/detail/R-HSA-1606328" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1606328" ; "dsDNA:ZBP1:pS-172-TBK:IRF3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "TGFB1:TGFBR2:p-TGFBR1" ; "https://reactome.org/content/detail/R-HSA-170841" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-170841" ; "TGFB1:TGFBR2:p-TGFBR1" , "TGF-beta 1:type II receptor:Phospho-type I receptor complex" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2" ; "https://reactome.org/content/detail/R-HSA-914047" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-914047" ; "High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "dADP" ; "https://reactome.org/content/detail/R-ALL-110090" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-110090" ; "dADP" , "dADP(3-)" , "2'-deoxyadenosine 5'-diphosphate" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Ub" ; "https://reactome.org/content/detail/R-HSA-9660007" ; ; [ a ; ; ] ; , , , ; "Reactome:R-HSA-9660007" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ; "Ub" , "ubiquitin" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DCN" ; "https://reactome.org/content/detail/R-HSA-2064056" ; ; [ a ; [ a ; [ a ; 359 ; ] ; [ a ; [ a ; 31 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2064056" ; "DCN" , "CSE-DCN" , "Decorin" , "PGS2_HUMAN" , "_DCN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "GADD45A:AURKA" ; "https://reactome.org/content/detail/R-HSA-6791236" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-6791236" ; "GADD45A:AURKA" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Protein N decamer" ; "https://reactome.org/content/detail/R-RSY-9823371" ; ; [ a ; ; ] ; [ a ; ; ; "10"^^ ] ; ; "Reactome:R-RSY-9823371" ; "Protein N decamer" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MUC5AC" ; "https://reactome.org/content/detail/R-HSA-1462332" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 5654 ; ] ; [ a ; [ a ; 28 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1462332" ; "MUC5AC" , "MUC5A_HUMAN" , "Core 2 (MUC5AC)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome" ; "https://reactome.org/content/detail/R-HSA-5682998" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-5682998" ; "Nucleosome with Histone K63PolyUb,gamma-H2A.x and H4K20Me2" , "K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "EGF:Phospho-EGFR" ; "https://reactome.org/content/detail/R-HSA-179860" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-179860" ; "EGF:Phospho-EGFR" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SLP-76 bound to Gads:LAT" ; "https://reactome.org/content/detail/R-HSA-202151" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-202151" ; "SLP-76 bound to Gads:LAT" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "EFOX-D6" ; "https://reactome.org/content/detail/R-ALL-9027537" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9027537" ; "(4Z,7Z,10Z,14E,16Z,19Z)-13-oxodocosahexaenoic acid" , "13-oxo-DHA" , "EFOX-D6" , "13-oxo-docosahexaenoic acid" . a ; "Isa http://purl.obolibrary.org/obo/PR_000016083" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TAS2R50" ; "https://reactome.org/content/detail/R-HSA-3299619" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 299 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-3299619" , "http://purl.obolibrary.org/obo/PR_P59544" ; "TAS2R50" , "T2R50_HUMAN" , "Taste receptor type 2 member 50" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P47755" ; "CAPZA2" ; "https://reactome.org/content/detail/R-HSA-879448" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 286 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_000046564" , "Reactome:R-HSA-879448" ; "CAPZA2" , "CAZA2_HUMAN" , "F-actin-capping protein subunit alpha-2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12" ; "https://reactome.org/content/detail/R-HSA-9033091" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9033091" ; "PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000001344" ; "ENPP3" ; "https://reactome.org/content/detail/R-HSA-8939012" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 875 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8939012" , "http://purl.obolibrary.org/obo/PR_O14638" ; "ENPP3_HUMAN" , "ENPP3" , "Ectonucleotide pyrophosphatase/phosphodiesterase family member 3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "activated RAF1 mutant:scaffold:MAP2K:MAPK complex" ; "https://reactome.org/content/detail/R-HSA-9656179" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9656179" ; "activated RAF1 mutant:scaffold:MAP2K:MAPK complex" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_Q6UXV4" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "APOOL" ; "https://reactome.org/content/detail/R-HSA-8862979" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 268 ; ] ; [ a ; [ a ; 28 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8862979" , "http://purl.obolibrary.org/obo/PR_000046367" ; "MIC27_HUMAN" , "MICOS complex subunit MIC27" , "APOOL" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HAGH-2" ; "https://reactome.org/content/detail/R-HSA-6783219" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 308 ; ] ; [ a ; [ a ; 14 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6783219" ; "GLO2_HUMAN" , "HAGH-2" , "Hydroxyacylglutathione hydrolase, mitochondrial ecNumber3.1.2.6/ecNumber" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "OR5M9" ; "https://reactome.org/content/detail/R-HSA-9751598" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 310 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9751598" ; "OR5M9" , "Olfactory receptor 5M9" , "OR5M9_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "USP17L22" ; "https://reactome.org/content/detail/R-HSA-8848674" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 530 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-8848674" ; "Ubiquitin carboxyl-terminal hydrolase 17-like protein 22 ecNumber3.4.19.12/ecNumber" , "U17LM_HUMAN" , "USP17L22" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 77 to 148 by CTSSSYTGGPCTSPLLAPVIFCPFPENLPGQLRFPSGLLAFWDSQVCDLHVLPCPQQDVLPTGQDLPCAAVG]" ; "TP53 P77Cfs*73" ; "https://reactome.org/content/detail/R-HSA-9718818" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 148 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9718818" ; "TP53 P77Cfs*73" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Ub-63-UBB" ; "https://reactome.org/content/detail/R-HSA-939224" ; ; [ a ; [ a ; [ a ; 76 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 63 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-939224" ; "K63 ubiquitin (UBB 1)" , "Ub-63-UBB" , "Ub-63-UBB(1-76)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "hSLU7" ; "https://reactome.org/content/detail/R-HSA-72073" ; ; [ a ; [ a ; [ a ; 586 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-72073" ; "SLU7_HUMAN" , "hSLU7" , "Pre-mRNA splicing factor SLU7" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GPI-ART4" ; "https://reactome.org/content/detail/R-HSA-8941009" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 285 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 285 ; ] ; [ a ; [ a ; 47 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-8941009" ; "Ecto-ADP-ribosyltransferase 4 ecNumber2.4.2.31/ecNumber" , "NAR4_HUMAN" , "cleaved GPI-ART4" , "GPI-ART4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "ChoP" ; "https://reactome.org/content/detail/R-ALL-6814794" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-6814794" ; "phosphocholine" , "Choline phosphate" , "ChoP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SLC6A3 R521W" ; "https://reactome.org/content/detail/R-HSA-5660729" ; ; [ a ; [ a ; [ a ; 620 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 521 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5660729" ; "SLC6A3 R521W" , "Sodium dependent Dopamine transporter" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-S423,S425-SMAD3 D258N" ; "https://reactome.org/content/detail/R-HSA-3315470" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 258 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 425 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 425 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 423 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-3315470" ; "p-Ser423,Ser425-SMAD3 Asp258Asn" , "p-S423,S425-SMAD3 D258N" . a ; "Isa http://purl.obolibrary.org/obo/PR_000003753" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ADCY2" ; "https://reactome.org/content/detail/R-HSA-379052" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1091 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q08462" , "Reactome:R-HSA-379052" ; "ADCY2_HUMAN" , "ADCY2" , "Adenylate cyclase type 2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 697 to 718 by QAFGPNYDVFHVWHMQSEEYRP]" ; "RB1 D697Qfs*23" ; "https://reactome.org/content/detail/R-HSA-9688119" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 718 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9688119" ; "RB1 D697Qfs*23" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000012411" ; "PCGF2" ; "https://reactome.org/content/detail/R-HSA-389115" ; ; [ a ; [ a ; [ a ; 344 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-389115" , "http://purl.obolibrary.org/obo/PR_P35227" ; "PCGF2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "RPA:DNA containing single strand gap" ; "https://reactome.org/content/detail/R-HSA-5358538" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5358538" ; "RPA:DNA containing single strand gap" . a ; "Isa http://purl.obolibrary.org/obo/PR_P23458" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "JAK1_HUMAN" ; "https://reactome.org/content/detail/R-HSA-1112543" ; ; [ a ; [ a ; [ a ; 1154 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1034 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-1112543" , "http://purl.obolibrary.org/obo/PR_000048083" ; "Janus kinase 1" , "Tyrosine-protein kinase JAK1" , "JAK1_HUMAN" , "p(Y1034)-JAK1" , "p-Y1034-JAK1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000017849" ; "ZNF354B" ; "https://reactome.org/content/detail/R-HSA-1247543" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 612 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q96LW1" , "Reactome:R-HSA-1247543" ; "ZNF354B" , "Z354B_HUMAN" , "Zinc finger protein 354B" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-STK3:p-SAV1" ; "https://reactome.org/content/detail/R-HSA-2028261" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-2028261" ; "p-STK3:p-SAV1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "C" ; "https://reactome.org/content/detail/R-DVI-9918825" ; ; [ a ; [ a ; [ a ; 100 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-DVI-9918825" ; "C" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000006989" ; "EIF4B" ; "https://reactome.org/content/detail/R-HSA-72589" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 611 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-72589" , "http://purl.obolibrary.org/obo/PR_P23588" ; "Eukaryotic translation initiation factor 4B" , "EIF4B" , "eIF4B" , "eIF-4B" , "eukaryotic translation initiation factor 4B" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SMAD4 E175*" ; "https://reactome.org/content/detail/R-HSA-9675637" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 174 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 175 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9675637" ; "SMAD4 Glu175*" , "SMAD4 E175TER" , "SMAD4 Glu175TER" , "SMAD4 E175*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MEF2 proteins" ; "https://reactome.org/content/detail/R-HSA-448868" ; ; [ a ; ; ] ; , , , ; "Reactome:R-HSA-448868" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "MEF2 proteins" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GNE A631V" ; "https://reactome.org/content/detail/R-HSA-4088376" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 722 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 631 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-4088376" ; "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase" , "GLCNE_HUMAN" , "GNE A631V" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "phosphorylated IRF3 and/or IRF7 dimer" ; "https://reactome.org/content/detail/R-HSA-450349" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-450349" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "phosphorylated IRF3 and/or IRF7 dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "HSPA1B:ATP" ; "https://reactome.org/content/detail/R-HSA-6792614" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-6792614" ; "HSPA1B:ATP" . a ; "Isa http://purl.obolibrary.org/obo/PR_000020366" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KARS" ; "https://reactome.org/content/detail/R-HSA-379568" ; ; [ a ; [ a ; [ a ; 597 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000027320" , "Reactome:R-HSA-379568" ; "Lysyl-tRNA synthetase" , "KARS" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CNN2" ; "https://reactome.org/content/detail/R-HSA-6800942" ; ; [ a ; [ a ; [ a ; 309 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6800942" ; "Calponin-2" , "CNN2_HUMAN" , "CNN2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "UDP-GlcA" ; "https://reactome.org/content/detail/R-ALL-174384" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-174384" ; "UDP-glucuronic acid" , "UDP-alpha-D-glucuronic acid" , "UDP-GlcA" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "LEP:p-LEPR:p-JAK2:p-SHP2" ; "https://reactome.org/content/detail/R-HSA-2671749" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-2671749" ; "LEP:p-LEPR:p-JAK2:p-SHP2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "BPGM dimer" ; "https://reactome.org/content/detail/R-HSA-6798333" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-6798333" ; "BPGM dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2" ; "https://reactome.org/content/detail/R-HSA-8863841" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1221 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1139 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1255 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1196 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1222 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1023 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-8863841" ; "p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "B-RAF" ; "https://reactome.org/content/detail/R-HSA-9648850" ; ; [ a ; [ a ; [ a ; 766 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 581 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 446 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 729 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9648850" ; "BRAF N581S" , "B-RAF" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000011648" ; "OPHN1" ; "https://reactome.org/content/detail/R-HSA-195201" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 802 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_O60890" , "Reactome:R-HSA-195201" ; "OPHN1" , "Oligophrenin-1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-CaMKK:CALM1:4xCa2+" ; "https://reactome.org/content/detail/R-HSA-9618956" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9618956" ; "p-CaMKK:CALM1:4xCa2+" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TeNT LC disulfide bonded" ; "https://reactome.org/content/detail/R-CTE-5228385" ; ; [ a ; [ a ; [ a ; 457 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 438 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-CTE-5228385" ; "TeNT(2-457) disulfide bonded" , "tetX(2-457) disulfide bonded" , "TeNT LC disulfide bonded" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "OR6M1 gene" ; "https://reactome.org/content/detail/R-HSA-9752460" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000196099" ; "ENSEMBL:ENSG00000196099" , "Reactome:R-HSA-9752460" ; "OR6M1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P05165" ; "Btn-PCCA" ; "https://reactome.org/content/detail/R-HSA-3323186" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 728 ; ] ; [ a ; [ a ; 53 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 694 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-3323186" , "http://purl.obolibrary.org/obo/PR_000048702" ; "PCCase alpha subunit" , "Propionyl-CoA carboxylase alpha chain, mitochondrial precursor" , "PCCA_HUMAN" , "Btn-PCCA" , "Propanoyl-CoA:carbon dioxide ligase alpha subunit" , "propionyl-CoA carboxylase alpha chain, apoprotein" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "C4 alpha 2" ; "https://reactome.org/content/detail/R-HSA-981501" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1336 ; ] ; [ a ; [ a ; 957 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-981501" ; "C4A-derived C4d" , "C4 alpha 2" , "C4A(957-1336)" , "CO4A_HUMAN" , "Complement factor 4 fragment d" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "3x4Hyp-3Hyp-GlcGalHyl-COL1A1(162-1464)" ; "https://reactome.org/content/detail/R-HSA-2268743" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1464 ; ] ; [ a ; [ a ; 162 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2268743" ; "3x4Hyp-3Hyp-GlcGalHyl-COL1A1(162-1464)" , "3,4-Hyp Glu-Gal-Hyl collagen alpha-1(I) -N propeptide" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "released pre-RNA Pol III oligonucleotide" ; "https://reactome.org/content/detail/R-ALL-111984" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-111984" ; "released pre-RNA Pol III oligonucleotide" . a ; "Isa http://purl.obolibrary.org/obo/PR_000014906" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SNO" ; "https://reactome.org/content/detail/R-HSA-2186596" ; ; [ a ; [ a ; [ a ; 684 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_P12757" , "Reactome:R-HSA-2186596" ; "SKIL" , "Ski-like protein" , "SNO" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "diaminomethylacridinium" ; "https://reactome.org/content/detail/R-ALL-9931570" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9931570" ; "3,6-diamino-10-methylacridinium" , "diaminomethylacridinium" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "VDAC2" ; "https://reactome.org/content/detail/R-HSA-9843314" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 294 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9843314" ; "VDAC2_HUMAN" , "Voltage-dependent anion-selective channel protein 2" , "VDAC2" , "K63polyUb-VDAC2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "GGC-RAB21:GDP" ; "https://reactome.org/content/detail/R-HSA-8876839" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8876839" ; "GGC-RAB21:GDP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "RAB30:GTP" ; "https://reactome.org/content/detail/R-HSA-8849729" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8849729" ; "RAB30:GTP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "UBD" ; "https://reactome.org/content/detail/R-HSA-8956123" ; ; [ a ; [ a ; [ a ; 165 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8956123" ; "UBD_HUMAN" , "Ubiquitin D" , "UBD" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "KEOPS complex" ; "https://reactome.org/content/detail/R-HSA-6784495" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-6784495" ; "KEOPS complex" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000004590" ; "B3GAT3" ; "https://reactome.org/content/detail/R-HSA-1889987" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 335 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-1889987" , "http://purl.obolibrary.org/obo/PR_O94766" ; "B3GAT3" , "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3" , "B3GA3_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HMGCR-2" ; "https://reactome.org/content/detail/R-HSA-191426" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 888 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-191426" ; "3-hydroxy-3-methylglutaryl-coenzyme A reductase-2" , "HMDH_HUMAN" , "HMGCR isoform 2" , "HMGCR-2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "Ligand of OR7C1" ; "https://reactome.org/content/detail/R-ALL-9737280" ; ; [ a ; ; ] ; , ; "Reactome:R-ALL-9737280" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "Ligand of OR7C1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KRTAP2s" ; "https://reactome.org/content/detail/R-HSA-6809961" ; ; [ a ; ; ] ; , , , ; "Reactome:R-HSA-6809961" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "KRTAP2s" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "SFTPD 12mer, SFTPAs" ; "https://reactome.org/content/detail/R-HSA-5687334" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-5687334" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "SFTPD 12mer, SFTPAs" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000017368" ; "FOE" ; "https://reactome.org/content/detail/R-HSA-2577090" ; ; [ a ; [ a ; [ a ; 1190 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q7Z5K2" , "Reactome:R-HSA-2577090" ; "Wings apart-like protein homolog" , "WAPL" , "WAPAL" , "FOE" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "BACE1_HUMAN" ; "https://reactome.org/content/detail/R-HSA-5693106" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 285 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 299 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 307 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 126 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 300 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 279 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 501 ; ] ; [ a ; [ a ; 46 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 275 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5693106" ; "7K-BACE1(46-501)" , "BACE1_HUMAN" , "Beta-secretase 1 ecNumber3.4.23.46/ecNumber" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B" ; "https://reactome.org/content/detail/R-HSA-8936615" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8936615" ; "H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "PDE6D:INPP5E" ; "https://reactome.org/content/detail/R-HSA-5624934" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5624934" ; "PDE6D:INPP5E" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GRK4-1" ; "https://reactome.org/content/detail/R-HSA-6787795" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 578 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6787795" ; "G protein-coupled receptor kinase 4 ecNumber2.7.11.16/ecNumber" , "GRK4_HUMAN" , "GRK4-1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CALCA" ; "https://reactome.org/content/detail/R-HSA-419836" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 119 ; ] ; [ a ; [ a ; 83 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-419836" ; "CALCA(83-119)" , "CALCA_HUMAN" , "CALCA" , "Calcitonin gene-related peptide 1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "IK" ; "https://reactome.org/content/detail/R-HSA-9770239" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 557 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9770239" ; "IK" , "RED_HUMAN" , "fullName evidence=\"9\"Protein Red" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_000008574" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HIST1H1A" ; "https://reactome.org/content/detail/R-HSA-211245" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 215 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_Q02539" , "Reactome:R-HSA-211245" ; "histone H1.1" , "HIST1H1A" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p10S/T-LRP5/6" ; "https://reactome.org/content/detail/R-HSA-1458891" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-1458891" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "p10S/T-LRP5/6" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PR (Protease) (P04585) protein" ; "https://reactome.org/content/detail/R-HIV-175182" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 587 ; ] ; [ a ; [ a ; 489 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HIV-175182" ; "PR (Protease) (P04585) protein" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Histone H3a" ; "https://reactome.org/content/detail/R-HSA-4722135" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 136 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 37 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-4722135" ; "Histone H3j" , "Histone H3d" , "Histone H3l" , "Histone H3f" , "Histone H3i" , "Histone H3.1" , "Histone H3a" , "Histone H3k" , "Histone H3c" , "Histone H3b" , "MeK37-HIST1H3A" , "Histone H3h" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000007542" ; "FKBP6" ; "https://reactome.org/content/detail/R-HSA-912512" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 327 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-912512" , "http://purl.obolibrary.org/obo/PR_O75344" ; "FKBP6" , "Peptidyl-prolyl cis-trans isomerase FKBP6" , "FKBP6_HUMAN" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RB1 W681*" ; "https://reactome.org/content/detail/R-HSA-9662661" ; ; [ a ; [ a ; [ a ; 680 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 681 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9662661" ; "RB1 Trp681*" , "RB1 W681*" , "RB1 Trp681TER" , "RB1 W681TER" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "APC_HUMAN" ; "https://reactome.org/content/detail/R-HSA-9666952" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1464 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1463 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9666952" ; "APC_HUMAN" , "Adenomatous polyposis coli protein" , "APC E1464TER" , "APC E1464*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ATP1A2" ; "https://reactome.org/content/detail/R-HSA-936827" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1020 ; ] ; [ a ; [ a ; 6 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-936827" ; "AT1A2_HUMAN" , "Sodium/potassium-transporting ATPase subunit alpha-2" , "ATP1A2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "UHRF1:DPPA3" ; "https://reactome.org/content/detail/R-HSA-9818471" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9818471" ; "UHRF1:DPPA3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "FOXO3,FOXO6,(FOXO1):CAT gene" ; "https://reactome.org/content/detail/R-HSA-9622806" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9622806" ; "FOXO3,FOXO6,(FOXO1):CAT gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SHC1" ; "https://reactome.org/content/detail/R-HSA-2404179" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 583 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2404179" ; "SHC1 p66" , "SHC1" , "SHC1_HUMAN" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-S184,T180-CD274" ; "https://reactome.org/content/detail/R-HSA-9929349" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 184 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 180 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9929349" ; "p-S184,T180-CD274" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "UBC9_HUMAN" ; "https://reactome.org/content/detail/R-HSA-2993782" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2993782" ; "SUMO-conjugating enzyme UBC9" , "SUMO3 S-glycyl-cys93 UBE2I" , "UBC9_HUMAN" , "SUMO3:UBE2I" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_Q02750" ; "p-T286,292-MEK1" ; "https://reactome.org/content/detail/R-HSA-112374" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 292 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 393 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 286 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_000048295" , "Reactome:R-HSA-112374" ; "MAP kinase kinase 1(phosphorylated)" , "MAPK/ERK kinase 1" , "p-T286,292-MEK1" , "Dual specificity mitogen-activated protein kinase kinase 1 phosphorylated" , "p-T286,T292-MAP2K1" , "ERK activator kinase 1(phosphorylated)" , "p-T286,292-MAPKK 1" , "MEK1(phosphorylated)" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "OR14C36 gene" ; "https://reactome.org/content/detail/R-HSA-9752159" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000177174" ; "ENSEMBL:ENSG00000177174" , "Reactome:R-HSA-9752159" ; "OR14C36 gene" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P18206" ; "VCL" ; "https://reactome.org/content/detail/R-HSA-6799711" ; ; [ a ; [ a ; [ a ; 1134 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6799711" , "http://purl.obolibrary.org/obo/PR_000049648" ; "Vinculin" , "VCL" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HLTF" ; "https://reactome.org/content/detail/R-HSA-8855007" ; ; [ a ; [ a ; [ a ; 1009 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8855007" ; "HLTF" , "HLTF_HUMAN" , "Helicase-like transcription factor ecNumber3.6.4.-/ecNumber ecNumber6.3.2.-/ecNumber" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "BBS/CCT complex" ; "https://reactome.org/content/detail/R-HSA-5624117" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5624117" ; "BBS/CCT complex" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Unfolded STAT3" ; "https://reactome.org/content/detail/R-HSA-6813811" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 770 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6813811" ; "Unfolded STAT3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "IKK complex" ; "https://reactome.org/content/detail/R-HSA-168113" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-168113" , "http://purl.obolibrary.org/obo/PR_000026457" ; "IKK complex" , "IKKA:IKBKB:IKBKG" , "CHUK:IKBKB:IKBKG" , "Inhibitor of KappaB kinase (IKK) Complex" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 65 to 147 by QNARGCSPRGPCTSSSYTGGPCTSPLLAPVIFCPFPENLPGQLRFPSGLLAFWDSQVCDLHVLPCPQQDVLPTGQDLPCAAVG]" ; "TP53 R65Qfs*84" ; "https://reactome.org/content/detail/R-HSA-9721081" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 147 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9721081" ; "TP53 R65Qfs*84" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Activated PPARG:RXRA:ACSL1 gene:nucleosomes" ; "https://reactome.org/content/detail/R-HSA-9864716" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9864716" ; "Activated PPARG:RXRA:ACSL1 gene:nucleosomes" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SLC25A15 L283F" ; "https://reactome.org/content/detail/R-HSA-9959759" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 301 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 283 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9959759" ; "Mitochondrial ornithine transporter 1" , "SLC25A15 L283F" , "Solute carrier family 25, member 15" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PXDN" ; "https://reactome.org/content/detail/R-HSA-2559628" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1479 ; ] ; [ a ; [ a ; 27 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2559628" ; "PXDN" , "Peroxidasin" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "FOXO4:MEF2C:NKX2-5:MYOCD gene" ; "https://reactome.org/content/detail/R-HSA-9735435" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9735435" ; "FOXO4:MEF2C:NKX2-5:MYOCD gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "F1" ; "https://reactome.org/content/detail/R-RSY-9829176" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 550 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 574 ; ] ; [ a ; [ a ; 137 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 500 ; ] ; () ] ] ] ; ; "Reactome:R-RSY-9829176" ; "F1" , "Fusion glycoprotein F1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CAMP(31-170)" ; "https://reactome.org/content/detail/R-HSA-5432964" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 170 ; ] ; [ a ; [ a ; 31 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5432964" ; "CAP-18 propeptide" , "CAMP(31-170)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 986 to 986 by K]" ; "BRCA2 N986Kfs*2" ; "https://reactome.org/content/detail/R-HSA-9712890" ; ; [ a ; [ a ; [ a ; 986 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9712890" ; "BRCA2 N986Kfs*2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_Q8N3U4" ; "p-STAG2" ; "https://reactome.org/content/detail/R-HSA-2466013" ; ; [ a ; [ a ; [ a ; 1231 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000049359" , "Reactome:R-HSA-2466013" ; "p-STAG2" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "ARNTL gene" ; "https://reactome.org/content/detail/R-HSA-5640173" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000133794" ; "ENSEMBL:ENSG00000133794" , "Reactome:R-HSA-5640173" ; "ARNTL gene" . a ; "Isa http://purl.obolibrary.org/obo/PR_000011774" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "OR2L13" ; "https://reactome.org/content/detail/R-HSA-378599" ; ; [ a ; [ a ; [ a ; 312 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-378599" , "http://purl.obolibrary.org/obo/PR_Q8N349" ; "Olfactory receptor 2L13" , "OR2LD_HUMAN" , "OR2L13" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SYT8 dimer" ; "https://reactome.org/content/detail/R-HSA-8862872" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8862872" ; "SYT8 dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "OR6C1" ; "https://reactome.org/content/detail/R-HSA-9751491" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 312 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9751491" ; "OR6C1_HUMAN" , "Olfactory receptor 6C1" , "OR6C1" . a ; "Isa http://purl.obolibrary.org/obo/PR_000027255" , "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "KIF15 dimer" ; "https://reactome.org/content/detail/R-HSA-984823" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-984823" , "http://purl.obolibrary.org/obo/PR_000027397" ; "KIF15 dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NS5:PML-3/4" ; "https://reactome.org/content/detail/R-HSA-9921708" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9921708" ; "NS5:PML-3/4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Man,Man9GlucNAc2-CDH1(23-882)" ; "https://reactome.org/content/detail/R-HSA-9933097" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 580 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 472 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 509 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 285 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 280 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 637 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 558 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 470 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 578 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 622 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 882 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 358 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 576 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 570 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9933097" ; "Man,Man9GlucNAc2-CDH1(23-882)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000017015" ; "UBR4" ; "https://reactome.org/content/detail/R-HSA-6801503" ; ; [ a ; [ a ; [ a ; 5183 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6801503" , "http://purl.obolibrary.org/obo/PR_Q5T4S7" ; "E3 ubiquitin-protein ligase UBR4" , "UBR4_HUMAN" , "UBR4" . a ; . a . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Prolyl 3-hydroxylases:Fe2+" ; "https://reactome.org/content/detail/R-HSA-1981160" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-1981160" ; "Prolyl 3-hydroxylases:Fe2+" . a ; "Unspecified modification type. Comment: [Replacement of residues 370 to 378 by LHTLQLGLL]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RB1 P370Lfs*10" ; "https://reactome.org/content/detail/R-HSA-9688012" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 378 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9688012" ; "RB1 P370Lfs*10" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000003852" ; "AT2L2_HUMAN" ; "https://reactome.org/content/detail/R-HSA-5696428" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 278 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 450 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5696428" , "http://purl.obolibrary.org/obo/PR_Q8IUZ5" ; "PXLP-K278-PHYKPL" , "5-phosphohydroxy-L-lysine phospho-lyase ecNumber4.2.3.134/ecNumber" , "AT2L2_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "maltotriose" ; "https://reactome.org/content/detail/R-ALL-191103" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-191103" ; "alpha-maltotriose" , "maltotriose" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "AcK-histone H2B" ; "https://reactome.org/content/detail/R-HSA-4549247" ; ; [ a ; ; ] ; , , , , , , , , , , , , , ; "Reactome:R-HSA-4549247" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "AcK-histone H2B" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RBM7" ; "https://reactome.org/content/detail/R-HSA-8985564" ; ; [ a ; [ a ; [ a ; 266 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8985564" ; "RNA-binding protein 7" , "RBM7" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HLA-DQA1" ; "https://reactome.org/content/detail/R-HSA-2130529" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 254 ; ] ; [ a ; [ a ; 24 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2130529" ; "HLA-DQA1" , "HA23_HUMAN" , "HLA class II histocompatibility antigen, DQ" . a ; "Isa http://purl.obolibrary.org/obo/PR_P46777" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RPL5" ; "https://reactome.org/content/detail/R-HSA-72482" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 297 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000049092" , "Reactome:R-HSA-72482" ; "60S ribosomal protein L5" , "RPL5" , "P46777" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "miR-132 Endonucleolytic RISC" ; "https://reactome.org/content/detail/R-HSA-9021192" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9021192" ; "miR-132 Endonucleolytic RISC" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000006449" ; "DGKK" ; "https://reactome.org/content/detail/R-HSA-426067" ; ; [ a ; [ a ; [ a ; 1271 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q5KSL6" , "Reactome:R-HSA-426067" ; "DGKK" , "Diacylglycerol kinase kappa" , "DGKK_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Kv7 subunits of voltage gated potassium channels" ; "https://reactome.org/content/detail/R-HSA-1296100" ; ; [ a ; ; ] ; , , , , ; "Reactome:R-HSA-1296100" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ; "Kv7 subunits of voltage gated potassium channels" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "DDR2-binding collagens" ; "https://reactome.org/content/detail/R-HSA-2465861" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-2465861" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ; "DDR2-binding collagens" , "Collagen type I, II, III, V, X fibrils" . a ; "Isa http://purl.obolibrary.org/obo/PR_000005637" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CNKSR1" ; "https://reactome.org/content/detail/R-HSA-5672629" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 720 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_Q969H4" , "Reactome:R-HSA-5672629" ; "CNKSR1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P25963" ; "IkBA" ; "https://reactome.org/content/detail/R-HSA-6782960" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 317 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_000048597" , "Reactome:R-HSA-6782960" ; "IkBA" , "NF-kappaB inhibitor alpha" , "PolyUb-NFKBIA" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_000016698" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TRPM2" ; "https://reactome.org/content/detail/R-HSA-937286" ; ; [ a ; [ a ; [ a ; 1503 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-937286" , "http://purl.obolibrary.org/obo/PR_O94759" ; "TRPM2" , "TRPM2_HUMAN" , "Transient receptor potential cation channel subfamily M member 2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide" ; "https://reactome.org/content/detail/R-HSA-9948313" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9948313" ; "ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "N-glycosyl WNT5A" ; "https://reactome.org/content/detail/R-HSA-3238239" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 380 ; ] ; [ a ; [ a ; 36 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-3238239" ; "N4GlycoAsn-WNT5A(36-380)" , "N-glycosyl WNT5A" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PSMB6" ; "https://reactome.org/content/detail/R-HSA-68756" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 239 ; ] ; [ a ; [ a ; 35 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-68756" ; "PSMB6" , "Proteasome subunit beta-1" , "Proteasome subunit beta-1 precursor" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DEFB108P1" ; "https://reactome.org/content/detail/R-HSA-8848266" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 73 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8848266" ; "Putative beta-defensin 108A" , "DEFB108P1" , "D108A_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Azurophil granule lumen proteins" ; "https://reactome.org/content/detail/R-HSA-6798742" ; ; [ a ; ; ] ; , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ; "Reactome:R-HSA-6798742" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ; "Azurophil granule lumen proteins" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "UL69" ; "https://reactome.org/content/detail/R-HCY-9605788" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 742 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HCY-9605788" ; "UL69" , "ICP27_HCMVM" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GPI-ULBP2" ; "https://reactome.org/content/detail/R-HSA-8940750" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 216 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 216 ; ] ; [ a ; [ a ; 26 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-8940750" ; "GPI-ULBP2" , "N2L2_HUMAN" , "NKG2D ligand 2 precursor" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SCF-FBXL7:PolyUb-AURKA" ; "https://reactome.org/content/detail/R-HSA-8854038" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8854038" ; "SCF-FBXL7:PolyUb-AURKA" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000000123" ; "p85 S6K1" ; "https://reactome.org/content/detail/R-HSA-165716" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 525 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_P23443" , "Reactome:R-HSA-165716" ; "RPS6KB1-1" , "p85 S6K1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RAC1 GAPs" ; "https://reactome.org/content/detail/R-HSA-9013175" ; ; [ a ; ; ] ; , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ; "Reactome:R-HSA-9013175" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ; "RAC1 GAPs" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "Ifenprodil" ; "https://reactome.org/content/detail/R-ALL-9635195" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9635195" ; "Ifenprodil" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "COL14A1" ; "https://reactome.org/content/detail/R-HSA-2192777" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1796 ; ] ; [ a ; [ a ; 29 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2192777" ; "COEA1_HUMAN" , "Collagen alpha-1(XIV) chain" , "COL14A1" . a ; "Isa http://purl.obolibrary.org/obo/PR_000009704" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "LCE1F" ; "https://reactome.org/content/detail/R-HSA-6814270" ; ; [ a ; [ a ; [ a ; 118 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q5T754" , "Reactome:R-HSA-6814270" ; "LCE1F_HUMAN" , "LCE1F" , "Late cornified envelope protein 1F" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NCAM complexed with Fyn" ; "https://reactome.org/content/detail/R-HSA-391844" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-391844" ; "NCAM complexed with Fyn" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 94 to 121 by HLLSLPRKPTRAATVSVWASCILGQPSL]" ; "TP53 S94Hfs*29" ; "https://reactome.org/content/detail/R-HSA-9720214" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 121 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9720214" ; "TP53 S94Hfs*29" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_000014879" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GEMIN2" ; "https://reactome.org/content/detail/R-HSA-191835" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 280 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_O14893" , "Reactome:R-HSA-191835" ; "Gemin 2" , "GEMIN2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ATM dimer:Ub-p-PEX5:SQSTM1:NBR1:MAP1LC3B" ; "https://reactome.org/content/detail/R-HSA-9665166" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9665166" ; "ATM dimer:Ub-p-PEX5:SQSTM1:NBR1:MAP1LC3B" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "c-KIT" ; "https://reactome.org/content/detail/R-HSA-9669457" ; ; [ a ; [ a ; [ a ; 976 ; ] ; [ a ; [ a ; 26 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 816 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9669457" ; "c-KIT" , "Mast/stem cell growth factor receptor precursor" , "KIT D816F" , "KIT_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MLN" ; "https://reactome.org/content/detail/R-HSA-444169" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 47 ; ] ; [ a ; [ a ; 26 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-444169" ; "MLN" , "Promotilin component recommendedName: Motilin /component component recommendedName: Motilin-associated peptide" , "Motilin" , "MOTI_HUMAN" , "MLN(26-47)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1" ; "https://reactome.org/content/detail/R-HSA-8851942" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8851942" ; "HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1" . a ; "Isa http://purl.obolibrary.org/obo/PR_P15586" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GNS" ; "https://reactome.org/content/detail/R-HSA-434208" ; ; [ a ; [ a ; [ a ; 552 ; ] ; [ a ; [ a ; 37 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000047580" , "Reactome:R-HSA-434208" ; "GNS" , "N-acetylglucosamine-6-sulfatase" , "GNS_HUMAN" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-11S,2T-N" ; "https://reactome.org/content/detail/R-COV-9729264" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 184 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 194 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 79 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 180 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 201 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 206 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 188 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 183 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 176 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 198 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 205 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 202 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 422 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-COV-9729264" ; "p-11S,2T-N" , "p-S23,79,176,180,183,184,188,194,201,202,206,T198,205-N" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Insertion of residues 1058 to 1620 at 959 from UniProt:Q9UM73 ALK]" ; "BIRC6_HUMAN" ; "https://reactome.org/content/detail/R-HSA-9713451" ; ; [ a ; [ a ; [ a ; 958 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1507 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1604 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1359 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1283 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1282 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1096 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1278 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9713451" ; "BIRC6(1-958)-p-7Y-ALK(1058-1620) fusion" , "Baculoviral IAP repeat-containing protein 6 ecNumber evidence=\"9 11\"2.3.2.27/ecNumber" , "BIRC6_HUMAN" . a ; "Isa http://purl.obolibrary.org/obo/PR_000004508" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ATXN7" ; "https://reactome.org/content/detail/R-HSA-201591" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 892 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-201591" , "http://purl.obolibrary.org/obo/PR_O15265" ; "*Ataxin-7" , "ATXN7" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-T402-PAK-2p34" ; "https://reactome.org/content/detail/R-HSA-211654" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 402 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 524 ; ] ; [ a ; [ a ; 213 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-211654" ; "p-T402-PAK2(213-524)" , "p-T402-PAK-2p34" , "phospho-PAK-2p34 (Thr 402)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "CCNA1:p-T14-CDK1" ; "https://reactome.org/content/detail/R-HSA-9929242" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9929242" ; "CCNA1:p-T14-CDK1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CPN1_HUMAN" ; "https://reactome.org/content/detail/R-HSA-5580290" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 503 ; ] ; [ a ; [ a ; 25 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 331 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5580290" ; "Cytochrome P450 11B1" , "CYP11B1 A331V" , "CPN1_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "G analog" ; "https://reactome.org/content/detail/R-ALL-9824768" ; ; [ a ; ; ] ; , , , ; "Reactome:R-ALL-9824768" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "G, dG, 2',3'-cGMP, 8-OHdG" , "guanosine or guanosine derivative" , "G analog" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL" ; "https://reactome.org/content/detail/R-HSA-5357462" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5357462" ; "VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "VENTX:IL6 Gene" ; "https://reactome.org/content/detail/R-HSA-8853886" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8853886" ; "VENTX:IL6 Gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "SDC1, 2, 4, (3)" ; "https://reactome.org/content/detail/R-HSA-2684511" ; ; [ a ; ; ] ; , , , ; "Reactome:R-HSA-2684511" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "SDC1, 2, 4, (3)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "BLK gene" ; "https://reactome.org/content/detail/R-HSA-8938968" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000136573" ; "ENSEMBL:ENSG00000136573" , "Reactome:R-HSA-8938968" ; "BLK gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "FOXO1,FOXO3,(FOXO4):FBXO32 gene" ; "https://reactome.org/content/detail/R-HSA-9624643" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9624643" ; "FOXO1,FOXO3,(FOXO4):FBXO32 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-Y-ERBB2 G776L" ; "https://reactome.org/content/detail/R-HSA-9664600" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1255 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 776 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9664600" ; "p-Y-ERBB2 Gly776Leu" , "p-Y-ERBB2 G776L" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "XRCC5:XRCC6:DNA DSBs" ; "https://reactome.org/content/detail/R-HSA-75906" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-75906" ; "XRCC5:XRCC6:DNA DSBs" , "Ku:DNA double-strand break ends" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HA1" ; "https://reactome.org/content/detail/R-FLU-189173" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 343 ; ] ; [ a ; [ a ; 18 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-FLU-189173" ; "HA1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P04275-1" ; "VWF" ; "https://reactome.org/content/detail/R-HSA-67271" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 763 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-67271" , "http://purl.obolibrary.org/obo/PR_000043586" ; "Von Willebrand factor precursor" , "VWF" , "vWF" , "VWF(23-763)" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "tRNA(Lys,Leu) containing 5-taurinomethyl-2-thioU-34" ; "https://reactome.org/content/detail/R-HSA-6787387" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-6787387" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "tRNA(Lys,Leu) containing 5-taurinomethyl-2-thioU-34" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "P2RY2:ATP" ; "https://reactome.org/content/detail/R-HSA-9860834" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9860834" ; "P2RY2:ATP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NS4A:AUP1" ; "https://reactome.org/content/detail/R-HSA-9921601" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9921601" ; "NS4A:AUP1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ATP:P2RX4,7" ; "https://reactome.org/content/detail/R-HSA-9660825" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9660825" ; "ATP:P2RX4,7" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "5bCHOL3a,7a,12a-triol" ; "https://reactome.org/content/detail/R-ALL-192078" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-192078" ; "5beta-cholestan-3alpha, 7alpha, 12alpha-triol" , "5beta-cholestane-3alpha,7alpha,12alpha-triol" , "5bCHOL3a,7a,12a-triol" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "Emilin-2 polymer" ; "https://reactome.org/content/detail/R-HSA-2161398" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-2161398" ; "Emilin-2 polymer" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "OR51E2:ligand" ; "https://reactome.org/content/detail/R-HSA-9737272" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9737272" ; "OR51E2:ligand" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-S1330-ROBO3.1:AKAP5:p-T497,T638,S657-PRKCA" ; "https://reactome.org/content/detail/R-HSA-9010778" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9010778" ; "p-S1330-ROBO3.1:AKAP5:p-T497,T638,S657-PRKCA" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000012983" ; "POLR1B" ; "https://reactome.org/content/detail/R-HSA-63496" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1135 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-63496" , "http://purl.obolibrary.org/obo/PR_Q9H9Y6" ; "DNA-directed RNA polymerase I 135 kDa polypeptide" , "RPA135" , "RNA polymerase I subunit 2" , "POLR1B" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "3,5-(PP)2-IP4" ; "https://reactome.org/content/detail/R-ALL-2023951" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-2023951" ; "3,5-(PP)2-IP4" , "3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SDC3" ; "https://reactome.org/content/detail/R-HSA-2076365" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 442 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2076365" ; "HS(2)-SDC3" , "Syndecan-3" , "SDC3_HUMAN" , "SDC3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Activated FGFR:p-FRS2" ; "https://reactome.org/content/detail/R-HSA-190350" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-190350" ; "Activated FGFR:p-FRS2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000013942" ; "ARHGEF28" ; "https://reactome.org/content/detail/R-HSA-3928474" ; ; [ a ; [ a ; [ a ; 1705 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q8N1W1" , "Reactome:R-HSA-3928474" ; "ARG28_HUMAN" , "Rho guanine nucleotide exchange factor 28" , "ARHGEF28" , "p190RhoGEF" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Edited GRIK2 homomer" ; "https://reactome.org/content/detail/R-HSA-451319" ; ; [ a ; ; ; "4"^^ ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-451319" ; "Edited GRIK2 homomer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HIST1H4A" ; "https://reactome.org/content/detail/R-HSA-4570531" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 103 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-4570531" ; "HIST1H4A" , "HIST1H4D" , "HIST1H4B" , "Histone H4" , "HIST1H4E" , "HIST1H4H" , "HIST1H4F" , "HIST1H4K" , "HIST1H4L" , "HIST1H4C" , "HIST1H4I" , "HIST1H4J" , "HIST2H4A" , "polySUMO3-HIST1H4" , "HIST2H4B" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Apo-GP96 dimer" ; "https://reactome.org/content/detail/R-HSA-1678941" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-1678941" ; "Apo-GP96 dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Nup96" ; "https://reactome.org/content/detail/R-HSA-376247" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 880 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-376247" ; "Nup96" , "NUP98-5" , "NUP98 isoform 5" . a ; . a ; . a ; . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TUT4,TUT7" ; "https://reactome.org/content/detail/R-HSA-8941311" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-8941311" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "TUT4,TUT7" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PSMB1" ; "https://reactome.org/content/detail/R-HSA-6803340" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 241 ; ] ; [ a ; [ a ; 29 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6803340" ; "Proteasome subunit beta type 1" , "PSMB1" , "Multicatalytic endopeptidase complex subunit C5" , "Proteasome gamma chain" , "Macropain subunit C5" , "Proteasome component C5" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ERK2" ; "https://reactome.org/content/detail/R-HSA-9652808" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 185 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 142 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 187 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 360 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9652808" ; "ERK-2" , "Mitogen-activated protein kinase 1 (EC 2.7.1.-) (Extracellular signal- regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1)" , "ERK2" , "Extracellular signal-regulated kinase 2" , "Mitogen-activated protein kinase 2" , "MAP kinase 2" , "Mitogen-activated protein kinase 1" , "p-T185,Y187 MAPK1 S142L" , "MAPK 2" , "p42-MAPK" , "ERT1" . a ; "Isa http://purl.obolibrary.org/obo/PR_000000409" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TGFBR2" ; "https://reactome.org/content/detail/R-HSA-170842" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 567 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000036408" , "Reactome:R-HSA-170842" ; "TGF-beta II receptor" , "TGFBR2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "STAT3" ; "https://reactome.org/content/detail/R-HSA-914048" ; ; [ a ; [ a ; [ a ; 770 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 705 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-914048" ; "Signal transducer and activator of transcription 3" , "STAT3" , "STAT3_HUMAN" , "p-Y705-STAT3" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "dCDP" ; "https://reactome.org/content/detail/R-ALL-110091" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-110091" ; "2'-deoxycytidine 5'-diphosphate" , "dCDP" , "dCDP(3-)" , "2'-Deoxycytidine diphosphate" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GPC6" ; "https://reactome.org/content/detail/R-HSA-2064057" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 529 ; ] ; [ a ; [ a ; 24 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2064057" ; "Glypican-6 component recommendedName: Secreted glypican-6 /component" , "GPC6_HUMAN" , "XylS-GPC6" , "xylosyl-GPC6" , "GPC6" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "UBC(305-380)" ; "https://reactome.org/content/detail/R-HSA-9660008" ; ; [ a ; [ a ; [ a ; 380 ; ] ; [ a ; [ a ; 305 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9660008" ; "ubiquitin (UBC 5)" , "UBC(305-380)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "GDF2 dimer" ; "https://reactome.org/content/detail/R-HSA-3222350" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-3222350" ; "GDF2 dimer" , "Dimeric BMP9" , "BMP9 dimer" , "Dimeric GDF2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000006681" ; "DPYSL3" ; "https://reactome.org/content/detail/R-HSA-398124" ; ; [ a ; [ a ; [ a ; 570 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-398124" , "http://purl.obolibrary.org/obo/PR_Q14195" ; "DPYSL3" , "DPYL3_HUMAN" , "Dihydropyrimidinase-related protein 3 (CRMP-4)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Deletion of residues 1223 to 1227]" ; "hZIP4" ; "https://reactome.org/content/detail/R-HSA-5654119" ; ; [ a ; [ a ; [ a ; 647 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5654119" ; "hZIP4" , "Zinc transporter ZIP4" , "SLC39A4 1223_1227del" , "S39A4_HUMAN" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "NF1 R1241*" ; "https://reactome.org/content/detail/R-HSA-9647473" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1240 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1241 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9647473" ; "NF1 R1241*" . a ; "Isa http://purl.obolibrary.org/obo/PR_O15260" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SURF4" ; "https://reactome.org/content/detail/R-HSA-6813919" ; ; [ a ; [ a ; [ a ; 269 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6813919" , "http://purl.obolibrary.org/obo/PR_000049389" ; "Surfeit locus protein 4" , "SURF4" . a . a ; "Isa http://purl.obolibrary.org/obo/PR_000007201" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ESP1" ; "https://reactome.org/content/detail/R-HSA-1638167" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 2120 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-1638167" , "http://purl.obolibrary.org/obo/PR_Q14674" ; "ESP1" , "KIAA0165" , "Separin" , "Extra spindle poles-like 1 protein" , "Caspase-like protein ESPL1" , "ESPL1" , "Separase" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1" ; "https://reactome.org/content/detail/R-HSA-5682999" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5682999" ; "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "G-protein alpha (q):GRK2" ; "https://reactome.org/content/detail/R-HSA-416515" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-416515" ; "G-protein alpha (q):GRK2" . a ; "Isa http://purl.obolibrary.org/obo/PR_Q04759" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-Y90,T538,S676,S695-PRKCQ" ; "https://reactome.org/content/detail/R-HSA-202152" ; ; [ a ; [ a ; [ a ; 706 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 695 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 538 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 90 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 676 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_000048922" , "Reactome:R-HSA-202152" ; "Active phosphorylated PKC theta" , "p-S676,S695,T538,Y90-PRKCQ" , "p-Y90,T538,S676,S695-PRKCQ" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "CTLA" ; "https://reactome.org/content/detail/R-ALL-215622" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-215622" ; "CTLA" , "(24S)-1alpha,24,25-trihydroxyvitamin D3" , "1,24,25-trihydroxyvitamin D3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "S100B homodimer" ; "https://reactome.org/content/detail/R-HSA-879449" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-879449" ; "S100B homodimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "SUCCSA" ; "https://reactome.org/content/detail/R-ALL-880046" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-880046" ; "SUCCSA" , "succinate semialdehyde" , "succinic semialdehyde" , "4-oxobutanoate" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PEX26" ; "https://reactome.org/content/detail/R-HSA-9033092" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 305 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9033092" ; "Peroxisome assembly protein 26" , "PEX26" , "PEX26_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "3x4Hyp-3Hyp-GlcGalHyl-COL23A1(?-540)" ; "https://reactome.org/content/detail/R-HSA-2473470" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 540 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2473470" ; "3x4Hyp-3Hyp-GlcGalHyl-COL23A1(?-540)" , "3,4-Hyp Glu-Gal-Hyl-collagen alpha-1(XXIII) ectodomain" . a ; "Isa http://purl.obolibrary.org/obo/PR_000017108" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "UPF1" ; "https://reactome.org/content/detail/R-HSA-927734" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1129 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-927734" , "http://purl.obolibrary.org/obo/PR_Q92900" ; "UPF1" , "RENT1_HUMAN" , "Regulator of nonsense transcripts 1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "OR2T29" ; "https://reactome.org/content/detail/R-HSA-9751599" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 315 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9751599" ; "Olfactory receptor 2T29" , "OR2T29" , "O2T29_HUMAN" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Ub-124-UBB(77-152)" ; "https://reactome.org/content/detail/R-HSA-939225" ; ; [ a ; [ a ; [ a ; 152 ; ] ; [ a ; [ a ; 77 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 124 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-939225" ; "K48 ubiquitin (UBB 2)" , "Ub-124-UBB(77-152)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Defensins alpha 1-4" ; "https://reactome.org/content/detail/R-HSA-1470049" ; ; [ a ; ; ] ; , , ; "Reactome:R-HSA-1470049" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "Defensins alpha 1-4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "OAS3:OAS3 ligand" ; "https://reactome.org/content/detail/R-HSA-8985156" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8985156" ; "OAS3:OAS3 ligand" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Bact complex" ; "https://reactome.org/content/detail/R-HSA-72074" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-72074" ; "Bact complex" , "Spliceosomal Intermediate C Complex" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "MAG" ; "https://reactome.org/content/detail/R-ALL-6814795" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-6814795" ; "monoglyceride" , "MAG" , "monoacylglycerol" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NS1:HDL:C1QA" ; "https://reactome.org/content/detail/R-HSA-9920632" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9920632" ; "NS1:HDL:C1QA" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Rna" ; "miR-424" ; "https://reactome.org/content/detail/R-HSA-9924923" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:MI0001446" ; "Reactome:R-HSA-9924923" , "miRBaseMI0001446" ; "miR-424" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-S465,S467-SMAD2 P305L" ; "https://reactome.org/content/detail/R-HSA-3315471" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 305 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 465 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 467 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 467 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-3315471" ; "p-Ser465,Ser467-SMAD2 Pro305Leu" , "p-S465,S467-SMAD2 P305L" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Adenylate cyclase" ; "https://reactome.org/content/detail/R-HSA-379053" ; ; [ a ; ; ] ; , , , , , , , , ; "Reactome:R-HSA-379053" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ; "Adenylate cyclase" . a ; "Unspecified modification type. Comment: [Replacement of residues 73 to 122 by RWPLHQQLLHRRPLHQPPPGPCHLLSLPRKPTRAATVSVWASCILGQPSL]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TP53 V73Rfs*51" ; "https://reactome.org/content/detail/R-HSA-9720623" ; ; [ a ; [ a ; [ a ; 122 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9720623" ; "TP53 V73Rfs*51" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "lyral" ; "https://reactome.org/content/detail/R-ALL-9712206" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9712206" ; "4-(4-Hydroxy-4-methylpentyl)cyclohex-3-enecarbaldehyde" , "lyral" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000012635" ; "PHC3" ; "https://reactome.org/content/detail/R-HSA-389116" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 983 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_Q8NDX5" , "Reactome:R-HSA-389116" ; "PHC3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 210 to 245 by KLFDIVWWCPMSRLRLALTVPPSTTTTCVTVPAWAA]" ; "TP53 N210Kfs*37" ; "https://reactome.org/content/detail/R-HSA-9722051" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 245 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9722051" ; "TP53 N210Kfs*37" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2" ; "https://reactome.org/content/detail/R-HSA-1368190" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-1368190" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2" . a ; "Isa http://purl.obolibrary.org/obo/PR_000017888" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ZNF43" ; "https://reactome.org/content/detail/R-HSA-1247544" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 809 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-1247544" , "http://purl.obolibrary.org/obo/PR_P17038" ; "ZNF43" , "Zinc finger protein 43" , "ZNF43_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "RRAGD:GTP" ; "https://reactome.org/content/detail/R-HSA-5653967" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5653967" ; "RRAGD:GTP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HIST1H2BC" ; "https://reactome.org/content/detail/R-HSA-6782552" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 126 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 120 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6782552" ; "Histone H2B type 1-C/E/F/G/I" , "HIST1H2BC" , "Ub-HIST1H2BC" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Dystroglycan:Dystrophin:Laminins" ; "https://reactome.org/content/detail/R-HSA-2396153" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-2396153" ; "Dystroglycan:Dystrophin:Laminins" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000007989" ; "GIT1" ; "https://reactome.org/content/detail/R-HSA-430326" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 761 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_Q9Y2X7" , "Reactome:R-HSA-430326" ; "GIT1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "OGG1-4 G12E" ; "https://reactome.org/content/detail/R-HSA-9657042" ; ; [ a ; [ a ; [ a ; 424 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 12 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9657042" ; "OGG1-4 G12E" , "OGG1beta G12E" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "HSF1:HSP90:HDAC6:VCP:PTGES3" ; "https://reactome.org/content/detail/R-HSA-5324677" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5324677" ; "HSF1:HSP90:HDAC6:VCP:PTGES3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "MV dsRNA intermediate form" ; "https://reactome.org/content/detail/R-MVI-9013943" ; ; [ a ; ; ] ; ; "Reactome:R-MVI-9013943" ; "MV dsRNA intermediate form" . a ; "Isa http://purl.obolibrary.org/obo/PR_000018745" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PSMD11" ; "https://reactome.org/content/detail/R-HSA-6800943" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 422 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6800943" , "http://purl.obolibrary.org/obo/PR_000027343" ; "26S proteasome regulatory subunit S9" , "PSMD11" , "26S proteasome non-ATPase regulatory subunit 11" , "26S proteasome regulatory subunit p44.5" . a ; "Isa http://purl.obolibrary.org/obo/PR_P07738" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "BPGM" ; "https://reactome.org/content/detail/R-HSA-6798334" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 259 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_000046501" , "Reactome:R-HSA-6798334" ; "BPGM" , "Bisphosphoglycerate mutase" , "PMGE_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ATRX W222*" ; "https://reactome.org/content/detail/R-HSA-9671670" ; ; [ a ; [ a ; [ a ; 221 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 222 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9671670" ; "ATRX Trp222TER" , "ATRX W222TER" , "ATRX W222*" , "ATRX Trp222*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "G6PC3 G260R" ; "https://reactome.org/content/detail/R-HSA-3276581" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 260 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 346 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-3276581" ; "G6PC3 G260R" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "OR51T1 gene" ; "https://reactome.org/content/detail/R-HSA-9752461" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000176900" ; "Reactome:R-HSA-9752461" , "ENSEMBL:ENSG00000176900" ; "OR51T1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "C4A-derived C4c" ; "https://reactome.org/content/detail/R-HSA-981502" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-981502" ; "C4A-derived C4c" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "RUNX1:NOTCH4 gene" ; "https://reactome.org/content/detail/R-HSA-9604705" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9604705" ; "RUNX1:NOTCH4 gene" . a ; "Isa http://purl.obolibrary.org/obo/PR_P60903" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "S100A10" ; "https://reactome.org/content/detail/R-HSA-5336168" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 97 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000049148" , "Reactome:R-HSA-5336168" ; "S10AA_HUMAN" , "Protein S100-A10" , "S100A10" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "COL3A1" ; "https://reactome.org/content/detail/R-HSA-2268744" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1466 ; ] ; [ a ; [ a ; 154 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2268744" ; "CO3A1_HUMAN" , "3x4Hyp-3Hyp-GlcGalHyl-COL3A1(154-1466)" , "3,4-Hyp Glu-Gal-Hyl collagen alpha-1(III) -N propeptide" , "COL3A1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SERPINA5:Activated protein C" ; "https://reactome.org/content/detail/R-HSA-5607007" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5607007" ; "SERPINA5:Activated protein C" . a ; "Isa http://purl.obolibrary.org/obo/PR_000010240" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MCL1" ; "https://reactome.org/content/detail/R-HSA-5661490" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 350 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_Q07820" , "Reactome:R-HSA-5661490" ; "MCL1_HUMAN" , "MCL1" , "Induced myeloid leukemia cell differentiation protein Mcl-1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "diaminoacridinium" ; "https://reactome.org/content/detail/R-ALL-9931571" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9931571" ; "3,6-diaminoacridine(1+)" , "diaminoacridinium" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "mammary basal progenitor cell" ; "https://reactome.org/content/detail/R-HSA-9925876" ; ; ; "Reactome:R-HSA-9925876" ; "mammary myoepithelial progenitor cell" , "mammary basal progenitor cell" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "AcK13-HIST1H2BC" ; "https://reactome.org/content/detail/R-HSA-4568620" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 13 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 126 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-4568620" ; "Histone H2B type 1-C/E/F/G/I" , "AcK13-HIST1H2BC" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KRTAP4-9" ; "https://reactome.org/content/detail/R-HSA-6809962" ; ; [ a ; [ a ; [ a ; 210 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6809962" ; "Keratin-associated protein 4-9" , "KRA49_HUMAN" , "KRTAP4-9" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p10S-GLI3:SUFU" ; "https://reactome.org/content/detail/R-HSA-5610581" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5610581" ; "p10S-GLI3:SUFU" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Deletion of residues 67 to 71]" ; "CDKN2A G67_N71del" ; "https://reactome.org/content/detail/R-HSA-9632252" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 156 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9632252" ; "CDKN2A Gly67_Asn71del" , "CDKN2A G67_N71del" , "p16INK4A G67_N71del" , "p16INK4A Gly67_Asn71del" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CPN2_HUMAN" ; "https://reactome.org/content/detail/R-HSA-5600620" ; ; [ a ; [ a ; [ a ; 503 ; ] ; [ a ; [ a ; 25 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 185 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5600620" ; "Cytochrome P450 11B2" , "CYP11B2 T185I" , "CPN2_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ATF6:HSPA5" ; "https://reactome.org/content/detail/R-HSA-9927406" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9927406" ; "ATF6-alpha:BiP" , "ATF6:HSPA5" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "membrane-tethered p-Y PDGFR fusion dimers" ; "https://reactome.org/content/detail/R-HSA-9673716" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-9673716" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ; "membrane-tethered p-Y PDGFR fusion dimers" . a ; "Isa http://purl.obolibrary.org/obo/PR_P27708" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CAD" ; "https://reactome.org/content/detail/R-HSA-73452" ; ; [ a ; [ a ; [ a ; 2225 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-73452" , "http://purl.obolibrary.org/obo/PR_000046548" ; "CAD" , "Glutamine-dependent carbamoyl-phosphate synthase" , "carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase" , "CAD protein (Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3))" , "Dihydroorotase" , "Aspartate carbamoyltransferase" . a ; "Isa http://purl.obolibrary.org/obo/PR_000009246" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KAZN" ; "https://reactome.org/content/detail/R-HSA-6814378" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 775 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6814378" , "http://purl.obolibrary.org/obo/PR_Q674X7" ; "KAZN" , "Kazrin" , "KAZRN_HUMAN" . a ; "Isa http://purl.obolibrary.org/obo/PR_P51511" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MT2-MMP" ; "https://reactome.org/content/detail/R-HSA-1604692" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 669 ; ] ; [ a ; [ a ; 42 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1604692" , "http://purl.obolibrary.org/obo/PR_000048398" ; "MT2-MMP" , "proMMP15" , "MMP15(42-669)" , "MMP15_HUMAN" , "Matrix metalloproteinase-15" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MTM(3)" ; "https://reactome.org/content/detail/R-HSA-1806231" ; ; [ a ; ; ] ; , , , ; "Reactome:R-HSA-1806231" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "MTM(3)" , "MTM1,MTMR2,MTMR4,MTMR7" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "APC_HUMAN" ; "https://reactome.org/content/detail/R-HSA-9666953" ; ; [ a ; [ a ; [ a ; 1316 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1317 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9666953" ; "APC E1317TER" , "Adenomatous polyposis coli protein" , "APC_HUMAN" , "APC E1317*" . a ; "Isa http://purl.obolibrary.org/obo/PR_P02671" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "FGA(20-866)" ; "https://reactome.org/content/detail/R-HSA-140841" ; ; [ a ; [ a ; [ a ; 866 ; ] ; [ a ; [ a ; 20 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000047397" , "Reactome:R-HSA-140841" ; "Fibrinogen alpha chain" , "FGA(20-866)" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SUMO1:C93-UBE2I" ; "https://reactome.org/content/detail/R-HSA-2993783" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-2993783" ; "SUMO1 S-glycyl-cys93 UBE2I" , "SUMO1:C93-UBE2I" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "CXCL12 gene" ; "https://reactome.org/content/detail/R-HSA-8954202" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000107562" ; "Reactome:R-HSA-8954202" , "ENSEMBL:ENSG00000107562" ; "CXCL12 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "TBK1:pp1ab-nsp6" ; "https://reactome.org/content/detail/R-HSA-9705026" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9705026" ; "TBK1:pp1ab-nsp6" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "SUCCA" ; "https://reactome.org/content/detail/R-ALL-29434" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-29434" ; "succinic acid" , "Succinate" , "succinate(2-)" , "SUCCA" , "Ethylenesuccinic acid" , "Butanedionic acid" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P53597" ; "SUCLG1" ; "https://reactome.org/content/detail/R-HSA-156623" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 346 ; ] ; [ a ; [ a ; 41 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000049379" , "Reactome:R-HSA-156623" ; "SUCLG1" , "Succinyl-CoA synthetase, alpha-chain" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000016397" ; "TMC6" ; "https://reactome.org/content/detail/R-HSA-6799712" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 805 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6799712" , "http://purl.obolibrary.org/obo/PR_Q7Z403" ; "Transmembrane channel-like protein 6" , "TMC6_HUMAN" , "TMC6" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Ub-SMAD4" ; "https://reactome.org/content/detail/R-HSA-9773863" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 552 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9773863" ; "Ub-SMAD4" . a ; "Isa http://purl.obolibrary.org/obo/PR_000001776" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "IKKB" ; "https://reactome.org/content/detail/R-HSA-168114" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 756 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-168114" , "http://purl.obolibrary.org/obo/PR_O14920" ; "IKK-beta" , "Inhibitor of nuclear factor kappa B kinase beta subunit" , "IKKB" , "IKK2" , "IKBKB" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 215 to 220 by KCGGAL]" ; "TP53 S215Kfs*7" ; "https://reactome.org/content/detail/R-HSA-9721082" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 220 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9721082" ; "TP53 S215Kfs*7" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ATG7 dimer" ; "https://reactome.org/content/detail/R-HSA-5682892" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-5682892" ; "ATG7 dimer" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Activated PPARG:RXRA:CEBPA gene:nucleosomes" ; "https://reactome.org/content/detail/R-HSA-9864717" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9864717" ; "Activated PPARG:RXRA:CEBPA gene:nucleosomes" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-Y705-STAT3:p-Y693-STAT4" ; "https://reactome.org/content/detail/R-HSA-8950427" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8950427" ; "p-Y705-STAT3:p-Y693-STAT4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "D4,6S-PGs" ; "https://reactome.org/content/detail/R-HSA-9941217" ; ; [ a ; ; ] ; , , , , , , ; "Reactome:R-HSA-9941217" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ; "D4,6S-PGs" , "Dermatan 4,6-sulfate proteoglycans" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "PGE2" ; "https://reactome.org/content/detail/R-ALL-391930" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-391930" ; "PGE2" , "prostaglandin E2" , "prostaglandin E2(1-)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "15k-LXA4" ; "https://reactome.org/content/detail/R-ALL-2142761" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-2142761" ; "15-oxolipoxin A4" , "15-oxolipoxin A4(1-)" , "15-keto-LXA4" , "15k-LXA4" , "15-oxo-LXA4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 1978 to 2002 by LAQQVENLSRYQMLHYKTQDKCFLK]" ; "BRCA2 F1978Lfs*26" ; "https://reactome.org/content/detail/R-HSA-9712891" ; ; [ a ; [ a ; [ a ; 2002 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9712891" ; "BRCA2 F1978Lfs*26" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Ac-Cohesin Complex" ; "https://reactome.org/content/detail/R-HSA-2466014" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-2466014" ; "Ac-Cohesin Complex" , "Acetylated Cohesin Complex" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "OPRD1 gene" ; "https://reactome.org/content/detail/R-HSA-6797365" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000116329" ; "ENSEMBL:ENSG00000116329" , "Reactome:R-HSA-6797365" ; "OPRD1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Active ALK dimer" ; "https://reactome.org/content/detail/R-HSA-9850879" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-9850879" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "Active ALK dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "OR1L8" ; "https://reactome.org/content/detail/R-HSA-9751492" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 309 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9751492" ; "Olfactory receptor 1L8" , "OR1L8_HUMAN" , "OR1L8" . a ; "Unspecified modification type. Comment: [Replacement of residues 246 to 336 by ISSHWKTPVVIYWDGTALRCVFVPVLGETGAQRKRISARKGSLTTSCPQGALSEHCPTTPAPLPSQRRNHWMENISPFRSVGVSASRCSES]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TP53 M246Ifs*92" ; "https://reactome.org/content/detail/R-HSA-9721598" ; ; [ a ; [ a ; [ a ; 336 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9721598" ; "TP53 M246Ifs*92" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "EGF gene" ; "https://reactome.org/content/detail/R-HSA-9795740" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000138798" ; "Reactome:R-HSA-9795740" , "ENSEMBL:ENSG00000138798" ; "EGF gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "PIP4K2A:PIP4K2C" ; "https://reactome.org/content/detail/R-HSA-6811465" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6811465" ; "PIP4K2A:PIP4K2C" . a ; "Isa http://purl.obolibrary.org/obo/PR_P13639" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "EEF2" ; "https://reactome.org/content/detail/R-HSA-6801504" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 858 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000047250" , "Reactome:R-HSA-6801504" ; "EEF2" , "eEF2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ASAP1 dimer:RAB11A:GTP:RAB11FIP3 dimer:PKD2, RHO, PKD1, 2xCNGA2:CNGA4:CNGB1:RAB3IP:RAB8A:GTP" ; "https://reactome.org/content/detail/R-HSA-5623450" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5623450" ; "RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins" , "ASAP1 dimer:RAB11A:GTP:RAB11FIP3 dimer:PKD2, RHO, PKD1, 2xCNGA2:CNGA4:CNGB1:RAB3IP:RAB8A:GTP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "NRAS Q60E" ; "https://reactome.org/content/detail/R-HSA-9656589" ; ; [ a ; [ a ; [ a ; 186 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 60 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9656589" ; "NRAS Q60E" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 330 to 330 by N]" ; "ATRX K330Nfs*2" ; "https://reactome.org/content/detail/R-HSA-9672231" ; ; [ a ; [ a ; [ a ; 330 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9672231" ; "ATRX K330NfsTER2" , "ATRX Lys330Asnfs*2" , "ATRX Lys330AsnfsTER2" , "ATRX K330Nfs*2" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PEX5S,L" ; "https://reactome.org/content/detail/R-HSA-9033603" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-9033603" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "PEX5S,L" . a ; "Isa http://purl.obolibrary.org/obo/PR_000005542" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CLDN15" ; "https://reactome.org/content/detail/R-HSA-432980" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 228 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-432980" , "http://purl.obolibrary.org/obo/PR_P56746" ; "Claudin-15" , "CLDN15" , "CLD15_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000007309" ; "FABP1" ; "https://reactome.org/content/detail/R-HSA-1989743" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 127 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1989743" , "http://purl.obolibrary.org/obo/PR_P07148" ; "FABPL_HUMAN" , "Fatty acid-binding protein, liver" , "FABP1" . a ; "Unspecified modification type. Comment: [Replacement of residues 593 to 602 by TLQQICIFLL]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RB1 N593Tfs*11" ; "https://reactome.org/content/detail/R-HSA-9688013" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 602 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9688013" ; "RB1 N593Tfs*11" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "PHYKPL tetramer" ; "https://reactome.org/content/detail/R-HSA-5696429" ; ; [ a ; ; ; "4"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5696429" ; "PHYKPL tetramer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TREH" ; "https://reactome.org/content/detail/R-HSA-189000" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 556 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 556 ; ] ; [ a ; [ a ; 24 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-189000" ; "TREH" , "N-seryl-glycosylphosphatidylinositolethanolamine-TREH" , "trehalase" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SLC36A2 mutants" ; "https://reactome.org/content/detail/R-HSA-5653860" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-5653860" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "SLC36A2 mutants" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KLK1" ; "https://reactome.org/content/detail/R-HSA-2990870" ; ; [ a ; [ a ; [ a ; 262 ; ] ; [ a ; [ a ; 25 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2990870" ; "KLK1_HUMAN" , "Kallikrein-1 ecNumber3.4.21.35/ecNumber" , "KLK1(25-262)" , "KLK1" . a ; "Unspecified modification type. Comment: [Replacement of residues 1106 to 1116 by IVHHLILRNIP]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ATRX D1106Ifs*12" ; "https://reactome.org/content/detail/R-HSA-9672747" ; ; [ a ; [ a ; [ a ; 1116 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9672747" ; "ATRX D1106Ifs*12" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Integrins alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1" ; "https://reactome.org/content/detail/R-HSA-4088270" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-4088270" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "Integrins alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RORA" ; "https://reactome.org/content/detail/R-HSA-400325" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 523 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-400325" ; "RORA_HUMAN" , "Nuclear receptor ROR-alpha" , "RORA" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_P15336" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-T69,T71-ATF2" ; "https://reactome.org/content/detail/R-HSA-450243" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 69 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 505 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 71 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000046410" , "Reactome:R-HSA-450243" ; "p-T69,T71-ATF2" , "Cyclic AMP-dependent transcription factor ATF-2 (phosphorylated)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "GR8470" ; "https://reactome.org/content/detail/R-ALL-4755468" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-4755468" ; "1,2,3,3a,4,6a-hexahydropentalene" , "GR8470" , "cis-bicyclo(3.3.0)oct-2-ene" , "bicyclo[3.3.0]oct-2-ene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Argonaute1/3/4: miR-132" ; "https://reactome.org/content/detail/R-HSA-9021193" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9021193" ; "miR-132 Nonendonucleolytic Minimal RISC" , "Argonaute1/3/4: miR-132" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "MLN518" ; "https://reactome.org/content/detail/R-ALL-9695994" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9695994" ; "MLN518" , "CT53518" , "tandutinib" , "MLN-518" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "MT1E:7Zn2+" ; "https://reactome.org/content/detail/R-HSA-5662567" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "7"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5662567" ; "MT1E:7Zn2+" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NODAL Receptor" ; "https://reactome.org/content/detail/R-HSA-1181125" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-1181125" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "NODAL Receptor" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000006444" ; "DGKD" ; "https://reactome.org/content/detail/R-HSA-426068" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1214 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q16760" , "Reactome:R-HSA-426068" ; "DGKD_HUMAN" , "Diacylglycerol kinase delta" , "DGKD" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KCND1,2,3" ; "https://reactome.org/content/detail/R-HSA-1296101" ; ; [ a ; ; ] ; , , ; "Reactome:R-HSA-1296101" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "Kv4 subunits of voltage gated potassium channels" , "KCND1,2,3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "BTLA-HVEM complex" ; "https://reactome.org/content/detail/R-HSA-389525" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-389525" ; "BTLA-HVEM complex" . a ; "Isa http://purl.obolibrary.org/obo/PR_000032662" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ZNF720" ; "https://reactome.org/content/detail/R-HSA-2586610" ; ; [ a ; [ a ; [ a ; 126 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2586610" , "http://purl.obolibrary.org/obo/PR_Q7Z2F6" ; "Putative protein ZNF720" , "ZN720_HUMAN" , "ZNF720" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-STK4/N dimer" ; "https://reactome.org/content/detail/R-HSA-2028671" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-2028671" ; "p-MST1/N dimer" , "p-STK4/N dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "dual mechanism MAP2K1/2 inhibitors" ; "https://reactome.org/content/detail/R-ALL-9657567" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9657567" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "dual mechanism MAP2K1/2 inhibitors" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NF-kappaB p50:p65:ub-p-IKB" ; "https://reactome.org/content/detail/R-HSA-1168590" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1168590" ; "NF-kappaB p50:p65:ub-p-IKB" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000014377" ; "RYR1" ; "https://reactome.org/content/detail/R-HSA-937287" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 5038 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_P21817" , "Reactome:R-HSA-937287" ; "RYR1_HUMAN" , "RYR1" , "Ryanodine receptor 1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PolyUb-p-S76,S79,T80,S82,S88-CDC25A" ; "https://reactome.org/content/detail/R-HSA-9944023" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 82 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 79 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 76 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 524 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 80 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 88 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9944023" ; "PolyUb-p-S76,S79,T80,S82,S88-CDC25A" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "UL14" ; "https://reactome.org/content/detail/R-HCY-9605789" ; ; [ a ; [ a ; [ a ; 327 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HCY-9605789" ; "UL14_HCMVM" , "UL14" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "FDFT:Mg2+" ; "https://reactome.org/content/detail/R-HSA-191320" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-191320" ; "FDFT:Mg2+" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "RNA primer" ; "https://reactome.org/content/detail/R-ALL-68422" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-68422" ; "RNA primer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SUMO2" ; "https://reactome.org/content/detail/R-HSA-2984281" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 93 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2984281" ; "Small ubiquitin-related modifier 2" , "SUMO2_HUMAN" , "SUMO2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "GCG gene" ; "https://reactome.org/content/detail/R-HSA-5653043" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000115263" ; "Reactome:R-HSA-5653043" , "ENSEMBL:ENSG00000115263" ; "GCG gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "AQP8 tetramer" ; "https://reactome.org/content/detail/R-HSA-3779353" ; ; [ a ; ; ] ; [ a ; ; ; "4"^^ ] ; ; "Reactome:R-HSA-3779353" ; "AQP8 tetramer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DEFB132" ; "https://reactome.org/content/detail/R-HSA-1471320" ; ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1471320" ; "DEFB132" , "DB132_HUMAN" , "DEFB132(?-95)" , "Beta-defensin 132" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_Q03692" ; "COL10A1" ; "https://reactome.org/content/detail/R-HSA-2192778" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 680 ; ] ; [ a ; [ a ; 19 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000046754" , "Reactome:R-HSA-2192778" ; "3,4-Hyp 5-Hyl-collagen alpha-1(X) chain" , "COAA1_HUMAN" , "3,4-hydroxyprolyl-collagen alpha-1(X) chain" , "COL10A1" , "3x4Hyp-3Hyp-5Hyl-COL10A1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000009700" ; "LCE1B" ; "https://reactome.org/content/detail/R-HSA-6814271" ; ; [ a ; [ a ; [ a ; 118 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6814271" , "http://purl.obolibrary.org/obo/PR_Q5T7P3" ; "LCE1B" , "LCE1B_HUMAN" , "Late cornified envelope protein 1B" . a ; "Isa http://purl.obolibrary.org/obo/PR_O00443" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PIK3C2A" ; "https://reactome.org/content/detail/R-HSA-432679" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1686 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000048769" , "Reactome:R-HSA-432679" ; "P3C2A_HUMAN" , "PIK3C2A" , "Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Fyn:NCAM1:RPTP-alpha" ; "https://reactome.org/content/detail/R-HSA-391845" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-391845" ; "Fyn:NCAM1:RPTP-alpha" . a ; "Isa http://purl.obolibrary.org/obo/PR_000007868" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GBA2" ; "https://reactome.org/content/detail/R-HSA-1861791" ; ; [ a ; [ a ; [ a ; 927 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q9HCG7" , "Reactome:R-HSA-1861791" ; "Non-lysosomal glucosylceramidase" , "GBA2" , "GBA2_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000030553" ; "WDR46" ; "https://reactome.org/content/detail/R-HSA-6790677" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 610 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6790677" , "http://purl.obolibrary.org/obo/PR_O15213" ; "WDR46" , "WD repeat-containing protein 46" , "WDR46_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "PI5P" ; "https://reactome.org/content/detail/R-ALL-1806240" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-1806240" ; "1-phosphatidyl-1D-myo-inositol 5-phosphate" , "PI5P" . a ; "Isa http://purl.obolibrary.org/obo/PR_000007933" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GEMIN4" ; "https://reactome.org/content/detail/R-HSA-191836" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1058 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-191836" , "http://purl.obolibrary.org/obo/PR_P57678" ; "GEMIN4" , "Gemin 4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ATM dimer:Ub-p-PEX5:SQSTM1:MAP1LC3B" ; "https://reactome.org/content/detail/R-HSA-9665167" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9665167" ; "ATM dimer:Ub-p-PEX5:SQSTM1:MAP1LC3B" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1" ; "https://reactome.org/content/detail/R-HSA-8851943" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-8851943" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "BACH1:Hemes" ; "https://reactome.org/content/detail/R-HSA-9707680" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9707680" ; "BACH1:Hemes" . a ; "Isa http://purl.obolibrary.org/obo/PR_000004112" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "AP4E1" ; "https://reactome.org/content/detail/R-HSA-434209" ; ; [ a ; [ a ; [ a ; 1137 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q9UPM8" , "Reactome:R-HSA-434209" ; "AP-4 complex subunit epsilon-1" , "AP4E1_HUMAN" , "AP4E1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "UDP-Glc" ; "https://reactome.org/content/detail/R-ALL-9608511" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9608511" ; "phys-ent-participant98890" , "UDP-Glc" , "UDP-alpha-D-glucose" . a ; "Isa http://purl.obolibrary.org/obo/PR_000007045" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ELP4" ; "https://reactome.org/content/detail/R-HSA-3318363" ; ; [ a ; [ a ; [ a ; 424 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q96EB1" , "Reactome:R-HSA-3318363" ; "ELP4_HUMAN" , "ELP4" , "Elongator complex protein 4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "HDAC1:2-containing complex" ; "https://reactome.org/content/detail/R-HSA-4657020" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-4657020" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "HDAC1:2-containing complex" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000010423" ; "MITF" ; "https://reactome.org/content/detail/R-HSA-201592" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 526 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-201592" , "http://purl.obolibrary.org/obo/PR_O75030" ; "Class E basic helix-loop-helix protein 32" , "MITF" , "bHLHe32" , "Microphthalmia-associated transcription factor" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "CO" ; "https://reactome.org/content/detail/R-ALL-9709326" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9709326" ; "CO" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "TGFB1:p-TGFBR:STRAP" ; "https://reactome.org/content/detail/R-HSA-2127564" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2127564" ; "TGFB1:p-TGFBR:STRAP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-S326-PIP4K2B:PIP4K2C" ; "https://reactome.org/content/detail/R-HSA-8877686" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8877686" ; "p-S326-PIP4K2B:PIP4K2C" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000006631" ; "DOK4" ; "https://reactome.org/content/detail/R-HSA-8847701" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 326 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_Q8TEW6" , "Reactome:R-HSA-8847701" ; "Insulin receptor substrate 5" , "DOK4" , "IRS5" , "Downstream of tyrosine kinase 4" , "Docking protein 4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "CDK5:p25" ; "https://reactome.org/content/detail/R-HSA-8863434" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8863434" ; "CDK5:p25" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 222 to 224 by GWL]" ; "TP53 P222Gfs*4" ; "https://reactome.org/content/detail/R-HSA-9719171" ; ; [ a ; [ a ; [ a ; 224 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9719171" ; "TP53 P222Gfs*4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "2xHC-SOD1" ; "https://reactome.org/content/detail/R-HSA-3777108" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 57 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 154 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-3777108" ; "Superoxide dismutase [Cu-Zn] ecNumber1.15.1.1/ecNumber" , "SODC_HUMAN" , "SOD1 (disulfide bonded)" , "2xHC-SOD1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000004475" ; "ATP6V0C" ; "https://reactome.org/content/detail/R-HSA-6806254" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 155 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_P27449" , "Reactome:R-HSA-6806254" ; "ATP6V0C" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SULT4A1 dimer" ; "https://reactome.org/content/detail/R-HSA-176540" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-176540" ; "SULT4A1 dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DAB2,LDLRAP1" ; "https://reactome.org/content/detail/R-HSA-8869153" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-8869153" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "DAB2,LDLRAP1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "FBXW7 WD mutants" ; "https://reactome.org/content/detail/R-HSA-1602340" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-1602340" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ; "FBXW7 WD mutants" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_Q01955" ; "3x4Hyp-5Hyl-COL4A3" ; "https://reactome.org/content/detail/R-HSA-2022974" ; ; [ a ; [ a ; [ a ; 1670 ; ] ; [ a ; [ a ; 29 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000046904" , "Reactome:R-HSA-2022974" ; "3x4Hyp-5Hyl-COL4A3" , "3x4Hyp-5Hyl-COL4A3(29-1670)" , "Goodpasture antigen" , "4-Hyp 5-Hyl collagen alpha-3(IV) propeptide" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "VENTX" ; "https://reactome.org/content/detail/R-HSA-8853887" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 258 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-8853887" ; "Homeobox protein VENTX" , "HPX42B" , "VENTX2" , "VENT-like homeobox protein 2" , "VENT homeobox homolog" , "VENTX" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SDC1,2,4,(3):FGF2" ; "https://reactome.org/content/detail/R-HSA-2684512" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-2684512" ; "SDC1,2,4,(3):FGF2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Ligand-bound PPARG:RXRA:NCoR/SMRT:PLIN1 gene:nucleosomes" ; "https://reactome.org/content/detail/R-HSA-9864610" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9864610" ; "Ligand-bound PPARG:RXRA:NCoR/SMRT:PLIN1 gene:nucleosomes" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "RUNX1:CBFB:ELF,ELF2,PAX5:BLK gene" ; "https://reactome.org/content/detail/R-HSA-8938969" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8938969" ; "RUNX1:CBFB:ELF,ELF2,PAX5:BLK gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MdtB" ; "https://reactome.org/content/detail/R-ECO-9638402" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1040 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-ECO-9638402" ; "MDTB_ECOLI" , "MdtB" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "HTR3A pentamer:HTR3A antagonists" ; "https://reactome.org/content/detail/R-HSA-9648959" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9648959" ; "HTR3A pentamer:HTR3A antagonists" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-Y-ERBB2 KD mutants (ERBB3)" ; "https://reactome.org/content/detail/R-HSA-9664601" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-9664601" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ; "p-Y-ERBB2 KD mutants (ERBB3)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "BPIL3" ; "https://reactome.org/content/detail/R-HSA-6809554" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 453 ; ] ; [ a ; [ a ; 19 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6809554" ; "BPIFB6" , "BPIL3" , "BPI fold-containing family B member 6" , "Bactericidal/permeability-increasing protein-like 3" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "DNA-PK holoenzyme" ; "https://reactome.org/content/detail/R-HSA-75907" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-75907" ; "DNA-PK:DNA complex" , "PRKDC:XRCC5:XRCC6:DNA DSB ends" , "DNA-PK holoenzyme" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NR3C1:(ALDO,11DCORST,CORST,CORT) dimer:NPAS4 gene" ; "https://reactome.org/content/detail/R-HSA-9769707" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9769707" ; "NR3C1:(ALDO,11DCORST,CORST,CORT) dimer:NPAS4 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Rna" ; "Genomic RNA Segment 2" ; "https://reactome.org/content/detail/R-FLU-189174" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:AF389116" ; "Reactome:R-FLU-189174" , "EMBLAF389116" ; "Genomic RNA Segment 2" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_Q9UM11" ; "p-FZR1" ; "https://reactome.org/content/detail/R-HSA-174193" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 496 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000047482" , "Reactome:R-HSA-174193" ; "p-FZR1" , "phospho-Cdh1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ACADM tetramer" ; "https://reactome.org/content/detail/R-HSA-77335" ; ; [ a ; ; ] ; [ a ; ; ; "4"^^ ] ; ; "Reactome:R-HSA-77335" ; "MCAD acyl-CoA dehydrogenase homotetramer" , "ACADM tetramer" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "ADR" ; "https://reactome.org/content/detail/R-ALL-549254" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-549254" ; "ADR" , "(R)-adrenaline(1+)" , "Epinephrine" , "(R)-adrenaline" , "Adrenaline" . a ; "Unspecified modification type. Comment: [Replacement of residues 71 to 147 by SPRGPCTSSSYTGGPCTSPLLAPVIFCPFPENLPGQLRFPSGLLAFWDSQVCDLHVLPCPQQDVLPTGQDLPCAAVG]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TP53 P71Sfs*78" ; "https://reactome.org/content/detail/R-HSA-9721491" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 147 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9721491" ; "TP53 P71Sfs*78" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ABCE1:ATP" ; "https://reactome.org/content/detail/R-HSA-9955878" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-9955878" ; "ABCE1:ATP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PTEN H93Q" ; "https://reactome.org/content/detail/R-HSA-2318565" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 93 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 403 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2318565" ; "PTEN His93Gln" , "PTEN H93Q" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "COL5A1" ; "https://reactome.org/content/detail/R-HSA-2023513" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1838 ; ] ; [ a ; [ a ; 38 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2023513" ; "CO5A1_HUMAN" , "5-Gal-Hyl collagen alpha-1(V) propeptide" , "GalHyl-COL5A1(38-1838)" , "COL5A1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "OR2F1:acetyleugenol" ; "https://reactome.org/content/detail/R-HSA-9737273" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9737273" ; "OR2F1:acetyleugenol" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Insertion of residues 429 to 822 at 164 from UniProt:P11362 FGFR1]" ; "FOP-p-FGFR1 fusion" ; "https://reactome.org/content/detail/R-HSA-1838994" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 766 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 163 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1838994" ; "FOP-p-FGFR1 fusion" , "t(6;8) FGFR1OP-p-FGFR1 fusion" , "FGFR1OP-p-FGFR1 fusion" , "FGFR1OP(2-163)-p-FGFR1(429-822) fusion" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HSPG2" ; "https://reactome.org/content/detail/R-HSA-2076366" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 4391 ; ] ; [ a ; [ a ; 22 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2076366" ; "HS(1)-HSPG2" , "HSPG2" , "Perlecan" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P61978" ; "HNRPK_HUMAN" ; "https://reactome.org/content/detail/R-HSA-4570532" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 422 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 463 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_000047887" , "Reactome:R-HSA-4570532" ; "Heterogeneous nuclear ribonucleoprotein K" , "HNRPK_HUMAN" , "polySUMO2-K422-HNRNPK" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_000016048" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TAO1" ; "https://reactome.org/content/detail/R-HSA-376248" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1001 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_Q7L7X3" , "Reactome:R-HSA-376248" ; "TAO1" , "TAOK1" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "unfolded protein:(Glc)2 (GlcNAc)2 (Man)9 (Asn)1:malectin" ; "https://reactome.org/content/detail/R-HSA-901051" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-901051" ; "unfolded protein:(Glc)2 (GlcNAc)2 (Man)9 (Asn)1:malectin" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "WRB:CAML" ; "https://reactome.org/content/detail/R-HSA-9609864" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9609864" ; "WRB:CAML" , "WRB:CAMLG" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "ITGBL1 gene" ; "https://reactome.org/content/detail/R-HSA-8939831" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000198542" ; "Reactome:R-HSA-8939831" , "ENSEMBL:ENSG00000198542" ; "ITGBL1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "PXN gene" ; "https://reactome.org/content/detail/R-HSA-9926330" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000089159" ; "Reactome:R-HSA-9926330" , "ENSEMBL:ENSG00000089159" ; "PXN gene" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000004102" ; "AP2M1" ; "https://reactome.org/content/detail/R-HSA-2130423" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 435 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2130423" , "http://purl.obolibrary.org/obo/PR_Q96CW1" ; "AP2M1" , "Clathrin -coated Pit Adapter Protein" , "AP-2 clathrin coat assembly protein" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "HRH4:Hist" ; "https://reactome.org/content/detail/R-HSA-390876" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-390876" ; "HRH4:Hist" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TNFAIP6" ; "https://reactome.org/content/detail/R-HSA-6803341" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 277 ; ] ; [ a ; [ a ; 18 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6803341" ; "Tumor necrosis factor-inducible gene 6 protein" , "TNFAIP6" , "TSG6_HUMAN" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2" ; "https://reactome.org/content/detail/R-HSA-914049" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-914049" ; "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2" . a ; "Isa http://purl.obolibrary.org/obo/PR_O15151" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-S403-MDM4" ; "https://reactome.org/content/detail/R-HSA-349461" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 403 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 490 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000048362" , "Reactome:R-HSA-349461" ; "phospho-Mdmx (Ser-403)" , "p-S403-MDM4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ANT1:Vpr complex" ; "https://reactome.org/content/detail/R-HSA-180906" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-180906" ; "ANT1:Vpr complex" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "dGDP" ; "https://reactome.org/content/detail/R-ALL-110092" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-110092" ; "dGDP" , "dGDP(3-)" , "2'-deoxyguanosine 5'-diphosphate" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Gal-Xyl-proteins" ; "https://reactome.org/content/detail/R-HSA-2064058" ; ; [ a ; ; ] ; , , , , , , , , , , , , , , , , , , ; "Reactome:R-HSA-2064058" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ; "(Gal)1 (Xyl)1 (Ser)1" , "Gal-Xyl-proteins" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "PolyUb-Misfolded Proteins:HDAC6" ; "https://reactome.org/content/detail/R-HSA-9660009" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9660009" ; "PolyUb-Misfolded Proteins:HDAC6" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "INSL3" ; "https://reactome.org/content/detail/R-HSA-444880" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 131 ; ] ; [ a ; [ a ; 106 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-444880" ; "Insulin-like peptide 3 A chain" , "INSL3_HUMAN" , "INSL3(106-131)" , "INSL3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "type I TKI sensitive FLT3 mutants" ; "https://reactome.org/content/detail/R-HSA-9702522" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-9702522" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ; "type I TKI sensitive FLT3 mutants" . a . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-S15,S20-TP53 Tetramer:ZNF385A:SFN Gene" ; "https://reactome.org/content/detail/R-HSA-6803857" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-6803857" ; "p-S15,S20-TP53 Tetramer:ZNF385A:SFN Gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KMT2D Y1559*" ; "https://reactome.org/content/detail/R-HSA-9951093" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1559 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 1558 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9951093" ; "KMT2D Y1559*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NOX2 complex" ; "https://reactome.org/content/detail/R-HSA-1222368" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-1222368" ; "NOX2 complex" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_Q8IVF7" ; "FMNL3" ; "https://reactome.org/content/detail/R-HSA-5665760" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1028 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5665760" , "http://purl.obolibrary.org/obo/PR_000047435" ; "FMNL3" , "Formin-like protein 3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000011949" ; "OR5P3" ; "https://reactome.org/content/detail/R-HSA-422186" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 311 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-422186" , "http://purl.obolibrary.org/obo/PR_Q8WZ94" ; "Olfactory receptor 5P3" , "OR5P3" , "OR5P3_HUMAN" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "S1P" ; "https://reactome.org/content/detail/R-ALL-9843733" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9843733" ; "sphingoid 1-phosphate" , "phys-ent-participant40241" , "phys-ent-participant40259" , "S1P" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HAO2" ; "https://reactome.org/content/detail/R-HSA-9033093" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 351 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9033093" ; "HAOX2_HUMAN" , "Hydroxyacid oxidase 2" , "HAO2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "bezafibrate" ; "https://reactome.org/content/detail/R-ALL-9734476" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9734476" ; "bezafibrate" , "Bezalip®" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "Glc-DAG-s2" ; "https://reactome.org/content/detail/R-ALL-8850080" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-8850080" ; "Glc-DAG-s2" , "1-O-palmitoyl-2-cis-O-vaccenoyl-3-O-α-D-glucosyl-sn-glycerol" , "1-palmitoyl-2-cis-vaccenoyl-3-alpha-D-glucosyl-sn-glycerol" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "25(R) DHCA-CoA" ; "https://reactome.org/content/detail/R-ALL-193457" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-193457" ; "25(R) DHCA-CoA" , "3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA" , "3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Cleaved Cohesin" ; "https://reactome.org/content/detail/R-HSA-2467801" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-2467801" ; "Cleaved Cohesin" . a ; "Isa http://purl.obolibrary.org/obo/PR_O76094" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SRP72" ; "https://reactome.org/content/detail/R-HSA-265069" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 671 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-265069" , "http://purl.obolibrary.org/obo/PR_000049347" ; "SRP72" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PKA catalytic subunits" ; "https://reactome.org/content/detail/R-HSA-111917" ; ; [ a ; ; ] ; , , ; "Reactome:R-HSA-111917" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "Protein Kinase A, catalytic subunits" , "cAMP-dependent protein kinase catalytic subunits" , "PKA catalytic subunits" . a ; "Isa http://purl.obolibrary.org/obo/PR_000018282" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "THBS1" ; "https://reactome.org/content/detail/R-HSA-114701" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1170 ; ] ; [ a ; [ a ; 19 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-114701" , "http://purl.obolibrary.org/obo/PR_000028410" ; "THBS1" , "Thrombospondin 1 precursor" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "UQCRFS1(1-274)" ; "https://reactome.org/content/detail/R-HSA-9906005" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 274 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9906005" ; "UQCRFS1(1-274)" , "Full length Rieske protein" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase" ; "https://reactome.org/content/detail/R-HSA-167554" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-167554" ; "Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "aspirin" ; "https://reactome.org/content/detail/R-ALL-9649959" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9649959" ; "Aspirin®" , "acetylsalicylic acid" , "Acetophen®" , "aspirin" . a ; "Isa http://purl.obolibrary.org/obo/PR_000003755" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ADCY4" ; "https://reactome.org/content/detail/R-HSA-379054" ; ; [ a ; [ a ; [ a ; 1077 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q8NFM4" , "Reactome:R-HSA-379054" ; "ADCY4" , "Adenylate cyclase type 4" , "ADCY4_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TMEM177" ; "https://reactome.org/content/detail/R-HSA-9865585" ; ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9865585" ; "TMEM177" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "HCQ" ; "https://reactome.org/content/detail/R-ALL-9685625" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9685625" ; "hydroxychloroquine" , "Dolquine®" , "Plaquenil®" , "HCQ" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000005089" ; "CBX8" ; "https://reactome.org/content/detail/R-HSA-389117" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 389 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-389117" , "http://purl.obolibrary.org/obo/PR_Q9HC52" ; "CBX8" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_000017837" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ZNF337" ; "https://reactome.org/content/detail/R-HSA-1247545" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 751 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1247545" , "http://purl.obolibrary.org/obo/PR_Q9Y3M9" ; "ZNF337" , "ZN337_HUMAN" , "Zinc finger protein 337" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SMAD4 E307*" ; "https://reactome.org/content/detail/R-HSA-9675639" ; ; [ a ; [ a ; [ a ; 306 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 307 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9675639" ; "SMAD4 E307TER" , "SMAD4 Glu307*" , "SMAD4 E307*" , "SMAD4 Glu307TER" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P63241" ; "EIF5A" ; "https://reactome.org/content/detail/R-HSA-3006308" ; ; [ a ; [ a ; [ a ; 154 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-3006308" , "http://purl.obolibrary.org/obo/PR_000047272" ; "Dhp50" , "IF5A1_HUMAN" , "Eukaryotic translation initiation factor 5A-1" , "EIF5A" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "HSPA1B:ADP" ; "https://reactome.org/content/detail/R-HSA-6792616" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6792616" ; "HSPA1B:ADP" . a ; "Isa http://purl.obolibrary.org/obo/PR_P16035" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TIMP2" ; "https://reactome.org/content/detail/R-HSA-6800944" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 220 ; ] ; [ a ; [ a ; 27 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6800944" , "http://purl.obolibrary.org/obo/PR_000049458" ; "TIMP2" , "TIMP2_HUMAN" , "Metalloproteinase inhibitor 2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 266 to 268 by EQL]" ; "TP53 G266Efs*4" ; "https://reactome.org/content/detail/R-HSA-9719580" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 268 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9719580" ; "TP53 G266Efs*4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ATRX K910*" ; "https://reactome.org/content/detail/R-HSA-9671671" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 910 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 909 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9671671" ; "ATRX Lys910TER" , "ATRX Lys910*" , "ATRX K910TER" , "ATRX K910*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "OR2A1 gene" ; "https://reactome.org/content/detail/R-HSA-9752462" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000221970" ; "ENSEMBL:ENSG00000221970" , "Reactome:R-HSA-9752462" ; "OR2A1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "4x(Btn-PC:Mn2+)" ; "https://reactome.org/content/detail/R-HSA-3323188" ; ; [ a ; ; ; "4"^^ ] ; [ a ; ; ; "4"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-3323188" ; "4x(Btn-PC:Mn2+)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "C4A" ; "https://reactome.org/content/detail/R-HSA-981503" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 956 ; ] ; [ a ; [ a ; 680 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-981503" ; "C4A(680-956)" , "C4A alpha3" , "CO4A_HUMAN" , "Complement factor 4A alpha3 fragment" , "C4A" . a ; "Isa http://purl.obolibrary.org/obo/PR_000030199" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "COX20" ; "https://reactome.org/content/detail/R-HSA-5336169" ; ; [ a ; [ a ; [ a ; 118 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5336169" , "http://purl.obolibrary.org/obo/PR_Q5RI15" ; "COX20" , "Cytochrome c oxidase protein 20 homolog" , "COX20_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Procollagen type III -N" ; "https://reactome.org/content/detail/R-HSA-2268745" ; ; [ a ; ; ] ; [ a ; ; ; "3"^^ ] ; ; "Reactome:R-HSA-2268745" ; "Procollagen type III -N" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "F8(582-640)" ; "https://reactome.org/content/detail/R-HSA-5607008" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 640 ; ] ; [ a ; [ a ; 582 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5607008" ; "F8(582-640)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "N-ter PDGF-A fragment" ; "https://reactome.org/content/detail/R-HSA-8865271" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-8865271" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "N-ter PDGF-A fragment" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "COL25A1" ; "https://reactome.org/content/detail/R-HSA-2172346" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 654 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2172346" ; "Collagen alpha-1(XXV) chain" , "COPA1_HUMAN" , "COL25A1(1-654)" , "COL25A1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "PKLR gene" ; "https://reactome.org/content/detail/R-HSA-9606134" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000143627" ; "Reactome:R-HSA-9606134" , "ENSEMBL:ENSG00000143627" ; "PKLR gene" . a ; "Isa http://purl.obolibrary.org/obo/PR_Q8TDY2" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "FIP200" ; "https://reactome.org/content/detail/R-HSA-5675845" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1594 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000049018" , "Reactome:R-HSA-5675845" ; "FAK family kinase-interacting protein of 200 kDa" , "RBCC1_HUMAN" , "RB1-inducible coiled-coil protein 1" , "p-RB1CC1" , "FIP200" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Rna" ; "MIR200B/C" ; "https://reactome.org/content/detail/R-HSA-1614240" ; ; [ a ; ; ] ; "ENSEMBL:MI0000650" , "ENSEMBL:MI0000342" ; "Reactome:R-HSA-1614240" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "MIR200B/C" , "miR-200B/C" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "androstadienone" ; "https://reactome.org/content/detail/R-ALL-9737282" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9737282" ; "androsta-4,16-dien-3-one" , "androstadienone" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "underrepresented Olfactory Receptor" ; "https://reactome.org/content/detail/R-HSA-9752978" ; ; [ a ; ; ] ; , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ; "Reactome:R-HSA-9752978" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ; "underrepresented Olfactory Receptor" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KRTAP4-7" ; "https://reactome.org/content/detail/R-HSA-6809963" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 155 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6809963" ; "Keratin-associated protein 4-7" , "KRA47_HUMAN" , "KRTAP4-7" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CPN2_HUMAN" ; "https://reactome.org/content/detail/R-HSA-5600621" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 181 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 503 ; ] ; [ a ; [ a ; 25 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5600621" ; "CPN2_HUMAN" , "Cytochrome P450 11B2" , "CYP11B2 R181W" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "PDE6D:INPP5E" ; "https://reactome.org/content/detail/R-HSA-5624936" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5624936" ; "PDE6D:INPP5E" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000010875" ; "MyoD" ; "https://reactome.org/content/detail/R-HSA-445441" ; ; [ a ; [ a ; [ a ; 320 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-445441" , "http://purl.obolibrary.org/obo/PR_P15172" ; "MYOD1" , "Myoblast determination protein 1" , "MYOD1_HUMAN" , "MyoD" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "sorafenib-sensitive PDGFR mutants" ; "https://reactome.org/content/detail/R-HSA-9673717" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-9673717" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "sorafenib-sensitive PDGFR mutants" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GRK7" ; "https://reactome.org/content/detail/R-HSA-6787797" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 550 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6787797" ; "GRK7" , "G protein-coupled receptor kinase 7 ecNumber evidence=\"8\"2.7.11.14/ecNumber ecNumber2.7.11.16/ecNumber" , "GRK7_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SOX17:TET2 gene" ; "https://reactome.org/content/detail/R-HSA-9828020" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9828020" ; "SOX17:TET2 gene" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GGC-RAB31" ; "https://reactome.org/content/detail/R-HSA-8877278" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 194 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 194 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 193 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-8877278" ; "RAB31_HUMAN" , "Ras-related protein Rab-31" , "GGC-RAB31" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PI13" ; "https://reactome.org/content/detail/R-HSA-8938045" ; ; [ a ; [ a ; [ a ; 391 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8938045" ; "Serpin B13" , "Headpin" , "SERPINB13" , "PI-13" , "HaCaT UV-repressible serpin" , "PI13" , "Proteinase inhibitor 13" , "SPB13_HUMAN" , "Hurpin" , "Peptidase inhibitor 13" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-10S-LRP5" ; "https://reactome.org/content/detail/R-HSA-1458893" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1615 ; ] ; [ a ; [ a ; 32 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1458893" ; "p-5S,5T-LRP5" , "p-10S-LRP5" , "p10S/T-LRP5" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-T172-CDK4,p-T177-CDK6" ; "https://reactome.org/content/detail/R-HSA-69211" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-69211" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "p-T172-CDK4,p-T177-CDK6" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "APC_HUMAN" ; "https://reactome.org/content/detail/R-HSA-9666954" ; ; [ a ; [ a ; [ a ; 1048 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1049 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9666954" ; "APC_HUMAN" , "Adenomatous polyposis coli protein" , "APC W1049*" , "APC W1049TER" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TP53 K305*" ; "https://reactome.org/content/detail/R-HSA-9723430" ; ; [ a ; [ a ; [ a ; 304 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 305 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9723430" ; "TP53 K305*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SMAD4 G352*" ; "https://reactome.org/content/detail/R-HSA-9678445" ; ; [ a ; [ a ; [ a ; 351 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 352 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9678445" ; "SMAD4 G352TER" , "SMAD4 Gly352TER" , "SMAD4 G352*" , "SMAD4 Gly352*" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "80S Ribosome:mRNA Complex" ; "https://reactome.org/content/detail/R-HSA-453157" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-453157" ; "elongating polypeptide chain" , "80S Ribosome:mRNA Complex" . a ; "Isa http://purl.obolibrary.org/obo/PR_Q9P2R7" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SUCLA2" ; "https://reactome.org/content/detail/R-HSA-156624" ; ; [ a ; [ a ; [ a ; 463 ; ] ; [ a ; [ a ; 53 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000049378" , "Reactome:R-HSA-156624" ; "Succinyl-CoA synthetase, betaA chain" , "SUCLA2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SULT2A1 dimer" ; "https://reactome.org/content/detail/R-HSA-176648" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-176648" ; "SULT2A1 dimer" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NAGK dimer" ; "https://reactome.org/content/detail/R-HSA-6803750" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-6803750" ; "NAGK dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000008519" ; "HES5" ; "https://reactome.org/content/detail/R-HSA-1606739" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 166 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-1606739" , "http://purl.obolibrary.org/obo/PR_Q5TA89" ; "Transcription factor HES-5" , "HES5" , "BHLHB38" , "Class B basic helix-loop-helix protein 38" , "Hairy and enhancer of split 5" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "LZTFL1 oligomer" ; "https://reactome.org/content/detail/R-HSA-5624119" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5624119" ; "LZTFL1 oligomer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "TrxB dimer" ; "https://reactome.org/content/detail/R-MTU-1222425" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; ; "Reactome:R-MTU-1222425" ; "TrxB dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CTF8" ; "https://reactome.org/content/detail/R-HSA-9668898" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 121 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9668898" ; "CHTF8" , "CTF8" , "fullName evidence=\"5\"Chromosome transmission fidelity protein 8 homolog" , "CTF8_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MARCO" ; "https://reactome.org/content/detail/R-HSA-2173724" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 447 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 488 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 460 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 520 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2173724" ; "6xHC-MARCO" , "MARCO" , "Macrophage receptor MARCO" , "MARCO_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Activated PPARG:RXRA:PEX11A gene:nucleosomes" ; "https://reactome.org/content/detail/R-HSA-9864718" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9864718" ; "Activated PPARG:RXRA:PEX11A gene:nucleosomes" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "C1-In Y496*" ; "https://reactome.org/content/detail/R-HSA-9650355" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 495 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 496 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9650355" ; "C1-In Y496*" , "C1Inh Y496*" , "SERPING1 Y496TER" , "SERPING1 Y496*" , "plasma protease C1 inhibitor Y496*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CFP" ; "https://reactome.org/content/detail/R-HSA-5173204" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 469 ; ] ; [ a ; [ a ; 28 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5173204" ; "CFP" , "Properdin" , "O-fuc-CFP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "LOK" ; "https://reactome.org/content/detail/R-HSA-9690312" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 968 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9690312" ; "STK10" , "Lymphocyte-oriented kinase" , "LOK" , "Serine/threonine-protein kinase 10 ecNumber2.7.11.1/ecNumber" , "STK10_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "cRaf" ; "https://reactome.org/content/detail/R-HSA-9656074" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 621 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 648 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 491 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 260 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 338 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 341 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 494 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9656074" ; "Raf-1" , "p-S338,Y341,T492,S494,S621 RAF1 T260I" , "C-RAF" , "RAF proto-oncogene serine/threonine-protein kinase" , "cRaf" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "T4" ; "https://reactome.org/content/detail/R-ALL-209937" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-209937" ; "Thyroxine" , "L-thyroxine" , "3,5,3'5'-tetraiodothyronine" , "T4" . a ; "Isa http://purl.obolibrary.org/obo/PR_000015269" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SMC1A" ; "https://reactome.org/content/detail/R-HSA-2466015" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1233 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_Q14683" , "Reactome:R-HSA-2466015" ; "SMC1alpha protein" , "SB1.8/DXS423E protein" , "SMC1A" , "Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (SB1.8/DXS423E protein) (Sb1.8)" , "Sb1.8" , "Structural maintenance of chromosome 1-like 1 protein" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "IL17RD:p-2S MAP2Ks:MAPKs" ; "https://reactome.org/content/detail/R-HSA-5674360" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5674360" ; "IL17RD:p-2S MAP2Ks:MAPKs" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "SLC2A4 gene (GLUT4 gene)" ; "https://reactome.org/content/detail/R-HSA-5640175" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000181856" ; "ENSEMBL:ENSG00000181856" , "Reactome:R-HSA-5640175" ; "SLC2A4 gene (GLUT4 gene)" . a ; "Unspecified modification type. Comment: [Replacement of residues 598 to 599 by EFDFREYEY]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MOLM-14" ; "https://reactome.org/content/detail/R-HSA-9696031" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 955 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 969 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 599 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 993 ; ] ; [ a ; [ a ; 27 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 768 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 591 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 589 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9696031" ; "MOLM-14" , "p-6Y-FLT3 E598_Y599insFDFREYE" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Cytochrome P450 (CYP7B1 based)" ; "https://reactome.org/content/detail/R-HSA-2975806" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-2975806" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "Cytochrome P450 (CYP7B1 based)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SYT11 dimer" ; "https://reactome.org/content/detail/R-HSA-8862874" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-8862874" ; "SYT11 dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000010488" ; "MMP3" ; "https://reactome.org/content/detail/R-HSA-8943665" ; ; [ a ; [ a ; [ a ; 477 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_P08254" , "Reactome:R-HSA-8943665" ; "Matrix metalloproteinase-3" , "Stromelysin-1" , "MMP3" , "MMP3_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "OR10H4" ; "https://reactome.org/content/detail/R-HSA-9751493" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 316 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9751493" ; "OR10H4" , "Olfactory receptor 10H4" , "O10H4_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-T235, S321-CEBPB" ; "https://reactome.org/content/detail/R-HSA-3857339" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 235 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 321 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 345 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-3857339" ; "p-T235, S321-CEBPB" . a ; "Isa http://purl.obolibrary.org/obo/PR_000009289" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KIF15" ; "https://reactome.org/content/detail/R-HSA-984825" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1388 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-984825" , "http://purl.obolibrary.org/obo/PR_Q9NS87" ; "KIF15_HUMAN" , "KIF15" , "Kinesin-like protein KIF15" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 110 to 147 by PSGLLAFWDSQVCDLHVLPCPQQDVLPTGQDLPCAAVG]" ; "TP53 R110Pfs*39" ; "https://reactome.org/content/detail/R-HSA-9718713" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 147 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9718713" ; "TP53 R110Pfs*39" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "factor VIIIa:factor IXa variant" ; "https://reactome.org/content/detail/R-HSA-9670804" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9670804" ; "factor VIIIa:factor IXa variant" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DPP3" ; "https://reactome.org/content/detail/R-HSA-9795741" ; ; [ a ; [ a ; [ a ; 737 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9795741" ; "DPP3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-S177,S181-IKKB:IKKA:pUb-NEMO" ; "https://reactome.org/content/detail/R-HSA-202562" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-202562" ; "p-S177,S181-IKKB:IKKA:pUb-NEMO" , "CHUK:p-S177,S181-IKBKB:pUb-IKBKG" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "PIP4K2 dimers" ; "https://reactome.org/content/detail/R-HSA-6811466" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-6811466" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ; "PIP4K2 dimers" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P06737" ; "PYGL" ; "https://reactome.org/content/detail/R-HSA-6801505" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 681 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 847 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6801505" , "http://purl.obolibrary.org/obo/PR_000048977" ; "PXLP-PYGL" , "glycogen phosphorylase, liver form" , "PYGL" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "OAS2:OAS2 ligand" ; "https://reactome.org/content/detail/R-HSA-8985050" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8985050" ; "OAS2:OAS2 ligand" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "IL38(1-?)" ; "https://reactome.org/content/detail/R-HSA-9007899" ; ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9007899" ; "IL1FA_HUMAN(1-?)" , "IL1F10(1-?)" , "Interleukin-1 family member 10(1-?)" , "IL38(1-?)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ub-DVL" ; "https://reactome.org/content/detail/R-HSA-4652685" ; ; [ a ; ; ] ; , , ; "Reactome:R-HSA-4652685" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "ub-DVL" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 329 to 330 by IR]" ; "ATRX K329Ifs*3" ; "https://reactome.org/content/detail/R-HSA-9672232" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 330 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9672232" ; "ATRX Lys329Ilefs*3" , "ATRX Lys329IlefsTER3" , "ATRX K329IfsTER3" , "ATRX K329Ifs*3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "PTPN1 gene" ; "https://reactome.org/content/detail/R-HSA-9023541" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000196396" ; "Reactome:R-HSA-9023541" , "ENSEMBL:ENSG00000196396" ; "PTP1B gene" , "PTPN1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "WT1:NR5A1:GATA4:ZFPM2:SRY gene" ; "https://reactome.org/content/detail/R-HSA-9692256" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9692256" ; "WT1:NR5A1:GATA4:ZFPM2:SRY gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Tau-F" ; "https://reactome.org/content/detail/R-HSA-9619519" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 441 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9619519" ; "Tau-F" , "Tau-4" , "MAPT-8" , "Microtubule-associated protein tau, Isoform Tau-F" , "TAU_HUMAN" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Ub:PEX5S,L" ; "https://reactome.org/content/detail/R-HSA-9033604" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-9033604" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "Ub:PEX5S,L" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 249 to 269 by FTSNTQARSEQECTDSKTTRK]" ; "RB1 S249Ffs*22" ; "https://reactome.org/content/detail/R-HSA-9688014" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 269 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9688014" ; "RB1 S249Ffs*22" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SHH" ; "https://reactome.org/content/detail/R-HSA-5358433" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 196 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 462 ; ] ; [ a ; [ a ; 24 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5358433" ; "SHH(24-462) G196V" , "SHH_HUMAN" , "SHH" , "Sonic hedgehog protein precursor" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "FPR1 gene" ; "https://reactome.org/content/detail/R-HSA-6785058" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000171051" ; "Reactome:R-HSA-6785058" , "ENSEMBL:ENSG00000171051" ; "FPR1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "kinase domain KIT mutants" ; "https://reactome.org/content/detail/R-HSA-9669760" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-9669760" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ; "kinase domain KIT mutants" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_Q8N257" ; "AcK-HIST3H2BB" ; "https://reactome.org/content/detail/R-HSA-4549249" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 126 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000047871" , "Reactome:R-HSA-4549249" ; "Histone H2B type 12" , "AcK-HIST3H2BB" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "FPR2 ligands" ; "https://reactome.org/content/detail/R-HSA-444472" ; ; [ a ; ; ] ; , , , , , ; "Reactome:R-HSA-444472" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ; "FPRL1 ligands" , "FPR2 ligands" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 1122 to 1128 by LTLLIRD]" ; "ATRX C1122Lfs*8" ; "https://reactome.org/content/detail/R-HSA-9672748" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1128 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9672748" ; "ATRX C1122Lfs*8" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_Q02878" ; "RPL6" ; "https://reactome.org/content/detail/R-HSA-72484" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 288 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-72484" , "http://purl.obolibrary.org/obo/PR_000049093" ; "RPL6" , "TAXREB107" , "60S ribosomal protein L6" , "Neoplasm-related protein C140" , "TAX-responsive enhancer element binding protein 107" . a ; "Isa http://purl.obolibrary.org/obo/PR_P46098" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HTR3A" ; "https://reactome.org/content/detail/R-HSA-975301" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 478 ; ] ; [ a ; [ a ; 24 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000047923" , "Reactome:R-HSA-975301" ; "5-hydroxytryptamine receptor 3A" , "5HT3A_HUMAN" , "HTR3A" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "4-Hyp 5-Gal-Hyl collagen alpha-4(IV) NC1 domain" ; "https://reactome.org/content/detail/R-HSA-4088271" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1690 ; ] ; [ a ; [ a ; 1461 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-4088271" ; "4-Hyp 5-Gal-Hyl collagen alpha-4(IV) NC1 domain" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "(HA)50" ; "https://reactome.org/content/detail/R-ALL-2160864" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-2160864" ; "Hyaluronic acid" , "(HA)50" , "Hyaluronan" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "MT1X:7Cd2+" ; "https://reactome.org/content/detail/R-HSA-5662568" ; ; [ a ; ; ; "7"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5662568" ; "MT1X:7Cd2+" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-ACVR1C:ACVR2B:EGF-CFC" ; "https://reactome.org/content/detail/R-HSA-1181126" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-1181126" ; "p-ACVR1C:ACVR2B:EGF-CFC" , "PhosphoALK7:ActRIIB:EGF-CFC Complex" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "K48polyUb-K,p-S-PER1,2,3" ; "https://reactome.org/content/detail/R-HSA-9932533" ; ; [ a ; ; ] ; , , ; "Reactome:R-HSA-9932533" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "K48polyUb-K,p-S-PER1,2,3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PRDX3" ; "https://reactome.org/content/detail/R-HSA-3323081" ; ; [ a ; [ a ; [ a ; 256 ; ] ; [ a ; [ a ; 62 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-3323081" ; "PRDX3" , "PRDX3_HUMAN" , "Thioredoxin-dependent peroxide reductase, mitochondrial ecNumber1.11.1.15/ecNumber" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ZNF729" ; "https://reactome.org/content/detail/R-HSA-2586611" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1252 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2586611" ; "ZN729_HUMAN" , "ZNF729" , "Zinc finger protein 729" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "USP11:NFKBIA" ; "https://reactome.org/content/detail/R-HSA-6782962" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-6782962" ; "USP11:NFKBIA" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MetMAb" ; "https://reactome.org/content/detail/R-ALL-9734068" ; ; [ a ; ; ] ; "Reactome:R-ALL-9734068" ; "MetMAb" , "onartuzumab" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "RELA:RELA" ; "https://reactome.org/content/detail/R-HSA-1168591" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-1168591" ; "NF-kB p65:p65" , "RELA:RELA" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000016700" ; "TRPM4" ; "https://reactome.org/content/detail/R-HSA-937288" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1214 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-937288" , "http://purl.obolibrary.org/obo/PR_Q8TD43" ; "Transient receptor potential cation channel subfamily M member 4" , "TRPM4" , "TRPM4_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000006726" ; "CTDNEP1" ; "https://reactome.org/content/detail/R-HSA-3632863" ; ; [ a ; [ a ; [ a ; 244 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_O95476" , "Reactome:R-HSA-3632863" ; "DULLARD" , "CTDNEP1" , "Serine/threonine-protein phosphatase dullard" , "CTD nuclear envelope phosphatase 1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-S76,S79,T80,S82-CDC25A" ; "https://reactome.org/content/detail/R-HSA-9944024" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 82 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 524 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 79 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 80 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 76 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9944024" ; "p-S76,S79,T80,S82-CDC25A" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ASCC3" ; "https://reactome.org/content/detail/R-HSA-9948315" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 2202 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9948315" ; "ASCC3" , "ASCC3_HUMAN" , "Activating signal cointegrator 1 complex subunit 3 ecNumber evidence=\"7 13 15\"3.6.4.12" . a ; "Isa http://purl.obolibrary.org/obo/PR_Q9Y6M9" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "NDUFB9" ; "https://reactome.org/content/detail/R-HSA-60176" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 179 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-60176" , "http://purl.obolibrary.org/obo/PR_000048559" ; "CI-B22" , "NDUFB9" , "Complex I-B22" , "NADH-ubiquinone oxidoreductase B22 subunit" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DEFB109P1" ; "https://reactome.org/content/detail/R-HSA-8848268" ; ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8848268" ; "DEFB109P1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:RORA gene" ; "https://reactome.org/content/detail/R-HSA-9922986" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9922986" ; "p-S90-ARNTL:p-T451,T461,S440,S441,S446-CLOCK:RORA gene" , "p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:RORA gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P30041" ; "PRDX6" ; "https://reactome.org/content/detail/R-HSA-6798744" ; ; [ a ; [ a ; [ a ; 224 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6798744" , "http://purl.obolibrary.org/obo/PR_000048899" ; "Peroxiredoxin-6" , "PRDX6" , "PRDX6_HUMAN" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GPI-LYPD3" ; "https://reactome.org/content/detail/R-HSA-8940752" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 326 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 326 ; ] ; [ a ; [ a ; 31 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8940752" ; "GPI-LYPD3" , "LYPD3_HUMAN" , "Ly6/PLAUR domain-containing protein 3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000010309" ; "MEF2A" ; "https://reactome.org/content/detail/R-HSA-199903" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 507 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_Q02078" , "Reactome:R-HSA-199903" ; "MEFA_HUMAN" , "MEF2A" , "Myocyte-specific enhancer factor 2A" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000012506" ; "PDK3" ; "https://reactome.org/content/detail/R-HSA-203940" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 406 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_Q15120" , "Reactome:R-HSA-203940" ; "PDK3" , "PDK3(?-406)" , "Pyruvate dehydrogenase kinase isoform 3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DEFB115" ; "https://reactome.org/content/detail/R-HSA-1471321" ; ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1471321" ; "DB115_HUMAN" , "DEFB115(?-88)" , "Beta-defensin 115" , "Beta defensin-15" , "DEFB115" . a ; "Isa http://purl.obolibrary.org/obo/PR_000013966" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "R9AP" ; "https://reactome.org/content/detail/R-HSA-2584264" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 235 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2584264" , "http://purl.obolibrary.org/obo/PR_Q6ZS82" ; "R9AP" , "Regulator of G-protein signaling 9-binding protein" , "R9BP_HUMAN" , "RGS9BP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Collagen alpha-1(XII) chains" ; "https://reactome.org/content/detail/R-HSA-2192779" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-2192779" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ] ] ; "Collagen alpha-1(XII) chains" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-S465,S467-SMAD2 D300A" ; "https://reactome.org/content/detail/R-HSA-3315064" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 300 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 467 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 467 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 465 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-3315064" ; "p-S465,S467-SMAD2 D300A" , "p-Ser465,Ser467-SMAD2 Asp300Ala" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000009714" ; "LCE4A" ; "https://reactome.org/content/detail/R-HSA-6814272" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 99 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q5TA78" , "Reactome:R-HSA-6814272" ; "LCE4A" , "Late cornified envelope protein 4A" , "LCE4A_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "IPAF elicitors:NLRC4:Procaspase-1" ; "https://reactome.org/content/detail/R-HSA-874083" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-874083" ; "IPAF elicitors:NLRC4:Procaspase-1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "UTP15" ; "https://reactome.org/content/detail/R-HSA-6790678" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 518 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6790678" ; "UTP15" , "U3 small nucleolar RNA-associated protein 15 homolog" , "UTP15_HUMAN" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ATM dimer:Ub-p-PEX5:SQSTM1" ; "https://reactome.org/content/detail/R-HSA-9665168" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9665168" ; "ATM dimer:Ub-p-PEX5:SQSTM1" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KMT2D W315*" ; "https://reactome.org/content/detail/R-HSA-9950635" ; ; [ a ; [ a ; [ a ; 314 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 315 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9950635" ; "KMT2D W315*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000007044" ; "ELP3" ; "https://reactome.org/content/detail/R-HSA-3318364" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 547 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q9H9T3" , "Reactome:R-HSA-3318364" ; "ELP3" , "ELP3_HUMAN" , "Elongator complex protein 3" , "KAT9" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Mi-2" ; "https://reactome.org/content/detail/R-HSA-4657021" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-4657021" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "Mi-2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000014468" ; "SATB1" ; "https://reactome.org/content/detail/R-HSA-201593" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 763 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-201593" , "http://purl.obolibrary.org/obo/PR_Q01826" ; "SATB1" , "Satb1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ESYT1:ESYT2:ESYT3" ; "https://reactome.org/content/detail/R-HSA-8857663" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8857663" ; "ESYT1:ESYT2:ESYT3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "BIL" ; "https://reactome.org/content/detail/R-ALL-9661418" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9661418" ; "bilirubin IXalpha" , "bilirubin" , "BIL" . a ; "Isa http://purl.obolibrary.org/obo/PR_000018010" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ZNF587" ; "https://reactome.org/content/detail/R-HSA-2127565" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 575 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_Q96SQ5" , "Reactome:R-HSA-2127565" ; "ZN587_HUMAN" , "Zinc finger protein 587" , "ZNF587" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-S326-PIP4K2B:p-S326-PIP4K2B" ; "https://reactome.org/content/detail/R-HSA-8877687" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8877687" ; "p-S326-PIP4K2B:p-S326-PIP4K2B" . a ; "Unspecified modification type. Comment: [Replacement of residues 3923 to 3977 by HSNFSSNSFNSSNSSSSFNNSSSNSFNSSNSSYNSNSNNNSSSFNSSSNSSRWAF]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KMT2D Q3923Hfs*56" ; "https://reactome.org/content/detail/R-HSA-9952063" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 3977 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9952063" ; "KMT2D Q3923Hfs*56" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Argonaute1/3/4: miR-17" ; "https://reactome.org/content/detail/R-HSA-8938454" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8938454" ; "miR-17 Nonendonucleolytic Minimal RISC" , "Argonaute1/3/4: miR-17" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P16144" ; "ITGB4" ; "https://reactome.org/content/detail/R-HSA-215947" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1822 ; ] ; [ a ; [ a ; 28 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-215947" , "http://purl.obolibrary.org/obo/PR_000048070" ; "Integrin beta-4" , "ITGB4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "GATA3:CHD4:EP300:p-S243-NFATC2:IL13 gene" ; "https://reactome.org/content/detail/R-HSA-9976378" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9976378" ; "GATA3:CHD4:EP300:p-S243-NFATC2:IL13 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SOD1 dimer" ; "https://reactome.org/content/detail/R-HSA-3777109" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-3777109" ; "SOD1 dimer" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_000031725" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DNAJC13" ; "https://reactome.org/content/detail/R-HSA-6806255" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 2243 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6806255" , "http://purl.obolibrary.org/obo/PR_O75165" ; "DnaJ homolog subfamily C member 13" , "DNAJC13" , "DJC13_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GNAT1" ; "https://reactome.org/content/detail/R-HSA-55459" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 350 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-55459" ; "GNAT1" , "Guanine nucleotide-binding protein G(T), alpha-1 subunit" , "Transducin alpha-1 chain" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks" ; "https://reactome.org/content/detail/R-HSA-508238" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-508238" ; "IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "cetyldimethylethylammonium" ; "https://reactome.org/content/detail/R-ALL-9931164" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9931164" ; "cetyldimethylethylammonium" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "FBXW7 R465/347C mutant" ; "https://reactome.org/content/detail/R-HSA-1602341" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-1602341" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "FBXW7 R465/347C mutant" , "FBXW7 Arg465/347Cys mutant" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GLUT2" ; "https://reactome.org/content/detail/R-HSA-5638264" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 301 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 524 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5638264" ; "SLC2A2 R301*" , "Glucose transporter type 2, liver" , "GLUT2" , "Solute carrier family 2, facilitated glucose transporter, member 2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P12110" ; "COL6A2" ; "https://reactome.org/content/detail/R-HSA-2022975" ; ; [ a ; [ a ; [ a ; 1019 ; ] ; [ a ; [ a ; 21 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2022975" , "http://purl.obolibrary.org/obo/PR_000046972" ; "CO6A2_HUMAN" , "3x4Hyp-5Hyl-COL6A2" , "COL6A2" , "4-Hyp 5-Hyl collagen alpha-2(VI) propeptide" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Ligand-bound PPARG:RXRA:NCoR/SMRT:DGAT2 gene:nucleosomes" ; "https://reactome.org/content/detail/R-HSA-9864611" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9864611" ; "Ligand-bound PPARG:RXRA:NCoR/SMRT:DGAT2 gene:nucleosomes" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-Y-ERBB2 G776V" ; "https://reactome.org/content/detail/R-HSA-9664602" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 776 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1255 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9664602" ; "p-Y-ERBB2 G776V" , "p-Y-ERBB2 Gly776Val" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CNBP" ; "https://reactome.org/content/detail/R-HSA-9759645" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 177 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9759645" ; "CCHC-type zinc finger nucleic acid binding protein" , "ZNF9" , "Cellular nucleic acid-binding protein" , "CNBP" , "RNF163" . a ; "Isa http://purl.obolibrary.org/obo/PR_000012939" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PNO1" ; "https://reactome.org/content/detail/R-HSA-6791540" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 252 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6791540" , "http://purl.obolibrary.org/obo/PR_Q9NRX1" ; "PNO1" , "PNO1_HUMAN" , "RNA-binding protein PNO1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "palmitoylated, myristoylated eNOS dimer" ; "https://reactome.org/content/detail/R-HSA-203639" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-203639" ; "palmitoylated, myristoylated eNOS dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Inter-Membrane Spanning HA2" ; "https://reactome.org/content/detail/R-FLU-189175" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 566 ; ] ; [ a ; [ a ; 345 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-FLU-189175" ; "Inter-Membrane Spanning HA2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GUCA2A,B" ; "https://reactome.org/content/detail/R-HSA-8936209" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-8936209" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "GUCA2A,B" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "S29A3_HUMAN" ; "https://reactome.org/content/detail/R-HSA-5628819" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 386 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 475 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5628819" ; "S29A3_HUMAN" , "SLC29A3 R386Q" , "Equilibrative nucleoside transporter 3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "WNT5:FZD7:p-DVL" ; "https://reactome.org/content/detail/R-HSA-9673309" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9673309" ; "WNT5:FZD7:p-DVL" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "OCT3 substrates" ; "https://reactome.org/content/detail/R-ALL-549255" ; ; [ a ; ; ] ; , , , , , , ; "Reactome:R-ALL-549255" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ; "OCT3 substrates" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "Lipid II" ; "https://reactome.org/content/detail/R-ALL-1973971" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-1973971" ; "Lipid II" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "PI4P" ; "https://reactome.org/content/detail/R-ALL-8868704" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-8868704" ; "PI4P" , "Phosphatidylinositol 4-phosphate" , "1-phosphatidyl-1D-myo-inositol 4-phosphate" , "1-phosphatidyl-1D-myo-inositol 4-phosphates" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "P2RX4,7" ; "https://reactome.org/content/detail/R-HSA-9660827" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-9660827" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "P2RX4,7" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "OR51D1:butyric acid" ; "https://reactome.org/content/detail/R-HSA-9737274" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9737274" ; "OR51D1:butyric acid" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000021030" ; "RPA40" ; "https://reactome.org/content/detail/R-HSA-63498" ; ; [ a ; [ a ; [ a ; 346 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000026766" , "Reactome:R-HSA-63498" ; "DNA-directed RNA polymerase I and III 40 kDa polypeptide" , "RPA40" , "DNA-directed RNA polymerases I and III subunit RPAC1" , "RPA39" , "POLR1C" , "HsRPAC1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "mTORC2:PIP3" ; "https://reactome.org/content/detail/R-HSA-9980228" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9980228" ; "mTORC2:PIP3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000005543" ; "CLDN16" ; "https://reactome.org/content/detail/R-HSA-421234" ; ; [ a ; [ a ; [ a ; 235 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q9Y5I7" , "Reactome:R-HSA-421234" ; "CLDN16" , "CLD16_HUMAN" , "Claudin-16" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Perlecan" ; "https://reactome.org/content/detail/R-HSA-2076367" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 4391 ; ] ; [ a ; [ a ; 22 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2076367" ; "GlcA-Gal-Gal-Xyl-HSPG2" , "Perlecan" , "Heparan-HSPG2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "3x4Hyp-GalHyl-COL4A3(1426-1670)" ; "https://reactome.org/content/detail/R-HSA-4085057" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1670 ; ] ; [ a ; [ a ; 1426 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-4085057" ; "3x4Hyp-GalHyl-COL4A3(1426-1670)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "Activated FGFR" ; "https://reactome.org/content/detail/R-HSA-190352" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-190352" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ; "Activated FGFR" . a ; "Isa http://purl.obolibrary.org/obo/PR_000007132" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "EPHB4" ; "https://reactome.org/content/detail/R-HSA-3928476" ; ; [ a ; [ a ; [ a ; 987 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_P54760" , "Reactome:R-HSA-3928476" ; "Ephrin type-B receptor 4 ecNumber2.7.10.1/ecNumber" , "EPHB4" , "EPHB4_HUMAN" , "EPHB4 (?-987)" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_Q9NYK1" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TLR7" ; "https://reactome.org/content/detail/R-HSA-1678943" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1049 ; ] ; [ a ; [ a ; 27 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1678943" , "http://purl.obolibrary.org/obo/PR_000049470" ; "full-length TLR7" , "TLR7" , "FL-TLR7" , "Toll Like Receptor 7 (TLR 7)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Lis1" ; "https://reactome.org/content/detail/R-HSA-376249" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 410 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-376249" ; "Lis1" , "PAFAH1B1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "GXYLT2 gene" ; "https://reactome.org/content/detail/R-HSA-9926331" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000172986" ; "Reactome:R-HSA-9926331" , "ENSEMBL:ENSG00000172986" ; "GXYLT2 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "HSP70s:ADP" ; "https://reactome.org/content/detail/R-HSA-5252057" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-5252057" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ; "ADP-bound Heat-shock proteins" , "HSP70s:ADP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TUT7" ; "https://reactome.org/content/detail/R-HSA-8941313" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1495 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8941313" ; "TUT7_HUMAN" , "TUT7" , "Terminal uridylyltransferase 7" , "ZCCHC6" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TP53 S240*" ; "https://reactome.org/content/detail/R-HSA-9723538" ; ; [ a ; [ a ; [ a ; 239 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 240 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9723538" ; "TP53 S240*" . a ; "Isa http://purl.obolibrary.org/obo/PR_000018708" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ITGB2" ; "https://reactome.org/content/detail/R-HSA-6803342" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 769 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_000027392" , "Reactome:R-HSA-6803342" ; "Integrin beta-2" , "ITB2_HUMAN" , "ITGB2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "UBQLN2,1" ; "https://reactome.org/content/detail/R-HSA-8866241" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-8866241" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "UBQLN2,1" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "dUDP" ; "https://reactome.org/content/detail/R-ALL-110093" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-110093" ; "2'-deoxyuridine 5'-diphosphate" , "dUDP" , "dUDP(3-)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000004374" ; "ASMT" ; "https://reactome.org/content/detail/R-HSA-2976652" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 345 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_P46597" , "Reactome:R-HSA-2976652" ; "Acetylserotonin O-methyltransferase ecNumber2.1.1.4/ecNumber" , "Hydroxyindole O-methyltransferase" , "ASMT" , "ASMT_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "RAN:GTP:KPNB1,TNPO1" ; "https://reactome.org/content/detail/R-HSA-9615960" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9615960" ; "RAN:GTP:KPNB1,TNPO1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GPC2" ; "https://reactome.org/content/detail/R-HSA-2064059" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 554 ; ] ; [ a ; [ a ; 24 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2064059" ; "GPC2" , "GPC2_HUMAN" , "Glypican-2 component recommendedName: Secreted glypican-2 /component" , "GlcA-Gal-Gal-Xyl-GPC2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GDNF family ligands (GFLs)" ; "https://reactome.org/content/detail/R-HSA-434920" ; ; [ a ; ; ] ; , , , ; "Reactome:R-HSA-434920" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "GDNF family ligands (GFLs)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "FOXH1:MIXL1 gene" ; "https://reactome.org/content/detail/R-HSA-9756732" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9756732" ; "FOXH1:MIXL1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "BoNT Heavy chain Type G" ; "https://reactome.org/content/detail/R-CBO-181581" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 450 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 1297 ; ] ; [ a ; [ a ; 443 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-CBO-181581" ; "BoNT Heavy chain Type G" , "botG(443-1297) disulfide bonded" , "BoNT/G HC disulfide bonded" . a ; "Isa http://purl.obolibrary.org/obo/PR_000006682" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DPYSL4" ; "https://reactome.org/content/detail/R-HSA-398126" ; ; [ a ; [ a ; [ a ; 572 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-398126" , "http://purl.obolibrary.org/obo/PR_O14531" ; "DPYSL4" , "Dihydropyrimidinase-related protein 4 (CRMP-3)" , "DPYL4_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "Ack-ACCS2,AcK-GLUD,AcK-IDH2,Ack-SOD2" ; "https://reactome.org/content/detail/R-HSA-5688306" ; ; [ a ; ; ] ; , , , , ; "Reactome:R-HSA-5688306" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "Ack-ACCS2,AcK-GLUD,AcK-IDH2,Ack-SOD2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "DLL3:NOTCH1" ; "https://reactome.org/content/detail/R-HSA-9793905" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9793905" ; "DLL3:NOTCH1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MUC13" ; "https://reactome.org/content/detail/R-HSA-1462335" ; ; [ a ; [ a ; [ a ; 512 ; ] ; [ a ; [ a ; 19 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1462335" ; "Core 2 (MUC13)" , "MUC13" , "MUC13_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000026930" ; "CD40-1" ; "https://reactome.org/content/detail/R-HSA-198117" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 277 ; ] ; [ a ; [ a ; 21 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000026931" , "Reactome:R-HSA-198117" ; "Tumor necrosis factor receptor superfamily member 5" , "CD40-1" , "CD40 isoform 1" , "TNR5_HUMAN" , "TNFRSF5" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Laminin-7" ; "https://reactome.org/content/detail/R-HSA-2328135" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-2328135" ; "Laminin-7" , "Laminin-321" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SHP-1/SHP-2:pBTLA:HVEM" ; "https://reactome.org/content/detail/R-HSA-389935" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-389935" ; "SHP-1/SHP-2:pBTLA:HVEM" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "EGF" ; "https://reactome.org/content/detail/R-HSA-179863" ; ; [ a ; [ a ; [ a ; 1023 ; ] ; [ a ; [ a ; 971 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-179863" ; "EGF" , "Epidermal Growth Factor" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "G-protein alpha (q):GRK5" ; "https://reactome.org/content/detail/R-HSA-416517" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-416517" ; "G-protein alpha (q):GRK5" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505)" ; "https://reactome.org/content/detail/R-HSA-202154" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-202154" ; "Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "PRKG dimer" ; "https://reactome.org/content/detail/R-HSA-4551462" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-4551462" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "PRKG dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "protein Z" ; "https://reactome.org/content/detail/R-HSA-9932942" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 67 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 51 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 73 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 48 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 70 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 55 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 75 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 57 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 80 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 61 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 60 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 66 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 400 ; ] ; [ a ; [ a ; 41 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 47 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9932942" ; "protein Z" , "13xCbxE-PROZ" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ECI2_HUMAN" ; "https://reactome.org/content/detail/R-HSA-9033094" ; ; [ a ; [ a ; [ a ; 394 ; ] ; [ a ; [ a ; 39 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9033094" ; "ECI2(39-394)" , "Enoyl-CoA delta isomerase 2, mitochondrial ecNumber5.3.3.8/ecNumber" , "ECI2_HUMAN" , "ECI2 isoform 2" . a ; "Isa http://purl.obolibrary.org/obo/PR_000015848" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SUZ12" ; "https://reactome.org/content/detail/R-HSA-212217" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 739 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q15022" , "Reactome:R-HSA-212217" ; "JJAZ1" , "SUZ12" , "CHET9" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "TVP-1012" ; "https://reactome.org/content/detail/R-ALL-9677910" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9677910" ; "rasagiline" , "TVP-1012" , "Azilect®" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Man,Man9GlucNAc2,p-3S-CDH1(23-882):JUP" ; "https://reactome.org/content/detail/R-HSA-9934370" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9934370" ; "Man,Man9GlucNAc2,p-3S-CDH1(23-882):JUP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "ligands of SLC38A1" ; "https://reactome.org/content/detail/R-ALL-352105" ; ; [ a ; ; ] ; , , , , ; "Reactome:R-ALL-352105" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ; "ligands of SLC38A1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer" ; "https://reactome.org/content/detail/R-HSA-2855087" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-2855087" ; "FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Cleaved Cohesin" ; "https://reactome.org/content/detail/R-HSA-2467802" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-2467802" ; "Cleaved Cohesin" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "TGFB1 homodimer" ; "https://reactome.org/content/detail/R-HSA-177102" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-177102" ; "TGFB1 homodimer" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000005477" ; "CHST4" ; "https://reactome.org/content/detail/R-HSA-6786006" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 386 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6786006" , "http://purl.obolibrary.org/obo/PR_Q8NCG5" ; "CHST4" , "Carbohydrate sulfotransferase 4 ecNumber2.8.2.-/ecNumber" , "CHST4_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "USP17" ; "https://reactome.org/content/detail/R-HSA-8848677" ; ; [ a ; ; ] ; , , , , , , , , , , , , , , , , , ; "Reactome:R-HSA-8848677" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ; "USP17" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "UQCRFS1(1-274)" ; "https://reactome.org/content/detail/R-HSA-9906006" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 274 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9906006" ; "Full length Rieske protein" , "UQCRFS1(1-274)" . a ; . a . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "GlcNAc (Man)9-5" ; "https://reactome.org/content/detail/R-ALL-8853381" ; ; [ a ; ; ] ; , , , , ; "Reactome:R-ALL-8853381" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ; "GlcNAc (Man)9-5" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PCSK9" ; "https://reactome.org/content/detail/R-HSA-8956943" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 692 ; ] ; [ a ; [ a ; 153 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8956943" ; "PCSK9" , "p-PCSK9" , "PCSK9_HUMAN" , "Proprotein convertase subtilisin/kexin type 9 ecNumber3.4.21.-/ecNumber" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_000003760" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ADCY9" ; "https://reactome.org/content/detail/R-HSA-379055" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1353 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_O60503" , "Reactome:R-HSA-379055" ; "ADCY9" , "ADCY9_HUMAN" , "Adenylate cyclase type 9" . a ; "Unspecified modification type. Comment: [Replacement of residues 26 to 37 by QRSVPLAVPSNG]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TP53 L26Qfs*13" ; "https://reactome.org/content/detail/R-HSA-9720625" ; ; [ a ; [ a ; [ a ; 37 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9720625" ; "TP53 L26Qfs*13" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Va:Xa:Factor Xa inhibitors" ; "https://reactome.org/content/detail/R-HSA-9015116" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9015116" ; "Va:Xa:Factor Xa inhibitors" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "TFAP2C homodimer:EGFR gene" ; "https://reactome.org/content/detail/R-HSA-8874796" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8874796" ; "TFAP2C homodimer:EGFR gene" . a ; "Isa http://purl.obolibrary.org/obo/PR_000005085" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CBX4" ; "https://reactome.org/content/detail/R-HSA-389118" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 560 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_O00257" , "Reactome:R-HSA-389118" ; "CBX4" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000017890" ; "ZNF431" ; "https://reactome.org/content/detail/R-HSA-1247546" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 576 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-1247546" , "http://purl.obolibrary.org/obo/PR_Q8TF32" ; "ZNF431" , "ZN431_HUMAN" , "Zinc finger protein 431" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "SFTPAs" ; "https://reactome.org/content/detail/R-HSA-5683863" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-5683863" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "SFTPAs" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "STK4 dimer" ; "https://reactome.org/content/detail/R-HSA-2028264" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-2028264" ; "MST1 dimer" , "STK4 dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HIST1H2BB" ; "https://reactome.org/content/detail/R-HSA-6782554" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 120 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 126 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6782554" ; "Histone H2B.f" , "Ub-HIST1H2BB" , "HIST1H2BB" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "EIF5A(Dhp)" ; "https://reactome.org/content/detail/R-HSA-3006309" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 50 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 154 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-3006309" ; "Dhp-K50-EIF5A" , "EIF5A(Dhp)" , "Eukaryotic translation initiation factor 5A-1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Trimeric gp120:gp41 oligomer" ; "https://reactome.org/content/detail/R-HIV-189840" ; ; [ a ; ; ; "3"^^ ] ; [ a ; ; ; "3"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HIV-189840" ; "Trimeric gp120:gp41 oligomer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000014982" ; "OAT4" ; "https://reactome.org/content/detail/R-HSA-561037" ; ; [ a ; [ a ; [ a ; 550 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-561037" , "http://purl.obolibrary.org/obo/PR_Q9NSA0" ; "OAT4" , "Solute carrier family 22 member 11" , "S22AB_HUMAN" , "SLC22A11" . a ; "Isa http://purl.obolibrary.org/obo/PR_000030450" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TMEM63A" ; "https://reactome.org/content/detail/R-HSA-6800945" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 807 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_O94886" , "Reactome:R-HSA-6800945" ; "CSC1-like protein 1" , "CSCL1_HUMAN" , "TMEM63A" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ALK_HUMAN" ; "https://reactome.org/content/detail/R-HSA-9715290" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1239 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1507 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1604 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1278 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 1620 ; ] ; [ a ; [ a ; 19 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1282 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1096 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1283 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1359 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9715290" ; "ALK_HUMAN" , "ALK tyrosine kinase receptor" , "p-7Y ALK Y1239H" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 271 to 343 by GCVFVPVLGETGAQRKRISARKGSLTTSCPQGALSEHCPTTPAPLPSQRRNHWMENISPFRSVGVSASRCSES]" ; "TP53 E271Gfs*74" ; "https://reactome.org/content/detail/R-HSA-9719581" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 343 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9719581" ; "TP53 E271Gfs*74" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000005228" ; "CdGAP" ; "https://reactome.org/content/detail/R-HSA-195204" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1444 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-195204" , "http://purl.obolibrary.org/obo/PR_Q2M1Z3" ; "ARHGAP31" , "CdGAP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "TeNT HC:LC dimer" ; "https://reactome.org/content/detail/R-CTE-5228388" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-CTE-5228388" ; "TeNT HC:LC dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "OR10D3 gene" ; "https://reactome.org/content/detail/R-HSA-9752463" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000197309" ; "Reactome:R-HSA-9752463" , "ENSEMBL:ENSG00000197309" ; "OR10D3 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "COL24A1" ; "https://reactome.org/content/detail/R-HSA-2268746" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1714 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2268746" ; "GalHyl-COL24A1(?-1714)" , "COOA1_HUMAN" , "COL24A1" , "5-Gal-Hyl-collagen alpha-1(XXIV) -N propeptide" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "elongating pre-RNA Pol III transcript" ; "https://reactome.org/content/detail/R-ALL-111987" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-111987" ; "elongating pre-RNA Pol III transcript" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "MITF-M dimer:DIAPH1 gene" ; "https://reactome.org/content/detail/R-HSA-9857569" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9857569" ; "MITF-M dimer:DIAPH1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DDX41" ; "https://reactome.org/content/detail/R-HSA-9769601" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 622 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9769601" ; "DDX41" , "DDX41_HUMAN" , "Probable ATP-dependent RNA helicase DDX41 ecNumber3.6.4.13/ecNumber" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "SLC2A2 gene" ; "https://reactome.org/content/detail/R-HSA-9606135" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000163581" ; "Reactome:R-HSA-9606135" , "ENSEMBL:ENSG00000163581" ; "SLC2A2 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-S432-RUNX2:CBFB" ; "https://reactome.org/content/detail/R-HSA-9008869" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9008869" ; "p-S432-RUNX2:CBFB" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "NUB1-2" ; "https://reactome.org/content/detail/R-HSA-8956126" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 615 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-8956126" ; "NEDD8 ultimate buster 1" , "NUB1_HUMAN" , "NUB1-2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "PD2n-3DPA" ; "https://reactome.org/content/detail/R-ALL-9026055" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9026055" ; "PD2n-3 DPA(1-)" , "PD2n-3DPA" , "16,17(S)-dihydroxy-(7Z,10Z,13E,14E,19Z)-docosapentaenoic acid" , "16,17(S)-dihydroxy-omega3-docosapentaenoic acid" , "16,17(S)-dihydroxy-docosapentaenoic acid" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000004062" ; "ANO7" ; "https://reactome.org/content/detail/R-HSA-2684922" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 933 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2684922" , "http://purl.obolibrary.org/obo/PR_Q6IWH7" ; "ANO7_HUMAN" , "Anoctamin-7" , "ANO7" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "FKBP1A:tacrolimus" ; "https://reactome.org/content/detail/R-HSA-2026019" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-2026019" ; "FKBP1A:tacrolimus" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CDH2" ; "https://reactome.org/content/detail/R-HSA-191429" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 906 ; ] ; [ a ; [ a ; 160 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-191429" ; "Neural-cadherin" , "N-cadherin" , "CDH2" , "CAD2_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "miR-206 Endonucleolytic RISC" ; "https://reactome.org/content/detail/R-HSA-1614241" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-1614241" ; "miR-206 Endonucleolytic RISC" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "underrepresented Olfactory Receptor" ; "https://reactome.org/content/detail/R-HSA-9752979" ; ; [ a ; ; ] ; , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ; "Reactome:R-HSA-9752979" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ; "underrepresented Olfactory Receptor" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "KRM:DKK:LRP5/6" ; "https://reactome.org/content/detail/R-HSA-3769399" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-3769399" ; "KRM:DKK:LRP5/6" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KRTAP2-2" ; "https://reactome.org/content/detail/R-HSA-6809964" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 123 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6809964" ; "KRTAP2-2" , "KRA22_HUMAN" , "Keratin-associated protein 2-2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "luminal hormone sensing cell" ; "https://reactome.org/content/detail/R-HSA-9960188" ; ; ; "Reactome:R-HSA-9960188" ; "luminal hormone sensing cell" , "hormone receptor positive mammary luminal epithelial cell" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "VPREB1" ; "https://reactome.org/content/detail/R-HSA-197148" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 145 ; ] ; [ a ; [ a ; 20 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-197148" ; "VPRE Immunoglobulin iota chain precursor" , "VPREB1" , "VPRE_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HIST2H3A" ; "https://reactome.org/content/detail/R-HSA-1214223" ; ; [ a ; [ a ; [ a ; 136 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 5 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1214223" ; "HIST2H3A" , "Me3K5-HIST2H3A" , "H32_HUMAN" , "Histone H3.2 with trimethylated lysine-4" . a ; "Isa http://purl.obolibrary.org/obo/PR_000016846" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TWIST1" ; "https://reactome.org/content/detail/R-HSA-445442" ; ; [ a ; [ a ; [ a ; 202 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q15672" , "Reactome:R-HSA-445442" ; "TWIST1" , "TWST1_HUMAN" , "Twist-related protein 1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "sorafenib-resistant PDGFR mutants" ; "https://reactome.org/content/detail/R-HSA-9673718" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-9673718" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "sorafenib-resistant PDGFR mutants" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GRK1,4,7" ; "https://reactome.org/content/detail/R-HSA-6787798" ; ; [ a ; ; ] ; , , ; "Reactome:R-HSA-6787798" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "GRK1,4,7" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Somatostatin" ; "https://reactome.org/content/detail/R-HSA-374714" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-374714" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "Somatostatin" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "high-mannose N-glycan folded Spike" ; "https://reactome.org/content/detail/R-COV-9696880" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 331 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 801 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 616 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 61 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 149 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 74 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 122 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1134 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 717 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1098 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1194 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 709 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 603 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 343 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 234 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 17 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 657 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1074 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1173 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 282 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 165 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 1273 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1158 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-COV-9696880" ; "high-mannose N-glycan folded Spike" . a ; "Isa http://purl.obolibrary.org/obo/PR_P16401" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HIST1H1B" ; "https://reactome.org/content/detail/R-HSA-211248" ; ; [ a ; [ a ; [ a ; 226 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-211248" , "http://purl.obolibrary.org/obo/PR_000047699" ; "HIST1H1B" , "histone H1.5" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "SERPINB13 gene" ; "https://reactome.org/content/detail/R-HSA-8938046" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000197641" ; "Reactome:R-HSA-8938046" , "ENSEMBL:ENSG00000197641" ; "SERPINB13 gene" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-5S-LRP6" ; "https://reactome.org/content/detail/R-HSA-1458894" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1613 ; ] ; [ a ; [ a ; 20 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1490 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1458894" ; "p-2S,S1490,2T-LRP6" , "p-5S-LRP6" , "p5S/T-LRP6" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "PIK3C(1)" ; "https://reactome.org/content/detail/R-HSA-1806233" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-1806233" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ] ; "PIK3C(1)" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "APC_HUMAN" ; "https://reactome.org/content/detail/R-HSA-9666955" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1429 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 1428 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9666955" ; "APC Q1429TER" , "Adenomatous polyposis coli protein" , "APC_HUMAN" , "APC Q1429*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "PYCR3 decamer" ; "https://reactome.org/content/detail/R-HSA-6783932" ; ; [ a ; ; ; "10"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6783932" ; "PYCR3 decamer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PIAS2-1" ; "https://reactome.org/content/detail/R-HSA-2993785" ; ; [ a ; [ a ; [ a ; 621 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2993785" ; "PIAS2_HUMAN" , "PIAS2xbeta" , "PIAS2 isoform 1" , "PIAS2-1" , "E3 SUMO-protein ligase PIAS2 ecNumber6.3.2.-/ecNumber" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ERBB4s80:ESR1:estrogen:PGR gene" ; "https://reactome.org/content/detail/R-HSA-8954204" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8954204" ; "ERBB4s80:ESR1:estrogen:PGR gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SUCLA2:SUCLG1" ; "https://reactome.org/content/detail/R-HSA-156625" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-156625" ; "SUCLA2:SUCLG1" , "Succinyl-CoA synthetase heterodimer (ADP-forming)" . a ; "Isa http://purl.obolibrary.org/obo/PR_O00391" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "QSOX1" ; "https://reactome.org/content/detail/R-HSA-6799714" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 747 ; ] ; [ a ; [ a ; 30 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000048979" , "Reactome:R-HSA-6799714" ; "QSOX1_HUMAN" , "Sulfhydryl oxidase 1" , "QSOX1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Connexin 43 hemi-channel" ; "https://reactome.org/content/detail/R-HSA-158053" ; ; [ a ; ; ] ; [ a ; ; ; "6"^^ ] ; ; "Reactome:R-HSA-158053" ; ; "Connexin 43 hemi-channel" . a ; "Isa http://purl.obolibrary.org/obo/PR_000015392" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SOCS1" ; "https://reactome.org/content/detail/R-HSA-204910" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 211 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_O15524" , "Reactome:R-HSA-204910" ; "Suppressor of cytokine signaling 1" , "SOCS-1" , "SOCS1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000018708" ; "ITGB2" ; "https://reactome.org/content/detail/R-HSA-198010" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 769 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000027392" , "Reactome:R-HSA-198010" ; "ITB2_HUMAN" , "Integrin beta-2" , "ITGB2" . a ; "Isa http://purl.obolibrary.org/obo/PR_000001772" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TAB2" ; "https://reactome.org/content/detail/R-HSA-168116" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 693 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-168116" , "http://purl.obolibrary.org/obo/PR_Q9NYJ8" ; "TAB2" , "Mitogen-activated protein kinase kinase kinase 7 interacting protein 2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ADAMTS5" ; "https://reactome.org/content/detail/R-HSA-5173205" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 930 ; ] ; [ a ; [ a ; 262 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5173205" ; "A disintegrin and metalloproteinase with thrombospondin motifs 5" , "ADAMTS5" , "ATS5_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "CoA-SH" ; "https://reactome.org/content/detail/R-ALL-8939024" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-8939024" ; "CoA-SH" , "coenzyme A" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "PAK2 gene" ; "https://reactome.org/content/detail/R-HSA-8950429" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000180370" ; "ENSEMBL:ENSG00000180370" , "Reactome:R-HSA-8950429" ; "PAK2 gene" , "Serine/threonine-protein kinase PAK 2 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "TXA2" ; "https://reactome.org/content/detail/R-ALL-391932" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-391932" ; "thromboxane A2(1-)" , "(5Z,13E)-(15S)-9alpha,11alpha-Epoxy-15-hydroxythromboxa-5,13-dienoate" , "thromboxane A2" , "TXA2" , "(5Z,9alpha,11alpha,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-oic acid" . a ; "Isa http://purl.obolibrary.org/obo/PR_000001594" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "LTB4R" ; "https://reactome.org/content/detail/R-HSA-416410" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 352 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q15722" , "Reactome:R-HSA-416410" ; "LTB4R" , "LT4R1_HUMAN" , "Leukotriene B4 receptor 1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "F(110-136)" ; "https://reactome.org/content/detail/R-RSY-9829179" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 136 ; ] ; [ a ; [ a ; 110 ; ] ; () ] ] ] ; ; "Reactome:R-RSY-9829179" ; "F(110-136)" . a ; "Unspecified modification type. Comment: [Replacement of residues 806 to 808 by MLN]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "BRCA2 D806Mfs*4" ; "https://reactome.org/content/detail/R-HSA-9712893" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 808 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9712893" ; "BRCA2 D806Mfs*4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "NPAS2 gene" ; "https://reactome.org/content/detail/R-HSA-5640176" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000170485" ; "Reactome:R-HSA-5640176" , "ENSEMBL:ENSG00000170485" ; "NPAS2 gene" . a ; "Unspecified modification type. Comment: [Insertion of residues 595 to 601 at 602 from UniProt:P36888 FLT3]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "N51" ; "https://reactome.org/content/detail/R-HSA-9696032" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 993 ; ] ; [ a ; [ a ; 27 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9696032" ; "N51" , "FLT3 R595_L601dup" , "W51" , "ITD3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "dRibP" ; "https://reactome.org/content/detail/R-ALL-112032" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-112032" ; "2-deoxy-D-ribofuranose 1-phosphate" , "2-deoxy-D-ribofuranose 1-phosphate(2-)" , "dRibP" , "2-deoxy-D-ribose 1-phosphate" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "OR2K2" ; "https://reactome.org/content/detail/R-HSA-9751494" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 316 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9751494" ; "OR2K2" , "Olfactory receptor 2K2" , "OR2K2_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "PC, PG" ; "https://reactome.org/content/detail/R-ALL-5684863" ; ; [ a ; ; ] ; , ; "Reactome:R-ALL-5684863" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "PC, PG" , "phosphatidylcholine, phosphatidylglycerol" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "ABCG2 gene" ; "https://reactome.org/content/detail/R-HSA-9795742" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000118777" ; "ENSEMBL:ENSG00000118777" , "Reactome:R-HSA-9795742" ; "ABCG2 gene" . a ; "Isa http://purl.obolibrary.org/obo/PR_P06744" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GPI" ; "https://reactome.org/content/detail/R-HSA-6801506" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 558 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000047596" , "Reactome:R-HSA-6801506" ; "PGI" , "Neuroleukin" , "Phosphohexose isomerase" , "Glucose-6-phosphate isomerase" , "GPI" , "NLK" , "SA-36" , "PHI" , "Sperm antigen-36" , "Phosphoglucose isomerase" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 268 to 284 by QSLCWTWSLHVTAYLRI]" ; "ATRX C268Qfs*18" ; "https://reactome.org/content/detail/R-HSA-9672233" ; ; [ a ; [ a ; [ a ; 284 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9672233" ; "ATRX Cis268GlnfsTER18" , "ATRX Cis268Glnfs*18" , "ATRX C268QfsTER18" , "ATRX C268Qfs*18" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "CDP-DAG" ; "https://reactome.org/content/detail/R-ALL-1524064" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-1524064" ; "Cytidine diphosphate diacylglycerol" , "CDP-diacylglycerol" , "CDP-DAG" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "WBSCR22:TRIMT112" ; "https://reactome.org/content/detail/R-HSA-6790980" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6790980" ; "WBSCR22:TRIMT112" . a ; "Unspecified modification type. Comment: [Replacement of residues 199 to 201 by FIS]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RB1 L199Ffs*4" ; "https://reactome.org/content/detail/R-HSA-9688015" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 201 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9688015" ; "RB1 L199Ffs*4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GALR1-3" ; "https://reactome.org/content/detail/R-HSA-389011" ; ; [ a ; ; ] ; , , ; "Reactome:R-HSA-389011" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "Galanin receptor" , "GALR1-3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "TNFRSF1A gene" ; "https://reactome.org/content/detail/R-HSA-6785059" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000067182" ; "Reactome:R-HSA-6785059" , "ENSEMBL:ENSG00000067182" ; "TNFRSF1A gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-Y IRS1:ALK fusion proteins" ; "https://reactome.org/content/detail/R-HSA-9712076" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9712076" ; "p-Y IRS1:ALK fusion proteins" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Prostate Specific Antigen" ; "https://reactome.org/content/detail/R-HSA-2990872" ; ; [ a ; ; ] ; , , , ; "Reactome:R-HSA-2990872" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "Prostate Specific Antigen" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NEXT complex" ; "https://reactome.org/content/detail/R-HSA-8985567" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8985567" ; "NEXT complex" , "Nuclear Exosome Targeting Complex" , "RBM7:ZCCHC8:SKIV2L2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "FLUAV dsRNA Stranded" ; "https://reactome.org/content/detail/R-FLU-6790580" ; ; [ a ; ; ] ; ; "Reactome:R-FLU-6790580" ; "5ppp RNA duplex form" , "FLUAV dsRNA Stranded" , "Influenza A dsRNA intermediate form" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Endostatin:Integrins alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1" ; "https://reactome.org/content/detail/R-HSA-4088272" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-4088272" ; "Endostatin:Integrins alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "AQP12A tetramer" ; "https://reactome.org/content/detail/R-HSA-8862058" ; ; [ a ; ; ] ; [ a ; ; ; "4"^^ ] ; ; "Reactome:R-HSA-8862058" ; "AQP12A tetramer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "miR-132 Endonucleolytic Minimal RISC" ; "https://reactome.org/content/detail/R-HSA-9021195" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9021195" ; "Argonaute2: miR-132 (single-stranded)" , "miR-132 Endonucleolytic Minimal RISC" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "GCLC gene" ; "https://reactome.org/content/detail/R-HSA-5662569" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000001084" ; "ENSEMBL:ENSG00000001084" , "Reactome:R-HSA-5662569" ; "GCLC gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "ceftriaxone" ; "https://reactome.org/content/detail/R-ALL-9638901" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9638901" ; "ceftriaxone" , "ceftriaxone(1-)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Kv11 subunits of voltage gated potassium channels" ; "https://reactome.org/content/detail/R-HSA-1296103" ; ; [ a ; ; ] ; , , ; "Reactome:R-HSA-1296103" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "Kv11 subunits of voltage gated potassium channels" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "C to U edited ApoB RNA" ; "https://reactome.org/content/detail/R-ALL-75085" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-75085" ; "C to U edited ApoB RNA" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000018123" ; "ZNF740" ; "https://reactome.org/content/detail/R-HSA-2586612" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 193 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2586612" , "http://purl.obolibrary.org/obo/PR_Q8NDX6" ; "ZNF740" , "Zinc finger protein 740" , "ZN740_HUMAN" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "MAN2A2:Zn2+" ; "https://reactome.org/content/detail/R-HSA-975818" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-975818" ; "MAN2A2:Zn2+" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "CUL1:FBXW11:SKP1" ; "https://reactome.org/content/detail/R-HSA-1168592" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-1168592" ; "SCF-beta-TrCP2 complex" , "CUL1:FBXW11:SKP1" . a ; "Isa http://purl.obolibrary.org/obo/PR_000005707" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "COL23A1" ; "https://reactome.org/content/detail/R-HSA-2172240" ; ; [ a ; [ a ; [ a ; 540 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2172240" , "http://purl.obolibrary.org/obo/PR_Q86Y22" ; "COL23A1" , "Collagen alpha-1(XXIII) chain" , "CONA1_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TRPV6" ; "https://reactome.org/content/detail/R-HSA-937289" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 765 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-937289" ; "Transient receptor potential cation channel subfamily V member 6" , "TRPV6_HUMAN" , "TRPV6" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PolyUb-p-S76,S79,S82,S124-CDC25A" ; "https://reactome.org/content/detail/R-HSA-9944025" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 79 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 124 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 82 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 76 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 524 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9944025" ; "PolyUb-p-S76,S79,S82,S124-CDC25A" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "4a-carboxy-4b-me-5a-cholest-8-en-3b-ol" ; "https://reactome.org/content/detail/R-ALL-9945820" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9945820" ; "4a-carboxy-4b-me-5a-cholest-8-en-3b-ol" , "4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PSMB7" ; "https://reactome.org/content/detail/R-HSA-68759" ; ; [ a ; [ a ; [ a ; 277 ; ] ; [ a ; [ a ; 44 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-68759" ; "Proteasome subunit beta-2" , "PSMB7" , "Proteasome subunit beta-2 precursor" , "Proteasome subunit Z" , "Multicatalytic endopeptidase complex chain Z" , "Macropain chain Z" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-S90,Ac-K538-BMAL1:p-4S,2T-CLOCK:Target gene" ; "https://reactome.org/content/detail/R-HSA-9922987" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-9922987" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ; "p-S90,Ac-K538-BMAL1:p-4S,2T-CLOCK:Target gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "AMER1 gene" ; "https://reactome.org/content/detail/R-HSA-5251497" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000184675" ; "ENSEMBL:ENSG00000184675" , "Reactome:R-HSA-5251497" ; "AMER1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GPI-VNN2" ; "https://reactome.org/content/detail/R-HSA-8940753" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 493 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 493 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8940753" ; "Vascular non-inflammatory molecule 2" , "VNN2_HUMAN" , "GPI-VNN2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "DNA primer" ; "https://reactome.org/content/detail/R-ALL-68424" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-68424" ; "DNA primer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "RAC1 effectors" ; "https://reactome.org/content/detail/R-HSA-9013178" ; ; [ a ; ; ] ; , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ; "Reactome:R-HSA-9013178" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ; "RAC1 effectors" . a . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "BRCA2 K178*" ; "https://reactome.org/content/detail/R-HSA-9711510" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 178 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 177 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9711510" ; "BRCA2 K178*" . a ; "Isa http://purl.obolibrary.org/obo/PR_000012507" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PDK4" ; "https://reactome.org/content/detail/R-HSA-203941" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 411 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q16654" , "Reactome:R-HSA-203941" ; "Pyruvate dehydrogenase kinase isoform 4" , "PDK4" , "PDHK4" , "PDK4(?-411)" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000008966" ; "IGKC" ; "https://reactome.org/content/detail/R-HSA-197041" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 107 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-197041" , "http://purl.obolibrary.org/obo/PR_P01834" ; "IgK Ig kappa chain C region" , "KAC_HUMAN" , "IGKC" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NCAM1 complexed with Fyn" ; "https://reactome.org/content/detail/R-HSA-391847" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-391847" ; "NCAM1 complexed with Fyn" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 52 to 121 by HGSLKTQVQMKLPECQRLLPPWPLHQQLLHRRPLHQPPPGPCHLLSLPRKPTRAATVSVWASCILGQPSL]" ; "TP53 Q52Hfs*71" ; "https://reactome.org/content/detail/R-HSA-9720217" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 121 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9720217" ; "TP53 Q52Hfs*71" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SRSF8" ; "https://reactome.org/content/detail/R-HSA-9770135" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 282 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9770135" ; "SRSF8_HUMAN" , "SRSF8" , "Serine/arginine-rich splicing factor 8" . a ; . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_000029384" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DDX20" ; "https://reactome.org/content/detail/R-HSA-191838" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 824 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_Q9UHI6" , "Reactome:R-HSA-191838" ; "Gemin 3" , "DDX20" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "Spike inhibitors" ; "https://reactome.org/content/detail/R-ALL-9707798" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9707798" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ; "Spike inhibitors" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ATM" ; "https://reactome.org/content/detail/R-HSA-9665169" ; ; [ a ; [ a ; [ a ; 3056 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9665169" ; "Ataxia telangiectasia mutated" , "Serine-protein kinase ATM" , "ATM serine-protein kinase" , "Serine-protein kinase ATM (EC 2.7.1.37) (Ataxia telangiectasia mutated) (A-T, mutated)" , "A-T, mutated" , "ATM" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "acyl-CoA" ; "https://reactome.org/content/detail/R-ALL-6810523" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-6810523" ; "acyl-CoA(4-)" , "fatty acyl-CoA" , "acyl-CoA" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ACSL4" ; "https://reactome.org/content/detail/R-HSA-9632663" ; ; [ a ; [ a ; [ a ; 711 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9632663" ; "ACSL4" , "ACSL4_HUMAN" , "Long-chain-fatty-acid--CoA ligase 4 ecNumber6.2.1.3/ecNumber" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KMT2D Y1944*" ; "https://reactome.org/content/detail/R-HSA-9950636" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1943 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1944 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9950636" ; "KMT2D Y1944*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P20908" ; "COL5A1" ; "https://reactome.org/content/detail/R-HSA-2022460" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1838 ; ] ; [ a ; [ a ; 38 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_000046933" , "Reactome:R-HSA-2022460" ; "COL5A1(38-1838)" , "COL5A1" , "Collagen alpha-1(V) propeptide" , "CO5A1_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Ub-27-UBA52(1-76)" ; "https://reactome.org/content/detail/R-HSA-5689174" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 76 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 27 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5689174" ; "Ub-27-UBA52(1-76)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Insertion of residues 1058 to 1620 at 145 from UniProt:Q9UM73 ALK]" ; "E2AK3_HUMAN" ; "https://reactome.org/content/detail/R-HSA-9713454" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1278 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1507 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1282 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1283 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 144 ; ] ; [ a ; [ a ; 30 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1359 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1604 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1096 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9713454" ; "EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion" , "Eukaryotic translation initiation factor 2-alpha kinase 3 ecNumber2.7.11.1/ecNumber" , "E2AK3_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000018028" ; "ZNF613" ; "https://reactome.org/content/detail/R-HSA-2127566" ; ; [ a ; [ a ; [ a ; 617 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2127566" , "http://purl.obolibrary.org/obo/PR_Q6PF04" ; "ZNF613" , "ZN613_HUMAN" , "Zinc finger protein 613" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1" ; "https://reactome.org/content/detail/R-HSA-5368519" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5368519" ; "WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "bMC-CoA" ; "https://reactome.org/content/detail/R-ALL-70744" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-70744" ; "3-methylbut-2-enoyl-CoA" , "beta-methylcrotonyl-CoA" , "bMC-CoA" . a ; "Isa http://purl.obolibrary.org/obo/PR_P18084" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ITGB5" ; "https://reactome.org/content/detail/R-HSA-215948" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 799 ; ] ; [ a ; [ a ; 24 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000048071" , "Reactome:R-HSA-215948" ; "ITGB5" , "Integrin beta-5" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "G alpha (i)" ; "https://reactome.org/content/detail/R-HSA-112270" ; ; [ a ; ; ] ; , , , ; "Reactome:R-HSA-112270" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "G alpha (i)" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CPN1_HUMAN" ; "https://reactome.org/content/detail/R-HSA-5580293" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 503 ; ] ; [ a ; [ a ; 25 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 318 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5580293" ; "CPN1_HUMAN" , "Cytochrome P450 11B1" , "CYP11B1 T318M" . a ; "Isa http://purl.obolibrary.org/obo/PR_000007754" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GAB2" ; "https://reactome.org/content/detail/R-HSA-508239" ; ; [ a ; [ a ; [ a ; 676 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-508239" , "http://purl.obolibrary.org/obo/PR_Q9UQC2" ; "GAB2" , "GRB2-associated-binding protein 2" , "GAB2_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "FBXW7 R505/387C mutant" ; "https://reactome.org/content/detail/R-HSA-1602342" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-1602342" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "FBXW7 Arg505/387Cys mutant" , "FBXW7 R505/387C mutant" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GLUT9" ; "https://reactome.org/content/detail/R-HSA-5638265" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 540 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 171 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5638265" ; "SLC2A9 R171C" , "GLUT9" , "Solute carrier family 2, facilitated glucose transporter member 9" , "GTR9_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "HSP40s" ; "https://reactome.org/content/detail/R-HSA-3371594" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-3371594" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "HSP40s" , "J proteins" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ABO-B" ; "https://reactome.org/content/detail/R-HSA-9034064" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 268 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 266 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 354 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 235 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 176 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9034064" ; "ABO-B" , "BGAT_HUMAN" , "Histo-blood group ABO system B transferase" . a ; "Isa http://purl.obolibrary.org/obo/PR_P53420" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "3x4Hyp-5Hyl-COL4A4" ; "https://reactome.org/content/detail/R-HSA-2022976" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1690 ; ] ; [ a ; [ a ; 39 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_000046915" , "Reactome:R-HSA-2022976" ; "4-Hyp 5-Hyl collagen alpha-4(IV) propeptide" , "3x4Hyp-5Hyl-COL4A4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "IdoA2S-GlcNS3S- group" ; "https://reactome.org/content/detail/R-ALL-2090080" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-2090080" ; "IdoA2S-GlcNS3S- group" , "beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group" , "Heparan sulfate chain(5)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GCLC P185L" ; "https://reactome.org/content/detail/R-HSA-5602975" ; ; [ a ; [ a ; [ a ; 637 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 158 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5602975" ; "Glutamate--cysteine ligase heavy chain" , "GCLC P185L" , "gamma-glutamylcysteine heavy chain" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Ligand-bound PPARG:RXRA:NCoR/SMRT:FABP4 gene:nucleosomes" ; "https://reactome.org/content/detail/R-HSA-9864612" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9864612" ; "Ligand-bound PPARG:RXRA:NCoR/SMRT:FABP4 gene:nucleosomes" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "TRPV1:TRPV1 blockers" ; "https://reactome.org/content/detail/R-HSA-9701146" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9701146" ; "TRPV1:TRPV1 blockers" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-Y-STAT1,3,5 dimer:SOCS1 gene" ; "https://reactome.org/content/detail/R-HSA-9705437" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9705437" ; "p-Y-STAT1,3,5 dimer:SOCS1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "TOMM70:9b" ; "https://reactome.org/content/detail/R-HSA-9709728" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9709728" ; "TOMM70:9b" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4)" ; "https://reactome.org/content/detail/R-HSA-9664603" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9664603" ; "p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "8:IL17RA" ; "https://reactome.org/content/detail/R-HSA-9755355" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9755355" ; "8:IL17RA" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "NEP/NS2" ; "https://reactome.org/content/detail/R-FLU-189176" ; ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-FLU-189176" ; "NEP/NS2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "GDNF:RET:GFRA1" ; "https://reactome.org/content/detail/R-HSA-9830750" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9830750" ; "GDNF:RET:GFRA1" . a ; . a ; "Unspecified modification type. Comment: [Replacement of residues 91 to 121 by GPCHLLSLPRKPTRAATVSVWASCILGQPSL]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TP53 W91Gfs*32" ; "https://reactome.org/content/detail/R-HSA-9721493" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 121 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9721493" ; "TP53 W91Gfs*32" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P56945" ; "p-Y12-BCAR1" ; "https://reactome.org/content/detail/R-HSA-5218739" ; ; [ a ; [ a ; [ a ; 870 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 410 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 287 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 306 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 664 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 372 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 249 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 327 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 267 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 666 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 387 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 234 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 362 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5218739" , "http://purl.obolibrary.org/obo/PR_000046465" ; "p-Y12-P130CAS" , "p-Y12-BCAR1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "CDH11:CTNND1:CTNNB1:CTNNA1" ; "https://reactome.org/content/detail/R-HSA-9761450" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9761450" ; "CDH11:CTNND1:CTNNB1:CTNNA1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "COG complex:Golgi snares" ; "https://reactome.org/content/detail/R-HSA-6811360" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-6811360" ; "COG complex:Golgi snares" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SORL1" ; "https://reactome.org/content/detail/R-HSA-8871475" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 2214 ; ] ; [ a ; [ a ; 82 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8871475" ; "SORL_HUMAN" , "SORL1" , "Sortilin-related receptor" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "OR5D14:butyric acid" ; "https://reactome.org/content/detail/R-HSA-9737275" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9737275" ; "OR5D14:butyric acid" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "DENV virion:DENV E ligands" ; "https://reactome.org/content/detail/R-DVI-9956869" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-DVI-9956869" ; "DENV virion:DENV E ligands" . a ; "Isa http://purl.obolibrary.org/obo/PR_000005547" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CLDN2" ; "https://reactome.org/content/detail/R-HSA-421235" ; ; [ a ; [ a ; [ a ; 230 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-421235" , "http://purl.obolibrary.org/obo/PR_P57739" ; "CLD2_HUMAN" , "CLDN2" , "Claudin-2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "IGF2BP3:RNA" ; "https://reactome.org/content/detail/R-HSA-428310" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-428310" ; "IGF2BP3:RNA" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "5beta-cholestan-7alpha,24(S)-diol-3-one" ; "https://reactome.org/content/detail/R-ALL-193760" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-193760" ; "5beta-cholestan-7alpha,24(S)-diol-3-one" , "(24S)-7alpha,24-dihydroxy-5beta-cholestan-3-one" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GPC4" ; "https://reactome.org/content/detail/R-HSA-2076368" ; ; [ a ; [ a ; [ a ; 529 ; ] ; [ a ; [ a ; 19 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2076368" ; "HS(4)-GPC4" , "GPC4_HUMAN" , "GPC4" , "Glypican-4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Integrins alpha1beta1, alpha2beta1, alpha11beta1" ; "https://reactome.org/content/detail/R-HSA-4085058" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-4085058" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "Integrins alpha1beta1, alpha2beta1, alpha11beta1" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_Q13224" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-NR2B" ; "https://reactome.org/content/detail/R-HSA-3928477" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1474 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1336 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1484 ; ] ; [ a ; [ a ; 27 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1252 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_000047623" , "Reactome:R-HSA-3928477" ; "p-Y1252,Y1336,Y1474-GRIN2B" , "Glutamate (NMDA) receptor subunit epsilon-2" , "p-NR2B" , "p-Y1252,Y1336,Y1474-NR2B" . a ; . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "PL" ; "https://reactome.org/content/detail/R-ALL-171066" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-171066" ; "phospholipids" , "PL" , "phospholipid" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "STX1A" ; "https://reactome.org/content/detail/R-HSA-9609866" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 288 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9609866" ; "STX1A_HUMAN" , "STX1A" , "Syntaxin-1A" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Glycosylated and folded HA trimer" ; "https://reactome.org/content/detail/R-FLU-195787" ; ; [ a ; ; ; "3"^^ ] ; [ a ; ; ] ; ; "Reactome:R-FLU-195787" ; "Glycosylated and folded HA trimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "MHC class II alpha/beta/Ii nonamer" ; "https://reactome.org/content/detail/R-HSA-2130425" ; ; [ a ; ; ; "3"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-2130425" ; "MHC class II alpha/beta/Ii nonamer" . a ; "Isa http://purl.obolibrary.org/obo/PR_000017770" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ZNF234" ; "https://reactome.org/content/detail/R-HSA-1027390" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 700 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-1027390" , "http://purl.obolibrary.org/obo/PR_Q14588" ; "ZNF234" , "ZN234_HUMAN" , "Zinc finger protein 234" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000017653" ; "FOG2" ; "https://reactome.org/content/detail/R-HSA-996726" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1151 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q8WW38" , "Reactome:R-HSA-996726" ; "Zinc finger protein multitype 2" , "Zinc finger protein ZFPM2" , "FOG2" , "ZFPM2" . a ; "Isa http://purl.obolibrary.org/obo/PR_P09960" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "LTA4H" ; "https://reactome.org/content/detail/R-HSA-6803343" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 611 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_000048266" , "Reactome:R-HSA-6803343" ; "LKHA4_HUMAN" , "Leukotriene A-4 hydrolase-1" , "LTA4H" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "DENV-2 virion" ; "https://reactome.org/content/detail/R-DVI-9945917" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "90"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-DVI-9945917" ; "Dengue capsid:nxPS:90xE:M:M:E" , "DENV-2 virion" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NT5M dimer" ; "https://reactome.org/content/detail/R-HSA-109497" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-109497" ; "5',3'-nucleotidase, mitochondrial holoenzyme" , "NT5M dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "CDP" ; "https://reactome.org/content/detail/R-ALL-110094" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-110094" ; "cytidine 5'-diphosphate" , "CDP(3-)" , "CDP" , "Cytidine diphosphate" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "CSG452" ; "https://reactome.org/content/detail/R-ALL-9728190" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9728190" ; "Deberza®" , "tofogliflozin" , "CSG452" , "compound 16d [PMID: 22889351]" , "CSG-452" , "Apleway®" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "type II TKI sensitive FLT3 mutants" ; "https://reactome.org/content/detail/R-HSA-9702524" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-9702524" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ; "type II TKI sensitive FLT3 mutants" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "OTC L57Q trimer" ; "https://reactome.org/content/detail/R-HSA-9958170" ; ; [ a ; ; ; "3"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9958170" ; "OTC L57Q trimer" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 131 to 148 by VCLWGFIFSQLQQLQCSL]" ; "NF1 A131Vfs*19" ; "https://reactome.org/content/detail/R-HSA-9647476" ; ; [ a ; [ a ; [ a ; 148 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9647476" ; "NF1 A131Vfs*19" . a ; "Isa http://purl.obolibrary.org/obo/PR_Q14186" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DP-1" ; "https://reactome.org/content/detail/R-HSA-68652" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 410 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_000049427" , "Reactome:R-HSA-68652" ; "DRTF1" , "Transcription factor DP-1 (E2F dimerization partner 1)(DRTF1-polypeptide-1) (DRTF1)" , "E2F dimerization partner 1" , "DP-1" , "DRTF1- polypeptide-1" , "Transcription factor Dp-1" , "TFDP1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "GRB2:GAB1:PIK3R1" ; "https://reactome.org/content/detail/R-HSA-179864" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-179864" ; "GRB2:GAB1:PIK3R1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NFATC1:CaN:CaM" ; "https://reactome.org/content/detail/R-HSA-4551463" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-4551463" ; "NFATC1:CaN:CaM" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "DLL/JAG:NOTCH3" ; "https://reactome.org/content/detail/R-HSA-9013071" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-9013071" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "DLL/JAG:NOTCH3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CP7B_HUMAN" ; "https://reactome.org/content/detail/R-HSA-5603020" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 87 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 506 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5603020" ; "CYP7B1 G87V" , "CP7B_HUMAN" , "Cytochrome P450 7B1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "PEX13:PEX14" ; "https://reactome.org/content/detail/R-HSA-9033095" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9033095" ; "Peroxisomal Docking Complex" , "PEX13:PEX14" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "quinone" ; "https://reactome.org/content/detail/R-ALL-8936520" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-8936520" ; "quinone" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "VNN1,VNN2" ; "https://reactome.org/content/detail/R-HSA-8939016" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-8939016" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "VNN1,VNN2" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "pirlindole" ; "https://reactome.org/content/detail/R-ALL-9677911" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9677911" ; "pirlindole" , "Pyrazidol ®" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "IL5 homodimer" ; "https://reactome.org/content/detail/R-HSA-913383" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-913383" ; "IL5 homodimer" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP" ; "https://reactome.org/content/detail/R-HSA-9934371" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-9934371" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "COL23A1" ; "https://reactome.org/content/detail/R-HSA-2473473" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2473473" ; "3x4Hyp-GalHyl-COL23A1(1-?)" , "4-Hyp 5-Gal-Hyl-collagen alpha-1(XXIII) transmembrane region" , "CONA1_HUMAN" , "COL23A1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA" ; "https://reactome.org/content/detail/R-ALL-193459" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-193459" ; "3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA" , "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA" . a ; "Isa http://purl.obolibrary.org/obo/PR_000000128" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SMAD4" ; "https://reactome.org/content/detail/R-HSA-177103" ; ; [ a ; [ a ; [ a ; 552 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q13485" , "Reactome:R-HSA-177103" ; "Mothers against decapentaplegic homolog 4" , "SMAD4" , "Co-SMAD" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "R170H BCKDHB" ; "https://reactome.org/content/detail/R-HSA-9865071" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 170 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 392 ; ] ; [ a ; [ a ; 51 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9865071" ; "R170H BCKDHB" , "branched chain keto acid dehydrogenase E1, beta polypeptide" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "USP17L17" ; "https://reactome.org/content/detail/R-HSA-8848678" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 530 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-8848678" ; "U17LH_HUMAN" , "USP17L17" , "Ubiquitin carboxyl-terminal hydrolase 17-like protein 17 ecNumber3.4.19.12/ecNumber" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "beta-catenin" ; "https://reactome.org/content/detail/R-HSA-191731" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-191731" ; ; "beta-catenin" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "UBC(305-380)" ; "https://reactome.org/content/detail/R-HSA-939228" ; ; [ a ; [ a ; [ a ; 380 ; ] ; [ a ; [ a ; 305 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-939228" ; "ubiquitin (UBC 5)" , "UBC(305-380)" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-S465,S467-SMAD2 A354T" ; "https://reactome.org/content/detail/R-HSA-3315474" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 467 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 467 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 354 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 465 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-3315474" ; "p-S465,S467-SMAD2 A354T" , "p-Ser465,Ser467-SMAD2 Ala354Thr" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "BMP4" ; "https://reactome.org/content/detail/R-HSA-8956944" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 408 ; ] ; [ a ; [ a ; 293 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8956944" ; "BMP4" , "Bone morphogenetic protein 4" , "BMP4_HUMAN" , "p-BMP4" . a ; "Isa http://purl.obolibrary.org/obo/PR_000003752" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ADCY10" ; "https://reactome.org/content/detail/R-HSA-379056" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1610 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-379056" , "http://purl.obolibrary.org/obo/PR_Q96PN6" ; "ADCYA_HUMAN" , "ADCY10" , "Adenylate cyclase type 10" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_Q08ET2" ; "SIGLEC14" ; "https://reactome.org/content/detail/R-HSA-6800430" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 396 ; ] ; [ a ; [ a ; 17 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6800430" , "http://purl.obolibrary.org/obo/PR_000049242" ; "SIG14_HUMAN" , "SIGLEC14" , "Sialic acid-binding Ig-like lectin 14" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "COX20:TMEM177" ; "https://reactome.org/content/detail/R-HSA-9865587" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9865587" ; "COX20:TMEM177" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Insertion of residues 429 to 822 at 585 from UniProt:P11362 FGFR1]" ; "p-Y177-BCR-p-FGFR1 fusion" ; "https://reactome.org/content/detail/R-HSA-1839041" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 766 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 177 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 584 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-1839041" ; "t(8:22) BCR-p-FGFR1 fusion" , "p-Y177-BCR-p-FGFR1 fusion" , "p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion" . a ; "Isa http://purl.obolibrary.org/obo/PR_000014115" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RNF2" ; "https://reactome.org/content/detail/R-HSA-389119" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 336 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-389119" , "http://purl.obolibrary.org/obo/PR_Q99496" ; "RNF2" , "RING1B" , "E3 ubiquitin-protein ligase RING2" , "RING2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "GRIN1:GRIN2 NMDA receptors:PSD proteins" ; "https://reactome.org/content/detail/R-HSA-9611369" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9611369" ; "GRIN1:GRIN2 NMDA receptors:postsynaptic density proteins" , "GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2:LRRC7:CaMKII" , "GRIN1:GRIN2 NMDA receptors:PSD proteins" . a ; "Unspecified modification type. Comment: [Replacement of residues 304 to 343 by LSEHCPTTPAPLPSQRRNHWMENISPFRSVGVSASRCSES]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TP53 T304Lfs*41" ; "https://reactome.org/content/detail/R-HSA-9722054" ; ; [ a ; [ a ; [ a ; 343 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9722054" ; "TP53 T304Lfs*41" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ZNF434" ; "https://reactome.org/content/detail/R-HSA-1247547" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 697 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-1247547" ; "ZSCAN32" , "ZNF434" , "ZN434_HUMAN" , "Zinc finger protein 434" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "NS345" ; "https://reactome.org/content/detail/R-DVI-9918829" ; ; [ a ; [ a ; [ a ; 3391 ; ] ; [ a ; [ a ; 1476 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-DVI-9918829" ; "NS345" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Ub-HIST3H2BB" ; "https://reactome.org/content/detail/R-HSA-6782555" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 120 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 126 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6782555" ; "Ub-HIST3H2BB" , "Histone H2B type 12" . a . a ; "Isa http://purl.obolibrary.org/obo/PR_000008846" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HVCN1" ; "https://reactome.org/content/detail/R-HSA-6800946" ; ; [ a ; [ a ; [ a ; 273 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6800946" , "http://purl.obolibrary.org/obo/PR_Q96D96" ; "Voltage-gated hydrogen channel 1" , "HVCN1" , "HVCN1_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "YAP1:WWNT1:TEADs:CD274 gene" ; "https://reactome.org/content/detail/R-HSA-9909630" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9909630" ; "YAP1:WWNT1:TEADs:CD274 gene" . a ; "Unspecified modification type. Comment: [Insertion of residues 1058 to 1620 at 1173 from UniProt:Q9UM73 ALK]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RN213_HUMAN" ; "https://reactome.org/content/detail/R-HSA-9715291" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1172 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9715291" ; "fullName evidence=\"34\"E3 ubiquitin-protein ligase RNF213 ecNumber evidence=\"16\"2.3.2.27/ecNumber ecNumber evidence=\"16\"3.6.4.-/ecNumber" , "RN213_HUMAN" , "RNF213(1-1172)-ALK(1058-1620) fusion" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 178 to 241 by AQIAMVWPLLSILSEWKEICVWSIWMTETLFDIVWWCPMSRLRLALTVPPSTTTTCVTVPAWAA]" ; "TP53 H178Afs*65" ; "https://reactome.org/content/detail/R-HSA-9719582" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 241 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9719582" ; "TP53 H178Afs*65" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "MECP2:GAD2 gene" ; "https://reactome.org/content/detail/R-HSA-9022982" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9022982" ; "MECP2:GAD2 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "OR3A3 gene" ; "https://reactome.org/content/detail/R-HSA-9752464" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000159961" ; "ENSEMBL:ENSG00000159961" , "Reactome:R-HSA-9752464" ; "OR3A3 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "B-RAF" ; "https://reactome.org/content/detail/R-HSA-6802374" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 466 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 766 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6802374" ; "BRAF G466E" , "B-RAF" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "COL5A3" ; "https://reactome.org/content/detail/R-HSA-2268747" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1745 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2268747" ; "COL5A3" , "4-Hyp 5-Gal-Hyl collagen alpha-3(V) -N propeptide" , "CO5A3_HUMAN" , "3x4Hyp-GalHyl-COL5A3(?-1745)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "NKAP" ; "https://reactome.org/content/detail/R-HSA-9769602" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 415 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9769602" ; "NKAP" , "NF-kappa-B-activating protein" , "NKAP_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "S-NO-CysGly" ; "https://reactome.org/content/detail/R-ALL-1222680" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-1222680" ; "S-NO-CysGly" , "S-Nitroso-L-cysteinylglycine" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "benzalkonium" ; "https://reactome.org/content/detail/R-ALL-9931574" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9931574" ; "benzalkonium" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "viral minus strand DNA with sticky 3' end" ; "https://reactome.org/content/detail/R-HIV-177533" ; ; [ a ; ; ] ; ; "Reactome:R-HIV-177533" ; "viral minus strand DNA with sticky 3' end" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "H2O" ; "https://reactome.org/content/detail/R-ALL-113518" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-113518" ; "H2O" , "water" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "AcK6-HIST1H2BC" ; "https://reactome.org/content/detail/R-HSA-4568623" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 126 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 6 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-4568623" ; "Histone H2B type 1-C/E/F/G/I" , "AcK6-HIST1H2BC" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KRTAP9-2" ; "https://reactome.org/content/detail/R-HSA-6809965" ; ; [ a ; [ a ; [ a ; 174 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6809965" ; "KRA92_HUMAN" , "Keratin-associated protein 9-2" , "KRTAP9-2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p11S-GLI2:SUFU" ; "https://reactome.org/content/detail/R-HSA-5610584" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5610584" ; "p11S-GLI2:SUFU" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000001585" ; "GALR1" ; "https://reactome.org/content/detail/R-HSA-388967" ; ; [ a ; [ a ; [ a ; 349 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_P47211" , "Reactome:R-HSA-388967" ; "RecName: Full=Galanin receptor type 1; AltName: Full=GAL1-R; AltName: Full=GALR1;
GN Name=GALR1; Synonyms=GALNR, GALNR1;
OS Homo sapiens" , "GALR1_HUMAN" , "GALR1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "cytosolic p-Y PDGFR fusion dimers" ; "https://reactome.org/content/detail/R-HSA-9673719" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-9673719" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ; "cytosolic p-Y PDGFR fusion dimers" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "Resting T Cell surface" ; "https://reactome.org/content/detail/R-ALL-8851976" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-8851976" ; "Resting T Cell surface" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-TAZ:DVL2" ; "https://reactome.org/content/detail/R-HSA-2066300" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2066300" ; "p-WWTR1:DVL2" , "p-TAZ:DVL2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-10S-LRP6" ; "https://reactome.org/content/detail/R-HSA-1458895" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1613 ; ] ; [ a ; [ a ; 20 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1493 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1479 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1490 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-1458895" ; "p-10S-LRP6" , "p10S/T-LRP6" , "p-4S,3T,T1479,S1490,T1493-LRP6" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "IP6K1/2" ; "https://reactome.org/content/detail/R-HSA-2023924" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-2023924" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "IP6K1/2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2" ; "https://reactome.org/content/detail/R-HSA-926768" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-926768" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SARS-CoV-1 N:p-2S-SMAD3:SP1:EP300:SERPINE1 gene" ; "https://reactome.org/content/detail/R-HSA-9737684" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9737684" ; "SARS-CoV-1 N:p-2S-SMAD3:SP1:EP300:SERPINE1 gene" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "APC_HUMAN" ; "https://reactome.org/content/detail/R-HSA-9666956" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1308 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 1307 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9666956" ; "APC K1308TER" , "Adenomatous polyposis coli protein" , "APC K1308*" , "APC_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TP53 S315*" ; "https://reactome.org/content/detail/R-HSA-9723432" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 314 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 315 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9723432" ; "TP53 S315*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TPRX2" ; "https://reactome.org/content/detail/R-HSA-9818475" ; ; [ a ; [ a ; [ a ; 301 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9818475" ; "TPRX2_HUMAN" , "fullName evidence=\"4\"Tetrapeptide repeat homeobox protein 2" , "TPRX2" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "RBPJ:NICD1" ; "https://reactome.org/content/detail/R-HSA-9824247" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9824247" ; "RBPJ:NICD1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "gM:gN" ; "https://reactome.org/content/detail/R-HCY-9610912" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HCY-9610912" ; "gM:gN" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SUMO1:UBA2" ; "https://reactome.org/content/detail/R-HSA-2993786" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-2993786" ; "SAE2_HUMAN" , "SUMO1 S-glycyl-cys173 UBA2" , "SUMO1:UBA2" , "SUMO-activating enzyme subunit 2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SMAD4 G477*" ; "https://reactome.org/content/detail/R-HSA-9678447" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 477 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 476 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9678447" ; "SMAD4 G477*" , "SMAD4 G477TER" , "SMAD4 Gly477TER" , "SMAD4 Gly477*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000014937" ; "SLC13A5" ; "https://reactome.org/content/detail/R-HSA-433135" ; ; [ a ; [ a ; [ a ; 568 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-433135" , "http://purl.obolibrary.org/obo/PR_Q86YT5" ; "S13A5_HUMAN" , "Solute carrier family 13 member 5" , "SLC13A5" . a ; . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_000014943" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PHT1" ; "https://reactome.org/content/detail/R-HSA-6799715" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 577 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q8N697" , "Reactome:R-HSA-6799715" ; "SLC15A4" , "S15A4_HUMAN" , "Solute carrier family 15 member 4" , "Peptide/histidine transporter 1" , "PHT1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "Nitrite" ; "https://reactome.org/content/detail/R-ALL-1222379" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-1222379" ; "Nitrite" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PGK monomers" ; "https://reactome.org/content/detail/R-HSA-9965342" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-9965342" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "PGK monomers" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "TAB2" ; "https://reactome.org/content/detail/R-HSA-168117" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 693 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-168117" ; "Mitogen-activated protein kinase kinase kinase 7 interacting protein 2" , "TAB2-P" , "TAB2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GNS" ; "https://reactome.org/content/detail/R-HSA-1638063" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 91 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 552 ; ] ; [ a ; [ a ; 37 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-1638063" ; "GNS_HUMAN" , "OxA-GNS" , "N-acetylglucosamine-6-sulfatase" , "GNS" , "active GNS" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "CERA" ; "https://reactome.org/content/detail/R-ALL-1605673" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-1605673" ; "N-acylsphingosine" , "CERA" , "Ceramide" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ADAMTS2" ; "https://reactome.org/content/detail/R-HSA-5173206" ; ; [ a ; [ a ; [ a ; 1211 ; ] ; [ a ; [ a ; 254 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5173206" ; "O-fuc-ADAMTS2" , "glc-fuc-ADAMTS2" , "A disintegrin and metalloproteinase with thrombospondin motifs 2" , "ADAMTS2" , "ATS2_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-T12, Me2K-10-H3F3A" ; "https://reactome.org/content/detail/R-HSA-5625800" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 10 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 10 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 136 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5625800" ; "p-T12, Me2K-10-H3F3A" , "Histone H3.3 with dimethylated lysine9 (H3K9) and phosphorylated Thr11 (H3T11)" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SMARCA2,SMARCA4" ; "https://reactome.org/content/detail/R-HSA-5225680" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-5225680" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "SMARCA2,SMARCA4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "recombinant IFNB1a" ; "https://reactome.org/content/detail/R-ALL-9696149" ; ; [ a ; ; ] ; "Reactome:R-ALL-9696149" ; "Interferon beta-1a" , "recombinant IFNB1a" . a ; "Unspecified modification type. Comment: [Replacement of residues 926 to 958 by PWFYMETQVINKQPKCQLKKIWFMFLQRRTKIV]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "BRCA2 T926Pfs*34" ; "https://reactome.org/content/detail/R-HSA-9712894" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 958 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9712894" ; "BRCA2 T926Pfs*34" . a ; "Isa http://purl.obolibrary.org/obo/PR_000015704" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SA1" ; "https://reactome.org/content/detail/R-HSA-2466017" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1258 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2466017" , "http://purl.obolibrary.org/obo/PR_Q8WVM7" ; "SA1" , "STAG1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "IL17RD:p-2S MAP2Ks:p-T,Y MAPKs" ; "https://reactome.org/content/detail/R-HSA-5674362" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5674362" ; "IL17RD:p-2S MAP2Ks:p-T,Y MAPKs" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "LPL gene" ; "https://reactome.org/content/detail/R-HSA-5640177" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000175445" ; "ENSEMBL:ENSG00000175445" , "Reactome:R-HSA-5640177" ; "LPL gene" . a ; "Unspecified modification type. Comment: [Replacement of residues 598 to 599 by EGLVQVTGSSDNEYFYVDFREYEY]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "W78" ; "https://reactome.org/content/detail/R-HSA-9696033" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 993 ; ] ; [ a ; [ a ; 27 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9696033" ; "W78" , "FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "S416" ; "https://reactome.org/content/detail/R-ALL-9708768" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9708768" ; "S416" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SYT2 dimer" ; "https://reactome.org/content/detail/R-HSA-8862876" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-8862876" ; "SYT2 dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "USP30:PolyUb-MOM proteins" ; "https://reactome.org/content/detail/R-HSA-6783116" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-6783116" ; "USP30:PolyUb-MOM proteins" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "3x4Hyp-3Hyp-5Hyl-COL4A1(1445-1669)" ; "https://reactome.org/content/detail/R-HSA-4084901" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1669 ; ] ; [ a ; [ a ; 1445 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-4084901" ; "3x4Hyp-3Hyp-5Hyl-COL4A1(1445-1669)" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "OR13J1" ; "https://reactome.org/content/detail/R-HSA-9751495" ; ; [ a ; [ a ; [ a ; 312 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9751495" ; "OR13J1" , "O13J1_HUMAN" , "Olfactory receptor 13J1" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_000012614" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PGM1" ; "https://reactome.org/content/detail/R-HSA-6801507" ; ; [ a ; [ a ; [ a ; 562 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_P36871" , "Reactome:R-HSA-6801507" ; "PGM1" , "Glucose phosphomutase" , "Phosphoglucomutase" , "phosphoglucomutase 1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "exocyst complex" ; "https://reactome.org/content/detail/R-HSA-5623453" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-5623453" ; "exocyst complex" , "EXOC1:EXOC2:EXOC3:EXOC4:EXOC5:EXOC6:EXOC7:EXOC8" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "S26A3_HUMAN" ; "https://reactome.org/content/detail/R-HSA-5627744" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 764 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 187 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5627744" ; "Chloride anion exchanger" , "S26A3_HUMAN" , "SLC26A3 G187*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "TFAP2A,TFAP2C homodimers:CGA Gene" ; "https://reactome.org/content/detail/R-HSA-8864406" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8864406" ; "TFAP2A,TFAP2C homodimers:CGA Gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "LF" ; "https://reactome.org/content/detail/R-BAN-5211332" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-BAN-5211332" ; "LF" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "DTM complex" ; "https://reactome.org/content/detail/R-HSA-9033606" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9033606" ; "PEX13:PEX14:PEX2:PEX10:PEX12" , "DTM complex" , "Docking and translocation module" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SP100_HUMAN" ; "https://reactome.org/content/detail/R-HSA-3000382" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 297 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 879 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-3000382" ; "SUMO1 N-glycyl-lys297 SP100" , "monoSUMO1-K297-SP100" , "SP100_HUMAN" , "Nuclear autoantigen Sp-100" . a ; "Isa http://purl.obolibrary.org/obo/PR_000032057" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "WBSCR22" ; "https://reactome.org/content/detail/R-HSA-6790981" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 281 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6790981" , "http://purl.obolibrary.org/obo/PR_O43709" ; "WBS22_HUMAN" , "WBSCR22" , "Probable 18S rRNA" . a ; "Unspecified modification type. Comment: [Replacement of residues 803 to 808 by TSIFHP]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RB1 N803Tfs*7" ; "https://reactome.org/content/detail/R-HSA-9688016" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 808 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9688016" ; "RB1 N803Tfs*7" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "Cl-" ; "https://reactome.org/content/detail/R-ALL-2730999" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-2730999" ; "chloride" , "Cl-" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "G-protein heterotrimer" ; "https://reactome.org/content/detail/R-HSA-8850568" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8850568" ; "G-protein heterotrimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "masitinib resistant KIT mutants" ; "https://reactome.org/content/detail/R-HSA-9669762" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-9669762" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ; "masitinib resistant KIT mutants" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KLK13" ; "https://reactome.org/content/detail/R-HSA-2990873" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 277 ; ] ; [ a ; [ a ; 17 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2990873" ; "KLK13" , "Kallikrein-13 ecNumber3.4.21.-/ecNumber" , "KLK13_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RB1 R661W" ; "https://reactome.org/content/detail/R-HSA-9659801" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 928 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 661 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9659801" ; "RB1 Arg661Trp" , "RB1 R661W" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Kir3 heterotetramer" ; "https://reactome.org/content/detail/R-HSA-975303" ; ; [ a ; ; ; "4"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-975303" ; "Kir3 heterotetramer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000014232" ; "RPL7" ; "https://reactome.org/content/detail/R-HSA-72486" ; ; [ a ; [ a ; [ a ; 248 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_P18124" , "Reactome:R-HSA-72486" ; "RPL7" , "60S ribosomal protein L7" , "P18124" . a ; "Isa http://purl.obolibrary.org/obo/PR_000003337" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Collagen alpha-4(IV) NC1 domain" ; "https://reactome.org/content/detail/R-HSA-4088273" ; ; [ a ; [ a ; [ a ; 1690 ; ] ; [ a ; [ a ; 1461 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-4088273" , "http://purl.obolibrary.org/obo/PR_P53420" ; "Collagen alpha-4(IV) NC1 domain" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_O96019" ; "ACTL6A" ; "https://reactome.org/content/detail/R-HSA-2980912" ; ; [ a ; [ a ; [ a ; 429 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2980912" , "http://purl.obolibrary.org/obo/PR_000046254" ; "ACTL6A" , "ACL6A_HUMAN" , "Actin-like protein 6A" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "PolyUb-TP53 Tetramer" ; "https://reactome.org/content/detail/R-HSA-8856287" ; ; [ a ; ; ] ; [ a ; ; ; "4"^^ ] ; ; "Reactome:R-HSA-8856287" ; "PolyUb-TP53 Tetramer" . a ; "Isa http://purl.obolibrary.org/obo/PR_Q49AN0" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-CRY2" ; "https://reactome.org/content/detail/R-HSA-400328" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 593 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-400328" , "http://purl.obolibrary.org/obo/PR_000047075" ; "p-CRY2" , "Phosphorylated Cryptochrome-2" , "p-S-CRY2" , "CRY2_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "NPPA(1-25)" ; "https://reactome.org/content/detail/R-HSA-5578791" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 25 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5578791" ; "NPPA signal peptide" , "NPPA(1-25)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "IgE Heavy Chain" ; "https://reactome.org/content/detail/R-HSA-1591209" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-1591209" ; "Ig epsilon heavy chain" , "IgE Heavy Chain" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "Gua, Hyp" ; "https://reactome.org/content/detail/R-ALL-500259" ; ; [ a ; ; ] ; , ; "Reactome:R-ALL-500259" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "guanine, hypoxanthine" , "Gua, Hyp" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ALYREF:SARNP:THO" ; "https://reactome.org/content/detail/R-HSA-8849110" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8849110" ; "ALYREF:SARNP:THO" , "TREX (minus DDX39B)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "(HA)2" ; "https://reactome.org/content/detail/R-ALL-2160866" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-2160866" ; "Hyaluronan" , "(HA)2" , "Hyaluronic acid" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Cell surface:C3b:CFB" ; "https://reactome.org/content/detail/R-HSA-173737" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-173737" ; "Cell surface:C3b:CFB" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "miR-132 Nonendonucleolytic RISC" ; "https://reactome.org/content/detail/R-HSA-9021196" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9021196" ; "miR-132 Nonendonucleolytic RISC" . a ; "Isa http://purl.obolibrary.org/obo/PR_000013008" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "RPC8" ; "https://reactome.org/content/detail/R-HSA-1964440" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 204 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1964440" , "http://purl.obolibrary.org/obo/PR_Q9Y535" ; "DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide" , "HsRPC8" , "POLR3H" , "RPC8" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "B3GALT6 mutants" ; "https://reactome.org/content/detail/R-HSA-4420346" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-4420346" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ; "B3GALT6 mutants" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "P40" ; "https://reactome.org/content/detail/R-HSA-9922472" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 295 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9922472" ; "40S ribosomal protein SA" , "P08865" , "RPSA" , "Colon carcinoma laminin-binding protein" , "NEM/1CHD4" , "34/67 kDa laminin receptor" , "P40" , "40S small ribosomal protein P4" , "Multidrug resistance- associated protein MGr1-Ag" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "dsRNA duplex" ; "https://reactome.org/content/detail/R-ALL-75086" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-75086" ; "dsRNA duplex" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P02458" ; "Alpha-1 type II collagen" ; "https://reactome.org/content/detail/R-HSA-2268640" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1487 ; ] ; [ a ; [ a ; 26 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2268640" , "http://purl.obolibrary.org/obo/PR_000046885" ; "Collagen type II alpha 1 chain" , "3,4-Hyp 5-Hyl collagen alpha-1(II) propeptide" , "Alpha-1 type II collagen" , "3x4Hyp-3Hyp-5Hyl-COL2A1(26-1487)" . a ; "Isa http://purl.obolibrary.org/obo/PR_000018196" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ZNF860" ; "https://reactome.org/content/detail/R-HSA-2586613" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 632 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2586613" , "http://purl.obolibrary.org/obo/PR_A6NHJ4" ; "Zinc finger protein 860" , "ZN860_HUMAN" , "ZNF860" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "FFAR1:rosiglitazone" ; "https://reactome.org/content/detail/R-HSA-9732526" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9732526" ; "FFAR1:rosiglitazone" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NF-kappa-B p50,p65,c-Rel:IKB" ; "https://reactome.org/content/detail/R-HSA-1168593" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-1168593" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "NF-kappa-B p50,p65,c-Rel:IKB" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-Y705-STAT3" ; "https://reactome.org/content/detail/R-HSA-8983130" ; ; [ a ; [ a ; [ a ; 770 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 705 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8983130" ; "p-Y705-STAT3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-S76,S79,S82,S124-CDC25A" ; "https://reactome.org/content/detail/R-HSA-9944026" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 524 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 82 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 79 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 76 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 124 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9944026" ; "p-S76,S79,S82,S124-CDC25A" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GRIN3B" ; "https://reactome.org/content/detail/R-HSA-432166" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1043 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-432166" ; "GRIN3B" , "Glutamate (NMDA) receptor subunit 3B" . a ; "Isa http://purl.obolibrary.org/obo/PR_O43678" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CI-B8" ; "https://reactome.org/content/detail/R-HSA-60178" ; ; [ a ; [ a ; [ a ; 99 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-60178" , "http://purl.obolibrary.org/obo/PR_000048540" ; "NADH-ubiquinone oxidoreductase B8 subunit" , "NDUFA2" , "CI-B8" , "Complex I-B8" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-S90,Ac-K538-ARNTL:p-T451,T461,S440,S441,S446-CLOCK:CBP:MLL1:NR1D1 gene" ; "https://reactome.org/content/detail/R-HSA-9922988" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9922988" ; "p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene" , "p-S90,Ac-K538-ARNTL:p-T451,T461,S440,S441,S446-CLOCK:CBP:MLL1:NR1D1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "LYZ" ; "https://reactome.org/content/detail/R-HSA-6798746" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 148 ; ] ; [ a ; [ a ; 19 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6798746" ; "Lysozyme C" , "LYZ" , "LYSC_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000015375" ; "ARHGAP33" ; "https://reactome.org/content/detail/R-HSA-3604399" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1287 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_O14559" , "Reactome:R-HSA-3604399" ; "ARHGAP33" , "Rho GTPase-activating protein 33" , "RHG33_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "RAC1:GDP:RAC1 GDIs" ; "https://reactome.org/content/detail/R-HSA-9013179" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9013179" ; "RAC1:GDP:RAC1 GDIs" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "GIP gene" ; "https://reactome.org/content/detail/R-HSA-5653046" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000159224" ; "Reactome:R-HSA-5653046" , "ENSEMBL:ENSG00000159224" ; "GIP gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "BRCA2 K2392*" ; "https://reactome.org/content/detail/R-HSA-9711511" ; ; [ a ; [ a ; [ a ; 2391 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 2392 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9711511" ; "BRCA2 K2392*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CFHR2" ; "https://reactome.org/content/detail/R-HSA-8851430" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 270 ; ] ; [ a ; [ a ; 19 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-8851430" ; "FHR2_HUMAN" , "Complement factor H-related protein 2" , "CFHR2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "APP" ; "https://reactome.org/content/detail/R-HSA-5693003" ; ; [ a ; [ a ; [ a ; 671 ; ] ; [ a ; [ a ; 18 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5693003" ; "Beta-APP40" , "PN-II" , "ABPP" , "Soluble APP-alpha" , "Gamma-secretase C-terminal fragment 50" , "Soluble APP-beta" , "APPI" , "Alzheimer's disease amyloid protein" , "C99" , "Beta-APP42" , "S-APP- alpha" , "Amyloid intracellular domain 57" , "Gamma-CTF(57)" , "P3(42)" , "APP(18-671)" , "Gamma-secretase C-terminal fragment 59" , "PreA4" , "Beta-amyloid protein 42" , "Gamma-CTF(50)" , "Protease nexin-II" , "Beta-amyloid protein 40" , "APP" , "AID(57)" , "Amyloid intracellular domain 59" , "S-APP-beta" , "CVAP" , "Amyloid beta A4 protein precursor" , "C83" , "AID(50)" , "Gamma- secretase C-terminal fragment 57" , "Cerebral vascular amyloid peptide" , "Amyloid intracellular domain 50" , "AID(59)" , "Gamma-CTF(59)" , "C31" , "P3(40)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Ig Heavy Chain V Region" ; "https://reactome.org/content/detail/R-HSA-197042" ; ; [ a ; ; ] ; , , , , , , , , , , , , , , , , , , ; "Reactome:R-HSA-197042" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ; "Ig Heavy Chain V Region" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "DEFB106A" ; "https://reactome.org/content/detail/R-HSA-1471323" ; ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1471323" ; "Beta defensin-6" , "Beta-defensin 106" , "DEFB106A" , "D106A_HUMAN" , "DEFB106A(?-65)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-S465,S467-SMAD2 D300N" ; "https://reactome.org/content/detail/R-HSA-3315066" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 465 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 300 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 467 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 467 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-3315066" ; "p-Ser465,Ser467-SMAD2 Asp300Asn" , "p-S465,S467-SMAD2 D300N" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "GCLC gene:p-AcK-NFE2L2:CREBBP, EP300" ; "https://reactome.org/content/detail/R-HSA-9760073" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-9760073" ; "GCLC gene:p-AcK-NFE2L2:CREBBP, EP300" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000007791" ; "GADL1_HUMAN" ; "https://reactome.org/content/detail/R-HSA-6787692" ; ; [ a ; [ a ; [ a ; 521 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 333 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_Q6ZQY3" , "Reactome:R-HSA-6787692" ; "GADL1_HUMAN" , "PXLP-K333-GADL1" , "Acidic amino acid decarboxylase GADL1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Multiple phosphorylated FAK bound to NCAM:pFyn" ; "https://reactome.org/content/detail/R-HSA-391848" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-391848" ; "Multiple phosphorylated FAK bound to NCAM:pFyn" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "gp120 homotrimer after second conformation change" ; "https://reactome.org/content/detail/R-HIV-173651" ; ; [ a ; ; ; "3"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HIV-173651" ; "gp120 homotrimer after second conformation change" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "shuttling SRSFs" ; "https://reactome.org/content/detail/R-HSA-9770136" ; ; [ a ; ; ] ; , , , , , ; "Reactome:R-HSA-9770136" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ; "shuttling SRSFs" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000013459" ; "MEG" ; "https://reactome.org/content/detail/R-HSA-8877173" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 926 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_P29074" , "Reactome:R-HSA-8877173" ; "PTPN4" , "Tyrosine-protein phosphatase non-receptor type 4" , "PTN4_HUMAN" , "PTPase-MEG1" , "MEG" , "Protein-tyrosine phosphatase MEG1" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_Q16637" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SMN" ; "https://reactome.org/content/detail/R-HSA-191839" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 294 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-191839" , "http://purl.obolibrary.org/obo/PR_000049296" ; "SMN" , "SMN1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SQR:FAD" ; "https://reactome.org/content/detail/R-HSA-1614651" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1614651" ; "SQR:FAD" . a ; "Isa http://purl.obolibrary.org/obo/PR_000013155" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PPP4R2" ; "https://reactome.org/content/detail/R-HSA-5687747" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 417 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5687747" , "http://purl.obolibrary.org/obo/PR_Q9NY27" ; "Serine/threonine-protein phosphatase 4 regulatory subunit 2" , "PPP4R2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "PVALB gene" ; "https://reactome.org/content/detail/R-HSA-9006518" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000100362" ; "Reactome:R-HSA-9006518" , "ENSEMBL:ENSG00000100362" ; "PVALB gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "NRG2:p-ERBB4 homodimers:GABRA1 heteropentamers:GABA" ; "https://reactome.org/content/detail/R-HSA-9612640" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9612640" ; "NRG2:p-ERBB4 homodimers:GABRA1 heteropentamers:GABA" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "FAD" ; "https://reactome.org/content/detail/R-ALL-9861429" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9861429" ; "FAD" , "FAD(3-)" , "Flavin adenine dinucleotide" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Insertion of residues 1059 to 1620 at 1205 from UniProt:Q9UM73 ALK]" ; "GCC2_HUMAN" ; "https://reactome.org/content/detail/R-HSA-9713455" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1283 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1278 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 1204 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1604 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1096 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1507 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1282 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1359 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9713455" ; "GCC2_HUMAN" , "GRIP and coiled-coil domain-containing protein 2" , "GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CYP(4)" ; "https://reactome.org/content/detail/R-HSA-2161805" ; ; [ a ; ; ] ; , , , ; "Reactome:R-HSA-2161805" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ; "CYP(4)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SDC4" ; "https://reactome.org/content/detail/R-HSA-2076670" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 198 ; ] ; [ a ; [ a ; 19 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2076670" ; "HS(4)-SDC4" , "Syndecan-4" , "SDC4_HUMAN" , "SDC4" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000018023" ; "ZNF607" ; "https://reactome.org/content/detail/R-HSA-2127567" ; ; [ a ; [ a ; [ a ; 696 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q96SK3" , "Reactome:R-HSA-2127567" ; "ZN607_HUMAN" , "Zinc finger protein 607" , "ZNF607" . a ; "Isa http://purl.obolibrary.org/obo/PR_000009741" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "LDHAL6B" ; "https://reactome.org/content/detail/R-HSA-6807613" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 381 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q9BYZ2" , "Reactome:R-HSA-6807613" ; "LDHAL6B" , "L-lactate dehydrogenase A-like 6B" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ASS1 T91P" ; "https://reactome.org/content/detail/R-HSA-9959140" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 412 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 91 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9959140" ; "Citrulline--aspartate ligase" , "argininosuccinate synthase" , "ASS1 T91P" , "argininosuccinic acid synthetase" , "citrulline-aspartate ligase" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_000004004" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "AMPH" ; "https://reactome.org/content/detail/R-HSA-8867728" ; ; [ a ; [ a ; [ a ; 695 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_P49418" , "Reactome:R-HSA-8867728" ; "Amphiphysin" , "AMPH_HUMAN" , "AMPH" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "MATE substrates" ; "https://reactome.org/content/detail/R-ALL-446589" ; ; [ a ; ; ] ; , , , , , , ; "Reactome:R-ALL-446589" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ; "MATE substrates" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_O00462" ; "MANBA" ; "https://reactome.org/content/detail/R-HSA-6806257" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 879 ; ] ; [ a ; [ a ; 18 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-6806257" , "http://purl.obolibrary.org/obo/PR_000048288" ; "MANBA_HUMAN" , "MANBA" , "Beta-mannosidase ecNumber3.2.1.25/ecNumber" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CPN1_HUMAN" ; "https://reactome.org/content/detail/R-HSA-5580294" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 448 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 503 ; ] ; [ a ; [ a ; 25 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5580294" ; "Cytochrome P450 11B1" , "CYP11B1 R448C" , "CPN1_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "AP-2 dileucine-containing cargo" ; "https://reactome.org/content/detail/R-HSA-8869156" ; ; [ a ; ; ] ; , , , , , ; "Reactome:R-HSA-8869156" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ; "AP-2 dileucine-containing cargo" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "3x4Hyp-5Hyl-COL1A2(23-1366)" ; "https://reactome.org/content/detail/R-HSA-2022977" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1366 ; ] ; [ a ; [ a ; 23 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2022977" ; "4-Hyp 5-Hyl collagen alpha-2(I) propeptide" , "3x4Hyp-5Hyl-COL1A2(23-1366)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Alpha-1(V) propeptides" ; "https://reactome.org/content/detail/R-HSA-2025761" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-2025761" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ] ] ] ] ] ] ; "Alpha-1(V) propeptides" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SHH" ; "https://reactome.org/content/detail/R-HSA-5387360" ; ; [ a ; [ a ; [ a ; 462 ; ] ; [ a ; [ a ; 24 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 374 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5387360" ; "SHH_HUMAN" , "ub SHH(24-462) H374R" , "Sonic hedgehog protein precursor" , "SHH" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element" ; "https://reactome.org/content/detail/R-HSA-1535906" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-1535906" ; "SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "GLUT1" ; "https://reactome.org/content/detail/R-HSA-5632870" ; ; [ a ; [ a ; [ a ; 492 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 256 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5632870" ; "Solute carrier family 2, facilitated glucose transporter, member 1" , "Glucose transporter type 1, erythrocyte/brain" , "GLUT1" , "HepG2 glucose transporter" , "SLC2A1 K256V" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HNRNPDL" ; "https://reactome.org/content/detail/R-HSA-8950323" ; ; [ a ; [ a ; [ a ; 420 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8950323" ; "HNRNPDL" , "Heterogeneous nuclear ribonucleoprotein D-like" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "EntS" ; "https://reactome.org/content/detail/R-ECO-9638405" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 416 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-ECO-9638405" ; "ENTS_ECOLI" , "EntS" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4)" ; "https://reactome.org/content/detail/R-HSA-9664604" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9664604" ; "p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4)" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CTSD" ; "https://reactome.org/content/detail/R-HSA-9816123" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 161 ; ] ; [ a ; [ a ; 65 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9816123" ; "Cathepsin D light chain" , "CATD_HUMAN" , "CTSD(65-161)" , "CTSD" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Acidified Influenza A Viral Particle Docked At The Endocytic Vesicle Membrane With An Open Pore" ; "https://reactome.org/content/detail/R-FLU-189177" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "3000"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "165"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-FLU-189177" ; "Acidified Influenza A Viral Particle Docked At The Endocytic Vesicle Membrane With An Open Pore" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "MAG gene:EGR2:SOX10" ; "https://reactome.org/content/detail/R-HSA-9616114" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-9616114" ; "MAG gene:EGR2:SOX10" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "hBUBR1:hBUB3:MAD2* complex" ; "https://reactome.org/content/detail/R-HSA-174196" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-174196" ; "hBUBR1:hBUB3:MAD2* complex" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ALG13:ALG14" ; "https://reactome.org/content/detail/R-HSA-449326" ; ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-449326" ; "ALG13:ALG14" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "nsp2" ; "https://reactome.org/content/detail/R-COV-9682221" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 818 ; ] ; [ a ; [ a ; 181 ; ] ; () ] ] ] ; ; "Reactome:R-COV-9682221" ; "rep (181-818)" , "pp1ab-nsp2" , "nsp2" , "Non-structural protein 2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "PTEN R335*" ; "https://reactome.org/content/detail/R-HSA-2318568" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 335 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 334 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2318568" ; "PTEN Arg335*" , "PTEN R335*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P62937" ; "PPIA" ; "https://reactome.org/content/detail/R-HSA-6801400" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 165 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-6801400" , "http://purl.obolibrary.org/obo/PR_000048858" ; "PPIA" , "Cyp A protein" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ACIN1(1-1093)" ; "https://reactome.org/content/detail/R-HSA-212520" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1093 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-212520" ; "Acinus fragment (1-1093)" , "ACIN1(1-1093)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "OR6F1:O-methyleugenol" ; "https://reactome.org/content/detail/R-HSA-9737276" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9737276" ; "OR6F1:O-methyleugenol" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_000005546" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CLDN19" ; "https://reactome.org/content/detail/R-HSA-421236" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 224 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-421236" , "http://purl.obolibrary.org/obo/PR_Q8N6F1" ; "Claudin-19" , "CLDN19" , "CLD19_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_P00749" ; "uPA" ; "https://reactome.org/content/detail/R-HSA-158979" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 431 ; ] ; [ a ; [ a ; 21 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-158979" , "http://purl.obolibrary.org/obo/PR_000048797" ; "uPA" , "PLAU(21-431)" , "urokinase plasminogen activator (one-chain)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "FGFR1OP-p-FGFR1 fusion mutant dimer" ; "https://reactome.org/content/detail/R-HSA-1838997" ; ; [ a ; ; ] ; [ a ; ; ; "2"^^ ] ; ; "Reactome:R-HSA-1838997" ; "FGFR1OP-p-FGFR1 fusion mutant dimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "3x4Hyp-COL4A2(1486-1712)" ; "https://reactome.org/content/detail/R-HSA-4085059" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1712 ; ] ; [ a ; [ a ; 1486 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-4085059" ; "3x4Hyp-COL4A2(1486-1712)" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SGLT1" ; "https://reactome.org/content/detail/R-HSA-5656368" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 28 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 664 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5656368" ; "SLC5A1 D28G" , "Sodium/glucose cotransporter 1" , "SGLT1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HA folded and glycosylated" ; "https://reactome.org/content/detail/R-FLU-195788" ; ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-FLU-195788" ; "HA folded and glycosylated" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "RUNX2:CBFB:ITGBL1 gene" ; "https://reactome.org/content/detail/R-HSA-8939834" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-HSA-8939834" ; "RUNX2:CBFB:ITGBL1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MITF-M" ; "https://reactome.org/content/detail/R-HSA-9926333" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 419 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9926333" ; "MITF-M" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HLA-DQB2" ; "https://reactome.org/content/detail/R-HSA-2130426" ; ; [ a ; [ a ; [ a ; 268 ; ] ; [ a ; [ a ; 33 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2130426" ; "HLA class II histocompatibility antigen, DQ beta 2 chain" , "HLA-DQB2" , "HLA class II histocompatibility antigen, DX beta chain precursor" , "HB2X_HUMAN" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Unspecified modification type. Comment: [Replacement of residues 859 to 867 by EWIIKGTKI]" ; "ATRX G859Efs*10" ; "https://reactome.org/content/detail/R-HSA-9672643" ; ; [ a ; [ a ; [ a ; 867 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9672643" ; "ATRX G859Efs*10" . a ; "Isa http://purl.obolibrary.org/obo/PR_000017790" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ZNF266" ; "https://reactome.org/content/detail/R-HSA-1027391" ; ; [ a ; ; ] ; [ a ; [ a ; [ a ; 549 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "http://purl.obolibrary.org/obo/PR_Q14584" , "Reactome:R-HSA-1027391" ; "ZN266_HUMAN" , "ZNF266" , "Zinc finger protein 266" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "ERBB4jmAcyt2 homodimer" ; "https://reactome.org/content/detail/R-HSA-1250321" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1250321" ; "ERBB4jmAcyt2 homodimer" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_Q9NR96" ; "TLR9" ; "https://reactome.org/content/detail/R-HSA-187882" ; ; [ a ; [ a ; [ a ; 1032 ; ] ; [ a ; [ a ; 26 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-187882" , "http://purl.obolibrary.org/obo/PR_000049472" ; "full length TLR9" , "TLR9" , "Toll Like Receptor 9" , "fl-TLR9" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "EPS15,EPN1,EPN2" ; "https://reactome.org/content/detail/R-HSA-8866243" ; ; [ a ; ; ] ; , , ; "Reactome:R-HSA-8866243" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "EPS15,EPN1,EPN2" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "TDP" ; "https://reactome.org/content/detail/R-ALL-110095" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-110095" ; "thymidine 5'-diphosphate" , "deoxythymidine 5'-diphosphate" , "TDP" , "dTDP" , "dTDP(3-)" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MECP2" ; "https://reactome.org/content/detail/R-HSA-9005549" ; ; [ a ; ; ] ; , ; "Reactome:R-HSA-9005549" ; [ a ; [ a ; ; [ a ; ; () ] ] ] ; "MECP2" . a ; . a ; "Isa http://purl.obolibrary.org/obo/PR_000001634" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "HCRTR2" ; "https://reactome.org/content/detail/R-HSA-389421" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 444 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "http://purl.obolibrary.org/obo/PR_O43614" , "Reactome:R-HSA-389421" ; "Orexin receptor 2" , "HCRTR2" , "OX2R_HUMAN" , "RecName: Full=Orexin receptor type 2; AltName: Full=Ox2r; AltName: Full=Hypocretin receptor type 2;
GN Name=HCRTR2;
OS Homo sapiens" . a ; . a ; "Unspecified modification type. Comment: [Replacement of residues 1199 to 1206 by VTKVLLVI]" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "BRCA2 D1199Vfs*9" ; "https://reactome.org/content/detail/R-HSA-9712486" ; ; [ a ; [ a ; [ a ; 1206 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9712486" ; "BRCA2 D1199Vfs*9" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Dna" ; "MIXL1 gene" ; "https://reactome.org/content/detail/R-HSA-9756734" ; ; [ a ; ; ] ; [ a ; ; ] ; "ENSEMBL:ENSG00000185155" ; "Reactome:R-HSA-9756734" , "ENSEMBL:ENSG00000185155" ; "MIXL1 gene" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "KMT2D S1632*" ; "https://reactome.org/content/detail/R-HSA-9951096" ; ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 1632 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 1631 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9951096" ; "KMT2D S1632*" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "AcK-CYCS" ; "https://reactome.org/content/detail/R-HSA-5688308" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 105 ; ] ; [ a ; [ a ; 2 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-5688308" ; "Cytochrome c" , "AcK-CYCS" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "OTC E52K trimer" ; "https://reactome.org/content/detail/R-HSA-9958171" ; ; [ a ; ; ; "3"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-9958171" ; "OTC E52K trimer" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000012522" ; "PDSS2" ; "https://reactome.org/content/detail/R-HSA-2162264" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 399 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-2162264" , "http://purl.obolibrary.org/obo/PR_Q86YH6" ; "DLP1_HUMAN" , "Decaprenyl-diphosphate synthase subunit 2 ecNumber2.5.1.91/ecNumber" , "PDSS2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "FhuBCD" ; "https://reactome.org/content/detail/R-ECO-9930920" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; ; "Reactome:R-ECO-9930920" ; "FhuBCD" , "FhuB:FhuC:FhuD" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "MUCL1" ; "https://reactome.org/content/detail/R-HSA-1462337" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 90 ; ] ; [ a ; [ a ; 21 ; ] ; () ] ] ] ; [ a ; ; ] ; ; "Reactome:R-HSA-1462337" ; "Core 5 (MUCL1)" , "MUCL1_HUMAN" , "MUCL1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "BCAP Signalosome" ; "https://reactome.org/content/detail/R-HSA-2045909" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2045909" ; "BCAP Signalosome" , "p-BCAP:PI3K delta" , "p-PIK3AP1:PIK3CD:PIK3R1" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "DP1/2:E2F1" ; "https://reactome.org/content/detail/R-HSA-68653" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-68653" ; "E2F1:TFDP1,TFDP2" , "DP1/2:E2F1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "Laminin-4" ; "https://reactome.org/content/detail/R-HSA-2328137" ; ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ; "1"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2328137" ; "Laminin-4" , "Laminin-221" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "CRAT" ; "https://reactome.org/content/detail/R-HSA-9033096" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 626 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-9033096" ; "CRAT" , "Carnitine O-acetyltransferase" , "CACP_HUMAN" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "FCN1 ligands" ; "https://reactome.org/content/detail/R-ALL-2855114" ; ; [ a ; ; ] ; , , ; "Reactome:R-ALL-2855114" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "FCN1 ligands" , "Ficolin-1 ligands" . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Complex" ; "High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc" ; "https://reactome.org/content/detail/R-HSA-913384" ; ; [ a ; ; ; "2"^^ ] ; [ a ; ; ] ; ; "Reactome:R-HSA-913384" ; "High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc" . a . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "COL23A1" ; "https://reactome.org/content/detail/R-HSA-2473474" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-2473474" ; "CONA1_HUMAN" , "5-hydroxylysyl-collagen alpha-1(XXIII) transmembrane region" , "COL23A1" , "5Hyl-COL23A1(1-?)" . a ; "Isa http://purl.obolibrary.org/obo/PR_P84022" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-2S-SMAD3" ; "https://reactome.org/content/detail/R-HSA-177104" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 423 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; ; ] ; [ a ; [ a ; 425 ; ] ; () ] ] ] ; [ a ; [ a ; [ a ; 425 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-177104" , "http://purl.obolibrary.org/obo/PR_000049285" ; "Phospho-SMAD 3" , "p-S423,S425-SMAD3" , "p-2S-SMAD3" , "Mothers against decapentaplegic homolog 3" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-Y,S,T-WAVE" ; "https://reactome.org/content/detail/R-HSA-2263504" ; ; [ a ; ; ] ; , , ; "Reactome:R-HSA-2263504" ; [ a ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ; "p-Y,S,T-WAVE" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.PhysicalEntity" ; "Mature intronless transcript derived Histone mRNA" ; "https://reactome.org/content/detail/R-ALL-113820" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-113820" ; "Mature intronless transcript derived Histone mRNA" . a ; . a ; . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" , "Isa http://purl.obolibrary.org/obo/PR_000010019" ; "LZTFL1" ; "https://reactome.org/content/detail/R-HSA-5617789" ; ; [ a ; ; ] ; [ a ; ; ] ; [ a ; [ a ; [ a ; 299 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; ; "Reactome:R-HSA-5617789" , "http://purl.obolibrary.org/obo/PR_Q9NQ48" ; "LZTFL1" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "p-2S-SMAD2 MH2 Domain Mutants" ; "https://reactome.org/content/detail/R-HSA-3315475" ; ; [ a ; ; ] ; ; "Reactome:R-HSA-3315475" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; () ] ] ] ] ] ] ] ; "p-2S-SMAD2 MH2 Domain Mutants" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "SDC2" ; "https://reactome.org/content/detail/R-HSA-8956945" ; ; [ a ; [ a ; [ a ; 201 ; ] ; [ a ; [ a ; 19 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-8956945" ; "SDC2" , "SDC2_HUMAN" , "p-SDC2" , "Syndecan-2" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.SmallMolecule" ; "tolcapone" ; "https://reactome.org/content/detail/R-ALL-9679856" ; ; [ a ; ; ] ; ; "Reactome:R-ALL-9679856" ; "Tasmar®" , "tolcapone" , "Ro 40-7592" , "Ro-407592" . a ; "Isa http://purl.obolibrary.org/obo/PR_000003758" , "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "ADCY7" ; "https://reactome.org/content/detail/R-HSA-379057" ; ; [ a ; [ a ; [ a ; 1080 ; ] ; [ a ; [ a ; 1 ; ] ; () ] ] ] ; [ a ; ; ] ; [ a ; ; ] ; ; "Reactome:R-HSA-379057" , "http://purl.obolibrary.org/obo/PR_P51828" ; "ADCY7_HUMAN" , "Adenylate cyclase type 7" , "ADCY7" . a ; "BioPAX type: interface org.biopax.paxtools.model.level3.Protein" ; "Ficolin-rich granule lumen proteins" ; "https://reactome.org/content/detail/R-HSA-6800431" ; ; [ a ; ; ] ; , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ; "Reactome:R-HSA-6800431" ; [ a ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ; [ a ; ;